公开(公告)号：US09943256B2

公开(公告)日：2018-04-17

申请号：US14260948

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/00 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20170184527A1

公开(公告)日：2017-06-29

申请号：US14980185

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai ,  Andrea Varsavsky ,  Fei Yu

IPC: G01N27/02 ,  G01N33/487 ,  G01N27/416 ,  G01N33/49

CPC classification number: G01N27/026 ,  G01N33/48707 ,  G01N33/49

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US20150164384A1

公开(公告)日：2015-06-18

申请号：US14261011

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1495 ,  A61M5/172 ,  A61B5/1468 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20150031973A1

公开(公告)日：2015-01-29

申请号：US14512102

申请日：2014-10-10

Applicant: Medtronic MiniMed, Inc.

Inventor： Ning Yang ,  Rebecca K. Gottlieb ,  Kieth Nogueira ,  Xiaolong Li ,  Bradely Liang ,  Brian T. Kannard

IPC: A61B5/145 ,  A61M5/172 ,  A61B5/00 ,  A61B5/1473

CPC classification number: A61B5/14532 ,  A61B5/1451 ,  A61B5/14528 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/7242 ,  A61B5/7275 ,  A61M5/1723 ,  F04C2270/0421

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

公开(公告)号：US20130102866A1

公开(公告)日：2013-04-25

申请号：US13657642

申请日：2012-10-22

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Xiaolong Li ,  Brian T. Kannard ,  Rajiv Shah

IPC: A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/1451 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61M5/1723

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

公开(公告)号：US11382538B2

公开(公告)日：2022-07-12

申请号：US16522376

申请日：2019-07-25

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US10327680B2

公开(公告)日：2019-06-25

申请号：US14980205

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Raghavendhar Gautham ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai ,  Jeffrey Nishida

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US10152049B2

公开(公告)日：2018-12-11

申请号：US14281773

申请日：2014-05-19

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Xiaolong Li ,  Rajiv Shah ,  Brian T. Kannard

IPC: G05B23/00 ,  A61M5/172 ,  A61M5/142

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves determining one or more signal characteristics associated with a subset of the measurements corresponding to a monitoring period, determining a reliability metric for the monitoring period based on the one or more signal characteristics, and providing indication of a maintenance condition when the reliability metric violates a threshold.

公开(公告)号：US20170185733A1

公开(公告)日：2017-06-29

申请号：US14980293

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Benyamin Grosman ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai ,  Andrea Varsavsky ,  Jeffrey Nishida

IPC: G06F19/00 ,  G06N3/12 ,  G06N99/00

CPC classification number: G06N20/00 ,  A61B5/14532 ,  A61B5/14735 ,  A61B5/1495 ,  A61B5/6849 ,  G06N3/126 ,  G16H40/40

Abstract: A method for retrospective calibration of a glucose sensor uses stored values of measured working electrode current (Isig) to calculate a final sensor glucose (SG) value retrospectively. The Isig values may be preprocessed, discrete wavelet decomposition applied. At least one machine learning model, such as, e.g., Genetic Programming (GP) and Regression Decision Tree (DT), may be used to calculate SG values based on the Isig values and the discrete wavelet decomposition. Other inputs may include, e.g., counter electrode voltage (Vcntr) and Electrochemical Impedance Spectroscopy (EIS) data. A plurality of machine learning models may be used to generate respective SG values, which are then fused to generate a fused SG. Fused SG values may be filtered to smooth the data, and blanked if necessary.

公开(公告)号：US09603561B2

公开(公告)日：2017-03-28

申请号：US14260755

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.