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41.
公开(公告)号:US06787088B2
公开(公告)日:2004-09-07
申请号:US10316571
申请日:2002-12-10
IPC分类号: B29C4516
CPC分类号: B01L3/502707 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00995 , B01L3/50273 , B01L2200/0689 , B01L2200/12 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/12 , B01L2400/0418 , G01N27/44791 , Y10S366/03 , Y10T29/49229 , Y10T137/2224
摘要: Microfluidic devices are provided for the performance of chemical and biochemical analyzes, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.
摘要翻译: 提供微流控器件用于化学和生物化学分析,合成和检测的性能。 本发明的装置将精确的流体控制系统与微制造的聚合物基底结合在一起,以提供精确,低成本的小型化分析装置,其在化学,生物化学,生物技术,分子生物学和许多其它领域中具有广泛的应用。
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公开(公告)号:US06558944B1
公开(公告)日:2003-05-06
申请号:US09346660
申请日:1999-07-01
IPC分类号: G01N33558
CPC分类号: G01N33/5091 , B01J19/0093 , B01L3/5025 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L9/527 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5044 , G01N33/5064 , G01N33/5094 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809
摘要: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
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43.
公开(公告)号:US06479299B1
公开(公告)日:2002-11-12
申请号:US09132963
申请日:1998-08-12
IPC分类号: G01N33558
CPC分类号: G01N33/502 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0487 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/5091 , G01N33/5097 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/817 , Y10S436/804 , Y10S436/805 , Y10S436/806 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/117497 , Y10T436/25
摘要: Microfluidic devices having predisposed assay components for increased throughput and prolonged shelf life are provided.
摘要翻译: 提供具有易于检测成分的用于增加产量和延长保质期的微流体装置。
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44.
公开(公告)号:US06429025B1
公开(公告)日:2002-08-06
申请号:US09214035
申请日:1998-12-22
IPC分类号: G01N33558
CPC分类号: G01N33/502 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00952 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0487 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/5091 , G01N33/5097 , G01N33/5304 , G01N33/57415 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/817 , Y10S436/804 , Y10S436/805 , Y10S436/806 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/117497 , Y10T436/25
摘要: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
摘要翻译: 本发明提供了可用于进行高通量筛选测定的新型微流体装置和方法。 特别地,本发明的装置和方法可用于筛选大量不同的化合物,因为它们对多种化学品,优选生物化学体系的影响。
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公开(公告)号:US06379974B1
公开(公告)日:2002-04-30
申请号:US09377682
申请日:1999-08-19
IPC分类号: G01N118
CPC分类号: B01L3/50273 , B01L3/5025 , B01L3/502753 , B01L2200/10 , B01L2300/0645 , B01L2300/0809 , B01L2300/0816 , B01L2300/0864 , B01L2400/0418 , B01L2400/0421 , B01L2400/0688 , G01N27/44791 , Y10T436/2575
摘要: The present invention generally provides microfluidic devices and systems that utilize electrokinetic material transport systems to selectively control and direct the transport of materials through and among complex arrangements of integrated, interconnected microscale channels disposed within integrated body structures. Channels are sized and positioned to provide equal resistance in different paths.
摘要翻译: 本发明通常提供微流体装置和系统,其利用电动材料传输系统来选择性地控制和引导材料的输送通过设置在一体化身体结构内的集成的互连微通道的复杂布置。 通道的尺寸和位置可以在不同的路径上提供相等的电阻。
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公开(公告)号:US6046056A
公开(公告)日:2000-04-04
申请号:US761575
申请日:1996-12-06
IPC分类号: B01J19/00 , B01L3/00 , B01L9/00 , G01N27/447 , G01N33/50 , G01N33/53 , G01N33/574 , G01N35/08 , G01N33/558 , G01N33/543
CPC分类号: G01N33/5091 , B01J19/0093 , B01L3/5025 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L3/502784 , G01N27/44791 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5044 , G01N33/5064 , G01N33/5094 , G01N33/5304 , G01N33/57415 , B01L2200/0605 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L9/527 , G01N35/08 , Y10S366/02 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809
摘要: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
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公开(公告)号:US06827831B1
公开(公告)日:2004-12-07
申请号:US09646241
申请日:2000-09-13
申请人: Calvin Y. H. Chow , J. Wallace Parce , Richard J. McReynolds , Colin B. Kennedy , Luc J. Bousse
发明人: Calvin Y. H. Chow , J. Wallace Parce , Richard J. McReynolds , Colin B. Kennedy , Luc J. Bousse
IPC分类号: G01N2726
CPC分类号: G01N27/453 , B01J19/0093 , B01J2219/00853 , B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2300/0816 , B01L2400/0415 , G01N27/44743 , G01N27/44791 , Y10T436/2575
摘要: The present invention is generally directed to improved methods, structures and systems for interfacing microfluidic devices with ancillary systems that are used in conjunction with such devices. These systems typically include control and monitoring systems (620) for controlling the performance of the processes carried out within the device, e.g., monitoring and controlling environmental conditions and monitoring results of the processes performed, e.g., detection.
摘要翻译: 本发明总体上涉及用于将微流体装置与与这种装置结合使用的辅助系统进行接口的改进的方法,结构和系统。 这些系统通常包括用于控制在设备内执行的过程的性能的控制和监视系统(620),例如监视和控制环境条件并监视所执行的过程的结果,例如检测。
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公开(公告)号:US06582576B1
公开(公告)日:2003-06-24
申请号:US09413766
申请日:1999-10-07
申请人: Calvin Y. H. Chow , John Wallace Parce , Richard J. McReynolds , Colin B. Kennedy , Luc J. Bousse
发明人: Calvin Y. H. Chow , John Wallace Parce , Richard J. McReynolds , Colin B. Kennedy , Luc J. Bousse
IPC分类号: G01N2726
CPC分类号: G01N27/453 , B01J19/0093 , B01J2219/00853 , B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2300/0816 , B01L2400/0415 , G01N27/44743 , G01N27/44791 , Y10T436/2575
摘要: The present invention is generally directed to improved methods, structures and systems for interfacing microfluidic devices with ancillary systems that are used in conjunction with such devices. These systems typically include control and monitoring systems for controlling the performance of the processes carried out within the device, e.g., controlling internal fluid transport and direction, monitoring and controlling environmental conditions and monitoring results of the processes performed, e.g., detection.
摘要翻译: 本发明总体上涉及用于将微流体装置与与这种装置结合使用的辅助系统进行接口的改进的方法,结构和系统。 这些系统通常包括用于控制在装置内执行的过程的性能的控制和监测系统,例如控制内部流体输送和方向,监测和控制环境条件并监测所执行的过程例如检测的结果。
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公开(公告)号:US06444461B1
公开(公告)日:2002-09-03
申请号:US09666948
申请日:2000-09-20
IPC分类号: C12M100
CPC分类号: C12Q1/6869 , B01F13/0059 , B01L3/0262 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502784 , B01L7/52 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/0421 , G01N2035/1053 , G01N2035/1058 , C12Q2565/629
摘要: Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.
摘要翻译: 提供了用于进行生物化学分析的综合系统,设备,软件和方法,包括DNA测序,基因组筛选,核酸和其他生物组分的纯化以及药物筛选。 提供了用于使用这些装置和系统进行各种流体操作的微流体装置,系统和方法。 这些装置和系统用于执行需要大量迭代,连续或平行流体操作的流体操作,其以微型或密封且容易自动的格式。
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公开(公告)号:US06406905B1
公开(公告)日:2002-06-18
申请号:US09346660
申请日:1999-07-01
IPC分类号: G01N33558
摘要: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
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