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196 条记录 (耗时 0.109 秒)

    Antibodies to Chemokine Alpha-5
    43.
    发明申请
    Antibodies to Chemokine Alpha-5 失效
    趋化因子α-5抗体

    公开(公告)号：US20060008882A1

    公开(公告)日：2006-01-12

    申请号：US11224076

    申请日：2005-09-13

    申请人： Ying-Fei Wei ,  Yi Li ,  Jian Ni ,  Craig Rosen ,  Steven Ruben

    发明人： Ying-Fei Wei ,  Yi Li ,  Jian Ni ,  Craig Rosen ,  Steven Ruben

    IPC分类号： C12P21/02 ,  C07H21/04 ,  C07K14/52 ,  C07K16/24

    CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K14/522 ,  C07K2319/00 ,  C12N2799/026 ,  Y02A50/423 ,  Y10T436/143333

    摘要： The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKα-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及作为α趋化因子家族成员的新型CKalpha-5蛋白。 特别地，提供编码人CKalpha-5蛋白的分离的核酸分子。 还提供了CKalpha-5多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还公开了特异性结合CKalpha-5多肽的抗体及其片段，以及制备这种抗体的组合物和方法。 本发明还涉及鉴定CKalpha-5活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Novel Metalloproteinases
    46.
    发明申请
    Novel Metalloproteinases 审中-公开
    新型金属蛋白酶

    公开(公告)号：US20070238130A1

    公开(公告)日：2007-10-11

    申请号：US11627246

    申请日：2007-01-25

    申请人： Jian Ni ,  Steven Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    发明人： Jian Ni ,  Steven Ruben ,  Laurie Brewer ,  Reiner Gentz ,  Craig Rosen

    IPC分类号： C12P1/04 ,  C07H21/04 ,  C07K14/00 ,  C07K16/18 ,  G01N33/53 ,  C12N15/00 ,  C12N5/06

    CPC分类号： C12N9/6489 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70535 ,  C12N9/00 ,  C12N9/6475 ,  C12N9/6491 ,  C12N2799/026

    摘要： The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.

    摘要翻译： 本发明涉及新型金属蛋白酶样蛋白质。 特别地，提供了分离的核酸分子，其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体，宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。