公开(公告)号：US11862335B2

公开(公告)日：2024-01-02

申请号：US18147546

申请日：2022-12-28

Applicant: Cytiva Sweden AB

Inventor： Key Hyckenberg ,  Kjell Karlsson ,  Stefan Willehadson ,  Orjan Bo Grelsson

IPC: G08B21/18 ,  G06K19/077 ,  G06F9/445 ,  G06F9/455 ,  G16H40/67 ,  G06F16/955 ,  G06F3/0483 ,  G06F3/04842 ,  H04L67/025 ,  H04L67/125

CPC classification number: G16H40/67 ,  G06F3/0483 ,  G06F3/04842 ,  G06F16/9558 ,  H04L67/025 ,  H04L67/125

Abstract: A method, system, gateway and computer program for remote controlling and monitoring of at least one instrument, for example a bioproces sing instrument. The system can comprise: at least one instrument to be controlled and/or monitored; at least one instrument server connected to the at least one instrument, said instrument server comprising an instrument control software; at least one gateway connected to the at least one instrument server; a transferring means provided in the at least one instrument server, said transferring means being arranged to receive information from the at least one connected instrument and forward said information to the at least one gateway.

公开(公告)号：US11850391B2

公开(公告)日：2023-12-26

申请号：US17174533

申请日：2021-02-12

Applicant: Cytiva Sweden AB

Inventor： Eric Faldt ,  Klaus Gebauer

IPC: A61M39/16 ,  A61M39/10 ,  F16L39/00 ,  A61M39/18

CPC classification number: A61M39/105 ,  A61M39/16 ,  A61M39/18 ,  F16L39/00 ,  F16L2201/44

Abstract: Aseptic connectors are described. An aseptic connector includes a first connection unit and a second connection unit provided with at least one first and second openings orientated to substantially coincide when said first and second connection units are connected to each other. The first and second openings are sealed by at least one film, so that the contact between the film and each connection unit is aseptic. The at least one film is adapted to be mated with a corresponding film on the other connection unit; and the mated films are adapted to be pulled out together two and two after mating such that corresponding first and second openings are mated aseptically.

公开(公告)号：US11815451B2

公开(公告)日：2023-11-14

申请号：US16316276

申请日：2017-06-27

Applicant: Cytiva Sweden AB

Inventor： Mikael Anders Hornqvist

IPC: G01N21/33 ,  G01N21/05 ,  G01N30/74 ,  G01N21/85 ,  G01N21/31 ,  G01N30/02

CPC classification number: G01N21/33 ,  G01N21/05 ,  G01N21/8507 ,  G01N30/74 ,  G01N2021/3125 ,  G01N2030/027 ,  G01N2201/0624 ,  G01N2201/0625 ,  G01N2201/0691 ,  G01N2201/127

Abstract: Disclosed is a method for measuring the absorbance of light of a substance in a solution in a measuring cell (23; 223′), said method comprising the steps of: transmitting (S1) a first light beam (27; 27′) from a light source (25; 25′) towards a beam splitter (29; 29′); dividing (S3) the first light beam (27; 27′) into a signal light ray (31; 31′) and a reference light ray (33; 33′) by the beam splitter (29; 29′); modulating (S5) the signal light ray (31; 31′); modulating the reference light ray (33; 33′); providing (S9) the measuring cell (23; 23′) such that the signal light ray (31; 31′) passes through the measuring cell; detecting (S11) a signal in a detector (39; 39′), which signal is the combined signal intensity of the signal light ray (31; 31′) and the reference light ray (33; 33′) detected by the detector (39; 39′); performing synchronous detection (S15) of the detected signal in order to reconstruct the intensities of the signal light ray (31; 31′) and the reference light ray (33; 33′) from the combined signal detected by the detector (39; 39′), said synchronous detection being based on the modulation performed to the signal light ray and the reference light ray. Disclosed also is a measuring device for carrying out said method.

公开(公告)号：US11815075B2

公开(公告)日：2023-11-14

申请号：US16645022

申请日：2018-09-06

Applicant: Cytiva Sweden AB

Inventor： Andreas Torbjorn Lundin ,  Klas Marteleur ,  Mats Lundkvist ,  Andreas Marcstrom ,  David Gronowitz

IPC: F04B1/047 ,  F04B43/02

CPC classification number: F04B1/047 ,  F04B43/02 ,  F04B43/026

Abstract: A multiple cavity reciprocating positive displacement pump (200) comprises a plurality of pump cavities (222), each pump cavity (222) including at least an inlet valve (228) and an outlet valve (231), wherein respective inlet valves (228) are in fluid communication with a common inlet (224) and respective outlet valves (231) are in fluid communication with a common outlet (238), and wherein the pump cavities (222) are arranged about a pump axis (AR) and around said common inlet (224) and said common outlet (238).

公开(公告)号：US20230349867A1

公开(公告)日：2023-11-02

申请号：US18350588

申请日：2023-07-11

Applicant: Cytiva Sweden AB

Inventor： Nils Stafstrom ,  Lars Olof Nils Rosengren ,  Kerstin Elisabet Erickson ,  Tomas Yngve Agren ,  Yngve L. Hareland ,  Tim Francois ,  Anita Jonsson ,  Jeanne Cheng ,  Anna Andersson

IPC: G01N30/44 ,  G01N30/32 ,  G01N30/46 ,  G01N30/60 ,  G01N30/86

CPC classification number: G01N30/44 ,  G01N30/32 ,  G01N30/46 ,  G01N30/6052 ,  G01N30/8696 ,  G01N2030/326

Abstract: Disclosed is a chromatography system (100) comprising: plural modules (1-25) including at least one pump and a column valve unit (8) connectable to plural chromatography columns; and a controller (600), the controller being operable to control the or each pump and the column valve to perform different chromatographic processes, including chromatography employing just one column, as well as chromatography employing just one column, as well as chromatography employing two or more columns by selective valve opening in said unit. The system includes a housing (110) into which the plural modules (1-25) are interchangeably mountable in apertures of one generally vertical face of housing, the modules are adapted for selective fluidic interconnection by tubing substantially at said one face such that in use the modules and tubing occupy a generally vertically extending volume to minimize the footprint of the system.

公开(公告)号：US11781659B2

公开(公告)日：2023-10-10

申请号：US16981114

申请日：2019-03-21

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer

IPC: F16K7/04 ,  F16K7/12 ,  F16K31/12 ,  F16K31/122 ,  F16K31/126

CPC classification number: F16K7/04 ,  F16K7/12 ,  F16K31/12 ,  F16K31/122 ,  F16K31/126

Abstract: A method for controlling at least one valve provided to a tube in a bioprocess flow system, said method comprising the steps of: —controlling the at least one valve to be in a first state, which is an open state when a flow through the tube should be allowed; —controlling the at least one valve to be in a second state during some parts of a process run in the system, said second state is a closed state were a first closing force is provided; and—controlling the at least one valve to be in a third state during some parts of a process run in the system, said third state is a closed state were a second closing force is provided which is a higher force than the first closing force.

公开(公告)号：US20230258616A1

公开(公告)日：2023-08-17

申请号：US18006769

申请日：2021-08-09

Applicant: CYTIVA SWEDEN AB

Inventor： Olle Bjernulf ,  Tomas Yngve Agren

IPC: G01N30/60 ,  G01N30/80

CPC classification number: G01N30/6004 ,  G01N30/80

Abstract: The present invention relates to a nozzle assembly 200 for a fraction collection unit 120 configured to collect one or more fluid samples, said nozzle assembly comprising a conduit adapter 210 configured to fluidly couple to a conduit, a nozzle body 220, wherein the nozzle body comprises at least a nozzle part 221 configured to release drops of the one or more collected fluid samples at a tip 223 of the nozzle part 221, and an interface part 222 configured to mechanically couple the assembly 200 to the fraction collection unit, wherein the assembly, when the conduit adapter 210 is attached to the nozzle body 220, forms a fluid channel from an inlet 219 of the conduit adapter 210 to the tip 223 of the nozzle part 221.

公开(公告)号：US11643627B2

公开(公告)日：2023-05-09

申请号：US16474626

申请日：2017-12-27

Applicant: CYTIVA SWEDEN AB

Inventor： Klaus Gebauer ,  Nagaraj Raghavendra Rao ,  Anindya Kanti De ,  Anindya Sengupta ,  Mats Olsson ,  Colin R. Tuohey ,  Jonathan A. Kenney ,  Richard Lee Damren ,  Ralph Stankowski ,  Nirmal Kumar Thanikachalam

IPC: C12M1/00 ,  C12M3/00

CPC classification number: C12M23/14 ,  C12M23/26 ,  C12M23/28 ,  C12M23/48

Abstract: A support housing for a flexible bioprocess bag, the housing comprising at least one side wall having a first segment and a second segment, the first segment movable in relation to the second segment between an open and a closed position, wherein at least a supporting part of the housing is translatable from an operating position to a bag loading position, wherein the supporting part comprises one or more retainers for holding the flexible bioprocess bag upon re-translation of the supporting part to the operating position and movement of the first segment to the closed position, and wherein the first segment comprises a first drive unit for connecting and driving a first mixing unit in the flexible bioprocess bag.

公开(公告)号：US11613726B2

公开(公告)日：2023-03-28

申请号：US15653501

申请日：2017-07-18

Applicant: Cytiva Sweden AB

Inventor： Andreas Andersson ,  Lars Johan Carlsson ,  Christian Elnegard ,  Henrik K. Eriksson ,  Thomas Falkman ,  Patric Fricking ,  Linnea Pauler ,  Claes Peterson

IPC: C12M1/00 ,  C12M3/06 ,  B01F31/23 ,  B01F35/513

Abstract: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).

公开(公告)号：US20230031710A1

公开(公告)日：2023-02-02

申请号：US17782591

申请日：2020-12-17

Applicant: CYTIVA SWEDEN AB

Inventor： Praveen Paul ,  Sahebagouda Alagur ,  Thomas Falkman ,  Prashanth Hosabettu Mohan

IPC: C12M1/00 ,  C12M1/34

Abstract: Systems (700) and methods (800) for method of continuous fluid flow in a bioreactor (700) is provided. The method (800) comprises providing (805) a bioreactor system (700) including a bioreactor volume (720), a filtration part (730), and a recirculation line (721) including a recirculation pump (722) is provided between the bioreactor volume (720) and the filtration part (730). The method (800) further comprises providing (810) a plurality of sensors (760) along the recirculation line (721) and monitoring the fluid flow parameters using the sensors (760). The method further comprises sending (820) a plurality of signals from the sensors (760) indicative of the fluid flow parameters to one or more controllers; and controlling (830) the fluid flow rate at the recirculation pump (722) by means of the or each controller.