摘要:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30 etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要:
An aluminum alloy sheet contains 0.1% to 0.4% by mass of Cu, 0.5% to 1.5% by mass of Mg, 0.5% to 1.5% by mass of Mn, 0.2% to 0.7% by mass of Fe, and 0.1% to 0.3% by mass of Si. The number density of Al—Mn—Fe—Si-based intermetallic compound having a maximum length of 8 to 15 μm per unit area is 179 grains/mm2 or less. An oxide film having an average thickness of 30 nm or less is formed on the surface of the aluminum alloy sheet. The arithmetic average roughness Ra of the surface of the aluminum alloy sheet is 0.30 to 0.45 μm.
摘要翻译:铝合金板含有0.1质量%〜0.4质量%的Cu,0.5〜1.5质量%的Mg,0.5〜1.5质量%的Mn,0.2〜0.7质量%的Fe,0.1〜0.3 质量%的Si。 每单位面积最大长度为8〜15μm的Al-Mn-Fe-Si系金属间化合物的数密度为179粒/ mm 2以下。 在铝合金板的表面上形成平均厚度为30nm以下的氧化膜。 铝合金板的表面的算术平均粗糙度Ra为0.30〜0.45μm。
摘要:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X1 is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1-(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要:
A method of manufacturing a ceramic honeycomb structure, includes: an extruding step of extruding a raw material including a ceramic material, and obtaining a ceramic honeycomb intermediate formed article which has substantially the same shape as that of the ceramic honeycomb structure to obtain and whose outer peripheral wall has a thickness of 1/15 to 1/120 with respect to an outer diameter of ceramic honeycomb intermediate formed article; a firing step of firing the obtained ceramic honeycomb intermediate formed article to obtain a ceramic honeycomb fired article; and a machining step of machining the outer peripheral wall of the obtained ceramic honeycomb fired article, and securing a dimensional precision of a predetermined outer diameter. According to the method of manufacturing a ceramic honeycomb structure, a partition wall inside an outer peripheral wall, or the outer peripheral wall itself does not easily deform at an extruding time, and the inside partition walls and through-holes are not exposed at the time of machining of the outer peripheral wall, and any coating layer does not have to be disposed.
摘要:
A copper alloy sliding material which can bring about superior resistance to fatigue as well as good anti-seizure property without containing any Pb. The copper alloy sliding material is made to have the structure in which both of the hard copper alloy phase and the soft copper alloy phase coexist in a mixture state. On the surface of the sliding material, the soft copper alloy phase comes to have a shape more concave than that of the hard copper alloy phase when receiving a load or when being in a sliding wear relation, in which concave portions is retained lubricant with the result that the anti-seizure property is enhanced. Further, since the soft phase and the hard phase are made of the same copper alloy, the wettability thereof becomes good, and Ni and etc. contained in the hard copper alloy phase are diffused into the soft copper alloy phase, so that the hardness of the boundary portion defined between the phases come to be gradually varied. Thus, because of the unclear boundary, the load received in the hard phase comes to be spread in a wide range without being concentrated at the boundary, so that the fatigue strength is enhanced.
摘要:
There is disclosed a sliding member which slidably contacts an counterpart member with friction and in which a friction force is varied without changing a contact pressure. A sliding member 11 is formed by covering a steel plate with sliding materials 13a to 13e different in friction coefficient. In this case, when a sliding direction of the counterpart member 14 is set to directions of arrows A and B, a sliding material 13a of a low friction coefficient is disposed in the middle, and the sliding materials 13b to 13e are arranged so that the friction coefficient gradually increases toward both terminal sides in the directions of arrows A and B of the sliding material 13a. According to the sliding member 11, the friction force increases as the counterpart member 14 moves in the directions of arrows A and B from the middle.
摘要:
A method for producing an amide derivative of the formula [XV] wherein each-symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The production method of the present invention is extremely easy and simple as compared to the conventional methods, and enables effective production of compound [XV] at high yields, which includes compound [XVI] having an HIV protease inhibitory action. In addition, the novel intermediates of the present invention are extremely useful as intermediates for producing not only the aforementioned compound [XVI] but also compounds useful as X-ray contrast media.
摘要:
A method for producing an amide derivative of the formula [XV] ##STR1## wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof.The production method of the present invention is extremely easy and simple as compared to the conventional methods, and enables effective production of compound [XV] at high yields, which includes compound [XVI] having an HIV protease inhibitory action. In addition, the novel intermediates of the present invention are extremely useful as intermediates for producing not only the aforementioned compound [XVI] but also compounds useful as X-ray contrast media.
摘要:
A method for producing an amide derivative of the formula [XV] ##STR1## wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof.The production method of the present invention is extremely easy and simple as compared to the conventional methods, and enables effective production of compound [XV] at high yields, which includes compound [XVI] having an HIV protease inhibitory action. In addition, the novel intermediates of the present invention are extremely useful as intermediates for producing not only the aforementioned compound [XVI] but also compounds useful as X-ray contrast media.
摘要:
A method for producing an amide derivative of the formula �XV! ##STR1## wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The production method of the present invention is extremely easy and simple as compared to the conventional methods, and enables effective production of compound �XV! at high yields, which includes compound �XVI! having an HIV protease inhibitory action. In addition, the novel intermediates of the present invention are extremely useful as intermediates for producing not only the aforementioned compound �XVI! but also compounds useful as X-ray contrast media.