公开(公告)号：US07504153B2

公开(公告)日：2009-03-17

申请号：US10556431

申请日：2004-05-12

Applicant: Takashi Kurose ,  Tatsuhiro Takahashi ,  Chiaki Sotowa ,  Toshio Morita

Inventor： Takashi Kurose ,  Tatsuhiro Takahashi ,  Chiaki Sotowa ,  Toshio Morita

IPC: B32B9/00

CPC classification number: C08J9/0085 ,  B01J21/18 ,  B01J31/06 ,  B01J31/061 ,  B01J31/08 ,  B01J32/00 ,  B01J35/002 ,  B01J35/0033 ,  B01J35/023 ,  B01J35/026 ,  B01J35/06 ,  B01J35/10 ,  B01J35/1014 ,  B01J37/32 ,  B22F2998/10 ,  C02F1/283 ,  C02F2303/185 ,  C04B38/0045 ,  C04B41/009 ,  C04B41/48 ,  C04B41/4888 ,  C04B41/51 ,  C04B41/63 ,  C04B41/69 ,  C04B41/83 ,  C04B41/88 ,  C04B2111/00793 ,  C04B2111/0081 ,  C08J9/26 ,  C08J9/28 ,  C08J9/40 ,  C08J2201/038 ,  C08J2201/048 ,  C08J2201/0504 ,  C08J2305/00 ,  C08J2375/04 ,  C22C47/08 ,  H01M4/9083 ,  H01M4/926 ,  H01M8/0234 ,  Y02P70/56 ,  Y10S977/842 ,  Y10T428/249927 ,  Y10T428/24994 ,  Y10T428/30 ,  C04B35/52 ,  C04B38/04 ,  C04B40/0078 ,  C04B14/386 ,  C04B30/02 ,  C04B38/00 ,  C04B38/0074 ,  C04B38/10 ,  C04B41/457 ,  C04B41/4523 ,  C04B35/83 ,  C22C47/06 ,  B22F3/114

Abstract: A porous material comprising vapor grown carbon fiber in an amount of 10 to 90 mass %, fiber filaments of the carbon fiber forming a three-dimensional network and having a diameter of 1 to 1,000 nm, an aspect ratio of 5 to 15,000, a specific surface area (by BET method) of 2 to 2,000 m2/g, and the ratio of the intensity of the peak at 1,360 cm−1 in a Raman scattering spectrum of the carbon fiber to that of the peak at 1,580 cm−1 in the spectrum(I1360/I1580) is 0.1 to 2.0, wherein the porosity of the porous material (V/V0) is 0.50 to 0.99 and a specific surface area is 5 to 1,000 m2/g; and a production method and use thereof. The vapor grow carbon fiber impregnated in the porous material of the present invention does not contain aggregates and a three-dimensional network is formed between the fiber filaments, wherein length of each of the fiber filaments is maintained. Therefore, the vapor grown carbon fiber enables to readily produce a composite material (porous material), in which even a small amount of addition of vapor grown carbon fiber can exhibit sufficient effect.

Abstract translation: 10.一种多孔材料，其含有10〜90质量％的蒸气生长碳纤维，所述碳纤维的纤维丝形成三维网状物，直径为1〜1000nm，长径比为5〜15000， 表面积（BET法）为2〜2000m 2 / g，碳纤维的拉曼散射光谱中的1,360cm -1处的峰强度与1580cm -1的峰的强度的比例 光谱（I1360 / I1580）为0.1〜2.0，其中多孔材料的孔隙率（V / V0）为0.50〜0.99，比表面积为5〜1000m 2 / g; 及其制造方法及其用途。 浸渍在本发明的多孔材料中的蒸气生长碳纤维不含有聚集体，并且在纤维长丝之间形成三维网络，其中维持每根纤维丝的长度。 因此，气相生长碳纤维能够容易地生产即使少量添加气相生长碳纤维也能发挥足够的效果的复合材料（多孔材料）。

公开(公告)号：US20070282024A1

公开(公告)日：2007-12-06

申请号：US11791192

申请日：2006-03-10

Applicant: Toshinobu Sajiki ,  Junichi Ide ,  Naoyuki Hanaki ,  Yoji Matsuura

Inventor： Toshinobu Sajiki ,  Junichi Ide ,  Naoyuki Hanaki ,  Yoji Matsuura

IPC: C08J9/28

CPC classification number: A61L27/18 ,  A61L27/56 ,  C08J9/28 ,  C08J2201/048 ,  C08J2367/04 ,  C08L67/04

Abstract: A process for producing a porous object is provided that makes it possible to control pore sizes, particularly not only smaller pore sizes but also larger pore sizes. The pore sizes are controlled by: preparing a mixed solution containing a polymer including a copolymer of lactide and caprolactone, a solvent in which the polymer has a relatively low solubility, and a solvent in which the polymer has a relatively high solubility and that is compatible with the solvent in which the polymer has a relatively low solubility; varying the content of the solvent in which the polymer has a relatively low solubility in the mixed solution, when the mixed solution is frozen and dried to produce the porous object; and cooling the mixed solution at a rate of 300° C./hr or lower in freeze-treating. Thus a porous object with a pore size of 30 to 1800 μm can be obtained.

Abstract translation: 提供一种制造多孔物体的方法，其使得可以控制孔径，特别是不仅具有更小的孔径，而且更大的孔径。 孔径的控制是：制备含有包含丙交酯和己内酯的共聚物的聚合物的混合溶液，其中聚合物具有较低溶解度的溶剂和其中聚合物具有相对较高的溶解度并且是相容的溶剂 其中聚合物具有较低溶解度的溶剂; 当混合溶液冷冻干燥以产生多孔物体时，改变聚合物在混合溶液中具有较低溶解度的溶剂的含量; 并在冷冻处理中以300℃/小时或更低的速率冷却混合溶液。 因此，可以获得孔径为30至1800μm的多孔物体。

公开(公告)号：US06562374B1

公开(公告)日：2003-05-13

申请号：US09699213

申请日：2000-10-27

Applicant: Dong Keun Han ,  Kwang-Duk Ahn ,  Jong-Man Kim ,  Young Min Ju

Inventor： Dong Keun Han ,  Kwang-Duk Ahn ,  Jong-Man Kim ,  Young Min Ju

IPC: C08J900

CPC classification number: C08J9/08 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  C08J9/28 ,  C08J2201/048 ,  C08J2367/04 ,  Y10S514/802 ,  Y10S514/945 ,  Y10S514/955 ,  C08L67/04

Abstract: The present invention provides a method for preparing biodegradable porous polymer scaffolds for tissue engineering, comprising: a) fabricating a polymer sample from a polymer solution containing at least one biodegradable polymer and an effervescent mixture; b) effervescing the polymer sample in the presence of an effervescent medium such as an aqueous alcohol solution; and c) drying. The method for preparing biodegradable polymer scaffolds of the present invention has the advantages that the process is simple, that pore size can be easily controlled, that the problem caused by the secretion and existence of the toxic substance can be avoid by using a material harmless to human body, and that high efficiency can be achieved. In addition, biodegradable porous polymer scaffolds prepared by above method have the advantages that high porosity can be achieved and an open cell structure in which pores are interconnected is obtained.

Abstract translation: 本发明提供了一种制备用于组织工程的可生物降解的多孔聚合物支架的方法，包括：a）从含有至少一种可生物降解的聚合物和泡腾混合物的聚合物溶液制备聚合物样品; b）在存在聚合物样品的情况下， 泡腾介质如醇水溶液; 和.c）干燥。本发明的可生物降解的聚合物支架的制备方法具有以下优点：该方法简单，可以容易地控制孔径，通过使用可以避免由分解和存在的有毒物质引起的问题 对人体无害的物质，可以实现高效率。 此外，通过上述方法制备的可生物降解的多孔聚合物支架具有能够获得高孔隙率并且获得孔互连的开孔结构的优点。

公开(公告)号：US6103255A

公开(公告)日：2000-08-15

申请号：US293118

申请日：1999-04-16

Applicant: Howard B. Levene ,  Christelle M. Lhommeau ,  Joachim B Kohn

Inventor： Howard B. Levene ,  Christelle M. Lhommeau ,  Joachim B Kohn

IPC: A61L27/38 ,  A61L27/56 ,  C08J9/26 ,  C08J9/28 ,  C12N5/00 ,  A61F2/00 ,  C12N11/00

CPC classification number: A61L27/3839 ,  A61L27/56 ,  C08J9/26 ,  C08J9/28 ,  C12N5/0068 ,  C08J2201/044 ,  C08J2201/0446 ,  C08J2201/046 ,  C08J2201/048 ,  C12N2533/30

Abstract: Biodegradable and biocompatible porous scaffolds characterized by a substantially continuous polymer phase, having a highly interconnected bimodal distribution of open pore sizes with rounded large pores of about 50 to about 500 microns in diameter and rounded small pores less than 20 microns in diameter, wherein the small pores are aligned in an orderly linear fashion within the walls of the large pores. Methods of preparing polymeric tissue scaffolds are also disclosed.

公开(公告)号：US4522753A

公开(公告)日：1985-06-11

申请号：US287930

申请日：1981-07-29

Applicant: Ioannis V. Yannas ,  John F. Burke ,  Peter J. Stasikelis

Inventor： Ioannis V. Yannas ,  John F. Burke ,  Peter J. Stasikelis

IPC: A61F2/00 ,  A61F13/00 ,  A61L15/42 ,  A61L17/08 ,  A61L27/24 ,  B01J20/28 ,  C08J9/28 ,  B29D27/00

CPC classification number: C08J9/28 ,  A61F13/00008 ,  A61L15/425 ,  A61L17/08 ,  A61L27/24 ,  A61F2013/00255 ,  A61F2013/0074 ,  A61F2013/00863 ,  A61F2310/00365 ,  C08J2201/048 ,  C08J2389/00 ,  Y10S602/90

Abstract: A method for preserving the porosity of porous materials is disclosed. In this method, the porous material is subjected to elevated temperature and vacuum conditions to thereby produce a dimensionally-stable, non-collapsible porous material.

Abstract translation: 公开了一种保存多孔材料孔隙率的方法。 在该方法中，多孔材料经历升高的温度和真空条件，从而产生尺寸稳定的，不可折叠的多孔材料。

公开(公告)号：US3951899A

公开(公告)日：1976-04-20

申请号：US151735

申请日：1971-06-10

Applicant: Jerome A. Seiner

Inventor： Jerome A. Seiner

IPC: C08J9/28 ,  C09D5/02 ,  C09D157/00 ,  C08L9/10 ,  C08L13/02

CPC classification number: C09D5/02 ,  C08J9/28 ,  C09D157/00 ,  C08J2201/048 ,  C08J2201/05 ,  C08J2201/0546

Abstract: The disclosed invention relates to films from a novel latex mixture which are non-porous, microcellular and opaque in the absence of an opacifying agent. The preparation of the films of the disclosed invention comprises providing control techniques for entrapping a sufficient amount of a liquid non-solvent for the polymer in the polymer matrix of a latex after the continuous phase removal, so that upon evaporation of the non-solvent from a coalesced and tack-free polymer matrix, a resulting opaque and continuous, non-porous film is produced which will have minute, discrete and substantially closed voids and which is opaque in the absence of an opacifying agent such as pigment.The disclosed invention also relates to opaque films with enhanced optical properties produced by the inclusion of pigments, fluorescent materials and optical brighteners in the opaque films in such a manner as to maximize their effectiveness therein.

Abstract translation: 所公开的发明涉及在不存在不透明剂的情况下来自无孔，微孔和不透明的新型胶乳混合物的膜。 所公开的发明的膜的制备包括提供控制技术，用于在连续除去之后将聚合物的足够量的液体非溶剂包封在胶乳的聚合物基质中，使得当非溶剂从 产生聚结和无粘性的聚合物基质，产生不透明和连续的非多孔膜，其将具有微小的，离散的和基本上闭合的空隙，并且在不存在不透明剂如颜料的情况下是不透明的。