公开(公告)号：US20140299761A1

公开(公告)日：2014-10-09

申请号：US14240667

申请日：2012-08-22

Applicant: Kevin Giles ,  Martin Raymond Green ,  Daniel James Kenny ,  David J. Langridge ,  Jason Lee Wildgoose

Inventor： Kevin Giles ,  Martin Raymond Green ,  Daniel James Kenny ,  David J. Langridge ,  Jason Lee Wildgoose

IPC: H01J49/42

CPC classification number: H01J49/424 ,  H01J49/421 ,  H01J49/422 ,  H01J49/4285

Abstract: A mass or mass to charge ratio selective ion trap is disclosed having an increased charge storage capacity. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC voltage and/or an RF voltage acts to confine ions in a second (x) direction within the ion trap. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. Ions are excited in the third (z) direction and are caused to be mass or mass to charge ratio selectively ejected in the third (z) direction.

Abstract translation: 公开了具有增加的电荷存储容量的质量或质量 - 电荷比选择性离子阱。 RF电压用于将离子限制在离子阱内的第一（y）方向。 DC电压和/或RF电压用于将离子限制在离子阱内的第二（x）方向。 二次直流势阱用于将离子限制在离子阱内的第三（z）方向。 离子在第三（z）方向上被激发，并且被导致在第三（z）方向上选择性地喷射的质量或质量 - 充电比。

公开(公告)号：US20140291501A1

公开(公告)日：2014-10-02

申请号：US14130440

申请日：2012-07-06

Applicant: Jeffery Mark Brown ,  Kevin Giles ,  Daniel James Kenny ,  Paul Murray ,  Keith Richardson

Inventor： Jeffery Mark Brown ,  Kevin Giles ,  Daniel James Kenny ,  Paul Murray ,  Keith Richardson

IPC: H01J49/06 ,  H01J49/40 ,  H01J49/42 ,  H01J49/00

CPC classification number: H01J49/0059 ,  G01N27/624 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/10 ,  H01J49/26 ,  H01J49/40 ,  H01J49/422 ,  H01J49/4245

Abstract: A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser.

Abstract translation: 公开了一种质谱方法，其包括将来自激光器的第一光子引导到位于2D或线性离子导向器或离子阱内的离子上。 扫描第一光子的频率，并检测由离子发射的第一光子和/或第二光子。 然后使用飞行时间质量分析仪对离子进行质量分析。

公开(公告)号：US08847151B2

公开(公告)日：2014-09-30

申请号：US12946084

申请日：2010-11-15

Applicant: John Vandermey ,  Alexandre Loboda

Inventor： John Vandermey ,  Alexandre Loboda

IPC: H01J49/02 ,  H01J49/42 ,  H01F19/04

CPC classification number: H01J49/022 ,  H01F19/04 ,  H01J49/422 ,  H04B2203/5483 ,  H04B2203/5491

Abstract: An apparatus and method for coupling RF and AC signals to provide power to a multipole in a mass spectrometer is provided. A first circuit comprises: an RF power source for providing difference mode power to the multipole via the RF signal; at least one inductor for forming at least one resonant LC circuit with the multipole for providing voltage gain for the RF signal; and a transformer, comprising a secondary tap, the transformer connected in parallel to the RF power source and further connected to the at least one inductor such that the signals injected into the secondary tap are communicated to the at least one resonant LC circuit. A second circuit comprises: an AC power source for providing common mode power to the multipole via the AC signal, an output from the second circuit connected to the secondary tap such that the common mode power is injected into the first circuit and the multipole can be operated in common mode and difference mode simultaneously; and at least one inductor for forming a resonant LC circuit with the multipole via the transformer, to provide voltage gain for the AC signal.

Abstract translation: 提供了一种用于耦合RF和AC信号以在质谱仪中为多极提供功率的装置和方法。 第一电路包括：RF电源，用于经由RF信号向多极提供差模功率; 至少一个电感器，用于与用于为RF信号提供电压增益的多极形成至少一个谐振LC电路; 以及变压器，包括二次抽头，所述变压器并联连接到所述RF电源并进一步连接到所述至少一个电感器，使得注入到所述次级抽头中的信号被传送到所述至少一个谐振LC电路。 第二电路包括：AC电源，用于经由AC信号向多极提供共模功率，来自连接到次级抽头的第二电路的输出，使得共模功率注入到第一电路中，并且多极可以是 同时工作在共模和差模; 以及用于通过变压器与多极形成谐振LC电路的至少一个电感器，以为AC信号提供电压增益。

公开(公告)号：US08604420B2

公开(公告)日：2013-12-10

申请号：US13115372

申请日：2011-05-25

Applicant: Junkei Kou

Inventor： Junkei Kou

IPC: B01D59/44

CPC classification number: H01J49/4215 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/422

Abstract: A spectrometer is offered which can reduce ion loss compared with the prior art even when ions selected by the mass analyzer are modified. The spectrometer includes an ion source for ionizing a sample, an ion storage portion for repeatedly performing a storing operation for storing ions created by the ion source and an expelling operation for expelling the stored ions as pulsed ions, the mass analyzer for passing pulsed ions expelled from the ion storage portion and selecting desired ions according to their mass-to-charge ratio, a detector for detecting pulsed ions passed through the mass analyzer and outputting an analog signal responsive to the intensity of the detection, and a controller for maintaining constant the mass-to-charge ratio of the desired ions selected by the mass analyzer while pulsed ions including the desired ions are passing through the mass analyzer.

Abstract translation: 即使当质量分析器选择的离子被修改时，提供了与现有技术相比可以减少离子损失的光谱仪。 光谱仪包括用于电离样品的离子源，用于重复执行用于存储由离子​​源产生的离子的存储操作的离子存储部分和用于将存储的离子作为脉冲离子排出的排出操作，用于使脉冲离子通过的质量分析器被排出 从离子存储部分按照其质荷比选择所需的离子，检测器，用于检测通过质量分析器的脉冲离子，并响应于检测强度输出模拟信号;以及控制器，用于保持恒定 质量分析器选择的期望离子的质荷比通过包含所需离子的脉冲离子通过质量分析器。

公开(公告)号：US08563925B2

公开(公告)日：2013-10-22

申请号：US13722421

申请日：2012-12-20

Applicant: Hitachi High-Technologies Corporation

Inventor： Hisaaki Kanai ,  Fujio Ohnishi ,  Masami Makuuchi

IPC: H01J49/00

CPC classification number: H01J49/00 ,  H01J49/0009 ,  H01J49/022 ,  H01J49/36 ,  H01J49/422

Abstract: In order to enable the mass spectroscope to reduce the operation load of the adjustment of the amplitude difference, and to reduce the increase in power consumption caused by the difference between the resonance frequency and the drive frequency, the resonance circuit unit of the ion trap section is configured to control the amplitude difference adjustment section of the resonance circuit unit to adjust that the amplitude difference between the high-voltage RF signals decreases, and controls the frequency synchronizing section of the resonance circuit unit to adjust that the resonance frequency of the resonance circuit is aligned with the drive frequency of the RF signal source, on the basis of the information about the amplitude difference between the high-voltage RF signals and the resonance frequency of the resonance circuit unit, which have been measured by a resonance frequency/amplitude difference measuring unit.

Abstract translation: 为了使质谱仪能够降低振幅差的调整的操作负荷，并且为了减少由共振频率和驱动频率之间的差引起的功率消耗的增加，离子阱部分的谐振电路单元 被配置为控制谐振电路单元的幅度差调整部分，以调节高压RF信号之间的幅度差减小，并且控制谐振电路单元的频率同步部分，以调节谐振电路的谐振频率 根据关于高压RF信号之间的振幅差和谐振电路单元的谐振频率的信息，RF信号源的驱动频率与谐振频率/振幅差 测量单位

公开(公告)号：US20130240724A1

公开(公告)日：2013-09-19

申请号：US13818570

申请日：2011-08-25

Applicant: Mircea Guna

Inventor： Mircea Guna

IPC: H01J49/42

CPC classification number: H01J49/4285 ,  H01J49/422 ,  H01J49/4225

Abstract: A system and method involving processing ions in a linear ion trap are provided, involving a two-dimensional asymmetric substantially quadrupole field having a hexapole and octopole component.

Abstract translation: 提供了涉及在线性离子阱中处理离子的系统和方法，涉及具有六极和八极分量的二维不对称基本四极场。

公开(公告)号：US20110278917A1

公开(公告)日：2011-11-17

申请号：US12946084

申请日：2010-11-15

Applicant: John Vandermey ,  Alexandre Loboda

Inventor： John Vandermey ,  Alexandre Loboda

IPC: H02J3/00

CPC classification number: H01J49/022 ,  H01F19/04 ,  H01J49/422 ,  H04B2203/5483 ,  H04B2203/5491

Abstract: An apparatus and method for coupling RF and AC signals to provide power to a multipole in a mass spectrometer is provided. A first circuit comprises: an RF power source for providing difference mode power to the multipole via the RF signal; at least one inductor for forming at least one resonant LC circuit with the multipole for providing voltage gain for the RF signal; and a transformer, comprising a secondary tap, the transformer connected in parallel to the RF power source and further connected to the at least one inductor such that the signals injected into the secondary tap are communicated to the at least one resonant LC circuit. A second circuit comprises: an AC power source for providing common mode power to the multipole via the AC signal, an output from the second circuit connected to the secondary tap such that the common mode power is injected into the first circuit and the multipole can be operated in common mode and difference mode simultaneously; and at least one inductor for forming a resonant LC circuit with the multipole via the transformer, to provide voltage gain for the AC signal.

Abstract translation: 提供了一种用于耦合RF和AC信号以在质谱仪中为多极提供功率的装置和方法。 第一电路包括：RF电源，用于经由RF信号向多极提供差模功率; 至少一个电感器，用于与用于为RF信号提供电压增益的多极形成至少一个谐振LC电路; 以及变压器，包括二次抽头，所述变压器并联连接到所述RF电源并进一步连接到所述至少一个电感器，使得注入到所述次级抽头中的信号被传送到所述至少一个谐振LC电路。 第二电路包括：AC电源，用于经由AC信号向多极提供共模功率，来自连接到次级抽头的第二电路的输出，使得共模功率注入到第一电路中，并且多极可以是 同时工作在共模和差模; 以及用于通过变压器与多极形成谐振LC电路的至少一个电感器，以为AC信号提供电压增益。

公开(公告)号：US08044349B2

公开(公告)日：2011-10-25

申请号：US12173328

申请日：2008-07-15

Applicant: Hiroyuki Satake ,  Yuichiro Hashimoto ,  Yasuaki Takada

Inventor： Hiroyuki Satake ,  Yuichiro Hashimoto ,  Yasuaki Takada

IPC: H01J49/00

CPC classification number: H01J49/004 ,  H01J49/422 ,  H01J49/4255 ,  H01J49/427

Abstract: A mass spectrometer includes a linear multipole electrode, an auxiliary electrode that applies a DC potential on the center axis of the linear multipole electrode, and a DC power supply that supplies a DC power to the auxiliary electrode. The DC potential slope formed on the center axis of the multipole electrode is changed according to the measuring condition. The ejection time of ions can be adjusted optimally by adjusting the potential slope so as to satisfy the measuring condition. If the ejection time of ions is shortened, confusion of different ion information items that might otherwise occur on a spectrum can be avoided. If the ejection time of ions is lengthened, detection limit exceeding can be avoided and ions can be measured efficiently, thereby highly efficient ion measurements are always assured.

Abstract translation: 质谱仪包括线性多极电极，在线性多极电极的中心轴上施加直流电位的辅助电极和向辅助电极提供直流电力的直流电源。 根据测量条件改变在多极电极的中心轴上形成的直流电位斜率。 通过调整电位斜率以满足测量条件，可以最佳地调节离子的喷射时间。 如果离子的喷射时间缩短，则可以避免在光谱上可能发生的不同离子信息项的混淆。 如果离子的喷射时间延长，则可以避免超过检测极限，有效测量离子，从而确保高效的离子测量。

公开(公告)号：US20110253678A1

公开(公告)日：2011-10-20

申请号：US13062601

申请日：2009-09-03

Applicant: Jason Duffin ,  Stephen Taylor

Inventor： Jason Duffin ,  Stephen Taylor

IPC: B23H1/00

CPC classification number: H01J49/0013 ,  B23H9/00 ,  B33Y10/00 ,  B33Y80/00 ,  H01J49/0022 ,  H01J49/062 ,  H01J49/422

Abstract: The present invention relates to a method for fabricating a quadrupole mass filter (QMF) or a quadrupole ion trap (QIT).

Abstract translation: 本发明涉及四极质量过滤器（QMF）或四极离子阱（QIT）的制造方法。

公开(公告)号：US20090014647A1

公开(公告)日：2009-01-15

申请号：US11777926

申请日：2007-07-13

Applicant: Michael W. Senko

Inventor： Michael W. Senko

IPC: B01D59/44

CPC classification number: H01J49/004 ,  H01J49/38 ,  H01J49/422 ,  H01J49/427

Abstract: The present invention pertains to a method and apparatus which increases the efficiency with which ions are transported from a first ion trap to a second ion trap, and subsequently trapped in the second ion trap. In one aspect the invention, increased efficiency takes the form or enabling ions of both high and low mass to charge ratios to be trapped in the second ion trap at substantially the same time, or at least within a relatively small window of time. This can be achieved by minimizing the undesirable time-of-flight separation by the high and low mass to charge ratio ions as they are transported from a first ion trap to the second ion trap. This minimization can be realized by adjusting the potential energy applied to ion transfer optics disposed between the two ion traps.

Abstract translation: 本发明涉及提高离子从第一离子阱传递到第二离子阱的效率的方法和装置，并随后被捕获在第二离子阱中。 在一个方面，本发明提供的效率使得高质量和低质量的电荷离子的形式或使得能够在基本上相同的时间或至少在相对较小的时间窗内被捕获在第二离子阱中。 这可以通过将高质量和低质量与电荷比的离子在从第一离子阱传输到第二离子阱时最小化不期望的飞行时间分离来实现。 这种最小化可以通过调节施加到设置在两个离子阱之间的离子传递光学器件的势能来实现。