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公开(公告)号：US09484194B2
公开(公告)日：2016-11-01
申请号：US13885913
申请日：2011-11-16
CPC分类号： H01J49/0077 , H01J49/00 , H01J49/0031 , H01J49/0036 , H01J49/0054 , H01J49/0072 , H01J49/06 , H01J49/065 , H01J49/26
摘要： A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.
摘要翻译： 公开了一种质谱仪，其包括用于分离离子的液相色谱装置。 气相离子中性反应装置设置在下游以进行气相离子 - 中性反应如氢氘交换。 控制系统被布置成在第一操作模式和第二操作模式之间来回自动重复地切换反应装置，其中在第一操作模式中，使至少一些母体或前体离子在反应中反应 器件，并且其中在第二操作模式中基本上较少或没有使母体或前体离子发生反应。
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公开(公告)号：US20130122599A1
公开(公告)日：2013-05-16
申请号：US13522513
申请日：2011-01-31
申请人： Jeffery Mark Brown , Iain Campuzano , Darryl W. Brousmiche , Craig Dorschel , Jonathan Paul Williams , Steven Derek Pringle , Keith Richardson
发明人： Jeffery Mark Brown , Iain Campuzano , Darryl W. Brousmiche , Craig Dorschel , Jonathan Paul Williams , Steven Derek Pringle , Keith Richardson
IPC分类号： G01N33/68 , C07C205/06 , C07C47/55 , C07C255/51 , C07C47/54 , C07C205/44
摘要： A mass spectrometry electron transfer dissociation reagent comprising an unsaturated compound having a Frank Condon factor between 0.1 and 1.0 and an electron affinity having a positive value between 0.1 to 150 kJ/mol.
摘要翻译： 一种质谱电子转移离解试剂，其包含Frank Condon因子在0.1至1.0之间的不饱和化合物和具有0.1至150kJ / mol的正值的电子亲和力。
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43.发明申请公开(公告)号：US20150034813A1
公开(公告)日：2015-02-05
申请号：US13885913
申请日：2011-11-16
CPC分类号： H01J49/0077 , H01J49/00 , H01J49/0031 , H01J49/0036 , H01J49/0054 , H01J49/0072 , H01J49/06 , H01J49/065 , H01J49/26
摘要： A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.
摘要翻译： 公开了一种质谱仪，其包括用于分离离子的液相色谱装置。 气相离子中性反应装置设置在下游以进行气相离子 - 中性反应如氢氘交换。 控制系统被布置成在第一操作模式和第二操作模式之间来回自动重复地切换反应装置，其中在第一操作模式中，使至少一些母体或前体离子在反应中反应 器件，并且其中在第二操作模式中基本上较少或没有使母体或前体离子发生反应。
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公开(公告)号：US20110189788A1
公开(公告)日：2011-08-04
申请号：US13055612
申请日：2009-07-27
CPC分类号： H01J49/12 , G01N24/00 , H01J49/0009 , H01J49/0072 , H01J49/0495 , H01J49/107 , H01J49/165 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode (14) which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
摘要翻译： 公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。 辉光放电装置可以包括设置在真空室中的隔离阀（15）内的管状电极（14）。 可以通过管状电极（14）提供试剂蒸气，然后其随后通过辉光放电电离。 所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。 考虑其他实施例，其中由辉光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。
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公开(公告)号：US09080936B2
公开(公告)日：2015-07-14
申请号：US13055612
申请日：2009-07-27
CPC分类号： H01J49/12 , G01N24/00 , H01J49/0009 , H01J49/0072 , H01J49/0495 , H01J49/107 , H01J49/165 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapor may be provided through the tubular electrode (14) which is then subsequently ionized by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
摘要翻译： 公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。 辉光放电装置可以包括设置在真空室中的隔离阀（15）内的管状电极（14）。 可以通过管状电极（14）提供试剂蒸汽，然后其随后通过辉光放电电离。 所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。 考虑其他实施例，其中由辉光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。
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公开(公告)号：US08987663B2
公开(公告)日：2015-03-24
申请号：US14123566
申请日：2012-06-01
CPC分类号： H01J49/04 , H01J49/067 , H01J49/24
摘要： An ion inlet for a mass spectrometer is disclosed comprising a housing having a sampling orifice and an atmospheric pressure orifice. One or more gas outlets are provided in the housing. Gas is drawn through the sampling orifice by a pump so that the gas exits via the one or more gas outlets.
摘要翻译： 公开了一种用于质谱仪的离子入口，其包括具有采样孔和大气压力孔的壳体。 一个或多个气体出口设置在壳体中。 通过泵将气体抽吸通过采样孔，使得气体经由一个或多个气体出口排出。
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公开(公告)号：US20090302209A1
公开(公告)日：2009-12-10
申请号：US12297481
申请日：2007-04-30
IPC分类号： H01J49/28
CPC分类号： H01J49/065 , H01J49/0031 , H01J49/022 , H01J49/062 , H01J49/36 , H01J49/4235 , Y10T436/24
摘要： An ion guide or mass analyser (2) is disclosed comprising a plurality of electrodes (2a) having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser (2). The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages (4) are applied to the electrodes (2a) of the ion guide or mass analyser (2) in order to urge ions along the length of the ion guides or mass analyser (2). The amplitude of the transient DC voltage (4) applied to the electrode (2a) may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser (2) in reverse order of their mass to charge ratio.
摘要翻译： 公开了一种离子导向器或质量分析器（2），其包括具有孔的多个电极（2a），在使用中通过该孔具有离子。 在离子导向器或质量分析器（2）的出口处产生伪势垒。 伪势垒的幅度或深度与离子的质荷比成反比。 一个或多个瞬态DC电压（4）被施加到离子导向器或质量分析器（2）的电极（2a），以促使沿着离子导向器或质量分析器（2）的长度的离子。 施加到电极（2a）的瞬态直流电压（4）的振幅可以随时间增加，从而离子引导或质量分析器（2）以与其质荷比相反的顺序发射离子。
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公开(公告)号：US20140306103A1
公开(公告)日：2014-10-16
申请号：US14123566
申请日：2012-06-01
IPC分类号： H01J49/04
CPC分类号： H01J49/04 , H01J49/067 , H01J49/24
摘要： An ion inlet for a mass spectrometer is disclosed comprising a housing having a sampling orifice and an atmospheric pressure orifice. One or more gas outlets are provided in the housing. Gas is drawn through the sampling orifice by a pump so that the gas exits via the one or more gas outlets.
摘要翻译： 公开了一种用于质谱仪的离子入口，其包括具有采样孔和大气压力孔的壳体。 一个或多个气体出口设置在壳体中。 通过泵将气体抽吸通过采样孔，使得气体经由一个或多个气体出口排出。
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49.发明授权Method of screening a sample for the presence of one or more known compounds of interest and a mass spectrometer performing this method 有权筛选样品中存在一种或多种已知的目标化合物的方法和进行该方法的质谱仪公开(公告)号：US08822914B2
公开(公告)日：2014-09-02
申请号：US13394089
申请日：2010-09-06
IPC分类号： B01D59/44
CPC分类号： H01J49/40 , H01J49/0027 , H01J49/004
摘要： A method of screening a sample for the presence of one or more known compounds of interest is disclosed. A fragmentation device is repeatedly switched between a fragmentation mode of operation and a non-fragmentation mode of operation. A determination is made whether a candidate parent ion of interest is present in a non-fragmentation data set and whether one or more corresponding fragment ions of interest are present in a fragmentation data set. A further determination is made to check if the candidate parent ion of interest and the one or more corresponding fragment ions of interest have substantially similar elution or retention times and/or ion mobility drift times.
摘要翻译： 公开了筛选样品中存在一种或多种已知化合物的方法。 分段设备在分段操作模式和非分段操作模式之间重复切换。 确定感兴趣的候选母体离子是否存在于非碎裂数据集中，以及感兴趣的一个或多个相应的碎片离子是否存在于碎裂数据集中。 进一步确定检查感兴趣的候选亲本离子和感兴趣的一个或多个相应碎片离子是否具有基本相似的洗脱或保留时间和/或离子迁移率漂移时间。
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公开(公告)号：US08294088B2
公开(公告)日：2012-10-23
申请号：US12745265
申请日：2008-12-01
申请人： Steven Derek Pringle
发明人： Steven Derek Pringle
IPC分类号： H01J49/02
CPC分类号： H01J49/025 , H01J47/02
摘要： A mass spectrometer is disclosed comprising a Gas Electron Multiplier ion detector. The ion detector comprises three gas electron multiplier stages GEM1, GEM2, GEM3 wherein a counter electrode (12) is arranged adjacent the first electron multiplier stage GEM1.
摘要翻译： 公开了一种质谱仪，其包括气体电子倍增器离子检测器。 离子检测器包括三个气体电子倍增器级GEM1，GEM2，GEM3，其中相对电极（12）被布置为与第一电子倍增器级GEM1相邻。
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