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公开(公告)号：US4784699A
公开(公告)日：1988-11-15
申请号：US036035
申请日：1987-04-08
IPC分类号： A62D3/00 , A62D3/38 , A62D101/02 , A62D101/26 , A62D101/28 , C11D3/395 , D06L3/02 , B08B5/00
CPC分类号： A62D3/38 , C11D3/3953 , D06L3/028 , A62D2101/02 , A62D2101/26 , A62D2101/28
摘要： The invention provides a process for decontaminating military nerve agents and blister agents. The process involves contacting the nerve agent and blister agent, particularly clothing and other items contaminated therewith, with gaseous ozone or chlorine dioxide, whereby the agents are oxidized to non-toxic products and thereby decontaminated rapidly, e.g. within a few minutes. The treatment with ozone or chlorine dioxide does not seriously affect the mechanical properties of the contaminated materials, such as fabrics.
摘要翻译： 本发明提供了一种去除军事神经药剂和起泡剂的方法。 该方法包括使神经毒剂和起泡剂，特别是衣服和其它被污染的物品与气态臭氧或二氧化氯接触，由此将这些试剂氧化成无毒产物，从而快速去污。 在几分钟内。 用臭氧或二氧化氯处理不会严重影响被污染物质如织物的机械性能。
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公开(公告)号：US4655777A
公开(公告)日：1987-04-07
申请号：US563191
申请日：1983-12-19
申请人： Richard L. Dunn , Robert A. Casper
发明人： Richard L. Dunn , Robert A. Casper
摘要： Method of producing biodegradable prostheses comprising a composite of resorbable fibers reinforcing a biodegradable polymer matrix and the use thereof in medical applications such as bone plates and other orthopedic devices. The fibers include ceramic powders, .beta.-TCP and CaAl and a biodegradable glass, CMP.
摘要翻译： 生产可生物降解的假体的方法，其包括增强可生物降解的聚合物基质的可再吸收纤维的复合材料及其在诸如骨板和其它整形外科设备的医学应用中的用途。 纤维包括陶瓷粉末，β-TCP和CaAl以及可生物降解的玻璃CMP。
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公开(公告)号：US08187640B2
公开(公告)日：2012-05-29
申请号：US12812670
申请日：2009-01-13
申请人： Richard L. Dunn
发明人： Richard L. Dunn
CPC分类号： A61L29/06 , A61K9/0024 , A61K31/445 , A61K31/485 , A61K31/65 , A61K33/24 , A61L27/18 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/58 , A61L29/085 , A61L29/14 , A61L29/148 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/148 , A61L31/16 , A61L2300/406 , A61L2300/416 , A61L2300/43 , A61L2300/604 , A61L2400/06 , C08L67/04
摘要： Low viscosity biodegradable polymer solutions of a liquid biodegradable polymer and biocompatible solvent and methods of using the compositions to form a biodegradable liquid polymer implant are provided.
摘要翻译： 提供了液体可生物降解聚合物和生物相容性溶剂的低粘度可生物降解聚合物溶液和使用该组合物形成可生物降解的液体聚合物植入物的方法。
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公开(公告)号：US06537565B2
公开(公告)日：2003-03-25
申请号：US09874831
申请日：2001-06-05
IPC分类号： A61F200
CPC分类号： C08J5/18
摘要： The invention is directed to a filamentous porous film that can act as a support for cellular attachment, growth and organization. The film is formed from filaments which define a matrix structure with pores.
摘要翻译： 本发明涉及可作为细胞附着，生长和组织的支持物的丝状多孔膜。 该膜由限定具有孔的基质结构的长丝形成。
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45.再颁专利公开(公告)号：USRE37950E1
公开(公告)日：2002-12-31
申请号：US09536579
申请日：2000-03-28
IPC分类号： A61K908
CPC分类号： A61K9/0024 , A61F2002/30062 , A61F2002/30583 , A61F2210/0004 , A61F2210/0085 , A61L15/44 , A61L15/62 , A61L24/0042 , A61L24/046 , A61L26/009 , A61L27/18 , A61L27/50 , A61L2300/252 , A61L2300/404 , A61L2300/406 , C08L75/04 , C08L67/04
摘要： A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.
摘要翻译： 提供可生物降解的聚合物用于为动物提供可注射的，原位成型的固体可生物降解植入物。 将聚合物以液体形式置于动物体内并固化以原位形成植入物。 形成所述植入物的热塑性体系包括以下步骤：将非反应性聚合物溶解在生物相容性溶剂中以形成液体，将液体置于动物体内，并允许溶剂消散以产生植入物。 一种替代的热固性体系包括将有效量的液体丙烯酸酯封端的，可生物降解的预聚物和固化剂混合在一起，将液体混合物置于动物体内并使预聚物固化以形成植入物。 两种系统通过在注射到体内之前向液体中添加有效水平的生物活性剂来提供可注射的，可固体的可生物降解的递送系统。
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公开(公告)号：US06395293B2
公开(公告)日：2002-05-28
申请号：US09520735
申请日：2000-03-08
申请人： Alan M. Polson , Deryl D. Swanbom , Richard L. Dunn , Charles P. Cox , Richard L. Norton , Bryan K. Lowe , Kenneth S. Peterson
发明人： Alan M. Polson , Deryl D. Swanbom , Richard L. Dunn , Charles P. Cox , Richard L. Norton , Bryan K. Lowe , Kenneth S. Peterson
IPC分类号： A61F200
CPC分类号： A61K9/0024 , A61K9/0063 , A61K9/1647 , A61K31/74 , A61K33/42 , A61K47/34 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , B29C41/08 , B29C41/12 , B29C67/06 , B29K2995/0056 , B29K2995/006 , C08L67/04
摘要： The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.
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公开(公告)号：US6120789A
公开(公告)日：2000-09-19
申请号：US282036
申请日：1999-03-30
申请人： Richard L. Dunn
发明人： Richard L. Dunn
CPC分类号： A61K9/0024 , A61K47/34 , A61K47/14 , A61K47/20 , A61K47/22
摘要： The invention relates to a method and composition for forming an implant in-situ within a body using non-polymeric materials, and the use of such implants as medical devices and drug delivery systems. The composition can be applied to an animal to treat periodontal disease or other tissue defect, enhance compatibility and performance of an implantable article, and deliver a biologically active agent.
摘要翻译： 本发明涉及一种使用非聚合材料在体内原位形成植入物的方法和组合物，以及使用这种植入物作为医疗装置和药物递送系统。 组合物可以应用于动物以治疗牙周疾病或其他组织缺陷，增强可植入制品的相容性和性能，并递送生物活性剂。
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公开(公告)号：US6071530A
公开(公告)日：2000-06-06
申请号：US883260
申请日：1997-06-26
申请人： Alan M. Polson , Deryl D. Swanbom , Richard L. Dunn , Charles P. Cox , Richard L. Norton , Bryan K. Lowe , Kenneth S. Peterson
发明人： Alan M. Polson , Deryl D. Swanbom , Richard L. Dunn , Charles P. Cox , Richard L. Norton , Bryan K. Lowe , Kenneth S. Peterson
IPC分类号： A61C8/00 , A61C19/06 , A61F2/02 , A61F2/08 , A61F2/28 , A61K6/00 , A61K9/00 , A61K9/16 , A61K31/74 , A61K33/42 , A61K47/34 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , B29C41/00 , B29C41/08 , B29C41/12 , B29C67/00 , B29C67/06 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K33/42 , A61K47/34 , A61K9/0063 , A61K9/1647 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , B29C41/08 , B29C41/12 , B29C67/06 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , B29K2995/0056 , B29K2995/006
摘要： The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.
摘要翻译： 本发明涉及具有由外囊和液体含量制成的两部分结构的可生物降解的植入物前体。 植入物前体由可生物降解的水凝性热塑性聚合物和水混溶性有机溶剂组成。 当施用到动物的植入部位时，植入物前体将通过将有机溶剂消散到周围的组织流体和聚合物的凝结而原位固化成固体，微孔基质。 本发明还包括制备植入物前体，用于形成前体的装置和包含该装置的试剂盒的方法。 还提供了使用植入物前体来治疗动物中的组织缺陷的方法，例如用于增强细胞生长和组织再生，伤口和器官修复，神经再生，软和硬组织再生等，用于递送 生物活性物质到组织或器官，以及其他类似疗法。
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公开(公告)号：US5759563A
公开(公告)日：1998-06-02
申请号：US486262
申请日：1995-06-07
申请人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
发明人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
IPC分类号： A61K9/00 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/70 , A61K47/48 , A61K49/00 , A61L15/44 , A61K9/127 , A61F13/00
CPC分类号： A61K9/0024 , A61K31/4439 , A61K31/485 , A61K31/704 , A61K38/09 , A61K38/27 , A61K47/34 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48784 , A61K47/48853 , A61K49/0017 , A61K49/0036 , A61K49/0054 , A61K49/0063 , A61K49/0091 , A61K9/10 , A61K9/146 , A61K9/5026 , A61K9/5047 , A61L26/0019 , A61L26/0066 , A61L26/0085 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , A61L31/16 , A61K47/42 , A61L2300/604 , A61L2300/62 , A61L2400/06 , Y10S514/90 , Y10S525/937 , Y10S977/774 , Y10S977/783 , Y10S977/906 , Y10S977/907 , Y10S977/915 , Y10S977/918
摘要： Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.
摘要翻译： 提供改进的生物相容性液体递送组合物，其可用于形成活性剂的缓释递送系统。 组合物包括与受控释放组分组合的生物相容性聚合物或预聚物的液体制剂。 受控释放组分包括活性剂。 这些组合物可以以液体形式引入受试者的身体，其然后在现场固化或固化以形成控释植入物或膜敷料。 液体递送组合物也可以非原位地用于产生控释植入物。 还提供了形成受控释放植入物并使用液体制剂治疗受试者的方法。
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公开(公告)号：US5736152A
公开(公告)日：1998-04-07
申请号：US549414
申请日：1995-10-27
申请人： Richard L. Dunn
发明人： Richard L. Dunn
CPC分类号： A61K9/0024 , A61K47/34 , A61K47/14 , A61K47/20 , A61K47/22
摘要： The invention relates to a method and composition for forming an implant in-situ within a body using non-polymeric materials, and the use of such implants as medical devices and drug delivery systems. The composition can be applied to an animal to treat periodontal disease or other tissue defect, enhance compatibility and performance of an implantable article, and deliver a biologically active agent.
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