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公开(公告)号：US20190315804A1
公开(公告)日：2019-10-17
申请号：US16451081
申请日：2019-06-25
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Moshe OREN , Varda ROTTER , Perry TAL
Abstract: The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.
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502.发明授权公开(公告)号：US10434121B2
公开(公告)日：2019-10-08
申请号：US14367923
申请日：2012-12-20
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Yair Reisner , Esther Bachar-Lustig
IPC: A61K35/28 , A61K35/17 , A61K35/22 , A61K35/38 , A61K35/39 , A61K35/407 , A61K35/42 , A61K31/675 , A61K31/661 , A61K35/34 , A61K35/36 , C12N5/00 , A61K31/198 , A61K31/255 , A61K31/7076 , A61K39/395 , A61K39/00 , A61K35/12
Abstract: A method of treating a subject in need of a non-syngeneic cell or tissue graft is disclosed. The method comprising: (a) transplanting into a subject a dose of T cell depleted immature hematopoetic cells, wherein the T cell depleted immature hematopoetic cells comprise less than 5×105 CD3+ T cells per kilogram body weight of the subject, and wherein the dose comprises at least about 5×106 CD34+ cells per kilogram body weight of the subject, and wherein the T cell depleted immature hematopoetic cells are obtained by separating the T cells from the immature hematopoetic cells by magnetic cell sorting, and (b) administering to the subject a therapeutically effective amount of cyclophosphamide, wherein the therapeutically effective amount comprises 25-200 mg per body weight, thereby treating the subject.
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503.发明授权公开(公告)号：US10377994B2
公开(公告)日：2019-08-13
申请号：US16162427
申请日：2018-10-17
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Arren Bar-Even , Ron Milo , Elad Noor , Oren Yishai
IPC: C12N9/88 , C12N9/04 , C12N15/52 , C12P7/64 , C12N9/02 , C12N9/00 , C12P7/40 , C12M1/42 , C12N9/06 , C12N9/78 , C12N13/00
Abstract: An isolated microorganism that expresses enzymes of the reductive glycine pathway is disclosed. The microorganism is capable of converting formate to pyruvate or glycerate via the formation of glycine and serine. Methods of generating same are further described.
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公开(公告)号：US10361003B2
公开(公告)日：2019-07-23
申请号：US15022643
申请日：2015-04-28
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Eran Segal , Eran Elinav
Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.
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公开(公告)号：US20190211016A1
公开(公告)日：2019-07-11
申请号：US16311700
申请日：2017-06-21
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Dvir GUR , Lia ADDADI , Stephen WEINER
IPC: C07D473/18
CPC classification number: C07D473/18 , C07B2200/13
Abstract: This invention is directed to synthetic co-crystals of anhydrous guanine and at least one additional material, wherein the co-crystals have a high refraction index and therefore, provide products with pearlescence or whiteness with high coverage. The invention is further directed to a process for the preparation of anhydrous guanine and of the co crystals.
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Patent Agency Ranking
公开(公告)号：US20190203270A1
公开(公告)日：2019-07-04
申请号：US16319499
申请日：2016-07-24
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Ido AMIT , David LARA-ASTIASO , Meital GURY
IPC: C12Q1/6811 , C12Q1/6818 , C12Q1/6876
CPC classification number: C12Q1/6811 , C12Q1/6816 , C12Q1/6818 , C12Q1/6876 , C12Q2600/154 , C12Q2600/156 , G01N33/6875 , C12Q2522/101 , C12Q2563/185
Abstract: Methods of analyzing DNA molecules in a cell sample are provided. The DNA molecules have DNA binding moiety signatures which are defined by at least two non-identical DNA binding moieties. Kits for analyzing the DNA are also provided.
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公开(公告)号：US20190201452A1
公开(公告)日：2019-07-04
申请号：US16353680
申请日：2019-03-14
Inventor： Daniel OFFEN , Michal DADON-NACHUM , Tali BEN-ZUR , Eldad MELAMED , David YAFFE
Abstract: An isolated muscle progenitor cell being MyoD positive, CD34 negative and CD45 negative is disclosed. The muscle progenitor cell is genetically modified to express at least one neurotrophic factor. In addition, cell populations are disclosed, comprising at least four subpopulations of muscle cells each being genetically modified to express a different neurotrophic factor, wherein said neurotrophic factor is selected from the group consisting of glial derived neurotrophic factor (GDNF), insulin growth factor (IGF-1), vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). Uses of the cell populations are also disclosed.
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508.发明申请公开(公告)号：US20190185563A1
公开(公告)日：2019-06-20
申请号：US16284081
申请日：2019-02-25
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Michal Eisenbach-Schwartz , Kuti Baruch , Neta Rosenzweig
IPC: C07K16/28 , A61K38/02 , A61K38/00 , A61K31/4155 , A61K38/16 , A61K38/18 , A61K38/20 , A61K38/14 , A61K45/06 , A61K31/404 , A61K39/395 , A61K33/36 , A61K31/7068
CPC classification number: C07K16/2803 , A61K31/404 , A61K31/4155 , A61K31/7068 , A61K33/36 , A61K38/00 , A61K38/005 , A61K38/02 , A61K38/14 , A61K38/168 , A61K38/18 , A61K38/208 , A61K39/395 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/545 , A61K2039/57 , A61K2039/572 , A61K2121/00 , C07K16/2818 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/75 , C07K2317/76 , A61K2300/00
Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.
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公开(公告)号：US20190171673A1
公开(公告)日：2019-06-06
申请号：US16244139
申请日：2019-01-10
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Noam SOBEL , Lavi SECUNDO , Kobi SNITZ , Kineret WEISSLER , Liron PINCHOVER , Idan FRUMIN , Dana Shoshana BAR ZVI MILDWORF , Sagit SHUSHAN
IPC: G06F16/903 , G16H10/20 , A61B5/00
Abstract: A method of determining olfactory perception signature of a subject is disclosed. The method comprises: providing the subject with a plurality of physical odorant samples for sniffing; for each sniffed odorant sample, presenting to the subject, by a user interface, a set of odorant descriptors and a respective set of rating controls, and receiving ratings entered by the subject using the rating controls. Each rating is indicative of a descriptiveness of a respective odorant descriptor for the odorant sample, thereby obtaining a set of descriptiveness levels for the odorant sample. The method also comprises calculating, by a computer, relations between pairs of sets of descriptiveness levels corresponding to pairs of odorant samples, to provide a vector of relations, wherein the vector represents the olfactory perception signature of the subject.
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公开(公告)号：US20190153482A1
公开(公告)日：2019-05-23
申请号：US16217090
申请日：2018-12-12
Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizat , Yeda Research and Development Co. Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor： Itzhak MIZRAHI , Naama SHTERZER , Raphael LAMED , Inna ROZMAN GRINBERG , Edward A. BAYER , Sarah MORAIS , Etai LANDOU
Abstract: Lactic acid bacterial cultures, cell populations and articles of manufacture comprising same are disclosed for generating ethanol from lignocellulse.
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