公开(公告)号：US20230302114A1

公开(公告)日：2023-09-28

申请号：US17998208

申请日：2021-05-07

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey WONG ,  Hsin-Yu LIAO ,  Shih-Chi WANG ,  Yi-An KO ,  Kuo-I LIN ,  Che MA ,  Ting-Jen CHENG

IPC: A61K39/145 ,  C07K14/005 ,  A61P31/16

CPC classification number: A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  A61K2039/575

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of H1 subtype HA (H1 HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of H1 subtype HA (H1 HA) or H5 subtype HA (H5 HA).

公开(公告)号：US11741984B2

公开(公告)日：2023-08-29

申请号：US17335487

申请日：2021-06-01

Applicant: ACADEMIA SINICA

Inventor： Tsao Yu ,  Syu-Siang Wang ,  Szu-Wei Fu ,  Alexander Chao-Fu Kang ,  Hsin-Min Wang

IPC: G10L21/0272 ,  G10L25/48 ,  G10L15/20

CPC classification number: G10L21/0272 ,  G10L15/20 ,  G10L25/48

Abstract: An acoustic scene conversion method, comprising: receiving sound signals including user's speech and scenic sounds; processing the sound signals according to an artificial intelligence model to generate enhanced speech signals without scenic sounds; and mixing the enhanced speech signals with new scenic sounds to produce converted sound signals.

公开(公告)号：US20230243810A1

公开(公告)日：2023-08-03

申请号：US18116952

申请日：2023-03-03

Applicant: ACADEMIA SINICA

Inventor： Yuan-Tsong Chen ,  Yi-Ching Lee ,  Jer-Yuarn Wu ,  Hsiao-Jung Kao

IPC: G01N33/50 ,  A61P19/00 ,  A61P35/00 ,  A01K67/027 ,  A61K31/409 ,  A61K36/21

CPC classification number: G01N33/502 ,  A61P19/00 ,  A61P35/00 ,  A01K67/0278 ,  A61K31/409 ,  A61K36/21 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/0331 ,  G01N2500/10

Abstract: A method of inhibiting an overactive fibroblast growth factor receptor 3 (FGFR3) in a cell by contacting the cell with a composition that contains an effective amount of Pheophorbide a, Pyropheophorbide a, or an active derivative thereof. Also disclosed is a method for treating a disorder associated with an overactive FGFR3 with a composition containing an effective amount of Pheophorbide a, Pyropheophorbide a, or an active derivative thereof. Further, a composition for treating a disorder associated with an overactive FGFR3 is described. The composition contains an ethanol extract of Amaranthus viridis.

公开(公告)号：US11713441B2

公开(公告)日：2023-08-01

申请号：US17958234

申请日：2022-09-30

Applicant: Academia Sinica

Inventor： Ying-Chih Chang

IPC: G01N33/50 ,  C12N5/09 ,  C12M1/00

CPC classification number: C12M23/20 ,  C12N5/0693 ,  G01N33/5011 ,  G01N33/5088 ,  C12N2502/1164 ,  C12N2513/00 ,  C12N2533/32 ,  C12N2533/40 ,  C12N2533/50

Abstract: The present disclosure provides methods of evaluating a therapeutic agent for cancer, and methods of cancer treatment.

公开(公告)号：US20230201359A1

公开(公告)日：2023-06-29

申请号：US17927743

申请日：2021-05-26

Applicant: Academia Sinica

Inventor： PATRICK CH HSIEH ,  HSIEN-MING LEE ,  KENG-JUNG LEE ,  HUNG-CHIH CHEN

IPC: A61K47/54 ,  A61K47/69 ,  C12N15/10 ,  C12N15/115 ,  A61K47/60 ,  A61P9/10

CPC classification number: A61K47/549 ,  A61K47/60 ,  A61K47/6911 ,  A61K47/6929 ,  A61P9/10 ,  C12N15/115 ,  C12N15/1048 ,  C12N2310/16

Abstract: Monocyte-specific nucleic acid aptamers and lipid nanoparticles comprising such for use in drug delivery. Also disclosed herein are use of the aptamer-based lipid nanoparticle drug delivery system for treating heart injury.

公开(公告)号：US11686885B2

公开(公告)日：2023-06-27

申请号：US16721343

申请日：2019-12-19

Applicant: ACADEMIA SINICA

Inventor： Din-Ping Tsai ,  Cheng-Hung Chu ,  Ren-Jie Lin ,  Mu-Ku Chen ,  Pin-Chieh Wu

IPC: G02B3/00 ,  G02B1/00 ,  H04N23/55

CPC classification number: G02B3/0068 ,  G02B1/002 ,  G02B3/0087 ,  H04N23/55

Abstract: Compound eyes of insects are great optical system for imaging and sensing by the nature creator, which is an unsurpassed challenge due to its precision and small size. Here, we use meta-lens consisting of GaN nano-antenna to open the fascinating doorway to full-color achromatic light field imaging and sensing. A 60×60 multi-channels meta-lens array is used for effectively capturing multi-dimensional optical information including image and depth. Based on this, the multi-dimensional light field imaging and sensing of a moving object is capable to be experimentally implemented. Our system presents a diffraction-limit resolution of 1.95 micrometer via observing the standard resolution test chart under white light illumination. This is the first mimic optical light field imaging and sensing system of insect compound eye, which has potential applications in micro robotic vision, non-men vehicle sensing, virtual and augmented reality, etc.

公开(公告)号：US11672853B2

公开(公告)日：2023-06-13

申请号：US16431099

申请日：2019-06-04

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Che Ma ,  Cheng-Chi Wang ,  Juine-Ruey Chen

IPC: A61K39/145 ,  C12N7/00 ,  A61K39/12 ,  C07K16/10 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K39/12 ,  C07K16/1018 ,  C12N7/00 ,  A61K2039/55505 ,  C07K2317/76 ,  C12N2740/11034 ,  C12N2740/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2770/24134 ,  Y02A50/30

Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

公开(公告)号：US20230176063A1

公开(公告)日：2023-06-08

申请号：US17913101

申请日：2021-03-19

Applicant: Academia Sinica

Inventor： Chih-Wei CHANG ,  Yi-De CHEN ,  Jung-Chi LIAO

IPC: G01N33/58

CPC classification number: G01N33/581

Abstract: Compositions including photoreactive and cleavable probes and methods of using the probes. The probes may include a tag conjugatable to a label, a cleavable linker linkable to a bait molecule, and a light activated warhead. The compositions and methods may be useful for analyzing biomolecules.

公开(公告)号：US20230168249A1

公开(公告)日：2023-06-01

申请号：US17922590

申请日：2021-05-04

Applicant: Academia Sinica

Inventor： An-Suei YANG ,  Chao-Ping TUNG ,  Chung-Ming YU ,  Chi-Yung CHEN ,  Yu-Chuan HUANG ,  Pei-Hsun TSAI ,  Szu-Yu LIN ,  Hung-Ju HSU ,  Hung-Pin PENG ,  Fei-Hung HUNG

IPC: G01N33/569 ,  C07K16/10

CPC classification number: G01N33/56983 ,  C07K16/10 ,  C07K2317/622 ,  C07K2317/92 ,  G01N2333/165 ,  G01N2470/04 ,  G01N2469/10

Abstract: Disclosed herein are recombinant antibodies or the fragment thereof for detecting severe acute respiratory syndrome coronavirus (SARS-CoV). According to some embodiments, the SARS-CoV is SARS-CoV-1. According to some alternative embodiments, the SARS-CoV is SARS-CoV-2. Also disclosed herein are a kit comprising the recombinant antibodies, and a method for diagnosing the infection of SARS-CoV by using the recombinant antibody or the kit.

公开(公告)号：US11638705B2

公开(公告)日：2023-05-02

申请号：US16831346

申请日：2020-03-26

Applicant: Academia Sinica

Inventor： Rong-Jie Chein ,  Pan-Chyr Yang ,  Chi-Huey Wong ,  Ming-Shiu Lin ,  Ting-Jen Cheng ,  Ting-Hung Chou

IPC: A61K31/47 ,  A61P35/00 ,  A61K45/06 ,  C07D215/233

Abstract: Compounds of Formula (I) and methods for treating, delaying, and/or preventing the adverse effects of proliferative diseases, such as cancers including, for example, lung cancer, breast cancer, ovarian cancer, prostate cancer, head cancer, neck cancer, head and neck cancer, or leukemia (e.g., cancer resistant to treatment by one or more microtubule-targeting agents, e.g., cancer resistant to multiple drugs associated with P-glycoprotein (P-gp) overexpression). Methods of inhibiting polymerization of a cancer cell microtubule in a subject in need thereof or a cell, tissue, or biological sample, binding β-tubulin, inhibiting microtubule assembly and, inducing apoptosis in a cancer cell resistant to multiple drugs in a tissue, biological sample, or subject. Pharmaceutical compositions, kits, and methods of using the compounds for treating any of the target diseases described herein.