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公开(公告)号：US08134941B2
公开(公告)日：2012-03-13
申请号：US12066436
申请日：2005-09-12
CPC分类号： H04B1/1615 , H04W52/0225 , Y02D70/168 , Y02D70/40
摘要： A method of receiving a signal in bursts including frames each including payload data and error correction data received in separate time periods, the bursts being separated by time intervals during which power is saved by disabling at least some signal processing components of the receiver, signal processing components of the receiver are disabled to save power before all the error correction data for all the frames in the burst is received.
摘要翻译： 一种接收信号的方法，包括帧，每个帧包括在不同的时间段内接收到的有效载荷数据和纠错数据，这些脉冲串通过禁止接收机的至少一些信号处理部件，信号处理来节省电力的时间间隔分开 在接收到突发中所有帧的所有纠错数据之前，接收机的组件被禁用以节省功率。
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公开(公告)号：US20110070235A1
公开(公告)日：2011-03-24
申请号：US12855553
申请日：2010-08-12
申请人： Andres G. Grandea, III , Gordon King , Thomas C. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
发明人： Andres G. Grandea, III , Gordon King , Thomas C. Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Phil Hammond
CPC分类号： G01N33/56983 , A61K2039/505 , C07K16/1018 , C07K2317/21 , C07K2317/34 , C07K2317/515 , C07K2317/92 , G01N2333/11
摘要： The present invention provides compositions, vaccines, and methods for diagnosing, treating, and preventing influenza infection using a combination of antibodies raised against the influenza hemagglutinin and the matrix 2 ectodomain polypeptides.
摘要翻译： 本发明提供使用针对流感血凝素和基质2胞外域多肽产生的抗体的组合来诊断，治疗和预防流感感染的组合物，疫苗和方法。
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公开(公告)号：US20090226433A1
公开(公告)日：2009-09-10
申请号：US12269781
申请日：2008-11-12
申请人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
发明人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
IPC分类号： A61K39/395 , C07K16/08 , C07K16/18 , A61P37/02 , C12Q1/70
CPC分类号： C07K16/1018 , A61K2039/505 , C07K14/005 , C07K2317/21 , C07K2317/32 , C07K2317/34 , C12N2760/16122 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译： 本发明提供新的人类抗流感抗体及相关组合物和方法。 这些抗体用于流感感染的诊断和治疗。
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公开(公告)号：US20060166915A1
公开(公告)日：2006-07-27
申请号：US11088472
申请日：2005-03-24
申请人： Egon Persson , Ole Olsen
发明人： Egon Persson , Ole Olsen
IPC分类号： A61K48/00 , C07H21/04 , C12P21/04 , C07K14/745
CPC分类号： C12N9/6437 , A61K38/4846 , C12Y304/21021
摘要： The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as polynucleotide constructs encoding such variants, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.
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45.发明申请Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) 审中-公开取代噻吩化合物作为蛋白酪氨酸磷酸酶（PTPases）的调节剂公开(公告)号：US20050119332A1
公开(公告)日：2005-06-02
申请号：US10983559
申请日：2004-11-08
申请人： Lone Jeppesen , Henrik Andersen , Ole Olsen , Luke Judge , Daniel Holsworth , Farid Bakir , Frank Axe , Yu Ge
发明人： Lone Jeppesen , Henrik Andersen , Ole Olsen , Luke Judge , Daniel Holsworth , Farid Bakir , Frank Axe , Yu Ge
IPC分类号： C07C233/56 , C07C237/22 , C07D207/34 , C07D209/08 , C07D209/14 , C07D213/79 , C07D213/80 , C07D231/40 , C07D239/42 , C07D239/54 , C07D239/557 , C07D261/08 , C07D271/10 , C07D333/38 , C07D333/66 , C07D333/68 , C07D409/04 , C07D409/06 , C07D413/04 , C07D495/04 , C07D495/10 , C07D495/14 , A61K31/381 , C07D49/02
CPC分类号： C07D213/79 , C07C233/56 , C07C237/22 , C07D207/34 , C07D209/08 , C07D209/14 , C07D213/80 , C07D231/40 , C07D239/42 , C07D239/557 , C07D261/08 , C07D271/10 , C07D333/38 , C07D333/66 , C07D333/68 , C07D409/04 , C07D409/06 , C07D413/04 , C07D495/04 , C07D495/10 , C07D495/14
摘要： The present invention provides novel compounds of formula 1a, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.
摘要翻译： 本发明提供了新颖的式1a化合物，新的组合物，其使用方法及其制备方法，其中这些化合物是蛋白酪氨酸磷酸酶（PTPase）如PTP1B，CD45，SHP-1，SHP- 2，PTPalpha，LAR和HePTP等。 该化合物可用于治疗I型糖尿病，II型糖尿病，葡萄糖耐量降低，胰岛素抵抗，肥胖症，免疫功能障碍，包括凝血系统功能障碍的自身免疫疾病，包括哮喘，过度性疾病，骨质疏松症，增殖性疾病，包括癌症和牛皮癣 ，具有减少或增加的生长激素合成或作用的疾病，调节生长激素释放/或对生长激素的反应，包括阿尔茨海默氏病和精神分裂症的疾病以及传染病的激素或细胞因子合成减少或增加的疾病。
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46.发明授权Monoclonal antibodies directed against trimeric forms of the HIV-1 envelope glycoprotein with broad and potent neutralizing activity 有权针对三聚体形式的HIV-1包膜糖蛋白的单克隆抗体具有广泛和有效的中和活性公开(公告)号：US09051362B2
公开(公告)日：2015-06-09
申请号：US12726245
申请日：2010-03-17
申请人： Po-Ying Chan-Hui , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
发明人： Po-Ying Chan-Hui , Steven Frey , Ole Olsen , Jennifer Mitcham , Matthew Moyle , Sanjay K. Phogat , Dennis R. Burton , Laura Marjorie Walker , Pascal Raymond Georges Poignard , Wayne Koff , Melissa Danielle De Jean De St. Marcel Simek-Lemos
CPC分类号： C07K16/1045 , A61K39/21 , A61K2039/505 , C07K16/1063 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要翻译： 本发明提供一种获得广泛中和抗体（bNab）的方法，包括筛选来自供体PBMC样品的记忆B细胞培养物，以对多种HIV-1物质进行中和活性，克隆显示广泛中和活性的记忆B细胞; 并从该记忆B细胞培养物中拯救单克隆抗体。 所得单克隆抗体的特征在于它们以天然或单体形式选择性地结合来自Env蛋白的表位的能力，以及抑制HIV-1物种从多个进化枝的感染。 提供了含有用于预防，诊断和治疗HIV感染的人单克隆抗HIV抗体的组合物。 提供了通过使用来自gp120的可变环内的保守区域的表位进行免疫来产生这种抗体的方法。 还提供了产生抗艾滋病毒1型免疫球蛋白的免疫原。 此外，提供了使用合适表位的疫苗接种方法。
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公开(公告)号：US08900590B2
公开(公告)日：2014-12-02
申请号：US13208754
申请日：2011-08-12
IPC分类号： A61K39/00 , A61K39/42 , A61K39/145 , A61K45/06 , A61K47/48 , A61K39/395 , C07K16/10 , G01N33/569
CPC分类号： C07K16/1018 , A61K39/395 , A61K39/42 , A61K45/06 , A61K47/48384 , A61K47/4853 , A61K47/6803 , A61K47/6841 , A61K49/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/11 , G01N2469/10 , A61K2300/00
摘要： The present invention provides novel human anti-Influenza antibodies and related compositions and methods. These antibodies are used in the prevention, inhibition, neutralization, diagnosis, and treatment of influenza infection.
摘要翻译： 本发明提供新型人类抗流感抗体及相关组合物和方法。 这些抗体用于预防，抑制，中和，诊断和治疗流感感染。
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公开(公告)号：US08114402B2
公开(公告)日：2012-02-14
申请号：US12726297
申请日：2010-03-17
申请人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
发明人： Andres Grandea, III , Gordon King , Thomas Cox , Ole Olsen , Jennifer Mitcham , Matthew Moyle
CPC分类号： C07K16/1018 , A61K2039/505 , C07K14/005 , C07K2317/21 , C07K2317/32 , C07K2317/34 , C12N2760/16122 , G01N33/56983
摘要： The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
摘要翻译： 本发明提供新的人类抗流感抗体及相关组合物和方法。 这些抗体用于流感感染的诊断和治疗。
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49.发明申请COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF CYTOMEGALOVIRUS 有权用于治疗和诊断CYPEGEGEGOVIRUS的组合物和方法公开(公告)号：US20110305708A1
公开(公告)日：2011-12-15
申请号：US13109632
申请日：2011-05-17
申请人： Ole Olsen
发明人： Ole Olsen
CPC分类号： C07K16/088 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56994 , G01N2333/045
摘要： The present invention provides novel anti-cytomegalovirus antibodies and related compositions and methods. These antibodies may be used in the diagnosis, prevention, and treatment of cytomegalovirus infection.
摘要翻译： 本发明提供新型抗巨细胞病毒抗体及相关组合物和方法。 这些抗体可用于巨细胞病毒感染的诊断，预防和治疗。
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公开(公告)号：US20110195151A1
公开(公告)日：2011-08-11
申请号：US12951569
申请日：2010-11-22
申请人： Klaus Breddam , Ole Olsen , Birgitte Skadhauge , Finn Lok , Søren Knudsen , Lene Mølskov Bech
发明人： Klaus Breddam , Ole Olsen , Birgitte Skadhauge , Finn Lok , Søren Knudsen , Lene Mølskov Bech
CPC分类号： C12C1/18 , A01H5/10 , C12C5/004 , C12C7/04 , C12C7/047 , C12C11/003 , C12C12/00 , C12N9/0069 , C12N15/8242 , C12N15/8243
摘要： According to the invention, there is provided null-LOX-1 barley and plant products produced thereof, such as malt manufactured by using barley kernels defective in synthesis of the fatty acid-converting enzyme lipoxygenase-1. Said enzyme accounts for the principal activity related to conversion of linoleic acid into 9-hydroperoxy octadecadienoic acid, a lipoxygenase pathway metabolite, which-through further enzymatic or spontaneous reactions-may lead to the appearance of trans-2-nonenal. The invention enables brewers to produce a beer devoid of detectable trans-2-nonenal-specific off flavors, even after prolonged storage of the beverage.
摘要翻译： 根据本发明，提供了无效LOX-1大麦及其生产的植物产品，例如通过使用缺乏合成脂肪酸转化酶脂氧合酶-1的大麦籽粒制备的麦芽。 所述酶涉及与将亚油酸转化为9-氢过氧十八碳二烯酸（脂氧合酶途径代谢物）相关的主要活性，其通过进一步的酶促或自发反应可能导致反式-2-壬烯醛的出现。 本发明使酿造商能够生产没有可检测的反式-2-壬烯醛特异性异味的啤酒，甚至在长时间储存饮料之后。
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