-
公开(公告)号：US20170204460A1
公开(公告)日：2017-07-20
申请号：US15462763
申请日：2017-03-17
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Everett Hurteau Meyer
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C07K16/00 , C07K2317/622 , C12N15/1006 , C12N15/1065 , C12N15/1075 , C12Q1/6837 , C12Q1/6846 , C12Q1/6883 , C12Q1/6886 , C12Q1/6888 , C12Q2600/156 , C40B50/06 , C12Q2525/161 , C12Q2525/307 , C12Q2563/159
Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.
-
42.发明授权公开(公告)号：US09422547B1
公开(公告)日：2016-08-23
申请号：US14734953
申请日：2015-06-09
Applicant: Gigagen, Inc.
Inventor： David Scott Johnson , Adam Adler , Rena Mizrahi
CPC classification number: C12N15/1037 , C07K14/7051 , C07K16/00 , C07K2317/14 , C07K2317/622 , C12N15/1075 , C12N15/1093 , C12Q1/6876 , C40B50/06
Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
Abstract translation: 本文公开了用于从免疫细胞产生重组融合多肽的所有组成成分的方法和组合物及其应用。
-
公开(公告)号：US20150125865A1
公开(公告)日：2015-05-07
申请号：US14368091
申请日：2012-12-20
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Gary Withey , Philip Homewood , Timothy Atkins
CPC classification number: C12N1/06 , B01F3/08 , B01F13/0071 , B01F13/0094 , B01F2215/0422 , B01F2215/0431 , B01L3/502715 , B01L3/50273 , B01L3/502784 , B01L2200/0647 , B01L2300/0867 , B01L2300/18 , B81B7/00 , G01N35/08
Abstract: Methods and systems are provided for merging a droplet with a volume of fluid in a microfluidic system. In particular, the methods of the invention use a microfluidic structure designed to merge a fluid with a droplet in order to dilute, add volume, or add selected reagents, biological materials, or synthetic materials to a droplet. Also provided are related systems and methods for cell lysis.
Abstract translation: 提供了用于在微流体系统中将液滴与一定体积的流体合并的方法和系统。 特别地，本发明的方法使用设计用于将流体与液滴合并的微流体结构，以稀释，添加体积或将选定的试剂，生物材料或合成材料添加到液滴中。 还提供了细胞裂解的相关系统和方法。
-
公开(公告)号：US11718660B2
公开(公告)日：2023-08-08
申请号：US17469493
申请日：2021-09-08
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Sheila Keating , Adam Shultz Adler , Michael Asensio , Kacy Stadtmiller , Emily Benzie , Ariel Niedecken , Angelica V. Medina-Cucurella , Rena Aviva Mizrahi , Yoong Wearn Lim
CPC classification number: C07K16/1081 , A61P31/14 , C07K2317/52 , C07K2317/565 , C07K2317/622
Abstract: Provided herein are compositions comprising recombinant polyclonal protein (RPP) derived from mammalian plasma cells and plasmablasts. Specifically, RPPs specific to Zika virus are provided. Also provided are the methods of using the RPP for treatment of viral infection and the methods of making the RPPs.
-
公开(公告)号：US20220064302A1
公开(公告)日：2022-03-03
申请号：US17418764
申请日：2019-12-27
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Rena Aviva Mizrahi , Yoong Wearn Lim , Michael Asensio
Abstract: Provided herein are antigen-binding proteins (ABPs) that selectively bind to PD-1 and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.
-
Patent Agency Ranking
公开(公告)号：US20220056137A1
公开(公告)日：2022-02-24
申请号：US17418768
申请日：2019-12-27
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Rena Aviva Mizrahi , Yoong Wearn Lim , Michael Asensio
Abstract: Provided herein are antigen-binding proteins (ABPs) that selectively bind to PD-L1 and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.
-
公开(公告)号：US20210292835A1
公开(公告)日：2021-09-23
申请号：US17337369
申请日：2021-06-02
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Everett Hurteau Meyer
IPC: C12Q1/6874 , C12N15/10 , C07K16/00 , C12Q1/6844 , C12Q1/6886 , C12Q1/6881 , C12Q1/6837 , C12Q1/6883 , C12Q1/6888
Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.
-
公开(公告)号：US20190390190A1
公开(公告)日：2019-12-26
申请号：US16414548
申请日：2019-05-16
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C12N15/10 , C12Q1/6806 , C12Q1/6869 , C07K14/74 , C07K14/725 , C07K16/00 , C12Q1/6888
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
-
公开(公告)号：US10214740B2
公开(公告)日：2019-02-26
申请号：US15156217
申请日：2016-05-16
Applicant: Gigagen, Inc.
Inventor： David Scott Johnson , Adam Adler , Rena Mizrahi
IPC: C40B50/06 , C12N15/10 , C07K16/00 , C07K14/725 , C12Q1/6876
Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
-
公开(公告)号：US09738699B2
公开(公告)日：2017-08-22
申请号：US15159705
申请日：2016-05-19
Applicant: Gigagen, Inc.
Inventor： David Scott Johnson , Adam Adler , Rena Mizrahi
IPC: C40B50/06 , C07K14/725 , C07K16/00 , C12N15/10 , C12Q1/68
CPC classification number: C12N15/1037 , C07K14/7051 , C07K16/00 , C07K2317/14 , C07K2317/622 , C12N15/1075 , C12N15/1093 , C12Q1/6876 , C40B50/06
Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
-
-
-
-
-
-
-
-
-
Search Results
55
records
(took 0.025 seconds)
