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公开(公告)号:US07449485B2
公开(公告)日:2008-11-11
申请号:US12037608
申请日:2008-02-26
申请人: Steven W. Elmore , Cheol-Min Park , Xilu Wang
发明人: Steven W. Elmore , Cheol-Min Park , Xilu Wang
IPC分类号: A61K31/4418 , C07D211/70
CPC分类号: C07D295/215 , A61K31/4025 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/553 , A61K31/554 , C07D211/16 , C07D211/18 , C07D211/26 , C07D211/58 , C07D211/82 , C07D295/205
摘要: Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号:US20070072860A1
公开(公告)日:2007-03-29
申请号:US11600445
申请日:2006-11-16
申请人: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
发明人: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
IPC分类号: A61K31/53 , A61K31/501 , A61K31/497 , A61K31/444 , A61K31/4439 , C07D413/02 , C07D403/02
CPC分类号: C07D295/155 , C07C311/51 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/06 , C07D233/22 , C07D233/24 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/20 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/04 , C07D277/36 , C07D277/74 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08 , C07D498/08
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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公开(公告)号:US20060264476A1
公开(公告)日:2006-11-23
申请号:US11459745
申请日:2006-07-25
申请人: Akiyo Claiborne , Stephen Gwaltney , Lisa Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert Mantei , Todd Rockway , Hing Sham , Gerard Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人: Akiyo Claiborne , Stephen Gwaltney , Lisa Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert Mantei , Todd Rockway , Hing Sham , Gerard Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号: A61K31/4439 , C07D403/02
CPC分类号: C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译: 具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。 还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。
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公开(公告)号:US07030115B2
公开(公告)日:2006-04-18
申请号:US10394985
申请日:2003-03-21
申请人: Steven W. Elmore , Cheol-Min Park , Xilu Wang
发明人: Steven W. Elmore , Cheol-Min Park , Xilu Wang
IPC分类号: A61K31/5377 , A61K31/495 , C07D295/195 , C07D413/10
CPC分类号: C07D295/215 , A61K31/4025 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/553 , A61K31/554 , C07D211/16 , C07D211/18 , C07D211/26 , C07D211/58 , C07D211/82 , C07D295/205
摘要: Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号:US08354404B2
公开(公告)日:2013-01-15
申请号:US13093753
申请日:2011-04-25
申请人: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
发明人: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
IPC分类号: C07D241/04 , A61K31/496
CPC分类号: C07D295/155 , C07C311/51 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/06 , C07D233/22 , C07D233/24 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/20 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/04 , C07D277/36 , C07D277/74 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08 , C07D498/08
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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公开(公告)号:US20110144112A9
公开(公告)日:2011-06-16
申请号:US11600445
申请日:2006-11-16
申请人: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
发明人: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
IPC分类号: A61K31/53 , A61K31/501 , A61K31/497 , A61K31/444 , A61K31/4439 , C07D413/02 , C07D403/02
CPC分类号: C07D295/155 , C07C311/51 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D209/02 , C07D209/52 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/06 , C07D233/22 , C07D233/24 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/20 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/04 , C07D277/36 , C07D277/74 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08 , C07D498/08
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
摘要翻译: 公开了抑制抗凋亡蛋白家族成员的活性的化合物,含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途,其中发生表达一种或多种抗凋亡蛋白家族成员。
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公开(公告)号:US07777076B2
公开(公告)日:2010-08-17
申请号:US11914772
申请日:2006-05-17
IPC分类号: C07C321/00
CPC分类号: C07D273/02 , C07D273/00 , C07D413/12
摘要: Macrocyclic compounds of formula (I), in which B1 and X1 taken together are alkylene which is unsubstituted or substituted with ═O and having one CH2 moiety unreplaced or replaced with CH═CH, O, NH or N(alkyl), which inhibit the activity of antiapoptotic Bcl-2 family protein members, compositions containing the compounds and methods of treating diseases during which are expressed one or more than one of an anti-apoptotic family protein member are disclosed.
摘要翻译: 式(I)的大环化合物,其中B1和X1一起是未被取代或被= O取代且具有一个CH2部分未被置换或被CH = CH,O,NH或N(烷基)取代的亚烷基,其抑制 公开了抗凋亡性Bcl-2家族蛋白质成员的活性,含有化合物的组合物和治疗疾病的方法,其中表达一种或多种抗凋亡家族蛋白质成员。
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公开(公告)号:US20100022773A1
公开(公告)日:2010-01-28
申请号:US12390945
申请日:2009-02-23
申请人: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Noah Tu , Xilu Wang , Michael Wendt
发明人: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Noah Tu , Xilu Wang , Michael Wendt
IPC分类号: C07D241/04
CPC分类号: C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
摘要翻译: 公开了抑制抗凋亡蛋白家族成员的活性的化合物,含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途,其中发生表达一种或多种抗凋亡蛋白家族成员。
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公开(公告)号:US07390799B2
公开(公告)日:2008-06-24
申请号:US11432937
申请日:2006-05-12
申请人: Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol Min Park , Xiahong Song , Xilu Wang
发明人: Milan Bruncko , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol Min Park , Xiahong Song , Xilu Wang
IPC分类号: C07D413/02 , C07D403/02 , A61K31/553 , A61K31/55 , A61K31/5377 , A61K31/496
CPC分类号: C07D295/155 , C07D487/08 , C07D491/08
摘要: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.
摘要翻译: 公开了抑制抗凋亡家族蛋白成员的活性的化合物,含有该化合物的组合物和治疗疾病的方法,其中表达一种或多种抗凋亡家族蛋白质成员。
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公开(公告)号:US20070027135A1
公开(公告)日:2007-02-01
申请号:US11432937
申请日:2006-05-12
申请人: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol Park , Xiahong Song , Xilu Wang
发明人: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol Park , Xiahong Song , Xilu Wang
IPC分类号: A61K31/553 , A61K31/55 , A61K31/5377 , A61K31/496 , C07D413/02 , C07D403/02
CPC分类号: C07D295/155 , C07D487/08 , C07D491/08
摘要: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti-apoptotic family protein member are disclosed.
摘要翻译: 公开了抑制抗凋亡家族蛋白成员的活性的化合物,含有该化合物的组合物和治疗疾病的方法,其中表达一种或多种抗凋亡家族蛋白质成员。
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