公开(公告)号：US20110077195A1

公开(公告)日：2011-03-31

申请号：US12848638

申请日：2010-08-02

申请人： Masaru Matsumoto ,  Masako Matsumoto ,  Takeshi Hanada ,  Naomi Wakabayashi

发明人： Masaru Matsumoto ,  Masako Matsumoto ,  Takeshi Hanada ,  Naomi Wakabayashi

IPC分类号： A61K38/02 ,  A61K38/28 ,  A61K38/18 ,  A61K38/27 ,  A61K38/26 ,  A61K38/29 ,  A61K38/22

CPC分类号： A61K9/0019 ,  A61K38/25 ,  A61K47/10 ,  A61K47/12 ,  A61K47/22 ,  A61K47/26 ,  A61K47/40

摘要： An effective liquid preparation achieves high bioavailability (BA) of physiologically active peptides or proteins, including ghrelins, that are administered as drugs. Also provided is a method for improving the BA of physiologically active peptides or proteins, including ghrelins, that are subcutaneously injected in aqueous solutions. The liquid preparation contains: a physiologically active peptide or protein, such as ghrelins, as an active ingredient; an acid solution including one or a combination of two or more selected form the group consisting of acetic acid, lactic acid, phosphoric acid, glycine, citric acid, hydrochloric acid, propionic acid, butyric acid, benzoic acid and salts thereof; an alcohol; and a polar organic liquid including one or a combination of two or more selected from the group consisting of N-methyl-2-pyrrolidone, dimethylformamide, dimethylsulfoxide and methylparaben.

摘要翻译： 有效的液体制剂实现了作为药物施用的生理活性肽或蛋白质（包括生长素释放肽）的高生物利用度（BA）。 还提供了一种用于改善皮下注射在水溶液中的生理活性肽或蛋白质（包括生长素释放肽）的BA的方法。 液体制剂含有：生理活性肽或蛋白质，如生长素释放肽，作为活性成分; 包括选自乙酸，乳酸，磷酸，甘氨酸，柠檬酸，盐酸，丙酸，丁酸，苯甲酸及其盐中的一种或两种以上组合的酸溶液; 酒精; 以及包含选自N-甲基-2-吡咯烷酮，二甲基甲酰胺，二甲基亚砜和对羟基苯甲酸甲酯中的一种或两种以上的组合的极性有机液体。

公开(公告)号：US20100044203A1

公开(公告)日：2010-02-25

申请号：US12594129

申请日：2008-06-25

申请人： Masaru Matsumoto ,  Kimiaki Imai

发明人： Masaru Matsumoto ,  Kimiaki Imai

IPC分类号： H01H13/76

CPC分类号： H01H13/83 ,  G06F3/0202 ,  H01H13/84 ,  H01H2209/004 ,  H01H2209/082 ,  H01H2217/012 ,  H01H2219/044 ,  H01H2219/062 ,  H01H2221/004 ,  H01H2221/05 ,  H04M1/22 ,  H04M1/23

摘要： In a portable terminal, a plurality of operation keys 7 are formed in a key through hole, which is formed in a housing main body that covers a printed board 15, by partitioning a stainless steel sheet 26 (a key sheet) by slits 26a. A urethane sheet 28 is attached to the rear side of the stainless steel sheet 26, where the urethane sheet 28 has ridge portions 28a that bulge out through the slits 26a to the front side of the stainless steel sheet 26, and the rear sides of the ridge portions 28a have groove-like openings. A rubber layer 29 is attached to the rear side of the urethane sheet 28, where the rubber layer 29 has a plurality of protruding portions 23 that protrudes toward a substrate 25 at positions corresponding to a plurality of fixed contacts 16 over the substrate 25. LEDs (light emitting means) and a light guide sheet 21 are disposed closer to the substrate than the rubber layer 29 is. Recess grooves 29a (wrong operation preventing means), for preventing the operation keys 7 located adjacent to each ridge portion 28a from being depressed at the same time, are formed in the rubber layer 29 at locations corresponding to the rear sides of the ridge portions 28a. This implements the operation keys 7 that have a nice feel and are less likely to cause wrong operation, while uniformly guiding light from the LEDs to the operation keys 7.

摘要翻译： 在便携式终端中，通过利用狭缝26a分隔不锈钢板26（钥匙片），形成在形成在覆盖印刷电路板15的壳体主体内的钥匙通孔中的多个操作键7。 聚氨酯片28安装在不锈钢片26的后侧，其中聚氨酯片28具有通过狭缝26a向不锈钢片26的前侧凸出的脊部28a， 脊部28a具有槽状开口。 橡胶层29附着在聚氨酯片28的后侧，橡胶层29具有多个突出部23，该突出部23在与衬底25上的多个固定触点16相对应的位置处朝向衬底25突出。LED （发光装置）和导光片21比橡胶层29更靠近基板设置。 在对应于脊部28a的后侧的位置处，在橡胶层29中形成有用于防止位于与每个脊部28a相邻的操作键7同时被压下的凹槽29a（错误操作防止装置） 。 这实现了具有良好感觉的操作键7，并且不太可能导致错误的操作，同时将来自LED的光均匀地引导到操作键7。

公开(公告)号：US20080193997A1

公开(公告)日：2008-08-14

申请号：US11660406

申请日：2005-08-24

申请人： Masaru Matsumoto ,  Masako Matsumoto ,  Takeshi Hanada ,  Naomi Wakabayashi

发明人： Masaru Matsumoto ,  Masako Matsumoto ,  Takeshi Hanada ,  Naomi Wakabayashi

IPC分类号： C12N9/94

CPC分类号： A61K9/0019 ,  A61K38/25 ,  A61K47/10 ,  A61K47/12 ,  A61K47/22 ,  A61K47/26 ,  A61K47/40

摘要： An effective liquid preparation achieves high bioavailability (BA) of physiologically active peptides or proteins, including ghrelins, that are administered as drugs. Also provided is a method for improving the BA of physiologically active peptides or proteins, including ghrelins, that are subcutaneously injected in aqueous solutions. The liquid preparation contains: a physiologically active peptide or protein, such as ghrelins, as an active ingredient; an acid solution including one or a combination of two or more selected form the group consisting of acetic acid, lactic acid, phosphoric acid, glycine, citric acid, hydrochloric acid, propionic acid, butyric acid, benzoic acid and salts thereof; an alcohol; and a polar organic liquid including one or a combination of two or more selected from the group consisting of N-methyl-2-pyrrolidone, dimethylformamide, dimethylsulfoxide and methylparaben.

摘要翻译： 有效的液体制剂实现了作为药物施用的生理活性肽或蛋白质（包括生长素释放肽）的高生物利用度（BA）。 还提供了一种用于改善皮下注射在水溶液中的生理活性肽或蛋白质（包括生长素释放肽）的BA的方法。 液体制剂含有：生理活性肽或蛋白质，如生长素释放肽，作为活性成分; 包括选自乙酸，乳酸，磷酸，甘氨酸，柠檬酸，盐酸，丙酸，丁酸，苯甲酸及其盐中的一种或两种以上组合的酸溶液; 酒精; 以及包含选自N-甲基-2-吡咯烷酮，二甲基甲酰胺，二甲基亚砜和对羟基苯甲酸甲酯中的一种或两种以上的组合的极性有机液体。

公开(公告)号：US20080081787A1

公开(公告)日：2008-04-03

申请号：US11878532

申请日：2007-07-25

申请人： Yoshiharu Minamitake ,  Masaru Matsumoto

发明人： Yoshiharu Minamitake ,  Masaru Matsumoto

IPC分类号： A61K38/17 ,  C07K14/575

CPC分类号： A61K38/27 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/25 ,  A61K47/02 ,  A61K47/12 ,  A61K47/18 ,  A61K47/183 ,  A61K47/26

摘要： It is provided a pharmaceutical composition stably containing ghrelin or its derivative, which is an endogenous growth hormone secretagogue (GHS) to a growth hormone secretagogue-receptor (GHS-R), comprising a aqueous solution containing the ghrelins having pH range of 2 to 7, wherein the aqueous solution having pH range of 2 to 7 is a buffer solution, especially, glycine hydrochloride buffer, acetate buffer, citrate buffer, lactate buffer, phosphate buffer, citric acid-phosphate buffer, phosphate-acetate-borate buffer or phthalate buffer, and the concentration of the ghrelins in the solution is from 0.03 nmol/mL to 6 μmol/mL.

摘要翻译： 提供了稳定地含有生长激素促分泌素受体（GHS-R）的生长激素促分泌素（GHS）的生长素释放肽或其衍生物的药物组合物，其包含含有pH范围为2至7的生长素释放肽的水溶液 其中pH范围为2-7的水溶液是缓冲溶液，特别是甘氨酸盐酸缓冲液，乙酸盐缓冲液，柠檬酸盐缓冲液，乳酸盐缓冲液，磷酸盐缓冲液，柠檬酸 - 磷酸盐缓冲液，磷酸盐 - 乙酸盐 - 硼酸盐缓冲液或邻苯二甲酸盐缓冲液 ，并且溶液中生长素释放肽的浓度为0.03nmol / mL至6mumol / mL。

公开(公告)号：US06362553B1

公开(公告)日：2002-03-26

申请号：US09312982

申请日：1998-12-23

申请人： Yuji Nakahara ,  Kenichi Azuma ,  Masaru Matsumoto ,  Youichi Fujita ,  Satoru Akutsu ,  Akira Hashimoto ,  Yasunori Takai ,  Tadashi Hasegawa ,  Hiroshi Miyazaki ,  Junji Kawada

发明人： Yuji Nakahara ,  Kenichi Azuma ,  Masaru Matsumoto ,  Youichi Fujita ,  Satoru Akutsu ,  Akira Hashimoto ,  Yasunori Takai ,  Tadashi Hasegawa ,  Hiroshi Miyazaki ,  Junji Kawada

IPC分类号： H02K717

CPC分类号： H02K29/03 ,  H02K1/14 ,  H02K1/146 ,  H02K1/148 ,  H02K1/185 ,  H02K3/18 ,  H02K3/28 ,  H02K3/522 ,  H02K3/524 ,  H02K5/225 ,  H02K7/14 ,  H02K11/40 ,  H02K15/022 ,  H02K15/095 ,  H02K21/14 ,  H02K21/22 ,  H02K2201/06 ,  H02K2201/09 ,  H02K2201/15 ,  H02K2203/03 ,  H02K2203/06 ,  H02K2203/12 ,  H02K2211/03 ,  Y10T29/49009 ,  Y10T29/49073 ,  Y10T29/49078

摘要： An object of the present invention is to provide a low cost, high performance, thin structure rotary motor for driving medium used in magnetic disk drive unit, optical disk drive unit or the like, in order to improve the productivity of terminating processing and the reliability of the coils. Magnetic materials which are divided to a plurality of blocks or divided corresponding to respective magnetic pole teeth are connected by means of thin portions. The respective magnetic pole teeth are wound continuously with wire without cutting the wire at the positions in which the thin portions are connected. When a stator is assembled, a plurality of blocks or magnetic pole teeth are disposed on a substrate by separating or bending the thin portions.

摘要翻译： 本发明的目的是提供一种用于驱动磁盘驱动单元，光盘驱动单元等中使用的介质的低成本，高性能，薄结构的旋转电机，以提高终止处理的生产率和可靠性 的线圈。 被分割成多个块或对应于各个磁极齿分割的磁性材料通过薄的部分连接。 各个磁极齿连续地用线缠绕，而不会在连接薄部分的位置切断电线。 当组装定子时，通过分离或弯曲薄部分将多个块或磁极齿设置在基板上。

公开(公告)号：US6025973A

公开(公告)日：2000-02-15

申请号：US213759

申请日：1998-12-17

申请人： Yoshifumi Mizoshita ,  Tomoyoshi Yamada ,  Yasumasa Kuroba ,  Toru Kouhei ,  Takao Sugawara ,  Masaru Matsumoto ,  Hiroyuki Mase ,  Masao Tsunekewa ,  Shinji Koganezawa ,  Keiji Aruga

发明人： Yoshifumi Mizoshita ,  Tomoyoshi Yamada ,  Yasumasa Kuroba ,  Toru Kouhei ,  Takao Sugawara ,  Masaru Matsumoto ,  Hiroyuki Mase ,  Masao Tsunekewa ,  Shinji Koganezawa ,  Keiji Aruga

IPC分类号： G11B5/54 ,  G11B17/028 ,  G11B19/20 ,  G11B21/12 ,  G11B21/22 ,  G11B25/04 ,  G11B33/08 ,  G11B33/12 ,  H02K7/04 ,  H02K7/08 ,  H02K21/24 ,  H02K33/18 ,  H02K41/035 ,  G11B17/02 ,  G11B23/00

CPC分类号： G11B33/121 ,  G11B17/028 ,  G11B17/0282 ,  G11B17/0287 ,  G11B19/20 ,  G11B19/2009 ,  G11B21/12 ,  G11B21/22 ,  G11B25/043 ,  G11B33/08 ,  G11B33/122 ,  G11B5/54 ,  H02K21/24 ,  H02K33/18 ,  H02K41/0358 ,  H02K7/04 ,  H02K7/086

摘要： A compact card type disk drive includes a housing (21) for accommodating a disk for storing data, a disk drive for rotating the disk, a head assembly for writing and reading data to and from the disk and an electronic circuit including at least an interface circuit (39), the latter three being accommodated in the housing. A connector (42) connected to the electronic circuit is fixed to the outside portion of the housing (21). The electronic circuit preferably contains a read/write circuit (36) and a control circuit (38). The housing (21) preferably includes a lower base (22) and an upper cover (23), and a printed circuit board (14) is disposed along the inner wall of either one, or both, of the base (22) and the cover (23). The outer dimension of the plane of the disk drive is preferably about 85.6 mm.times.54 mm, and typically, the outer thickness is 5 mm. Preferably, one connector (42) is disposed on either one of the minor sides of the housing (21). The connector (42) is disposed at the substantial center of the housing in the direction of its thickness and is fixed to one of the minor sides of the housing (21) which opposes the head assembly with respect to the disk.

摘要翻译： 一种紧凑型卡式磁盘驱动器包括用于容纳用于存储数据的磁盘的壳体（21），用于旋转磁盘的磁盘驱动器，用于向磁盘写入和读取数据的磁头组件以及至少包括接口 电路（39），后者三个被容纳在壳体中。 连接到电子电路的连接器（42）固定到壳体（21）的外部。 电子电路优选地包含读/写电路（36）和控制电路（38）。 壳体（21）优选地包括下基部（22）和上盖（23），并且印刷电路板（14）沿着基座（22）的一个或两个的内壁设置，并且 盖（23）。 磁盘驱动器的平面的外部尺寸优选为约85.6mm×54mm，并且通常外部厚度为5mm。 优选地，一个连接器（42）设置在壳体（21）的任一个次侧上。 连接器（42）沿其厚度方向设置在壳体的大致中心处并且被固定到相对于盘相对于头组件的壳体（21）的一个小侧。

公开(公告)号：US6016237A

公开(公告)日：2000-01-18

申请号：US139765

申请日：1998-08-25

申请人： Yoshifumi Mizoshita ,  Tomoyoshi Yamada ,  Yasumasa Kuroba ,  Toru Kouhei ,  Takao Sugawara ,  Masaru Matsumoto ,  Hiroyuki Mase ,  Masao Tsunekewa ,  Shinji Koganezawa ,  Keiji Aruga

发明人： Yoshifumi Mizoshita ,  Tomoyoshi Yamada ,  Yasumasa Kuroba ,  Toru Kouhei ,  Takao Sugawara ,  Masaru Matsumoto ,  Hiroyuki Mase ,  Masao Tsunekewa ,  Shinji Koganezawa ,  Keiji Aruga

IPC分类号： G11B5/54 ,  G11B17/028 ,  G11B19/20 ,  G11B21/12 ,  G11B21/22 ,  G11B25/04 ,  G11B33/08 ,  G11B33/12 ,  H02K7/04 ,  H02K7/08 ,  H02K21/24 ,  H02K33/18 ,  H02K41/035 ,  G11B33/02

CPC分类号： G11B33/121 ,  G11B17/028 ,  G11B17/0282 ,  G11B17/0287 ,  G11B19/20 ,  G11B19/2009 ,  G11B21/12 ,  G11B21/22 ,  G11B25/043 ,  G11B33/08 ,  G11B33/122 ,  G11B5/54 ,  H02K21/24 ,  H02K33/18 ,  H02K41/0358 ,  H02K7/04 ,  H02K7/086

摘要： A compact card type disk a drive includes a housing (21) for accommodating a disk for storing data, a disk drive for rotating the disk, head assembly for writing and reading data to and from the disk and an electronic circuit including at least an interface circuit (39), the latter three being accommodated in the housing. A connector (42) connected to the electronic circuit is fixed to the outside portion of the housing (21). The electronic circuit preferably contains a read/write circuit (36) and a control circuit (38). The housing (21) preferably includes a lower base (22) and an upper cover (23), and a printed circuit board (14) is disposed along the inner wall of either one, or both, of the base (22) and the cover (23). The outer dimension of the plane of the disk drive is preferably about 85.6 mm.times.54 mm, and typically, the outer thickness is 5 mm. Preferably, one connector (42) is disposed on either one of the minor sides of the housing (21). The connector (42) is disposed at the substantial center of the housing in the direction of its thickness and is fixed to one of the minor sides of the housing (21) which opposes the head assembly with respect to the disk.

摘要翻译： 一种紧凑型卡式盘，驱动器包括用于容纳用于存储数据的盘的壳体（21），用于旋转盘的盘驱动器，用于向和从盘读取数据的头组件和至少包括界面的电子电路 电路（39），后者三个被容纳在外壳中。 连接到电子电路的连接器（42）固定到壳体（21）的外部。 电子电路优选地包含读/写电路（36）和控制电路（38）。 壳体（21）优选地包括下基部（22）和上盖（23），并且印刷电路板（14）沿着基座（22）的一个或两个的内壁设置，并且 盖（23）。 磁盘驱动器的平面的外部尺寸优选为约85.6mm×54mm，并且通常外部厚度为5mm。 优选地，一个连接器（42）设置在壳体（21）的任一个次侧上。 连接器（42）沿其厚度方向设置在壳体的大致中心处并且被固定到相对于盘相对于头组件的壳体（21）的一个小侧。

公开(公告)号：US5859486A

公开(公告)日：1999-01-12

申请号：US333142

申请日：1994-11-01

申请人： Yuji Nakahara ,  Ken-ichi Azuma ,  Masaru Matsumoto ,  Youichi Fujita ,  Satoru Akutsu ,  Akira Hashimoto ,  Yasunori Takai ,  Tadashi Hasegawa ,  Hiroshi Miyazaki ,  Junji Kawada

发明人： Yuji Nakahara ,  Ken-ichi Azuma ,  Masaru Matsumoto ,  Youichi Fujita ,  Satoru Akutsu ,  Akira Hashimoto ,  Yasunori Takai ,  Tadashi Hasegawa ,  Hiroshi Miyazaki ,  Junji Kawada

IPC分类号： H02K1/14 ,  H02K1/18 ,  H02K3/18 ,  H02K3/28 ,  H02K3/50 ,  H02K3/52 ,  H02K5/22 ,  H02K7/14 ,  H02K15/02 ,  H02K15/095 ,  H02K21/14 ,  H02K21/22 ,  H02K29/00 ,  H02K7/17 ,  H02K1/06 ,  G11B5/16

CPC分类号： H02K29/03 ,  H02K1/14 ,  H02K1/146 ,  H02K1/148 ,  H02K1/185 ,  H02K11/40 ,  H02K15/022 ,  H02K15/095 ,  H02K21/14 ,  H02K3/522 ,  H02K3/524 ,  H02K21/22 ,  H02K2201/06 ,  H02K2201/09 ,  H02K2201/15 ,  H02K2203/03 ,  H02K2203/06 ,  H02K2203/12 ,  H02K2211/03 ,  H02K3/18 ,  H02K3/28 ,  H02K5/225 ,  H02K7/14 ,  Y10T29/49009 ,  Y10T29/49073 ,  Y10T29/49078

摘要： An object of the present invention is to provide a low cost, high performance, thin structure rotary motor for driving medium used in magnetic disk drive unit, optical disk drive unit or the like, in order to improve the productivity of terminating processing and the reliability of the coils. Magnetic materials which are divided to a plurality of blocks or divided corresponding to respective magnetic pole teeth are connected by means of thin portions. The respective magnetic pole teeth are wound continuously with wire without cutting the wire at the positions in which the thin portions are connected. When a stator is assembled, a plurality of blocks or magnetic pole teeth are disposed on a substrate by separating or bending the thin portions.

公开(公告)号：US5651169A

公开(公告)日：1997-07-29

申请号：US692727

申请日：1996-08-06

申请人： Masatoshi Ohuchi ,  Masaru Matsumoto

发明人： Masatoshi Ohuchi ,  Masaru Matsumoto

IPC分类号： B21J15/10 ,  B21J15/00 ,  B21J15/06 ,  B21J15/16 ,  B21J15/32 ,  B21J15/34 ,  B21J15/36 ,  B21J15/22

CPC分类号： B21J15/32 ,  B21J15/105 ,  B21J15/323 ,  B21J15/326 ,  Y10S29/044 ,  Y10T29/49956 ,  Y10T29/53496 ,  Y10T29/53739 ,  Y10T29/53748

摘要： Although the conventional continuous riveting machine was able to use exclusively a special blind rivet having a longer core-stem than that of the standard type, the continuous riveting machine according to the present invention is able to use the standard blind rivet and also able to recover separately torn core rivet stems and a blind rivet-holding belt made of plastic material enabling the supply of blind rivets in series. When a lower piston 600 descends in a jaw cylinder 400, a nose piece 620 integrated in one piece with the lower piston 600 also descends while bending downwardly plastic upper and lower tabs of the blind rivet-holding belt, and holding the blind rivet. Torn-core-stems are absorbed and stored in a torn core rivet stems storing case installed on the upper portion of the jaw cylinder by applying vacuum air absorbing force generated in a vacuum ejector.

摘要翻译： 虽然传统的连续铆接机只能使用具有比标准型更长的芯杆的特殊的盲铆钉，但根据本发明的连续铆接机能够使用标准的盲铆钉并且还能够恢复 单独撕裂的芯铆钉杆和由塑料材料制成的盲铆钉保持带，能够串联供应盲铆钉。 当下活塞600在颚缸400中下降时，与下活塞600集成成一体的鼻片620也向下弯曲，同时向下弯曲盲铆钉保持带的塑料上下片，并保持盲铆钉。 撕心芯通过在真空喷射器中产生的真空空气吸收力被吸收并储存在安装在颚缸上部的撕裂芯铆钉杆的储存箱中。

公开(公告)号：US5631138A

公开(公告)日：1997-05-20

申请号：US381497

申请日：1995-01-31

申请人： Motonari Kano ,  Masaru Matsumoto

发明人： Motonari Kano ,  Masaru Matsumoto

IPC分类号： G01N33/53 ,  A61B10/00 ,  G01N33/50 ,  G01N33/531 ,  G01N33/543 ,  G01N33/576 ,  G01N33/92

CPC分类号： G01N33/92 ,  Y10S435/961 ,  Y10S435/973 ,  Y10S436/811 ,  Y10S436/822

摘要： A method for the measurement of serum bile acids by ELISA comprising: preparing a bile acid active ester, reacting the ester with a bovine serum albumin solution, dialyzing, and immunizing a mammal other than human being with the dialyzate thus obtained as an antigen to thereby give an anti-bile acid antibody; reacting said active ester with an enzyme to thereby prepare an enzyme-labeled bile acid as an enzyme-labeled antigen; to a secondary antibody-coated plate, adding a dilution of the serum to be assayed, an anti-bile acid antibody solution and an enzyme-labeled antigen solution and reacting these substances followed by the addition of a substrate and the reaction therewith; measuring the absorbance of the reaction mixture and determining the concentration of each bile acid on the basis of the standard curve measured simultaneously; and referring the sum of the concentrations of these bile acids to the total bile acid concentration; and a method for the diagnosis of a liver disease comprising: calculating the concentration ratio of each bile acid from the values measured by the former method; and comparing the concentration ratio thus obtained with the standard level scope of said concentration ratio obtained from healthy subjects are provided.

摘要翻译： 一种用于通过ELISA测量血清胆汁酸的方法，其包括：制备胆汁酸活性酯，使所述酯与牛血清白蛋白溶液反应，透析并用由此获得的透析液作为抗原免疫除人之外的哺乳动物，由此 给予抗胆汁酸抗体; 使所述活性酯与酶反应，从而制备酶标记的胆汁酸作为酶标记的抗原; 添加到待测细胞的稀释液，抗胆汁酸抗体溶液和酶标记的抗原溶液中，然后使这些物质反应，然后加入底物和与其反应; 测量反应混合物的吸光度，并根据同时测量的标准曲线测定每种胆汁酸的浓度; 并将这些胆汁酸的浓度之和表示为总胆汁酸浓度; 以及用于诊断肝脏疾病的方法，包括：从通过前一种方法测量的值计算每种胆汁酸的浓度比; 并比较由此获得的浓度比与从健康受试者获得的所述浓度比的标准水平范围。