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    Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
    41.
    发明申请
    Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading 失效
    用于扫描探针显微镜（SPM）读数的编码特定信息的纳米棒的受控比对

    公开(公告)号：US20050208554A1

    公开(公告)日：2005-09-22

    申请号：US11077577

    申请日：2005-03-11

    Applicant: Selena Chan ,  Xing Su ,  Mineo Yamakawa

    Inventor： Selena Chan ,  Xing Su ,  Mineo Yamakawa

    IPC: C12M1/34 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G01N33/543 ,  G01N33/573 ,  G01Q60/00 ,  G01Q70/12 ,  G01Q70/18 ,  G01Q80/00 ,  G06F19/00

    CPC classification number: C12Q1/6816 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  Y10S977/702 ,  Y10S977/704 ,  Y10S977/705 ,  Y10S977/728 ,  Y10S977/729 ,  Y10S977/734 ,  Y10S977/742 ,  Y10S977/773 ,  Y10S977/774 ,  Y10S977/924 ,  C12Q2565/601 ,  C12Q2563/185

    Abstract: The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nanobarcodes may be allowed to bind to one or more target molecules. After binding and separation from unbound coded probes, the bound coded probes may be aligned on a surface and analyzed by scanning probe microscopy. The nanobarcodes may be any molecule or complex that is distinguishable by SPM, such as carbon nanotubes, fullerenes, submicrometer metallic barcodes, nanoparticles or quantum dots. Where the probes are oligonucleotides, adjacent coded probes hybridized to a target nucleic acid may be ligated together before alignment and SPM analysis. Compositions comprising coded probes are also disclosed herein. Systems for biomolecule analysis may comprise an SPM instrument and at least one coded probe attached to a surface.

    Abstract translation: 本文公开的方法，装置和组合物涉及生物分子如核酸或蛋白质的检测，鉴定和/或测序。 在本发明的某些实施方案中，包含连接至一个或多个纳米糖基的探针分子的编码探针可以被允许与一个或多个靶分子结合。 在结合和分离未结合的编码探针之后，结合编码的探针可以在表面上对准并通过扫描探针显微镜进行分析。 纳米线可以是通过SPM可区分的任何分子或复合物，例如碳纳米管，富勒烯，亚微米金属条形码，纳米颗粒或量子点。 当探针是寡核苷酸时，与靶核酸杂交的相邻编码探针可以在对准和SPM分析之前连接在一起。 包含编码探针的组合物也在本文中公开。 用于生物分子分析的系统可以包括SPM仪器和附接到表面的至少一个编码探针。

    Chemically assembled nano-scale circuit elements
    42.
    发明授权
    Chemically assembled nano-scale circuit elements 失效
    化学组装的纳米级电路元件

    公开(公告)号：US06664103B2

    公开(公告)日：2003-12-16

    申请号：US09860046

    申请日：2001-05-17

    Applicant: Dennis Michael Connolly

    Inventor： Dennis Michael Connolly

    IPC: C12M134

    CPC classification number: G11C13/0019 ,  B82Y10/00 ,  C12N15/10 ,  C12Q1/68 ,  G11C13/0014 ,  H01L51/0002 ,  H01L51/0093 ,  H01L51/0595 ,  Y10S977/704 ,  Y10S977/728 ,  Y10S977/941 ,  Y10T436/143333

    Abstract: The present invention provides nano-scale devices, including electronic circuits, using DNA molecules as a support structure. DNA binding proteins are used to mask regions of the DNA as a material, such as a metal is coated onto the DNA. Included in the invention are DNA based transistors, capacitors, inductors and diodes. The present invention also provides methods of making integrated circuits using DNA molecules as a support structure. Methods are also included for making DNA based transistors, capacitors, inductors and diodes.

    Abstract translation: 本发明提供使用DNA分子作为支持结构的纳米级装置，包括电子电路。 DNA结合蛋白用于掩盖DNA的区域作为材料，例如将金属包被在DNA上。 本发明包括基于DNA的晶体管，电容器，电感器和二极管。 本发明还提供了使用DNA分子作为支持结构的集成电路的方法。 还包括用于制造基于DNA的晶体管，电容器，电感器和二极管的方法。

    Particles based on polyamino-acid(s) and methods for preparing same
    43.
    发明授权
    Particles based on polyamino-acid(s) and methods for preparing same 失效
    基于聚氨基酸的颗粒及其制备方法

    公开(公告)号：US06630171B1

    公开(公告)日：2003-10-07

    申请号：US09856378

    申请日：2001-07-06

    Applicant: Sylvain Huille ,  Florence Nicolas ,  Nathan Brison ,  Gérard Soula

    Inventor： Sylvain Huille ,  Florence Nicolas ,  Nathan Brison ,  Gérard Soula

    IPC: A61K914

    CPC classification number: A61K9/5146 ,  A61K8/0241 ,  A61K8/88 ,  A61K9/1075 ,  A61K9/1641 ,  A61K2800/10 ,  A61K2800/412 ,  A61K2800/56 ,  A61Q19/00 ,  Y10S977/727 ,  Y10S977/728 ,  Y10S977/729 ,  Y10S977/775 ,  Y10S977/795 ,  Y10S977/896 ,  Y10S977/906 ,  Y10S977/915

    Abstract: The invention concerns delivery particles (DP's) for active principles (AP's) based on linear amphiphilic polyamino-acids (PAA's), with &agr;-peptide chains, capable of being spontaneously formed by contacting PAA's with a liquid medium, preferably with water, wherein the hydrophile part of the PAA's is solubilized more than the hydrophobic parts of said PAA's, such that the latter precipitate while being organised in discrete supra-molecular arrangements, of average size ranging between 0.01 and 20 &mgr;m, capable of combining with at least an AP and releasing the latter in vivo, in prolonged and controlled manner. The inventive suspension is characterised in that the recurrent amino acids (rAA's) constituting the main chain of PAA's are identical to or different from one another and are glutamic acid and/or aspartic acid and/or their salts; and some of said rAA's bear at least one hydrophobic group, said hydrophobic group, being identical to or different from one another. The invention is useful as carriers for active principles, in particular pharmaceutical, insulin or for therapeutic uses.

    Abstract translation: 本发明涉及基于具有α-肽链的线性两亲性多氨基酸（PAA）的活性成分（AP）的递送颗粒（DP），其能够通过使PAA与液体介质优选与水接触而自发形成，其中 PAA的亲水部分比所述PAA的疏水部分溶解得多，使得后者沉淀，同时以分散的分子结构组织，平均尺寸范围为0.01至20μm，能够与至少一种AP和 以延长和受控的方式在体内释放后者。 本发明的悬浮液的特征在于，构成PAA主链的复发氨基酸（rAA）彼此相同或不同，为谷氨酸和/或天冬氨酸和/或其盐; 并且一些所述rAA携带至少一个疏水基团，所述疏水基团彼此相同或不同。 本发明可用作活性成分的载体，特别是药物，胰岛素或用于治疗用途。

    RNA COMPLEXES, METHODS OF THEIR PRODUCTION AND SENSORS AND ANALYTICAL METHODS INVOLVING SAME
    47.
    发明申请
    RNA COMPLEXES, METHODS OF THEIR PRODUCTION AND SENSORS AND ANALYTICAL METHODS INVOLVING SAME 有权
    RNA复合物，其生产和传感器的方法以及涉及其的分析方法

    公开(公告)号：US20120309646A1

    公开(公告)日：2012-12-06

    申请号：US13585225

    申请日：2012-08-14

    Applicant: Neocles Leontis

    Inventor： Neocles Leontis

    IPC: C40B30/04 ,  C07H21/02

    CPC classification number: C12Q1/6813 ,  Y10S977/728 ,  Y10S977/773 ,  C12Q2525/307 ,  C12Q2525/205

    Abstract: The invention includes RNA complexes comprising at least three monomeric units of an RNA molecule, each monomeric unit comprising an RNA polymer having first and second helical domains that have respective first and second binding sites, wherein the first binding sites are adapted to binding to one another and are not adapted to bind to the second binding sites, and the second binding sites are adapted to binding to one another and are not adapted to bind to the first binding sites; such that the at least three monomeric units are adapted to self-assemble by forming pairs of cognate interactions and so as to form the RNA complex in a circular closed complex. The invention also includes derivatives of these complexes including aptamers, and analytical methods and devices using same.

    Abstract translation: 本发明包括包含RNA分子的至少三个单体单元的RNA复合物，每个单体单元包含具有第一和第二螺旋结构域的RNA聚合物，其具有相应的第一和第二结合位点，其中第一结合位点适于彼此结合 并且不适于结合第二结合位点，并且第二结合位点适于彼此结合并且不适于结合第一结合位点; 使得所述至少三个单体单元适于通过形成一对同源相互作用而自组装，从而在环状闭合复合物中形成RNA复合物。 本发明还包括这些复合物的衍生物，包括适体，以及使用其的分析方法和装置。

    RNA complexes and methods of their production
    50.
    发明授权
    RNA complexes and methods of their production 有权
    RNA复合物及其生产方法

    公开(公告)号：US07553945B2

    公开(公告)日：2009-06-30

    申请号：US11196003

    申请日：2005-08-03

    Applicant: Neocles Leontis

    Inventor： Neocles Leontis

    IPC: C07H21/02

    CPC classification number: C12Q1/6813 ,  Y10S977/728 ,  Y10S977/773 ,  C12Q2525/307 ,  C12Q2525/205

    Abstract: The invention includes RNA complexes comprising at least three monomeric units of an RNA molecule, each monomeric unit comprising an RNA polymer having first and second helical domains that have respective first and second binding sites, wherein the first binding sites are adapted to binding to one another and are not adapted to bind to the second binding sites, and the second binding sites are adapted to binding to one another and are not adapted to bind to the first binding sites; such that the at least three monomeric units are adapted to self-assemble by forming pairs of cognate interactions and so as to form the RNA complex in a circular closed complex. The invention also includes derivatives of these complexes including aptamers, and analytical methods and devices using same.

    Abstract translation: 本发明包括包含RNA分子的至少三个单体单元的RNA复合物，每个单体单元包含具有第一和第二螺旋结构域的RNA聚合物，其具有相应的第一和第二结合位点，其中第一结合位点适于彼此结合 并且不适于结合第二结合位点，并且第二结合位点适于彼此结合并且不适于结合第一结合位点; 使得所述至少三个单体单元适于通过形成一对同源相互作用而自组装，从而在环状闭合复合物中形成RNA复合物。 本发明还包括这些复合物的衍生物，包括适体，以及使用其的分析方法和装置。

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