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    Clathrate hydrate containing quaternary ammonium salt as guest compound
    42.
    发明申请
    Clathrate hydrate containing quaternary ammonium salt as guest compound 有权
    含有季铵盐的笼形水合物作为客体化合物

    公开(公告)号：US20100004487A1

    公开(公告)日：2010-01-07

    申请号：US12584494

    申请日：2009-09-03

    Applicant: Keiji Tomura ,  Shingo Takao ,  Takao Kitagawa

    Inventor： Keiji Tomura ,  Shingo Takao ,  Takao Kitagawa

    IPC: C07C211/62

    CPC classification number: C09K5/063 ,  C07C211/63

    Abstract: An aqueous solution containing a quaternary ammonium salt as a guest compound of a clathrate hydrate, having a property of producing the clathrate hydrate when cooled, and further containing a phosphate of an alkali metal added thereto. A clathrate hydrate produced by cooling an aqueous solution containing a quaternary ammonium salt and a phosphate of an alkali metal, wherein the quaternary ammonium salt is the guest compound.

    Abstract translation: 含有作为笼形水合物的客体化合物的季铵盐的水溶液，其具有在冷却时产生笼形水合物的性质，并且还含有加入其中的碱金属磷酸盐。 通过冷却含有季铵盐和碱金属磷酸盐的水溶液而生成的笼形水合物，其中季铵盐是客体化合物。

    Transfection reagents
    45.
    发明授权
    Transfection reagents 有权

    公开(公告)号：US07479573B2

    公开(公告)日：2009-01-20

    申请号：US11040687

    申请日：2005-01-21

    Applicant: Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    Inventor： Yongliang Chu ,  Malek Masoud ,  Gulilat Gebeyehu

    IPC: C07C211/62 ,  C07C211/63 ,  C07C211/64 ,  A61K31/13 ,  A61K9/127 ,  A61K9/50 ,  C12N15/88

    CPC classification number: A61K47/48046 ,  A61K9/16 ,  A61K31/14 ,  A61K38/28 ,  A61K38/40 ,  A61K47/543 ,  C07C211/21 ,  C07C211/63 ,  C07C211/64 ,  C07C229/26 ,  C07D209/48 ,  C07D241/12 ,  C12N15/88 ,  Y10S435/81

    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i—Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L′—X2—Z or —Z; R1—R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wherein at least one of R1, R3, R4 and R6 is a straight chain or branched, cyclic, alkyl, alkenyl, alkynyl or aryl group; and anyone of R1, R3, R4 and/or R6 may optionally be covalently linked with each other, with Y or with L when L is C or CH to form a cyclic moiety; Z is selected from the group consisting of amine, spermiyl, carboxyspermiyl, guanidyl, spermidinyl, putricinyl, diaminoalkyl, pyridyl, piperidinyl, pyrrolidinyl, polyamine, amino acid, peptide, and protein; X1 and X2, independently of one another, are selected from the group consisting of NH, O, S, alkylene, and arylene; L′ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, alkylene ether, and polyether; D is Q or a bond; A1 and A2, independently of one another, are selected from the group consisting of CH2O, CH2S, CH2NH, C(O), C{NH), C(S) and (CH2)t; X is a physiologically acceptable anion; m, n, r, s, u, v, w and y are 0 or 1, with the proviso that when both m and n are 0 at least one of r, s, u and y is other than 0; i, j, k, l, p and are integers from 0 to about 100; q is an integer from 1 to about 1000; and a is the number of positive charge divided by the valence of the anion.

    Anomalous expansion materials
    46.
    发明申请
    Anomalous expansion materials 审中-公开
    异常膨胀材料

    公开(公告)号：US20050228166A1

    公开(公告)日：2005-10-13

    申请号：US10520249

    申请日：2003-07-04

    Applicant: Cameron Kepert ,  Andrew Goodwin

    Inventor： Cameron Kepert ,  Andrew Goodwin

    IPC: C01C3/08 ,  C01C3/11 ,  C01C3/12 ,  C07C211/62 ,  C07C211/63 ,  G02B1/00 ,  G02B1/02 ,  H01L21/58 ,  H01L23/14 ,  H01L41/16 ,  H01S3/16 ,  C08G73/00

    CPC classification number: C01C3/08 ,  C01C3/11 ,  C01C3/12 ,  C01P2002/76 ,  C01P2002/77 ,  C01P2002/82 ,  C01P2002/84 ,  C01P2006/32

    Abstract: A method for controlling the thermal expansion behaviour of a material comprises the step of incorporating into the material a component including one or more diatomic bridges. The or each diatomic bridge extends between two atoms in the component. The method is characterised in that the or each diatomic bridge has at least one vibrational mode that causes the two atoms on either side of the bridge to be moved together to a similar or greater extent than competing vibrational mode(s) that cause the two atoms on either side of the bridge to be moved apart. The bridge may also be polyatomic. New materials and devices comprising a plurality of such diatomic and polyatomic bridges are also defined.

    Abstract translation: 用于控制材料的热膨胀行为的方法包括将包括一个或多个双原子桥的组分掺入材料的步骤。 该或每个双原子桥在组件中的两个原子之间延伸。 该方法的特征在于，每个双原子桥具有至少一个振动模式，其使桥的任一侧上的两个原子一起移动到与引起两个原子的竞争振动模式相似或更大的程度 在桥的任一侧被分开。 桥也可能是多原子的。 还定义了包括多个这样的双原子和多原子桥的新材料和器件。

    Multivalent cationic lipids and methods of using same in the production of lipid particles
    49.
    发明申请
    Multivalent cationic lipids and methods of using same in the production of lipid particles 失效
    多价阳离子脂质及其在脂质颗粒生产中的应用方法

    公开(公告)号：US20030124727A1

    公开(公告)日：2003-07-03

    申请号：US10323248

    申请日：2002-12-18

    Inventor： Jerome Gaucheron ,  Kim Wong ,  Pieter Cullis

    IPC: C12N015/88 ,  C07C211/62

    CPC classification number: C07C211/63

    Abstract: A multivalent cationic lipid having a positively-charged head group including two quaternary amine groups and a hydrophobic portion including four hydrocarbon chains, which may be the same or different and which are optionally substituted alkyl and alkenyl groups, two alkyl chains attached to each of the two quaternary amine groups can be used for the introduction of polyanionic materials such a nucleic acid polymers into cells. Specific cationic lipids are N,N,Nnull,Nnull-tetraoleyl-N-Nnull-dimethyl-1,3-propanediammonium chloride and N,N,Nnull,Nnull-tetraoleyl-N-Nnull-dimethyl-1,6-hexanediammonium chloride.

    Abstract translation: 具有带正电荷的头基团的多价阳离子脂质，包括两个季胺基团和疏水部分，其包含四个烃链，其可以相同或不同，并且是任选取代的烷基和烯基，两个烷基链连接到 两个季胺基团可用于将诸如核酸聚合物的聚阴离子材料引入细胞中。 特定的阳离子脂质是N，N，N'，N'-四油基-N-N'-二甲基-1,3-丙二胺和N，N，N'，N'-四油基-N-N'-二甲基-1 ，6-己二胺氯化物。

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