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公开(公告)号：US11883180B2
公开(公告)日：2024-01-30
申请号：US17070530
申请日：2020-10-14
IPC分类号： A61B5/36 , A61B5/366 , A61B5/00 , A61B5/02 , A61B5/30 , A61B5/316 , A61B5/363 , A61B5/364 , A61B5/282
CPC分类号： A61B5/366 , A61B5/02007 , A61B5/303 , A61B5/316 , A61B5/363 , A61B5/364 , A61B5/6823 , A61B5/282
摘要： Disclosed herein are methods, systems, and devices for identifying increased likelihood of non-ST elevation myocardial infarction (NSTEMI) in a patient based on ECG data. The methods can include determining based on the ECG data that the patient lacks ST elevation (STE) and that the patient exhibits a ventricular repolarization dispersion (VRD) score that exceeds a predetermined threshold value. The VRD score can be based in part on a T wave complexity ratio that serves as a temporal marker of VRD for the patient. Other markers of spatial and time qualities of repolarization can also be included in the VRD score. An elevated VRD score in the absence of STE can indicate a likelihood of NSTEMI in the patient and a potential major adverse cardiac event.
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公开(公告)号：US11877885B2
公开(公告)日：2024-01-23
申请号：US16630964
申请日：2018-07-20
CPC分类号： A61B8/06 , A61B5/0004 , A61B5/725 , A61B5/7264 , A61B2560/0219
摘要： A system for monitoring free flap patency includes transmit and receive transducers structured to be coupled to a blood vessel, and a plurality of circuitry modules structured to insonify a blood flow volume within the blood vessel and receive a scattered signal from the receive transducer, extract a baseband Doppler blood flow signal, VBASEBAND, from the scattered signal, extract a plurality of features from VBASEBAND, and classify the plurality of features and generate a binary signal based on the classification of the plurality of features, wherein the binary signal will have a first state responsive to the classification of the plurality of features indicating that a flow rate within the blood vessel is less than a predetermined level and a second state responsive to the classification of the plurality of features indicating the flow rate within the blood vessel is greater than or equal to the predetermined level.
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公开(公告)号：US20240006050A1
公开(公告)日：2024-01-04
申请号：US18255727
申请日：2021-12-09
申请人： THE JOHNS HOPKINS UNIVERSITY , University of Pittsburgh-Of the Commonwealth System of Higher Education
CPC分类号： G16H20/40 , G16H50/20 , A61B5/7267 , A61B5/4094 , A61B5/015
摘要： A machine-implemented method, computing device, and at least one non-transitory computer-readable medium are provided. A dynamical network model is parameterized by state transition matrices based on monitored interictal brain data. A node influence-to network score for each respective node is calculated indicating how influential the respective node is. An influenced-by score is calculated for the each respective node indicating an amount by which the respective node is influenced by the nodes. A score is calculated for the each respective node based on a sink index, a source influence index, and a sink connectivity index. Nodes that are in the epileptogenic zone are determined based on the calculated score for each of the nodes. An indication of the nodes in the epileptogenic zone is provided.
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公开(公告)号：US11857550B2
公开(公告)日：2024-01-02
申请号：US16953201
申请日：2020-11-19
申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education , The United States Government as represented by the Department of Veterans Affairs
发明人： Beibei Chen , Rama K. Mallampalli
IPC分类号： A61K31/506 , A61K31/137 , C07D239/26 , C07D403/12 , A61P3/10 , A61P11/06 , A61P19/00 , A61P25/00 , A61P35/00 , C07D231/12 , C07D233/61 , A61K31/341 , A61K31/381 , A61K31/402 , A61K31/4155 , A61K31/427 , A61K31/4418 , A61K31/5375 , C07D213/36 , C07C211/01 , C07C211/53 , C07C229/38 , C07D207/06 , C07D211/14 , C07D213/06 , C07D213/38 , C07D265/30 , C07D277/28 , A61K31/4178 , A61K31/435 , A61K31/444 , C07D233/64 , C07D401/12 , C07D295/135
CPC分类号： A61K31/506 , A61K31/137 , A61K31/341 , A61K31/381 , A61K31/402 , A61K31/4155 , A61K31/4178 , A61K31/427 , A61K31/435 , A61K31/444 , A61K31/4418 , A61K31/5375 , A61P3/10 , A61P11/06 , A61P19/00 , A61P25/00 , A61P35/00 , C07C211/01 , C07C211/53 , C07C229/38 , C07D207/06 , C07D211/14 , C07D213/06 , C07D213/36 , C07D213/38 , C07D231/12 , C07D233/61 , C07D233/64 , C07D239/26 , C07D265/30 , C07D277/28 , C07D295/135 , C07D401/12 , C07D403/12 , Y02A50/30
摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of:
wherein X is a divalent linking moiety; and
R1-R10 are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R3 or R8 is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen.-
公开(公告)号：US20230414754A1
公开(公告)日：2023-12-28
申请号：US18035590
申请日：2021-11-05
IPC分类号： A61K39/00
CPC分类号： A61K39/4633 , A61K39/4631 , A61K39/4611 , A61K2239/26 , A61K2239/24
摘要： Disclosed are compositions and methods related to the construction and use of conditional universal synthetic notch (synNotch) receptors and conditional chimeric antigen receptor (CAR) T cells. Also disclosed herein are methods of using said synNotch receptors in the construction of engineered cells. It is contemplated herein that the disclosed synNotch receptors and engineered cells can be used in regenerative medicine. Additionally disclosed herein are methods of using the disclosed synNotch, CAR T cells, and engineered cells in the treatment of cancer, autoimmune disease, autoinflammatory disease, and infectious disease.
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46.发明授权公开(公告)号：US11845961B2
公开(公告)日：2023-12-19
申请号：US17151921
申请日：2021-01-19
发明人： Rocky S. Tuan , Hang Lin , Thomas P. Lozito , Peter Alexander , Douglas Allen Nelson, Jr. , Riccardo Gottardi
CPC分类号： C12N5/0697 , C12M21/08 , C12M23/12 , C12M23/16 , C12M23/34 , C12M35/04 , C12M35/08 , C12N2502/1311 , C12N2502/1317
摘要： Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a system can include a well plate having a plurality of wells and a bioreactor situated in each well of the well plate. In some cases, a bioreactor can include an inner body which divides the bioreactor into several distinct chambers and facilitates the growth of a multi-tissue sample in the bioreactor. In some cases, a system can include a mechanical actuator situated to mechanically stress tissues grown in a bioreactor.
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公开(公告)号：US20230381382A1
公开(公告)日：2023-11-30
申请号：US18204476
申请日：2023-06-01
发明人： PRASHANT N. KUMTA , ABHIJIT ROY , DA-TREN CHOU , DAEHO HONG , VIJAY S. GORANTLA
CPC分类号： A61L31/148 , A61L31/022 , C22C23/04 , A61L2430/02
摘要： The invention relates to biodegradable, magnesium alloys, compositions and composites, methods for their preparation and applications for their use as implantable medical devices in load-bearing conditions. The magnesium alloys are composed of alloying elements selected from yttrium, calcium, zirconium, zinc, and strontium, with the remainder being magnesium and impurities arising due to production, and preparation of the alloy by melting together the elements and casting the resulting melted mixture. In certain embodiments, the methods of preparation include solution treatment and hot extrusion.
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公开(公告)号：US11826572B2
公开(公告)日：2023-11-28
申请号：US17330883
申请日：2021-05-26
发明人： Changfeng Tai
CPC分类号： A61N1/36164 , A61N1/0551 , A61N1/36062 , A61N1/36071 , A61N1/36153 , A61N1/36157
摘要： A method of blocking a nerve or neuron by applying an electrical stimulation to the nerve or neuron, wherein the electrical stimulation is of an intensity below the excitation threshold of the nerve or neuron for a length of time sufficient to produce a block of nerve conduction or neuron excitation.
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公开(公告)号：US20230365457A1
公开(公告)日：2023-11-16
申请号：US18225825
申请日：2023-07-25
CPC分类号： C03C15/00 , C03C17/06 , C03C17/30 , C03C2217/76 , B82Y30/00 , C03C2217/77 , C03C2217/75 , B82Y40/00
摘要： The invention relates generally to optically high transparency and high haze structures and, more particularly, to plastic, e.g., polymer, and glass structures having a sub-wavelength texture formed on a surface thereof, which is effective to impart the optical properties of high transparency and high haze to the structures. The texture is in a grass-like or needle-like form. Additionally, the optically high transparency and high haze structures may include a transparent conductor. Furthermore, the glass structures may exhibit a self-cleaning function.
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50.发明公开公开(公告)号：US20230364301A1
公开(公告)日：2023-11-16
申请号：US18044969
申请日：2021-04-30
CPC分类号： A61L27/3633 , A61L27/52 , A61L27/54 , A61L2400/06 , A61L2430/34
摘要： A method is disclosed for treating a fistula in a subject, such as, but not limited to, an anal fistula. In some embodiments, the method includes administering locally to the fistula in the subject an effective amount of a composition comprising a mammalian acoustic extracellular matrix (ECM) hydrogel, and optionally trehalose. Compositions of use in these methods are also disclosed.
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