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41.发明授权Apparatus for assaying viscosity changes in fluid samples and method of conducting same 失效用于测定流体样品中粘度变化的装置及其传导方法
公开(公告)号：US5447440A
公开(公告)日：1995-09-05
申请号：US142130
申请日：1993-10-28
申请人： Graham Davis , Imants R. Lauks , Michael P. Zelin
发明人： Graham Davis , Imants R. Lauks , Michael P. Zelin
IPC分类号： G01N33/483 , G01N11/00 , G01N11/04 , G01N27/06 , G01N33/49 , G01N33/53 , G01N33/86 , C12Q1/68 , G01N11/02 , G01N21/85 , G01N27/07 , G01N33/00 , G01N33/15 , G01N33/48
CPC分类号： G01N33/4905 , G01N11/04 , Y10S435/96 , Y10S435/975 , Y10S436/806 , Y10S436/807 , Y10S436/816 , Y10S436/901 , Y10T436/115831 , Y10T436/12 , Y10T436/14 , Y10T436/141111 , Y10T436/143333
摘要： The present invention relates to an apparatus for conducting a variety of assays that are responsive to a change in the viscosity of a sample fluid and relates to methods of conducting such assays. In particular, the present invention is related to the use of a cartridge for conducting one or more coagulation assays or, conversely, fibrinolysis assays. The disclosed device enjoys simplicity and is adaptable to the point-of-care clinical diagnostic area, including use in accident sites, emergency rooms, surgery or intensive care units.
摘要翻译： 本发明涉及用于进行对样品流体的粘度变化的响应的各种测定的装置，并涉及进行这种测定的方法。 特别地，本发明涉及用于进行一次或多次凝血测定的药筒或相反地纤维蛋白溶解测定法。 所公开的设备具有简单性，并且适用于临床诊断区域，包括在事故现场，急诊室，手术或重症监护室中的使用。
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42.发明授权
公开(公告)号：US5112455A
公开(公告)日：1992-05-12
申请号：US555976
申请日：1990-07-20
申请人： Stephen N. Cozzette , Graham Davis , Lisa A. Holleritter , Imants R. Lauks , Sylvia Piznik , Nicolaas J. Smit , Jody A. Tirinato , Henry J. Wieck , Michael P. Zelin
发明人： Stephen N. Cozzette , Graham Davis , Lisa A. Holleritter , Imants R. Lauks , Sylvia Piznik , Nicolaas J. Smit , Jody A. Tirinato , Henry J. Wieck , Michael P. Zelin
IPC分类号： G01N27/26 , G01N27/27 , G01N27/327 , G01N27/414 , G01N27/416 , G01N33/543
CPC分类号： G01N27/3274
摘要： A method of determining the concentration of a preselected analyte species present in a sample fluid is disclosed, which method comprises: (a) providing an external computational means, a reference electrode and at least one substantially dry-stored sensor capable of exhibiting a response to changes in the concentration of a preselected analyte species before the sensor attains full equilibrated wet-up; (b) establishing electrical contact between the sensor, reference electrode and external computational means; (c) contacting the sensor and reference electrode with a calibrant fluid; (d) performing a first signal measurement in a first time window in the presence of the calibrant fluid; (e) displacing the calibrant fluid after performing the first signal measurement; (f) contacting the sensor and reference electrode with a sample fluid; (g) performing a second signal measurement in a second time window in the presence of the sample fluid; and (h) relating the first and second signal measurements to determine the concentration of the preselected analyte species in the sample fluid before said sensor attains full equilibrated wet-up. Alternative methods are disclosed further for collecting, relating and manipulating the results of the signal measurements to provide useful estimates of the analyte concentrations of interest.
摘要翻译： 公开了一种确定存在于样品流体中的预先选择的分析物种的浓度的方法，该方法包括：（a）提供外部计算装置，参考电极和至少一个基本上干燥储存的传感器，其能够显示对 在传感器达到完全平衡润湿之前，预选的分析物种的浓度变化; （b）建立传感器，参比电极和外部计算装置之间的电接触; （c）使传感器和参比电极与校准液接触; （d）在存在校准液的情况下在第一时间窗中执行第一信号测量; （e）在执行第一信号测量之后移动校准液; （f）使传感器和参比电极接触样品流体; （g）在存在样品流体的情况下在第二时间窗中执行第二信号测量; 和（h）将第一和第二信号测量值相关联，以确定在所述传感器达到完全平衡的润湿之前样品流体中预先选择的分析物种的浓度。 进一步披露替代方法来收集，相关和操纵信号测量结果，以提供感兴趣的分析物浓度的有用估计。
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公开(公告)号：US4758323A
公开(公告)日：1988-07-19
申请号：US607698
申请日：1984-05-07
申请人： Graham Davis , Hugh A. O. Hill
发明人： Graham Davis , Hugh A. O. Hill
CPC分类号： A61B5/1486 , A61B5/6848 , C12Q1/001 , C12Q1/004 , Y10S435/817
摘要： This specification discloses methods of detection or measurement of an enzyme or of its specific substrate, and sensors used in such methods. The present invention is concerned with a multi-enzyme system, and the specification discloses, as one aspect of the invention a method of assay in which an electrode poised at a suitable potential is contacted with a system comprising a first enzyme, a cofactor linked with said enzyme and a mediator compound which transfers charge to the electrode from the first enzyme when its electrical state is changed by reaction of cofactor material.The cofactor may be NAD, NADP (both collectively referred to herein as NAD(P)), cAMP, ATP, GTP, TTP, or CTP.The specification particularly illustrates a method of assay in which an electrode (1) poised at a suitable potential is contacted with a system comprising a first enzyme E.sub.1 a nicotinamide adenine dinucleotide compound N linked with said enzyme E.sub.1 and a mediator compound F which transfers charge to the electrodes from the first enzyme when its electrical state is changed by a NAD(P) NAD(P)H reaction. The NAD compound may act as a "bridge" between the said enzyme/mediator system and further NAD utilizing enzyme E2.
摘要翻译： 本说明书公开了检测或测量酶或其特定底物的方法，以及用于这些方法的传感器。 本发明涉及多酶系统，并且本说明书作为本发明的一个方面公开了一种测定方法，其中将以合适的电位稳定的电极与包含第一酶，辅因子 所述酶和介体化合物，当其电状态通过辅因子材料的反应而改变时，将电荷从第一酶转移到电极。 辅因子可以是NAD，NADP（两者统称为NAD（P）），cAMP，ATP，GTP，TTP或CTP。 该说明书特别说明了一种测定方法，其中使合适电位稳定的电极（1）与包含第一酶E1的系统接触，所述系统包括与所述酶E1连接的烟酰胺腺嘌呤二核苷酸化合物N和将电荷转移至 当其电状态由NAD（P）NAD（P）H反应改变时，来自第一酶的电极。 NAD化合物可以作为所述酶/介体体系之间的“桥”，还可以利用酶E2进一步的NAD。
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公开(公告)号：US08831983B2
公开(公告)日：2014-09-09
申请号：US13051520
申请日：2011-03-18
CPC分类号： G01K13/00 , G01K1/02 , G01K3/04 , G06Q10/087 , G06Q20/203 , G06Q30/0223 , G06Q30/0639 , Y10S707/99931
摘要： A system and method are disclosed for controlling an inventory of point-of-care diagnostic devices. The inventory includes a main inventory and at least one subinventory. Each device has an ambient temperature shelf life. Data associated with the devices is entered, including: the current quantity and predetermined minimum quantity of devices in the main inventory; and the current quantity and predetermined minimum quantity of devices in the subinventory. A first timestamp is associated with each device when the device is transferred from the main inventory to the ambient temperature subinventory. The first timestamp is compared to a second timestamp prior to use of the device to determine whether the device's ambient temperature shelf life is exceeded. The current quantity of devices in the subinventory is updated in response to an event that causes a change in the current quantity of devices in the subinventory.
摘要翻译： 公开了一种用于控制点护理诊断装置的库存的系统和方法。 库存包括主要库存和至少一个子库存。 每个设备具有环境温度保质期。 输入与设备相关的数据，包括：主库存中的当前数量和预定最小数量的设备; 以及子库存中的当前数量和预定的最小数量的设备。 当设备从主库存转移到环境温度子库时，第一个时间戳与每个设备相关联。 在使用设备之前，将第一个时间戳与第二个时间戳进行比较，以确定设备的环境温度保质期是否超过。 响应于导致子库中当前设备数量发生变化的事件，子库中当前的设备数量被更新。
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公开(公告)号：US08486721B2
公开(公告)日：2013-07-16
申请号：US13559753
申请日：2012-07-27
IPC分类号： G01N33/553 , G01N1/00
CPC分类号： G01N33/54326 , Y10T436/25125
摘要： Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample with magnetic sacrificial beads opsonized to leukocytes, binding leukocytes in the sample to the magnetic sacrificial beads, and magnetically retaining the beads out of contact from an immunosensor.
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公开(公告)号：US08476079B2
公开(公告)日：2013-07-02
申请号：US12771634
申请日：2010-04-30
申请人： John Lewis Emerson Campbell , Graham Davis , John Emegbero Omakor , Adam Roger Moss , Ganesh Guhados
发明人： John Lewis Emerson Campbell , Graham Davis , John Emegbero Omakor , Adam Roger Moss , Ganesh Guhados
CPC分类号： G01N33/54393 , G01N33/5306 , G01N33/5375 , G01N33/74 , G01N2333/475 , Y10T436/25125 , Y10T436/25375
摘要： Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample such as a whole blood sample with one or more leukocidal reagents that reduce or eliminate the metabolic activity of leukocytes, and performing an immunoassay on the amended sample to determine the concentration of analyte in the sample. Preferably, the sample is amended with one or more enzymes and optionally one or more enzyme substrates and cofactors.
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公开(公告)号：US08394325B2
公开(公告)日：2013-03-12
申请号：US12815132
申请日：2010-06-14
CPC分类号： G01N33/54326 , Y10T436/25125
摘要： Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample with magnetic sacrificial beads opsonized to leukocytes, binding leukocytes in the sample to the magnetic sacrificial beads, and magnetically retaining the beads out of contact from an immunosensor.
摘要翻译： 提供了用于减少分析物免疫测定中白细胞干扰的方法和装置。 在一个实施方案中，提供了一种方法，其包括以下步骤：利用调理到白细胞的磁性牺牲珠修饰生物样品，将样品中的白细胞与磁性牺牲珠结合，以及磁性地保持珠与免疫传感器接触。
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48.发明申请公开(公告)号：US20120295290A1
公开(公告)日：2012-11-22
申请号：US13559753
申请日：2012-07-27
IPC分类号： G01N27/26
CPC分类号： G01N33/54326 , Y10T436/25125
摘要： Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample with magnetic sacrificial beads opsonized to leukocytes, binding leukocytes in the sample to the magnetic sacrificial beads, and magnetically retaining the beads out of contact from an immunosensor.
摘要翻译： 提供了用于减少分析物免疫测定中白细胞干扰的方法和装置。 在一个实施方案中，提供了一种方法，其包括以下步骤：利用调理到白细胞的磁性牺牲珠修饰生物样品，将样品中的白细胞与磁性牺牲珠结合，以及磁性地保持珠与免疫传感器接触。
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公开(公告)号：US20110166427A1
公开(公告)日：2011-07-07
申请号：US13051520
申请日：2011-03-18
CPC分类号： G01K13/00 , G01K1/02 , G01K3/04 , G06Q10/087 , G06Q20/203 , G06Q30/0223 , G06Q30/0639 , Y10S707/99931
摘要： A system and method are disclosed for controlling an inventory of point-of-care diagnostic devices. The inventory includes a main inventory and at least one subinventory. Each device has an ambient temperature shelf life. Data associated with the devices is entered, including: the current quantity and predetermined minimum quantity of devices in the main inventory; and the current quantity and predetermined minimum quantity of devices in the subinventory. A first timestamp is associated with each device when the device is transferred from the main inventory to the ambient temperature subinventory. The first timestamp is compared to a second timestamp prior to use of the device to determine whether the device's ambient temperature shelf life is exceeded. The current quantity of devices in the subinventory is updated in response to an event that causes a change in the current quantity of devices in the subinventory.
摘要翻译： 公开了一种用于控制点护理诊断装置的库存的系统和方法。 库存包括主要库存和至少一个子库存。 每个设备具有环境温度保质期。 输入与设备相关的数据，包括：主库存中的当前数量和预定最小数量的设备; 以及子库存中的当前数量和预定的最小数量的设备。 当设备从主库存转移到环境温度子库时，第一个时间戳与每个设备相关联。 在使用设备之前，将第一个时间戳与第二个时间戳进行比较，以确定设备的环境温度保质期是否超过。 响应于导致子库中当前设备数量发生变化的事件，子库中当前的设备数量被更新。
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公开(公告)号：US20090204513A1
公开(公告)日：2009-08-13
申请号：US12428969
申请日：2009-04-23
IPC分类号： G06Q10/00
CPC分类号： G01K13/00 , G01K1/02 , G01K3/04 , G06Q10/087 , G06Q20/203 , G06Q30/0223 , G06Q30/0639 , Y10S707/99931
摘要： A system and method are disclosed for controlling an inventory of point-of-care diagnostic devices. The inventory includes a main inventory and at least one subinventory. Each device has an ambient temperature shelf life. Data associated with the devices is entered, including: the current quantity and predetermined minimum quantity of devices in the main inventory; and the current quantity and predetermined minimum quantity of devices in the subinventory. A first timestamp is associated with each device when the device is transferred from the main inventory to the ambient temperature subinventory. The first timestamp is compared to a second timestamp prior to use of the device to determine whether the device's ambient temperature shelf life is exceeded. The current quantity of devices in the subinventory is updated in response to an event that causes a change in the current quantity of devices in the subinventory.
摘要翻译： 公开了一种用于控制点护理诊断装置的库存的系统和方法。 库存包括主要库存和至少一个子库存。 每个设备具有环境温度保质期。 输入与设备相关的数据，包括：主库存中的当前数量和预定最小数量的设备; 以及子库存中的当前数量和预定的最小数量的设备。 当设备从主库存转移到环境温度子库时，第一个时间戳与每个设备相关联。 在使用设备之前，将第一个时间戳与第二个时间戳进行比较，以确定设备的环境温度保质期是否超过。 响应于导致子库中当前设备数量发生变化的事件，子库中当前的设备数量被更新。
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