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公开(公告)号：US20120289483A1
公开(公告)日：2012-11-15
申请号：US13558886
申请日：2012-07-26
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： A61K31/42 , C07D261/08 , C07F9/653 , C07D413/04 , A61P35/00 , A61K31/4439 , A61K31/4725 , A61K31/4709 , A61K31/422 , A61K31/675 , C07D413/10
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US20120065206A1
公开(公告)日：2012-03-15
申请号：US13132106
申请日：2009-12-01
申请人： Jun Jiang , Teresa Kowalczyk-Przewloka , Stefan M. Schweizer , Zhi-Qiang Xia , Shoujun Chen , Christopher Borella , Lijun Sun
发明人： Jun Jiang , Teresa Kowalczyk-Przewloka , Stefan M. Schweizer , Zhi-Qiang Xia , Shoujun Chen , Christopher Borella , Lijun Sun
IPC分类号： A61K31/5375 , A61K31/445 , A61K31/4409 , A61K31/426 , A61K31/421 , A61K31/402 , A61K31/381 , A61K31/357 , A61K31/341 , A61K31/27 , A61K31/16 , C07D295/215 , C07D241/28 , C07D211/98 , C07D213/78 , C07D277/56 , C07D263/34 , C07D207/12 , C07D333/68 , C07D317/46 , C07D307/68 , C07C333/12 , C07C327/18 , A61P35/00 , A61K31/4965
CPC分类号： C07D295/195 , C07C327/56 , C07C333/12 , C07C335/40 , C07C337/02 , C07C337/06 , C07C2601/02 , C07C2601/04 , C07D211/72 , C07D213/86 , C07D213/87 , C07D241/24 , C07D277/56 , C07D295/155 , C07D307/68 , C07D317/68 , C07D333/38 , C07D333/68
摘要： The present invention is directed to compounds represented by structural formula (I), or a pharmaceutically acceptable salt or a transition metal chelate, coordinate or complex thereof or a transition metal chelate, coordinate or complex of a deprotonated form of the compound. Pharmaceutical composition and method of use for these compounds are also included.
摘要翻译： 本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐或过渡金属螯合物，其配位体或络合物或过渡金属螯合物，化合物去质子化形式的配位体或络合物。 也包括这些化合物的药物组合物和使用方法。
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公开(公告)号：US08058297B2
公开(公告)日：2011-11-15
申请号：US12496902
申请日：2009-07-02
申请人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号： A61K31/425
CPC分类号： C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US07705029B2
公开(公告)日：2010-04-27
申请号：US11697207
申请日：2007-04-05
申请人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
发明人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
IPC分类号： A61K31/4196 , A61K31/4155 , C07D249/08 , C07D231/10
CPC分类号： C07D231/12 , C07D231/22 , C07D235/10 , C07D235/18 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10
摘要： What is claimed is a compound represented by the following structural formula: or a pharmaceutically acceptable salt, solvate or clathrate thereof. The variables for Structural Formula (I) are as described herein.
摘要翻译： 所要求的是由以下结构式表示的化合物：或其药学上可接受的盐，溶剂合物或包合物。 结构式（I）的变量如本文所述。
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公开(公告)号：US08785451B2
公开(公告)日：2014-07-22
申请号：US12310303
申请日：2007-08-20
申请人： Keizo Koya , Lijun Sun , Shoujun Chen , Jun Jiang
发明人： Keizo Koya , Lijun Sun , Shoujun Chen , Jun Jiang
IPC分类号： C07D273/01 , C07D307/52 , C07D333/20 , C07D339/08 , C07D317/28 , C07D247/02 , C07D213/53 , A61K31/655 , A61K31/341 , A61K31/357 , A61K31/381 , A61K31/385 , A61K31/539 , A61K31/505 , A61K31/44
CPC分类号： C07C327/56 , C07C337/08 , C07C2601/14 , C07C2601/18 , C07D211/84 , C07D213/53 , C07D239/04 , C07D263/10 , C07D271/10 , C07D307/52 , C07D317/28 , C07D333/22 , C07D339/08 , C07D413/14
摘要： Disclosed are compounds of formula (IA), formula (IV) or formula (V), wherein the variables are as defined herein, and pharmaceutical compositions containing them which are useful for treating a subject with a proliferative disorder, such as cancer. The disclosed compounds and pharmaceutical compositions are also useful for treating disorders responsive to Hsp70 induction and/or natural killer induction.
摘要翻译： 公开了式（IA），式（IV）或式（V）的化合物，其中变量如本文所定义，以及含有它们的药物组合物，其可用于治疗患有增殖性疾病如癌症的受试者。 所公开的化合物和药物组合物还可用于治疗对Hsp70诱导和/或天然杀伤诱导反应的病症。
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公开(公告)号：US20120283272A1
公开(公告)日：2012-11-08
申请号：US13552755
申请日：2012-07-19
申请人： Shoujun Chen , Junyi Zhang , Jun Jiang , Gary Bohnert , Nha Vo , Qinglin Che , Zhiqiang Xia , Lijun Sun
发明人： Shoujun Chen , Junyi Zhang , Jun Jiang , Gary Bohnert , Nha Vo , Qinglin Che , Zhiqiang Xia , Lijun Sun
IPC分类号： A61K31/444 , C07D417/04 , A61K31/497 , A61K31/4436 , C07D409/06 , C07D409/14 , C07D417/14 , A61K31/4439
CPC分类号： C07D417/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The invention relates to certain compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
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公开(公告)号：US08269017B2
公开(公告)日：2012-09-18
申请号：US12883883
申请日：2010-09-16
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： C07D261/02 , A61K31/42
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US20120040937A1
公开(公告)日：2012-02-16
申请号：US13269042
申请日：2011-10-07
申请人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号： A61K31/675 , C07D275/02 , C07D261/08 , A61P35/00 , A61K31/4439 , A61K31/4709 , A61K31/4725 , C07F9/09 , C12N5/07 , C07D417/10
CPC分类号： C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US20110059893A1
公开(公告)日：2011-03-10
申请号：US12883883
申请日：2010-09-16
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： A61K38/06 , A61K31/675 , A61K31/501 , A61K31/4725 , A61K31/4709 , A61K31/4439 , A61K31/42 , C07K5/08 , C07F9/09 , C07D261/08 , C07D413/10 , C07D413/04 , A61K31/422 , A61P35/00 , A61P7/00 , A61P27/02
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US20070270478A1
公开(公告)日：2007-11-22
申请号：US11697207
申请日：2007-04-05
申请人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
发明人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
IPC分类号： C07D231/00 , A61K31/415 , C07C255/00 , A61K31/275 , A61P37/00
CPC分类号： C07D231/12 , C07D231/22 , C07D235/10 , C07D235/18 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10
摘要： What is claimed is a compound represented by the following structural formula: or a pharmaceutically acceptable salt, solvate or clathrate thereof. The variables for Structural Formula (I) are as described herein.
摘要翻译： 所要求的是由以下结构式表示的化合物：或其药学上可接受的盐，溶剂合物或包合物。 结构式（I）的变量如本文所述。
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