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41.发明申请公开(公告)号：US20180286038A1
公开(公告)日：2018-10-04
申请号：US15928992
申请日：2018-03-22
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Bahram Jalali , Ata Mahjoubfar , Lifan Chen
CPC classification number: G06T7/0012 , G01N15/1429 , G01N15/1434 , G01N15/147 , G01N15/1475 , G01N2015/1006 , G01N2015/144 , G01N2015/1445 , G01N2015/1454 , G01N2015/149 , G06K9/00127 , G06K9/0014 , G06K9/00147 , G06K9/4628 , G06N3/04 , G06N3/086 , G16B40/00
Abstract: A method and apparatus for using deep learning in label-free cell classification and machine vision extraction of particles. A time stretch quantitative phase imaging (TS-QPI) system is described which provides high-throughput quantitative imaging, and utilizing photonic time stretching. In at least one embodiment, TS-QPI is integrated with deep learning to achieve record high accuracies in label-free cell classification. The system captures quantitative optical phase and intensity images and extracts multiple biophysical features of individual cells. These biophysical measurements form a hyperdimensional feature space in which supervised learning is performed for cell classification. The system is particularly well suited for data-driven phenotypic diagnosis and improved understanding of heterogeneous gene expression in cells.
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公开(公告)号：US20170350803A1
公开(公告)日：2017-12-07
申请号：US15672051
申请日：2017-08-08
Applicant: The Regents of the University of California
Inventor： Bahram Jalali , Eric Diebold , Brandon Buckley
CPC classification number: G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/64 , G01N21/6428 , G01N21/6458 , G01N21/6486 , G01N33/537 , G01N2015/1006 , G01N2015/1477 , G01N2021/6421 , G01N2201/067
Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.
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公开(公告)号：US09784661B2
公开(公告)日：2017-10-10
申请号：US15263419
申请日：2016-09-13
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Bahram Jalali , Eric Diebold , Brandon Buckley
CPC classification number: G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/64 , G01N21/6428 , G01N21/6458 , G01N21/6486 , G01N33/537 , G01N2015/1006 , G01N2015/1477 , G01N2021/6421 , G01N2201/067
Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.
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公开(公告)号：US20160223453A1
公开(公告)日：2016-08-04
申请号：US15016217
申请日：2016-02-04
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Bahram Jalali , Ata Mahjoubfar
CPC classification number: G01N15/1434 , G01B9/02043 , G01N15/1429 , G01N15/1459 , G01N2015/0065 , G01N2015/1006 , G01N2015/1087 , G01N2015/144 , G01N2015/1454 , G06K9/00147 , G06K9/46 , G06T7/0012 , G06T11/60 , G06T2207/10056 , G06T2207/30024 , G06T2207/30242
Abstract: A label-free imaging-based flow cytometer that measures size and cell protein concentration simultaneously is disclosed. Cell protein concentration adds a parameter to cell classification that improves the specificity and sensitivity of flow cytometers without the requirement of cell labeling. The system uses coherent dispersive Fourier transform to perform phase imaging at flow speeds as high as a few meters per second. To retrieve cell information in real-time, an analog signal processing system based on quadrature phase demodulation is described.
Abstract translation: 公开了一种同时测量大小和细胞蛋白浓度的无标记成像的流式细胞仪。 细胞蛋白浓度为细胞分类提供参数，提高流式细胞仪的特异性和灵敏度，无需细胞标记。 该系统使用相干色散傅里叶变换来以高达几米每秒的流速执行相位成像。 为了实时检索信元信息，描述了基于正交相位解调的模拟信号处理系统。
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公开(公告)号：US08873132B2
公开(公告)日：2014-10-28
申请号：US13693896
申请日：2012-12-04
Applicant: The Regents of the University of California
Inventor： Daniel R. Solli , Bahram Jalali , Claus Ropers
IPC: H01S3/06
CPC classification number: G02F1/353 , G02F1/365 , G02F2001/3528
Abstract: Methods and systems are provided for generation and detection of rogue waves, including hydrodynamic rogue waves and optical rogue waves. A method for generating an optical rogue wave comprises the steps of generating an input pulse into a nonlinear optical medium, and perturbing the input pulse by directing a narrow-band seed radiation into the input pulse. The seed radiation has a frequency and timing to generate broadband radiation within the nonlinear optical medium.
Abstract translation: 提供了用于产生和检测流氓波的方法和系统，包括流体动力学流氓波和光学流氓波。 一种用于产生光流氓波的方法包括以下步骤：将输入脉冲产生到非线性光学介质中，并通过将窄带种子辐射引入输入脉冲来扰乱输入脉冲。 种子辐射具有在非线性光学介质内产生宽带辐射的频率和时间。
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Patent Agency Ranking
46.发明申请公开(公告)号：US20130135529A1
公开(公告)日：2013-05-30
申请号：US13668239
申请日：2012-11-03
Applicant: The Regents of the University of California
Inventor： Bahram Jalali , Ali Motafakker
CPC classification number: G01J1/0411 , G02B21/002 , G02B21/14 , H04N5/14
Abstract: We describe methods and apparatus for high-speed high-contrast imaging one-, two- and three-dimensional imaging enabled by differential interference contrast time encoded amplified microscopy of transparent media without the need for chemical staining, that are suitable for a broad range of applications from semiconductor process monitoring to blood screening. Our methods and apparatus build on a unique combination of serial time-encoded amplified microscopy (STEAM) and differential interference contrast (DIC) microscopy. These methods and apparatus are ideally suited for identification of rare diseased cells in a large population of healthy cells and have the potential to revolutionize blood analysis and pathology including identification of cancer cells, such as Circulating Tumor Cells (CTC) in early stage disease.
Abstract translation: 我们描述了用于高速高对比度成像的一维，二维和三维成像的方法和装置，其通过差示干涉对比度时间编码的透明介质的放大显微镜而不需要化学染色，其适用于广泛的 从半导体工艺监测到血液筛查的应用。 我们的方法和设备基于串行时间编码放大显微镜（STEAM）和微分干涉对比（DIC）显微镜的独特组合。 这些方法和装置非常适用于大量健康细胞中罕见病变细胞的鉴定，并具有革命性的血液分析和病理学的潜力，包括癌症细胞的鉴定，如早期疾病中的循环肿瘤细胞（CTC）。
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公开(公告)号：US11280718B2
公开(公告)日：2022-03-22
申请号：US17068573
申请日：2020-10-12
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Bahram Jalali , Eric D. Diebold , Brandon Buckley
IPC: G01N15/14 , G01N33/537 , G01N21/64 , G01N15/10
Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.
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48.发明授权公开(公告)号：US10408758B2
公开(公告)日：2019-09-10
申请号：US15961678
申请日：2018-04-24
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Eric D. Diebold , Bahram Jalali , Brandon Buckley
Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.
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公开(公告)号：US10275891B2
公开(公告)日：2019-04-30
申请号：US15341789
申请日：2016-11-02
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Bahram Jalali , Mohammadhossein Asghari
Abstract: Object and shape detection in digital images utilizing edge detection is described. In a first edge detection approach, phase transformation is utilized in the frequency domain, such as in response to Fourier transform, followed by use of a frequency-domain phase kernel and inverse-Fourier transform. Edge detection is also provided using a phase transform in the spatial domain utilizing a convolution approach. In a second edge detection approach, phase stretching is utilized, such as in combination with phase histogramming along with thresholding and morphological operations. Numerous example images are provided illustrating benefits of the disclosed technology with different applications and under different conditions.
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公开(公告)号：US09835840B2
公开(公告)日：2017-12-05
申请号：US14610851
申请日：2015-01-30
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Bahram Jalali , Keisuke Goda , Kevin Kin-Man Tsia
CPC classification number: G02B21/361 , A61B1/00009 , A61B1/00193 , A61B1/0638 , A61B5/0062 , A61B5/0066 , A61B5/0075 , A61B5/0086 , A61B5/7257 , G01B9/02004 , G01B9/02014 , G01B9/02028 , G01B9/02044 , G01B9/02091 , G01B11/2441 , G01B2290/20 , G01B2290/65 , G06K9/2036 , G06K2209/05 , H04N9/045
Abstract: An apparatus and method for ultrafast real-time optical imaging that can be used for imaging dynamic events such as microfluidics or laser surgery is provided. The apparatus and methods encode spatial information from a sample into a back reflection of a two-dimensional spectral brush that is generated with a two-dimensional disperser and a light source that is mapped in to the time domain with a temporal disperser. The temporal waveform is preferably captured by an optical detector, converted to an electrical signal that is digitized and processed to provide two dimensional and three dimensional images. The produced signals can be optically or electronically amplified. Detection may be improved with correlation matching against a database in the time domain or the spatial domain. Embodiments for endoscopy, microscopy and simultaneous imaging and laser ablation with a single fiber are illustrated.
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