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公开(公告)号：US5972654A
公开(公告)日：1999-10-26
申请号：US8960
申请日：1998-01-20
申请人： Y. Tom Tang , Neil C. Corley , Purvi Shah
发明人： Y. Tom Tang , Neil C. Corley , Purvi Shah
CPC分类号： C07K14/4725
摘要： The invention provides a human microfibril-associated glycoprotein 4 splice variant (MAG4V) and polynucleotides which identify and encode MAG4V. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of MAG4V.
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公开(公告)号：US5945306A
公开(公告)日：1999-08-31
申请号：US991946
申请日：1997-12-16
摘要： The invention provides two human Ras proteins, referred to collectively as "RAPR" and individually as "RAPR-1" and "RAPR-2", and polynucleotides which identify and encode RAPR. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for preventing and treating disorders associated with expression of RAPR.
摘要翻译： 本发明提供两种人类Ras蛋白质，统称为“RAPR”，分别称为“RAPR-1”和“RAPR-2”，以及鉴定和编码RAPR的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了预防和治疗与RAPR表达相关的疾病的方法。
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公开(公告)号：US5795724A
公开(公告)日：1998-08-18
申请号：US928443
申请日：1997-09-12
申请人： Jennifer L. Hillman , Y. Tom Tang , Neil C. Corley
发明人： Jennifer L. Hillman , Y. Tom Tang , Neil C. Corley
CPC分类号： C12N9/104 , C12Q1/6883 , A61K38/00 , C12Q2600/158
摘要： The invention provides a human N-acetyl transferase (NACTH) and polynucleotides which identify and encode NACTH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NACTH.
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公开(公告)号：US08716445B2
公开(公告)日：2014-05-06
申请号：US13397592
申请日：2012-02-15
申请人： Preeti G. Lal , Y. Tom Tang , Gina A. Gorgone Simone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice K. Au-Young , Henry Yue , Chandra S. Arvizu , Roopa M. Reddy , Jennifer L. Hillman , Olga Bandman
发明人： Preeti G. Lal , Y. Tom Tang , Gina A. Gorgone Simone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice K. Au-Young , Henry Yue , Chandra S. Arvizu , Roopa M. Reddy , Jennifer L. Hillman , Olga Bandman
CPC分类号： G01N33/57419 , A61K38/00 , A61K38/1709 , A61K39/3955 , A61K45/06 , C07K14/47 , C07K16/18 , C07K16/40 , C07K2317/76 , G01N2333/916
摘要： The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
摘要翻译： 本发明提供了人信号肽肽蛋白（HSPP）和识别和编码HSPP的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与HSPP表达相关的障碍的方法。
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45.发明申请公开(公告)号：US20100267648A1
公开(公告)日：2010-10-21
申请号：US12590236
申请日：2009-11-03
申请人： Y. Tom Tang
发明人： Y. Tom Tang
IPC分类号： A61K38/17 , C07K14/435 , A61P25/28 , A61P35/02 , C12P21/02
CPC分类号： C07K14/475
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
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46.发明申请公开(公告)号：US20100227802A1
公开(公告)日：2010-09-09
申请号：US11637866
申请日：2006-12-11
申请人： Y. Tom Tang , Ping Zhou , Feiyan Ren , Tianhua Hu
发明人： Y. Tom Tang , Ping Zhou , Feiyan Ren , Tianhua Hu
IPC分类号： A61K38/16 , C07H21/04 , C12N15/63 , C12N5/00 , C12N1/00 , C07K14/00 , C07K16/00 , C12Q1/68 , G01N33/53 , C12P21/00 , C40B40/10 , C40B40/06 , A61P43/00
CPC分类号： C07K14/723 , A61K38/00 , G01N2800/042
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to PAQR polypeptides. Other aspects of the invention include vectors containing processes for producing novel human PAQR polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了由对应于PAQR多肽的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 本发明的其它方面包括含有生产新的人PAQR多肽的方法的载体和对这些多肽具有特异性的抗体。
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47.发明申请Methods and materials relating to novel stem cell growth factor-like polypeptides and polynucleotides 审中-公开与新型干细胞生长因子样多肽和多核苷酸相关的方法和材料公开(公告)号：US20080241882A1
公开(公告)日：2008-10-02
申请号：US11985824
申请日：2007-11-16
申请人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
发明人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
CPC分类号： C07K14/475 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K16/00 , C07K2319/00 , C12N9/16 , C12N9/6432 , C12Y304/21006 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes fro producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 这些多核苷酸包含从人胎儿皮肤（Hyseq克隆鉴定号15375176），成年脾（Hyseq克隆鉴定号14856094）和人内皮细胞的人睾丸细胞（Hyseq克隆鉴定号2880984和2881695）的cDNA文库中分离的核酸序列 （Hyseq克隆鉴定号13804756,13687487,13804756）。 本发明的其它方面包括含有产生新型人干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。
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48.发明申请Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides 审中-公开与干细胞生长因子样多肽和多核苷酸相关的方法和材料公开(公告)号：US20080227712A1
公开(公告)日：2008-09-18
申请号：US12080606
申请日：2008-04-03
申请人： Y. Tom Tang
发明人： Y. Tom Tang
CPC分类号： C07K14/475
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了由对应于新型人分泌的干细胞生长因子样多肽的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 本发明的其它方面包括含有用于产生新的人分泌的干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。
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49.发明授权公开(公告)号：US07320880B2
公开(公告)日：2008-01-22
申请号：US10478926
申请日：2002-06-11
申请人： Mitsuo Nishikawa , Radoje T. Drmanac , Ivan Lobal , Y. Tom Tang , Juhi Lee , Birgit Stache-Crain
发明人： Mitsuo Nishikawa , Radoje T. Drmanac , Ivan Lobal , Y. Tom Tang , Juhi Lee , Birgit Stache-Crain
IPC分类号： C07H21/04 , C07K14/475 , C12N5/00 , C12N1/00 , C12P21/02
CPC分类号： C12N5/0647 , A61K38/00 , C07K14/475
摘要： A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.
摘要翻译： 通过比较支持不支持增殖或存活的造血干细胞或造血祖细胞的增殖或存活的细胞之间的表达基因，分离编码具有支持造血干细胞或造血祖细胞的增殖或存活活性的多肽的基因 。 通过使用分离的基因表达的基质细胞或分离的基因的基因产物来支持造血干细胞或造血祖细胞的增殖或存活。
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50.发明授权Methods of therapy and diagnosis using insulin-like growth factor binding protein-like polypeptides and polynucleotides 失效使用胰岛素样生长因子结合蛋白样多肽和多核苷酸的治疗和诊断方法公开(公告)号：US07109030B2
公开(公告)日：2006-09-19
申请号：US10218325
申请日：2002-08-12
申请人： Douglas A. Dedera , Victoria Yamazaki , Vinod Asundi , Chenghua Liu , Y. Tom Tang , Radoje T. Drmanac
发明人： Douglas A. Dedera , Victoria Yamazaki , Vinod Asundi , Chenghua Liu , Y. Tom Tang , Radoje T. Drmanac
IPC分类号： C12N15/00 , G01N33/53 , A61K38/00 , C07K14/435
CPC分类号： G01N33/57488 , A61K38/00 , C07K14/71 , G01N2333/65
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted IGFBP-like polypeptides, compositions, and methods of use for such polypeptides including in cancer.
摘要翻译： 本发明提供由这样的多核苷酸编码的新型多核苷酸和多肽，其对应于新型人分泌的IGFBP样多肽的突变体或其变体。 本发明的其它方面包括含有生产新型人分泌IGFBP样多肽的方法的载体，组合物，以及包括癌症在内的多肽的使用方法。
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