公开(公告)号：US08127763B2

公开(公告)日：2012-03-06

申请号：US12246116

申请日：2008-10-06

Applicant: Hugh C. Smyth ,  Charles R. Truman

Inventor： Hugh C. Smyth ,  Charles R. Truman

IPC: A61M16/00

CPC classification number: A61M15/0028 ,  A61M15/0003 ,  A61M15/0005 ,  A61M15/0035 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  A61M15/0065 ,  A61M15/0068 ,  A61M15/0091 ,  A61M2202/064 ,  A61M2205/8275 ,  A61M2206/14 ,  A61M2206/16

Abstract: A dry powder inhaler for delivering medicament to a patient includes a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and an aeroelastic element in the chamber and associated with a dose of powdered medicament. A tensioning assembly is configured to apply a first amount of tension to the aeroelastic element such that the aeroelastic element is capable of vibrating in response to airflow through the chamber so as to aerosolize the dose of powdered medicament.

Abstract translation: 用于将药物递送到患者的干粉吸入器包括限定用于接收一定剂量的粉末药物的腔室的壳体，与腔室流体连通的吸入口，至少一个气流入口，其提供腔室与外部之间的流体连通 壳体和气动弹性元件，并与一定剂量的粉末状药物相关联。 张紧组件构造成向气动弹性元件施加第一量的张力，使得气动弹性元件响应于通过腔室的气流而能够振动，从而使粉末状药物的剂量雾化。

公开(公告)号：US08114464B2

公开(公告)日：2012-02-14

申请号：US11690922

申请日：2007-03-26

Applicant: Gabriel Lopez ,  Plamen Atanasov ,  Gautam Gupta

Inventor： Gabriel Lopez ,  Plamen Atanasov ,  Gautam Gupta

IPC: A61K9/127

CPC classification number: A61K9/1274 ,  Y10T428/24997 ,  Y10T428/249978 ,  Y10T428/249987 ,  Y10T428/31663 ,  Y10T428/31678

Abstract: The present disclosure provides various novel methods for forming hybrid thin films that contain multi-lamellar assemblies of phospholipid bilayers and can incorporate proteins, polypeptides, biological complexes, transmembrane proteins and other membrane-associated compounds. The present disclosure further provides uses for such bilayer lipid membranes including, biosensing for medical diagnosis and environmental monitoring, chemical and biological warfare agent sequestration, actuator development, and bio-fuel cell development.

Abstract translation: 本公开提供了用于形成含有磷脂双层的多层组件并可掺入蛋白质，多肽，生物复合物，跨膜蛋白和其它膜相关化合物的杂化薄膜的各种新颖方法。 本公开进一步提供了这种双层脂质膜的用途，包括用于医疗诊断和环境监测的生物传感，化学和生物战剂螯合，致动器开发和生物燃料电池开发。

公开(公告)号：US08097237B2

公开(公告)日：2012-01-17

申请号：US11507846

申请日：2006-08-22

Applicant: Jeffrey P. Norenberg ,  Richard S. Larson

Inventor： Jeffrey P. Norenberg ,  Richard S. Larson

IPC: A61K51/00 ,  A61M36/14

CPC classification number: C07F5/003 ,  A61K47/22 ,  A61K49/106 ,  A61K51/0474 ,  A61K51/0482 ,  A61K51/0485 ,  A61K51/0497 ,  C07F9/94

Abstract: The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probe is capable of detecting precancerous cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of NHL. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及用于对癌症特别是白血病和非霍奇金淋巴瘤（NHL）进行成像的新型非侵入性诊断工具，其体内毒性最小。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 该新型成像探针能够检测癌前细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。 该新型探针也可用于监测患者对化疗治疗的反应和用于治疗NHL的其他干预措施或疗法。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：US08084641B2

公开(公告)日：2011-12-27

申请号：US11546092

申请日：2006-10-11

Applicant: Wei Wang

Inventor： Wei Wang

IPC: C07C335/20 ,  C07C275/40

CPC classification number: C07C205/45 ,  B01J31/0231 ,  B01J31/0237 ,  B01J31/0249 ,  B01J31/0271 ,  C07B2200/07 ,  C07C45/72 ,  C07C205/16 ,  C07C335/20 ,  C07C403/08 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07D317/52 ,  C07C49/723 ,  C07C49/747 ,  C07C49/713

Abstract: The present invention is directed to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use.

Abstract translation: 本发明涉及包含促进立体选择性反应的有机催化剂及其合成和使用方法的组合物。 特别地，本发明涉及促进立体选择性反应的无金属有机催化剂及其合成和使用方法。

公开(公告)号：US20110310920A1

公开(公告)日：2011-12-22

申请号：US13223580

申请日：2011-09-01

Applicant: Seung Chang Lee ,  Steven R. J. Brueck

Inventor： Seung Chang Lee ,  Steven R. J. Brueck

IPC: H01S5/32 ,  H01L33/04 ,  H01L21/20 ,  H01L29/778 ,  B82Y40/00 ,  B82Y99/00

CPC classification number: H01L21/02603 ,  B82Y10/00 ,  B82Y40/00 ,  B82Y99/00 ,  H01L21/0237 ,  H01L21/02439 ,  H01L21/02507 ,  H01L21/02521 ,  H01L21/02639 ,  H01L29/0665 ,  H01L29/0673 ,  H01L29/127 ,  H01L29/158 ,  H01L29/7783 ,  H01L29/7853 ,  H01L33/06 ,  H01L33/18 ,  H01S5/32 ,  Y10S977/951 ,  Y10S977/962

Abstract: Exemplary embodiments provide semiconductor nanowires and nanowire devices/applications and methods for their formation. In embodiments, in-plane nanowires can be epitaxially grown on a patterned substrate, which are more favorable than vertical ones for device processing and three-dimensional (3D) integrated circuits. In embodiments, the in-plane nanowire can be formed by selective epitaxy utilizing lateral overgrowth and faceting of an epilayer initially grown in a one-dimensional (1D) nanoscale opening. In embodiments, optical, electrical, and thermal connections can be established and controlled between the nanowire, the substrate, and additional electrical or optical components for better device and system performance.

Abstract translation: 示例性实施例提供用于其形成的半导体纳米线和纳米线器件/应用和方法。 在实施例中，平面内纳米线可以在图案化衬底上外延生长，其比用于器件处理和三维（3D）集成电路的垂直纳米线更有利。 在实施方案中，可以通过使用最初在一维（1D）纳米尺度开口中生长的外延层的横向过生长和刻面的选择性外延来形成平面内纳米线。 在实施例中，可以在纳米线，衬底和附加电气或光学部件之间建立和控制光学，电气和热连接，以获得更好的器件和系统性能。

公开(公告)号：US08073096B2

公开(公告)日：2011-12-06

申请号：US12152386

申请日：2008-05-14

Applicant: Mohamed S. El-Genk ,  Jean-Michel Tournier

Inventor： Mohamed S. El-Genk ,  Jean-Michel Tournier

IPC: F01K3/18

CPC classification number: F28D15/0233 ,  F28D15/0266 ,  F28D15/0275 ,  F28D15/04 ,  F28D2021/0054

Abstract: Methods and apparatuses are provided for the removal and transportation of thermal energy from a heat source to a distant complex for use in thermochemical cycles or other processes. In one embodiment, an apparatus includes a hybrid heat pipes/thermosyphon intermediate heat exchanger (HPTIHX) system that is divided into three distinct sections, namely: an evaporation chamber, a condensation chamber, and a working fluid transport section of liquid and vapor counter-current flows.

Abstract translation: 提供了用于将热能从热源移除到远离的复合物以用于热化学循环或其它工艺中的方法和装置。 在一个实施例中，一种装置包括分为三个不同部分的混合热管/热虹吸中间热交换器（HPTIHX）系统，即：蒸发室，冷凝室和液体和蒸汽反应器的工作流体输送部分， 电流。

公开(公告)号：US08018159B2

公开(公告)日：2011-09-13

申请号：US12154658

申请日：2008-05-23

Applicant: Mikhail I. Fuks ,  Edl Schamiloglu

Inventor： Mikhail I. Fuks ,  Edl Schamiloglu

IPC: H01J25/50

CPC classification number: H01J23/18 ,  H01J23/36 ,  H01J25/587

Abstract: The present invention provides a relativistic magnetron with axial extraction, or magnetron with diffraction output (MDO), with a mode converter placed directly within the diffraction output of radiation to effectively convert the operating π-mode into a radiated mode of simpler radiation patterns.

Abstract translation: 本发明提供具有轴向提取的相对论磁控管或具有衍射输出（MDO）的磁控管，其中模式转换器直接放置在辐射的衍射输出内，以有效地将操作模式转换成更简单辐射模式的辐射模式。

公开(公告)号：US08009712B2

公开(公告)日：2011-08-30

申请号：US12460892

申请日：2009-07-24

Applicant: Marek A. Osinski ,  Omar K. Qassim ,  Nathan J. Withers ,  Gennady A. Smolyakov

Inventor： Marek A. Osinski ,  Omar K. Qassim ,  Nathan J. Withers ,  Gennady A. Smolyakov

IPC: H01S5/00 ,  H01S3/083

CPC classification number: H01S5/1071 ,  H01S5/026 ,  H01S5/0264 ,  H01S5/1003 ,  H01S5/1032 ,  H01S5/12 ,  H01S5/125 ,  H01S5/2275 ,  H01S5/4006 ,  H01S5/50

Abstract: A semiconductor ring laser (SRL) section is monolithically integrated with a DFB or DBR master laser section on a semiconductor substrate of a light-emitting device to provide an injection locking mode of operation that can result in low-cost ultrafast (over 100 GHz) functional chip that will be easy to use in practice.

Abstract translation: 半导体环形激光器（SRL）部分与发光器件的半导体衬底上的DFB或DBR主激光器部分单片集成，以提供可以导致低成本超快（超过100GHz）的注入锁定模式， 功能芯片在实践中将易于使用。

公开(公告)号：US20110142812A1

公开(公告)日：2011-06-16

申请号：US12312090

申请日：2007-11-06

Applicant: Terry W. Du Clos ,  Carolyn Mold

Inventor： Terry W. Du Clos ,  Carolyn Mold

IPC: A61K35/14 ,  A61K38/17 ,  A61K38/36 ,  A61P7/00 ,  C12N5/0786 ,  C12N5/0784

CPC classification number: A61K35/15 ,  A61K35/28 ,  A61K38/1745 ,  A61K2300/00

Abstract: The present invention relates to the use of suppressive macrophage or dendritic cells (activated with C-reactive protein or CRP-related compounds), for the treatment of various disease states and conditions associated with immune thrombocytopenic purpura (ITP) and/or systemic lupus erythematosus (SLE), including lupus of the skin (discoid), systemic lupus of the joints, lungs and kidneys, hematological conditions including hemolytic anemia and low lymphocyte counts, lymphadenopathy and CNS effects, including memory loss, seizures and psychosis, among numerous others as otherwise disclosed herein. In another aspect of the invention, the reduction in the likelihood that a patient who is at risk for an outbreak of a disease state or condition associated with systemic lupus erythematosus or ITP will have an outbreak is an additional aspect of the present invention. In the case of ITP, methods of the present invention are used to increase platelet counts in the treated patient. In addition, in the case of ITP, the present invention relates to the use of CRP or a CRP-related compound in the absence of suppressive macrophages for the treatment of ITP.

Abstract translation: 本发明涉及抑制性巨噬细胞或树突状细胞（用C反应蛋白或CRP相关化合物活化）用于治疗与免疫血小板减少性紫癜（ITP）和/或系统性红斑狼疮相关的各种疾病状态和病症 （SLE），包括皮肤（盘状）的狼疮，关节，肺和肾的系统性红斑狼疮，血液病症，包括溶血性贫血和低淋巴细胞计数，淋巴结病和CNS作用，包括记忆丧失，癫痫发作和精神病， 本文另有公开。 在本发明的另一方面，减少与系统性红斑狼疮或ITP相关的疾病状态或疾病爆发危险的患者将发生爆发的可能性是本发明的另外的方面。 在ITP的情况下，本发明的方法用于增加治疗患者的血小板计数。 此外，在ITP的情况下，本发明涉及在不存在抑制性巨噬细胞用于治疗ITP的情况下使用CRP或CRP相关化合物。

公开(公告)号：US07947950B2

公开(公告)日：2011-05-24

申请号：US11865812

申请日：2007-10-02

Applicant: Christie G Enke ,  Gareth S Dobson

Inventor： Christie G Enke ,  Gareth S Dobson

IPC: H01J49/06 ,  G01N27/62

CPC classification number: H01J49/40

Abstract: A distance-of-flight mass spectrometer (DOF-MS) imparts constant momentum acceleration to ions in an ion source and uses an ion mirror to enhance energy focusing. Embodiments of DOF-MS with ion mirror are shown. Further, a method of compensating for the dispersion of initial ion position and velocity in the ion source is discussed.

Abstract translation: 飞行时间质谱仪（DOF-MS）对离子源中的离子施加恒定的动量加速度，并使用离子镜增强能量聚焦。 示出了具有离子镜的DOF-MS的实施例。 此外，讨论了补偿离子源中初始离子位置和速度的分散的方法。