摘要:
This invention provides compounds of the formula: wherein X is wherein R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring and all other variables are as defined herein, their use in pulmonary inflammation or bronchoconstriction therapy and compositions comprising and processes for preparing the same are provided.
摘要:
A composition for treating, controlling, reducing, ameliorating, or preventing allergy comprises a dissociated glucocorticoid receptor agonist (“DIGRA”), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof. The composition can comprise an anti-allergic medicament and/or an additional anti-inflammatory agent and can be formulated for topical application, injection, or implantation. The anti-allergic medicament can comprise an antihistamine, a mast-cell stabilizer, a leukotriene inhibitor, an immunomodulator, an anti-IgE agent, or a combination thereof.
摘要:
A sports system may include a base and a support structure that is sized and configured to support a goal, such as a netball goal or a basketball goal, at a height above a playing surface. The base may be constructed from plastic and may include a hollow interior portion that is sized and configured to receive ballast. The base may also include a protrusion that is sized and configured to abut a support surface and the protrusion may have an at least substantially solid construction. The sports system may further include a brace that may be connected to the support structure and the base. The brace may be disposed through an opening formed in the base and it may be connected to the base by a sleeve and a pin that is disposed within a receiving portion formed in the base.
摘要:
An improved system and method for controlling the temperature of fluids during a mixing procedure or a chemical, pharmaceutical, or biological process is disclosed. One embodiment of the system comprises: a first collapsible bag including a perimeter and a maximum dimension thereacross measured at full expansion of the first collapsible bag; a first interior surface portion; a second interior surface portion; one or more welds connecting the first and second interior surface portions of the first collapsible bag so as to form a channel between the first and second interior surface portions, an inlet connected to a first portion of the channel; an outlet connected to a second portion of the channel, the channel defining a bulk fluid flow pathway through the first collapsible bag from the inlet to the outlet; and a first temperature-controlling surface in contact with a first exterior surface portion of the first collapsible bag. A heat exchanger in fluid communication with another vessel that can hold or store the heated or cooled fluid is also disclosed.
摘要:
A system, method and computer program product for describing a process visually, converting the visual description to an intermediate format, and directing the process.
摘要:
A composition for treating, controlling, reducing, ameliorating, or alleviating infections and their inflammatory sequelae comprises a dissociated glucocorticoid receptor agonist (“DIGRA”) and an anti-infective agent, such as an antibacterial, antiviral, antifungal, antiprotozoal agent, or a combination thereof. The composition can be formulated for topical application, injection, or implantation.
摘要:
The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b): enantiomers, diastereomers, salts and solvates thereof wherein R1, R2, R3, R4, R5, and R7 are as defined herein. The invention further includes a method of CCR5-mediated disorders employing such compounds.
摘要翻译:本发明涉及式(1a)或(1b)的CCR5受体拮抗剂:其对映异构体,非对映异构体,盐和溶剂化物,其中R 1,R 2,R 2 R 3,R 4,R 5和R 7如本文所定义。 本发明还包括使用这种化合物的CCR5介导的病症的方法。
摘要:
Piperidine derivatives of the following formulae I and II: and their pharmaceutically acceptable salts, which are functional antagonists of the CC chemokine receptor CCR1 and are thus useful as anti-inflammatory agents, a pharmaceutical compositions containing said piperidine derivatives or their pharmaceutically acceptable salts, and methods of their use.
摘要:
The present invention relates to compounds which are CCR-5 receptor antagonists of the general formula I: wherein R1, R2, R3, R4, Ra, Rb, Rc, Rd, X, m and n are as defined herein. The invention further comprises pharmaeceutical compositions comprising such compounds, as well as the use of such compounds to treat CCR-5 mediated disorders.