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    Detecting abnormal reactions in a red blood cell agglutination
    51.
    发明授权
    Detecting abnormal reactions in a red blood cell agglutination 失效
    检测红细胞凝集中的异常反应

    公开(公告)号：US5911000A

    公开(公告)日：1999-06-08

    申请号：US904506

    申请日：1997-08-01

    申请人： Jian Shen

    发明人： Jian Shen

    IPC分类号： G01N33/53 ,  G01N15/04 ,  G01N30/38 ,  G01N33/49 ,  G01N33/543 ,  G01N33/555 ,  G06K9/00

    CPC分类号： G01N33/4905 ,  G01N15/042 ,  G06K9/00127 ,  G01N2015/047 ,  G01N2030/381

    摘要： Abnormal reactions in a red blood cell classification by agglutination, are checked following centrifugation of a sample in a column of a cassette, the column containing microparticles. This is done by imaging the column on a detector array that is used to correlate the images with predefined red cell classes based upon the distribution of the images across the column. However, prior to the correlation step, abnormal reactions are checked for by detecting whether any of the following is present:i) errors that cause imaged features of the column or any pellet produced therein to be out of range;ii) hemolysis of the sample;iii) insufficient or too many blood cells present;iv) mixed field agglutination; andv) presence of fibrin at the top of the microparticles.

    摘要翻译： 在将样品置于盒的柱中，含有微粒的柱之后检查在通过凝集的红细胞分类中的异常反应。 这是通过将检测器阵列上的列成像，其用于基于跨越该列的图像的分布将图像与预定义的红细胞类别相关联。 然而，在相关步骤之前，通过检测是否存在以下任何一种来检查异常反应：i）导致柱的成像特征或其中产生的任何颗粒的失真超出范围; ii）样品溶血; iii）存在不足或太多血细胞; iv）混合场凝集; 和v）在微粒顶部存在纤维蛋白。

    Calibration cassette for use in calibrating an automated agglutination reaction analyzing system
    52.
    发明授权
    Calibration cassette for use in calibrating an automated agglutination reaction analyzing system 失效
    用于校准自动凝集反应分析系统的校准盒

    公开(公告)号：US5872860A

    公开(公告)日：1999-02-16

    申请号：US816314

    申请日：1997-03-13

    申请人： Jian Shen ,  Thierry Dupinet

    发明人： Jian Shen ,  Thierry Dupinet

    IPC分类号： G01B11/00 ,  B01L3/14 ,  G01N15/04 ,  G01N21/27 ,  G01N21/82 ,  G01N33/49 ,  G01N33/543 ,  G01N35/00 ,  G06T7/00 ,  G06K9/00 ,  G01N33/48

    CPC分类号： G06T7/0042 ,  B01L3/5021 ,  G01N21/82 ,  G01N2015/045 ,  G01N33/4905 ,  G06T2207/30004

    摘要： A method, and a calibration device, for calibrating a system for analyzing aqueous solutions and that includes a pixel array and a variable focus line for focusing onto the pixel array illuminated images of the aqueous solutions. The method includes the steps of illuminating a pattern on the calibration device to form an illuminated image of that pattern, and directing that illuminated image through the lens and onto the pixel array. The method includes the further step of deriving data values representing the image on the pixel array, and using those data values to adjust the focus of the lens and to adjust the position of the calibration device relative to the pixel array.

    摘要翻译： 一种用于校准用于分析水溶液的系统的方法和校准装置，其包括像素阵列和可变焦点线，用于聚焦在水溶液的像素阵列照明图像上。 该方法包括以下步骤：照亮校准装置上的图案以形成该图案的照明图像，并将该照明图像引导通过透镜并且到达像素阵列。 该方法还包括以下步骤：在像素阵列上导出表示图像的数据值，并使用这些数据值来调整透镜的焦点并调整校准装置相对于像素阵列的位置。

    High specific activity nucleotide probes having target recognition and signal generation moieties
    54.
    发明授权
    High specific activity nucleotide probes having target recognition and signal generation moieties 失效
    具有目标识别和信号产生部分的高比活性核苷酸探针

    公开(公告)号：US5521298A

    公开(公告)日：1996-05-28

    申请号：US142232

    申请日：1993-10-25

    申请人： Chander Bahl ,  Leopoldo Mendoza

    发明人： Chander Bahl ,  Leopoldo Mendoza

    IPC分类号： G01N33/58 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C07H21/00 ,  Y10S435/81

    摘要： The probes of the invention are made up of a target recognition moiety and a signal generation moiety. In the first step of the preparatory method of the invention, the 5' or 3' terminus or both of the target recognition moiety is chemically altered to incorporate a reactive functionality which will allow chemical linkage of this target recognition moiety with one or both termini of the signal generation moiety of the probe. Suitable functionalities vary widely, but may, in general be described as those that allow chemical attachment of the two moieties either at the 5' or 3' end of the target recognition moiety. The two moieties should not detach from each other upon hybridization of the target moiety to the target analyte. Thus, when the probe is hybridized to target analyte, it will then carry with it, signal moiety, to label this complex, which label is then later detected.

    摘要翻译： 本发明的探针由靶识别部分和信号产生部分组成。 在本发明的制备方法的第一步中，目标识别部分的5'或3'末端或两者被化学改变以引入反应性官能团，其将允许该目标识别部分与一个或两个末端的化学键合 探针的信号产生部分。 合适的功能性变化很大，但通常可以描述为允许两个部分在目标识别部分的5'或3'末端化学连接的功能。 当目标部分与目标分析物杂交时，两个部分不应相互分离。 因此，当探针与目标分析物杂交时，其随后携带信号部分，以标记该复合物，然后稍后检测该标记物。

    Nucleic acid probe for the detection of Salmonella human pathogens
    56.
    发明授权
    Nucleic acid probe for the detection of Salmonella human pathogens 失效
    用于检测沙门氏菌人类病原体的核酸探针

    公开(公告)号：US5486454A

    公开(公告)日：1996-01-23

    申请号：US243749

    申请日：1994-05-17

    申请人： M. Jane Madonna ,  Derek Woods

    发明人： M. Jane Madonna ,  Derek Woods

    IPC分类号： C12Q1/68 ,  C12R1/42 ,  C07H21/04

    CPC分类号： C12Q1/689

    摘要： Nucleic acid probes that detect Salmonella human pathogens are generated from the nucleotide sequences of a gene encoding a virulence factor involved in the pathogenesis of Salmonella, especially the Type 1 fimbriae protein. Preferred probe lengths are about 20 to about 100 nucleotide bases. The probes are highly specific and sensitive for detecting Salmonella organisms pathogenic to humans and are thus clinically useful in the detection of infection in diarrhea specimens. They also may be used in the detection of food-borne Salmonella, the causative agent of most salmonellosis in humans.

    摘要翻译： 检测沙门氏菌人类病原体的核酸探针是从编码涉及沙门氏菌发病机理的毒力因子的基因的核苷酸序列产生的，特别是1型菌毛蛋白。 探针长度优选为约20至约100个核苷酸碱基。 探针对于检测对人体致病的沙门氏菌具有高度的特异性和敏感性，因此在临床上可用于检测腹泻标本中的感染。 它们也可用于检测食源性沙门氏菌，这是人类大多数沙门氏菌病的致病因子。

    High specific activity nucleic acid probes having target recognition and signal generating moieties
    57.
    发明授权
    High specific activity nucleic acid probes having target recognition and signal generating moieties 失效
    具有靶识别和信号产生部分的高比活性核酸探针

    公开(公告)号：US5324829A

    公开(公告)日：1994-06-28

    申请号：US285274

    申请日：1988-12-16

    申请人： Chander Bahl ,  Leopoldo Mendoza

    发明人： Chander Bahl ,  Leopoldo Mendoza

    IPC分类号： G01N33/58 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/68 ,  C16Q1/68 ,  G01N33/53

    CPC分类号： C07H21/00 ,  Y10S435/81

    摘要： The probes of the invention are made up of a target recognition moiety and a signal generation moiety. In the first step of the preparatory method of the invention, the 5' or 3' terminus or both of the target recognition moiety is chemically altered to incorporate a reactive functionality which will allow chemical linkage of this target recognition moiety with one or both termini of the signal generation moiety of the probe. Suitable functionalities vary widely, but may, in general be described as those that allow chemical attachment of the two moieties either at the 5' or 3' end of the target recognition moiety. The two moieties should not detach from each other upon hybridization of the target moiety to the target analyte. Thus, when the probe is hybridized to target analyte, it will then carry with it, signal moiety, to label this complex, which label is then later detected.

    摘要翻译： 本发明的探针由靶识别部分和信号产生部分组成。 在本发明的制备方法的第一步中，目标识别部分的5'或3'末端或两者被化学改变以引入反应性官能团，其将允许该目标识别部分与一个或两个末端的化学键合 探针的信号产生部分。 合适的功能性变化很大，但通常可以描述为允许两个部分在目标识别部分的5'或3'末端化学连接的功能。 当目标部分与目标分析物杂交时，两个部分不应相互分离。 因此，当探针与目标分析物杂交时，其随后携带信号部分，以标记该复合物，然后稍后检测该标记物。

    Device for immunoassay determinations
    60.
    发明授权
    Device for immunoassay determinations 失效
    免疫测定装置

    公开(公告)号：US5017342A

    公开(公告)日：1991-05-21

    申请号：US201515

    申请日：1988-06-01

    申请人： Cecelia Haberzettl ,  Jack Geltosky ,  Renee Perst

    发明人： Cecelia Haberzettl ,  Jack Geltosky ,  Renee Perst

    IPC分类号： G01N33/53 ,  G01N33/543

    CPC分类号： B01L3/502 ,  G01N33/5304 ,  G01N33/54366 ,  Y10S436/809 ,  Y10S436/81

    摘要： An assay device is provided which includes a support, generally planar and elongated in shape, upon which a biological binding reaction may take place. This assay support includes in its broadest aspect, three sections, a sample receiving well section at one end and a gripping section at the opposite end, with a connecting section therebetween. The sample receiving well section includes at least two spaced-apart receiving wells, generally at the end of the assay support, for the addition of binding reactants. Each of the wells has an open end on a first face of the support, a concave inner surface extending concavely into the support, and a convex outer surface which projects convexly from an opposed face of the support. These wells may serve as a depository to contain aliquots of binding reagents, as well as a sample under analysis, the sample under analysis possibly containing a substance that will bind to the binding reagents.