公开(公告)号：US20170363602A1

公开(公告)日：2017-12-21

申请号：US15639522

申请日：2017-06-30

Applicant: Saudi Arabian Oil Company

Inventor： Omer Refa Koseoglu ,  Adnan Al-Hajji ,  Hendrik Muller

IPC: G01N33/28 ,  H01J49/00 ,  H01J49/38

Abstract: A system, method and computer program product are provided for calculating one or more indicative properties, e.g., one or more of the cetane number, octane number, pour point, cloud point and aniline point of oil fractions, from the density and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) of a sample of an oil sample.

公开(公告)号：US09786483B2

公开(公告)日：2017-10-10

申请号：US14787081

申请日：2014-04-24

Applicant: FOM INSTITUTE FOR ATOMIC AND MOLECULAR PHYSICS

Inventor： Ronald Martinus Alexander Heeren ,  Julia Helga Jungmann ,  Don Smith

IPC: H01J49/38 ,  H01J49/02 ,  H01J49/06 ,  H01J49/40 ,  H05K1/02

CPC classification number: H01J49/38 ,  H01J49/025 ,  H01J49/06 ,  H01J49/40 ,  H05K1/0206 ,  H05K2201/0195

Abstract: An ion trap such as an ion cyclotron resonance analyzer cell (trap) is described wherein the ion trap comprises a plurality of electrodes and has at least one integrated ion detector, preferably a position-sensitive and/or time-sensitive ion detector, wherein at least part of said ion detector is configured as an electrode of said ion trap. Methods of position-sensitive detection of ions in such ion trap are described as well.

公开(公告)号：US09520280B2

公开(公告)日：2016-12-13

申请号：US13993316

申请日：2011-12-14

Applicant: Alexander A. Makarov

Inventor： Alexander A. Makarov

IPC: H01J49/00 ,  H01J49/28 ,  H01J49/02 ,  H01J49/38 ,  H01J49/42

CPC classification number: H01J49/282 ,  H01J49/027 ,  H01J49/08 ,  H01J49/38 ,  H01J49/4245

Abstract: Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.

Abstract translation: 提供了用于质量分析仪的质量分析仪和离子检测方法。 静电场发生器提供静电场，使离子包沿着一个方向振荡。 在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。 还检测到谐波瞬态信号。 然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。

公开(公告)号：US09287101B2

公开(公告)日：2016-03-15

申请号：US14813513

申请日：2015-07-30

Applicant: Thermo Fisher Scientific (Bremen) GmbH

Inventor： Alexander A. Makarov

IPC: H01J49/40 ,  H01J49/38 ,  H01J49/00 ,  H01J49/04 ,  H01J49/06

CPC classification number: H01J49/0081 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0063 ,  H01J49/0422 ,  H01J49/061 ,  H01J49/40

Abstract: A tandem mass spectrometer and method are described. Precursor ions are generated in an ion source and an ion injector injects ions towards a downstream ion guide via a single or multi reflection TOF device that separates ions into packets in accordance with their m/z. A single pass ion page in the path of the precursor ions between the ion injector and the ion guide is controlled so that only a subset of precursor ion packets, containing precursor ions of interest, is allowed onward transmission to the ion guide. A high resolution mass spectrometer is provided for analysis of those ions, or their fragments, which have been allowed passage through the ion gate. The technique permits multiple m/z ranges to be selected from a wise mass range of precursors, with optional fragmentation of one or more of the chosen ion species.

Abstract translation: 描述了串联质谱仪和方法。 在离子源中产生前体离子，并且离子注入器通过单个或多反射TOF装置将离子注入下游离子导向器，根据它们的m / z将离子分离成分组。 控制在离子注入器和离子导向器之间的前体离子的路径中的单程离子页面，使得仅允许含有感兴趣的前体离子的前体离子包的子集向前传输到离子引导件。 提供了一种高分辨率质谱仪用于分析已经允许通过离子门的那些离子或其碎片。 该技术允许从明显质量范围的前体中选择多个m / z范围，任选地分离一种或多种选择的离子物质。

公开(公告)号：US09035244B2

公开(公告)日：2015-05-19

申请号：US14202531

申请日：2014-03-10

Applicant: 1st Detect Corporation

Inventor： David Rafferty ,  Michael Spencer ,  James Wylde ,  David Lorenz Gardner ,  Warren Mino

IPC: H01J49/38 ,  H01J49/42 ,  H01J49/14 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/147 ,  H01J49/0013 ,  H01J49/0031 ,  H01J49/067 ,  H01J49/424 ,  H01J49/4265

Abstract: A method and apparatus for performing mass spectrometry using an electron source, an ion trap, and a voltage-controlled lens located between the electron source and the ion trap. A controller applies a voltage to the lens. Features of the resulting output spectrum can be analyzed to determine whether to adjust the lens voltage.

Abstract translation: 使用位于电子源和离子阱之间的电子源，离子阱和电压控制透镜进行质谱分析的方法和装置。 控制器向镜头施加电压。 可以分析产生的输出光谱的特征，以确定是否调整透镜电压。

公开(公告)号：US08825413B2

公开(公告)日：2014-09-02

申请号：US12755977

申请日：2010-04-07

Applicant: Alexander Misharin ,  Konstantin Novoselov ,  Vladimir M. Doroshenko

Inventor： Alexander Misharin ,  Konstantin Novoselov ,  Vladimir M. Doroshenko

IPC: G01N31/00 ,  H01J49/38 ,  H01J49/00 ,  H03F1/26

CPC classification number: H01J49/0036 ,  H01J49/38

Abstract: A method and system for deconvolution of a frequency spectrum obtained in an ICR mass spectrometer based on a detection of ion oscillation overtones of the M-th order (where the integer M>1). A plurality of frequency peaks is collected within the frequency spectrum corresponding respectively to oscillations of different groups of ions, and associates at least one of the frequency peaks having a frequency f and a measured amplitude A with a particular group of the ions. The method and system identify whether the frequency peak is related to one of an overtone frequency, a subharmonic frequency, a higher harmonic frequency, or a side-shifted frequency of the oscillations of the different group of ions. The method and system derive calculated amplitudes of the overtone frequency peaks associated with the groups of ions by incorporating measured amplitudes of the frequency peaks related to the subharmonic frequency, the higher harmonic frequency, or the side-shifted frequency associated with the groups of ions into the calculated amplitudes of the overtone frequency peaks. The method and system generate a deconvoluted frequency spectrum including the overtone frequency peaks associated with the different groups of ions.

Abstract translation: 基于对M阶离子振荡泛音（其中整数M> 1）的检测，在ICR质谱仪中获得的频谱的去卷积方法和系统。 在分别对应于不同离子组的振荡的频谱内收集多个频率峰值，并且将具有频率f和测量幅度A的频率峰值中的至少一个与特定的一组离子相关联。 该方法和系统识别频率峰值是否与不同离子组的振荡的泛音频率，次谐波频率，高次谐波频率或侧移频率之一相关。 该方法和系统通过将与次谐波频率，高次谐波频率或与离子组相关联的侧移频率相关的频率峰值的测量幅度并入到离子组相关的泛音频率峰值中来计算振幅 计算的泛音频率峰值的幅度。 该方法和系统产生包括与不同离子组相关的泛音频率峰值的解卷积频谱。

公开(公告)号：US08796618B2

公开(公告)日：2014-08-05

申请号：US13511157

申请日：2010-11-16

Applicant: Seung Yong Kim ,  Hyun Sik Kim ,  Jong Shin Yoo

Inventor： Seung Yong Kim ,  Hyun Sik Kim ,  Jong Shin Yoo

IPC: H01J49/38 ,  H01J49/02

CPC classification number: H01J49/38 ,  H01J49/022

Abstract: The present invention relates to an apparatus and method for controlling a pipeline-type ion cyclotron resonance mass spectrometer, in which an ion trap unit of the ion cyclotron resonance mass spectrometer is capable of using two digitizers at the same time, thus enabling a measurement process for detecting an electrical signal which indicates the mass of ions corresponding to a specific purpose, and another measurement process for detecting another electrical signal which indicates the mass of ions corresponding to another specific purpose, to be simultaneously performed. Accordingly, it is an aim of the present invention to provide an apparatus and method for controlling a pipeline-type ion cyclotron resonance mass spectrometer, which can overcome the problems of time delay among control procedures, and can present a signal detection step wherein an excitation electrode is utilized to improve the sensitivity and speed of signal detection.

Abstract translation: 本发明涉及一种用于控制管道型离子回旋共振质谱仪的装置和方法，其中离子回旋共振质谱仪的离子阱单元能够同时使用两个数字化仪，因此能够进行测量过程 用于检测指示对应于特定目的的离子质量的电信号，以及用于检测指示与另一特定目的相对应的离子质量的另一电信号的另一测量处理。 因此，本发明的目的是提供一种用于控制管道型离子回旋共振质谱仪的装置和方法，其可以克服控制过程之间的时间延迟的问题，并且可以呈现信号检测步骤，其中激发 电极用于提高信号检测的灵敏度和速度。

公开(公告)号：US08766174B1

公开(公告)日：2014-07-01

申请号：US14096847

申请日：2013-12-04

Applicant: Bruker Daltonik GmbH

Inventor： Goekhan Baykut ,  Jochen Friedrich ,  Roland Jertz ,  Claudia Kriete

IPC: H01J49/26 ,  H01J49/38 ,  H01J49/00 ,  H01J49/02 ,  H01J49/34

CPC classification number: H01J49/38

Abstract: The invention relates to a method and a device for optimization of electric fields in measurement cells of Fourier transform ion cyclotron resonance mass spectrometers. The invention is based on the rationale that asymmetric electric fields with uniformly or non-uniformly perturbed field axes can appear in ion cyclotron resonance cells and therefore the axis of the magnetron orbit can become radially displaced. Shifted magnetron orbits negatively affect the cyclotron excitation, deteriorate the FT-ICR signal, increase the intensity of an even-numbered harmonics peak, lead to stronger side bands of the FT-ICR signal, and in extreme cases, cause loss of ions. The present invention helps in probing the shift of the magnetron motion, detecting parameters indicative of the offset of the electric field axis and/or correcting it by trimming it back to the geometric axis of the cell.

公开(公告)号：US20140070090A1

公开(公告)日：2014-03-13

申请号：US14024419

申请日：2013-09-11

Applicant: Bruker Daltonik GmbH

Inventor： Yury Kostyukevich ,  Evgeny Nikolaev ,  Gleb Vladimirov

IPC: H01J49/38

CPC classification number: H01J49/38 ,  H01J49/0027 ,  H01J49/34

Abstract: A method and apparatus of compensating a magnetic field inhomogeneity in a dynamically harmonized FT-ICR cell is presented, based on adding of extra electrodes into the cell, the extra electrodes being shaped in such a way that the averaged electric field created by these electrodes produces a counter force to the forces caused by the inhomogeneous magnetic field on the cycling ions.

Abstract translation: 提出了一种在动态协调的FT-ICR单元中补偿磁场不均匀性的方法和装置，基于向单元中添加额外的电极，额外的电极被成形为使得由这些电极产生的平均电场产生 对由循环离子上的不均匀磁场引起的力的反作用力。

公开(公告)号：US20050109934A1

公开(公告)日：2005-05-26

申请号：US10717833

申请日：2003-11-20

Applicant: Dean Davis

Inventor： Dean Davis

IPC: B01D59/44 ,  H01J49/38

CPC classification number: H01J49/38

Abstract: The present invention is a method and apparatus for identifying a mixture of particles using a Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS). The particles are first reacted in a charge exchange reaction within the FT-ICR MS chamber using ionic partners that are chosen to discriminate among components of the mixture based on ionization potential. Mass spectra of test runs using different ionic partners may then be compared to identify components based on information gathered about both molecular mass and ionization potential.