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41.发明授权公开(公告)号：US12001934B2
公开(公告)日：2024-06-04
申请号：US18196897
申请日：2023-05-12
发明人： Edwin Olson , Dhanvin H. Mehta , Gonzalo Ferrer
CPC分类号： G06N3/02 , G06N3/008 , G06N3/084 , G06N7/01 , H04N1/00002
摘要： In Multi-Policy Decision-Making (MPDM), many computationally-expensive forward simulations are performed in order to predict the performance of a set of candidate policies. In risk-aware formulations of MPDM, only the worst outcomes affect the decision making process, and efficiently finding these influential outcomes becomes the core challenge. Recently, stochastic gradient optimization algorithms, using a heuristic function, were shown to be significantly superior to random sampling. In this disclosure, it was shown that accurate gradients can be computed—even through a complex forward simulation—using approaches similar to those in dep networks. The proposed approach finds influential outcomes more reliably, and is faster than earlier methods, allowing one to evaluate more policies while simultaneously eliminating the need to design an easily-differentiable heuristic function.
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公开(公告)号：US12000140B2
公开(公告)日：2024-06-04
申请号：US17074090
申请日：2020-10-19
IPC分类号： E04B1/84 , B26F1/26 , C03B23/025 , G10K11/162
CPC分类号： E04B1/8409 , C03B23/0252 , G10K11/162 , B26F1/26 , E04B2001/8414 , E04B2001/8428
摘要： A method of fabricating an acoustic device includes forming a plurality of holes in a panel, disposing the panel in a support frame, and heating the panel to a temperature such that the panel sags while disposed in the support frame and each hole of the plurality of holes is modified.
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公开(公告)号：US11998513B2
公开(公告)日：2024-06-04
申请号：US16976382
申请日：2019-02-28
发明人： Joshua C. Doverspike , James Phan , Jianfeng Wu , Chuanwu Xi , Yu Qin , Mark E. Meyerhoff , Yang Zhou
IPC分类号： A61K31/04 , A61K31/198 , A61K33/30 , A61K38/06 , A61K47/06 , B01J23/72 , B01J31/02 , A61K9/00 , A61K9/06
CPC分类号： A61K31/04 , A61K31/198 , A61K33/30 , A61K38/063 , A61K47/06 , B01J23/72 , B01J31/0272 , A61K9/0014 , A61K9/06
摘要： A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.
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公开(公告)号：US11994096B2
公开(公告)日：2024-05-28
申请号：US18128293
申请日：2023-03-30
CPC分类号： F03B17/06 , F03B13/16 , F03B13/264 , F05B2240/40 , F05B2240/93 , F05B2240/95 , Y02E10/20 , Y02E10/30
摘要： A VIVACE converter to harness energy from currents as well as from waves— that is, the present teachings provide a method and apparatus to collect energy from both currents and waves—using the same physical components. The present teachings are particularly useful in that either currents and/or waves may exist on their own nearly everywhere in the oceans and frequently coexist.
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45.发明公开公开(公告)号：US20240168116A1
公开(公告)日：2024-05-23
申请号：US17990616
申请日：2022-11-18
CPC分类号： G01R33/5608 , G01R33/50 , G01R33/543
摘要： Methods and systems perform magnetic resonance fingerprinting (MRF) by obtaining magnetic resonance data over a main field-of-view (FOV) and resulting from providing a magnetic resonance fingerprinting pulse sequence to a sample. The pulse sequence includes gradient waveforms and radio frequency (RF) pulses that have pulse sequence parameters specifically tailored for scanning, not the entire main FOV but rather a reduced portion of that main FOV. The methods and systems further include comparing the magnetic resonance data from the sample to a fingerprint dictionary of signal profiles that specifically correspond to the reduced portion of the main FOV and generating tissue property maps that correspond only to that reduced portion.
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公开(公告)号：US11986993B2
公开(公告)日：2024-05-21
申请号：US17365099
申请日：2021-07-01
IPC分类号： B29C64/106 , B29C64/295 , B33Y10/00 , B33Y30/00 , B33Y40/20 , B29K101/10 , B29K105/16 , B29K505/00
CPC分类号： B29C64/106 , B29C64/295 , B33Y10/00 , B33Y30/00 , B33Y40/20 , B29K2101/10 , B29K2105/16 , B29K2505/00
摘要： The disclosure relates to methods of forming three-dimensional (3D) polymeric articles and additive manufacturing apparatuses for the same. The methods include providing a polymeric solution comprising a polymer dissolved in a solvent; providing a non-solvent, wherein the solvent is miscible in the non-solvent, and the polymer is insoluble in the non-solvent; and injecting the polymeric solution into the non-solvent in a pre-determined 3D pattern to provide a 3D polymeric article.
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公开(公告)号：US11986352B2
公开(公告)日：2024-05-21
申请号：US17424947
申请日：2020-02-05
CPC分类号： A61B8/463 , A61B8/486 , A61B8/488 , A61B8/5207 , A61B8/5223 , G06T7/0016 , G06T7/254 , G06T2207/10016 , G06T2207/10136 , G06T2207/30061
摘要： A method of estimating lung motion includes collecting multiple ultrasound image data captured at one or more locations of a sample region of tissue. The method further includes comparing the multiple ultrasound image data and determining temporal correlation coefficients between each of the multiple ultrasound image data. The method still further includes displaying an image of the sample region of the tissue with the temporal correlation coefficients identified, thereby indicating lung motion. In further methods, the determined temporal correlation coefficients are used to determine an amount of decorrelation, which can be used to determine strain of the tissue over the sample region and to calculate lung displacements and lung shape changes representing ventilation.
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公开(公告)号：US11985888B2
公开(公告)日：2024-05-14
申请号：US16943906
申请日：2020-07-30
发明人： Stephen R. Forrest , Jongchan Kim
CPC分类号： H10K85/346 , H10K30/353 , H10K71/164
摘要： An organic light emitting device (OLED) comprises an anode; a cathode; and a light emitting layer, disposed between the anode and the cathode; wherein the light emitting layer comprises at least one luminescent compound; and wherein the transition dipole moment of the at least one luminescent compound is oriented parallel to the surface of the light emitting layer. A method of fabricating a light emitting layer, comprises the steps of providing a substrate; depositing less than 2 nm of a template material on the substrate; and depositing a composition comprising at least one light emitting compound on the template material.
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49.发明授权公开(公告)号：US11984208B2
公开(公告)日：2024-05-14
申请号：US16749694
申请日：2020-01-22
发明人： Brian D. Athey , Gerald A. Higgins , Alex Ade , Alexandr Kalinin , Narathip Reamaroon , James S. Burns
IPC分类号： G16H20/10 , G16B5/00 , G16B5/10 , G16B20/00 , G16B30/00 , G16B40/00 , G16B45/00 , G16B50/10 , G16H50/20 , G16H50/50
摘要： Methods comprising an integrated, multiscale artificial intelligence-based system that reconstructs drug-specific pharmacogenomic networks and their constituent functional sub-networks are described. The system uses features of the functional topology of the three-dimensional architecture of drug-modulated spatial contacts in chromatin space. Discovery of a drug pharmacogenomic network is made through the selection of candidate SNPs by imputation, determination of the predicted causality of the SNPs using machine learning and deep learning, use of the causal SNPs to probe the spatial genome as determined by chromosome conformation capture analysis, combining targeted genes controlled by the same cell and tissue-specific enhancers, and reconstruction of the pharmacogenomic network using diverse data sources and metrics based on the results of genome-wide association studies. Knowledge-based segmentation methods are used to deconstruct the pharmacogenomic network into its constituent efficacy and adverse event sub-networks for applications in clinical decision support, drug re-purposing, and in silico drug discovery.
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公开(公告)号：US20240141017A1
公开(公告)日：2024-05-02
申请号：US18278676
申请日：2022-02-25
发明人： Wenjing Wang , Kayla Kroning
CPC分类号： C07K14/723 , C07K16/18 , G01N33/582 , C07K2317/569 , C07K2319/60
摘要： The present disclosure relates to fluorescent biosensors and methods of use thereof. In particular, provided herein is a genetically encoded fluorescent indicator (GEFI) comprising a circular-permuted fluorescent protein (cpFP) and an inhibitory molecule bound to the cpFP. In the basal state, the inhibitory molecule prevents fluorescence from the circular-permuted fluorescent protein. Upon conformational change and/or cleavage of the bond between the inhibitory molecule and the cpFP, the cpFP is disinhibited, thereby permitting fluorescence from the cpFP. The biosensors described herein may be used in methods for detecting a variety of cell-signaling events.
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