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41.发明申请In Situ Modification of Therapeutic Agents Using Heat Exchange Catheter System 审中-公开使用换热导管系统治疗药物的原位修饰公开(公告)号：US20120283562A1
公开(公告)日：2012-11-08
申请号：US13367910
申请日：2012-02-07
CPC分类号： A61F7/12 , A61B18/00 , A61B18/082 , A61B18/245 , A61B2017/00084 , A61B2017/22051 , A61B2018/00095 , A61F7/007 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0056 , A61F2007/0086 , A61F2007/0093 , A61F2007/0095 , A61F2007/0096 , A61F2007/126 , A61M25/00 , A61M25/1011 , A61M2025/0078 , A61M2025/1072 , A61M2025/1086 , A61M2205/366 , A61M2206/10 , A61M2230/50
摘要： Closed loop heat exchange catheter systems and methods for preparing and using such systems wherein a reservoir or fluid bag is connected to the catheter system and used for at least priming of the system with a heat exchange fluid.
摘要翻译： 闭环热交换导管系统以及用于制备和使用这种系统的方法，其中储存器或流体袋连接到导管系统并用于至少用热交换流体灌注系统。
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42.发明申请Methods for Preparing a Heat Exchange Catheter System and for Heating and/or Cooling a Subject's Body 审中-公开制备热交换导管系统和加热和/或冷却受试者身体的方法公开(公告)号：US20120203201A1
公开(公告)日：2012-08-09
申请号：US13367956
申请日：2012-02-07
CPC分类号： A61F7/12 , A61B18/00 , A61B18/082 , A61B18/245 , A61B2017/00084 , A61B2017/22051 , A61B2018/00095 , A61F7/007 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0056 , A61F2007/0086 , A61F2007/0093 , A61F2007/0095 , A61F2007/0096 , A61F2007/126 , A61M25/00 , A61M25/1011 , A61M2025/0078 , A61M2025/1072 , A61M2025/1086 , A61M2205/366 , A61M2206/10 , A61M2230/50
摘要： Closed loop heat exchange catheter systems and methods for preparing and using such systems wherein a reservoir or fluid bag is connected to the catheter system and used for at least priming of the system with a heat exchange fluid.
摘要翻译： 闭环热交换导管系统以及用于制备和使用这种系统的方法，其中储存器或流体袋连接到导管系统并用于至少用热交换流体灌注系统。
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43.发明授权公开(公告)号：US08163013B2
公开(公告)日：2012-04-24
申请号：US12924219
申请日：2010-09-23
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/0417 , A61B2017/0453 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61F2/2445 , A61F2/2451 , A61F2/2487
摘要： Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial retrievability. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize a bridge stop to secure the implant, and the methods of implantation employ various tools.
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公开(公告)号：US20120035718A1
公开(公告)日：2012-02-09
申请号：US13272716
申请日：2011-10-13
IPC分类号： A61F2/24
CPC分类号： A61F2/2487 , A61B17/00234 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/00876 , A61B2017/0417 , A61B2017/0453 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61F2/2445 , A61F2/2451 , A61F2/2454 , A61F2/2466 , A61F2210/009 , A61F2230/0093 , A61F2250/0012
摘要： Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial retrievability. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize a bridge stop to secure the implant, and the methods of implantation employ various tools.
摘要翻译： 植入物或植入物和方法的系统在左心房内或横过左心房施加选定的力向量或力向量的选择组合，这允许二尖瓣小叶更好地适应。 植入物和植入物和方法的植入物或系统使得可以快速部署，容易的血管内递送和完全的房内可检索性。 植入物或植入物和方法的植入物或系统也利用强荧光检查标志。 植入物和植入物和植入物的系统利用可调植入物和固定长度植入物。 植入物和植入物的方式的植入物或系统还可以利用桥接止动件来固定植入物，并且植入方法使用各种工具。
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45.发明申请Methods and Apparatus for Treating or Deterring Injuries to or Disorders of the Brain or Spinal Cord of a Subject 审中-公开用于治疗或阻止受试者的脑或脊髓的损伤或障碍的方法和装置公开(公告)号：US20110275935A1
公开(公告)日：2011-11-10
申请号：US13182805
申请日：2011-07-14
IPC分类号： A61F7/12 , A61M25/14 , A61M29/00 , A61M25/088 , A61M36/04 , A61M25/098 , A61M25/10 , A61M25/00 , A61B18/14
CPC分类号： A61F7/12 , A61B18/00 , A61B18/082 , A61B18/245 , A61B2017/00084 , A61B2017/22051 , A61B2018/00095 , A61F7/007 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0056 , A61F2007/0086 , A61F2007/0093 , A61F2007/0095 , A61F2007/0096 , A61F2007/126 , A61M25/00 , A61M25/1011 , A61M2025/0078 , A61M2025/1072 , A61M2025/1086 , A61M2205/366 , A61M2206/10 , A61M2230/50
摘要： Methods and apparatus for treating or deterring injuries to or disorders of the brain or spinal cord of a subject. A heat exchange catheter device is inserted into the subject's body and used to cause heating or cooling the subject's cerebrospinal fluid. In some embodiments, the heat exchanger may be positioned within the subject's vasculature so as to heat or cool the flowing blood, thereby resulting in heating or cooling of the cerebrobpinal fluid.
摘要翻译： 用于治疗或阻止受试者的脑或脊髓损伤或障碍的方法和装置。 将热交换导管装置插入受试者的身体并用于引起受试者脑脊液的加热或冷却。 在一些实施例中，热交换器可以被定位在受试者的脉管系统内，以便加热或冷却流动的血液，从而导致脑脊液的加热或冷却。
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46.发明授权公开(公告)号：US07771460B2
公开(公告)日：2010-08-10
申请号：US11931463
申请日：2007-10-31
申请人： Robert Ginsburg , Arlene S. Ginsburg, legal representative , Timothy R. Machold , Michael T. Dineen
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B18/00 , A61B18/082 , A61B18/245 , A61B2017/00084 , A61B2017/22051 , A61B2018/00095 , A61F7/007 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0056 , A61F2007/0086 , A61F2007/0093 , A61F2007/0095 , A61F2007/0096 , A61F2007/126 , A61M25/00 , A61M25/1011 , A61M2025/0078 , A61M2025/1072 , A61M2025/1086 , A61M2205/366 , A61M2206/10 , A61M2230/50
摘要： Methods and apparatus for temperature modification of selected body regions including an induced state of local hypothermia of the brain region for neuroprotection. A heat exchange catheter is provided with heat transfer fins projecting or extending outward from the catheter which may be inserted into selected blood vessels or body regions to transfer heat with blood or fluid in the selected blood vessels or body regions. Another aspect of the invention further provides methods and apparatus for controlling the internal body temperature of a patient. By selectively heating or cooling a portion of the catheter lying within a blood vessel, heat may be transferred to or from blood flowing within the vessel to increase or decrease whole body temperature or the temperature of a target region. Feed back from temperature sensors located within the patient's body allow for control of the heat transfer from the catheter to automatically control the temperature of the patient or of the target region within the patient. The apparatus may include a blood channeling sleeve that directs body fluid over a heat exchanger where the body fluid's temperature is altered, and then is discharged out the distal end of the sleeve to a desired location, for example, cooled blood to the brain for neuroprotection. The catheter may be used alone or in conjunction with other heat exchangers to cool one region of a patient's body while heating another.
摘要翻译： 包括神经保护用脑区局部低温诱导状态的选择体区的温度改变方法和装置。 热交换导管设置有从导管向外突出或向外延伸的传热翅片，其可以插入到选定的血管或身体区域中，以将热量与所选择的血管或身体区域中的血液或流体传热。 本发明的另一方面还提供了用于控制患者体内温度的方法和装置。 通过选择性地加热或冷却位于血管内的导管的一部分，热量可以转移到血管内流动的血液或从血液中流出的血液转移，以增加或减少全身体温或目标区域的温度。 从位于病人体内的温度传感器反馈，可以控制从导管传导的热量，以自动控制患者或患者内目标区域的温度。 该装置可以包括引导体液在体液温度改变的热交换器上引导体液，然后将其从套管的远端排出到期望的位置，例如冷却到脑的血液用于神经保护 。 导管可以单独使用或与其他热交换器结合使用以冷却患者身体的一个区域，同时加热另一个。
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公开(公告)号：US20100161044A1
公开(公告)日：2010-06-24
申请号：US12658909
申请日：2010-02-17
IPC分类号： A61F2/24
CPC分类号： A61F2/2487 , A61B17/00234 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/00876 , A61B2017/0417 , A61B2017/0453 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61F2/2445 , A61F2/2451 , A61F2/2454 , A61F2/2466 , A61F2210/009 , A61F2230/0093 , A61F2250/0012
摘要： Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial retrievability. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize a bridge stop to secure the implant, and the methods of implantation employ various tools.
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公开(公告)号：US07527646B2
公开(公告)日：2009-05-05
申请号：US10676729
申请日：2003-10-01
IPC分类号： A61F2/24
CPC分类号： A61F2/2454
摘要： Devices, systems and methods retain a native heart valve leaflet to prevent retrograde flow. The devices, systems, and methods employ an implant that, in use, rests adjacent a valve annulus and includes a retaining structure that is sized and shaped to overlay at least a portion of one or more native valve leaflets. The retaining structure retains the leaflet or leaflets it overlays, to resist leaflet eversion and/or prolapse. In this way, the implant prevents or reduces regurgitation. The implant does not interfere significantly with the opening of and blood flow through the leaflets during periods of antegrade flow.
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公开(公告)号：US20080140188A1
公开(公告)日：2008-06-12
申请号：US11980838
申请日：2007-10-31
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B2017/00243 , A61B2017/00783 , A61B2017/00876 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/0419 , A61B2017/0427 , A61B2017/0437 , A61B2017/0464 , A61B2017/0496 , A61B2017/0641 , A61B2017/0647 , A61F2002/30079 , A61F2210/009 , Y10S623/904
摘要： Devices, systems, and methods employ a heart implant structure that is sized and configured to be positioned in a left atrium above the plane of a native mitral heart valve annulus to affect mitral heart valve function. The implant structure includes a portion sized and configured to engage a wall of the left atrium above the plane of the native mitral valve annulus and to extend across the left atrium along a minor axis of the annulus.
摘要翻译： 装置，系统和方法使用心脏植入物结构，其尺寸和构造被定位成位于天然二尖瓣心瓣膜平面上方的左心房中以影响二尖瓣心脏瓣膜功能。 所述植入物结构包括尺寸和构造成使所述左心房的壁在所述天然二尖瓣环的平面上方接合并且沿着所述环的短轴延伸穿过所述左心房的部分。
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50.发明授权Methods and systems for performing thoracoscopic coronary bypass and other procedures 失效执行胸腔镜冠状动脉搭桥及其他手术的方法和系统公开(公告)号：US07131447B2
公开(公告)日：2006-11-07
申请号：US10832143
申请日：2004-04-26
申请人： Wesley D. Sterman , Lawrence C. Siegel , Patricia E. Curtis , John H. Stevens , William S. Peters , Timothy R. Machold
发明人： Wesley D. Sterman , Lawrence C. Siegel , Patricia E. Curtis , John H. Stevens , William S. Peters , Timothy R. Machold
IPC分类号： A61F17/00
CPC分类号： A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/064 , A61B17/068 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B17/29 , A61B17/2909 , A61B17/30 , A61B17/3403 , A61B18/1442 , A61B18/1492 , A61B90/50 , A61B2017/00053 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2017/00637 , A61B2017/00663 , A61B2017/00867 , A61B2017/00907 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2943 , A61B2017/306 , A61B2017/3405 , A61B2017/3427 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00982 , A61B2090/064 , A61F2/2427 , A61M25/0032 , A61M25/1011 , A61M39/0247 , A61M2025/0003 , A61M2025/0031 , A61M2025/028 , A61M2025/1052 , A61M2039/0258 , A61M2039/0273 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , A61M2230/005
摘要： A method for closed-chest cardiac surgical intervention relies on viewing the cardiac region through a thoracoscope or other viewing scope and endovascularly partitioning the patient's arterial system at a location within the ascending aorta The cardiopulmonary bypass and cardioplegia can be induced, and a variety of surgical procedures performed on the stopped heart using percutaneously introduced tools. The method of the present invention will be particularly suitable for forming coronary artery bypass grafts, where an arterial blood source is created using least invasive surgical techniques, and the arterial source is connected to a target location within a coronary artery while the patient is under cardiopulmonary bypass and cardioplegia.
摘要翻译： 闭胸心脏外科手术的方法依赖于通过胸腔镜或其他观察范围观察心脏区域，并且在升主动脉内的位置处血管内划分患者的动脉系统可以诱导心肺分流术和心麻痹，以及各种手术 使用经皮介绍的工具在停止的心脏上进行的程序。 本发明的方法将特别适用于形成冠状动脉旁路移植物，其中使用最少侵入性手术技术产生动脉血源，并且当患者处于心肺时，动脉源连接到冠状动脉内的目标位置 旁路和心麻痹。
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