公开(公告)号：US09220433B2

公开(公告)日：2015-12-29

申请号：US13174742

申请日：2011-06-30

Applicant: Tom Allen Ditter ,  Diana Gallardo ,  Shahram Moaddeb ,  Michael Olen Zirkle

Inventor： Tom Allen Ditter ,  Diana Gallardo ,  Shahram Moaddeb ,  Michael Olen Zirkle

IPC: A61B18/14 ,  A61B5/042 ,  A61B5/00 ,  A61B5/053 ,  A61B17/00 ,  A61B18/00 ,  A61B5/06 ,  A61B19/00

CPC classification number: A61B18/1492 ,  A61B5/0422 ,  A61B5/0538 ,  A61B5/062 ,  A61B5/6857 ,  A61B2017/00867 ,  A61B2018/00029 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/00375 ,  A61B2018/00577 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/1407 ,  A61B2018/1432 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61B2034/2051 ,  A61B2034/2063 ,  A61B2090/065 ,  A61B2217/007

Abstract: A catheter includes an elongated body, a distal assembly with a shape-memory member defining a generally circular form, and a control handle adapted to actuate a deflection puller wire for deflecting a portion of the elongated body, and a contraction wire for contracting the generally circular form. The generally circular form which carries at least one ring electrode has an off-edge configuration relative to the elongated body such that a longitudinal axis of the elongated body does not intersect the circumference of the circular form and the generally circular form spirals about the longitudinal axis of the elongated body. Moreover, the circular form can have an on-axis configuration such that the longitudinal axis of the elongated body is axially aligned with a central longitudinal axis of the circular form, or an off-axis configuration such that these axes are axially offset from each other. In a more detailed embodiment, the catheter has a distal assembly with a helical form or a crescent form carrying a plurality of irrigated ablation ring electrodes and a plurality of smaller ring electrodes adapted for impedance recording or PV potential recording. A support member with shape memory extends through the distal assembly to provide the helical or crescent form. The support member has a varying stiffness along its length, for example, a decreasing stiffness toward a distal end of the support member. The support member can also be hollow so that it can receive a mandrel whose stiffness is greater than that of the support member.

Abstract translation: 导管包括细长体，具有限定大致圆形形状的形状记忆构件的远端组件和适于致动用于偏转细长体的一部分的偏转牵引线的控制手柄，以及用于收缩一般的收缩线 圆形 承载至少一个环形电极的大致圆形形状具有相对于细长主体的非边缘构造，使得细长主体的纵向轴线不与圆形的圆周相交，并且大致圆形的形状围绕纵向轴线螺旋 的细长的身体。 此外，圆形形状可以具有轴上构造，使得细长体的纵向轴线与圆形的中心纵向轴线轴向对齐，或者离轴构造使得这些轴线彼此轴向偏移 。 在更详细的实施例中，导管具有远端组件，其具有螺旋形式或月牙形，其携带多个灌溉消融环电极和适于阻抗记录或PV电位记录的多个较小环形电极。 具有形状记忆的支撑构件延伸穿过远端组件以提供螺旋形或新月形。 支撑构件沿其长度具有变化的刚度，例如朝向支撑构件的远端的刚度的降低。 支撑构件也可以是中空的，使得其可以容纳其刚度大于支撑构件的刚度的心轴。

公开(公告)号：US08608735B2

公开(公告)日：2013-12-17

申请号：US12649417

申请日：2009-12-30

Applicant: Assaf Govari ,  Shahram Moaddeb ,  Michael Olen Zirkle ,  Christopher Beeckler ,  Philippa Hill ,  Andres Claudio Altmann

Inventor： Assaf Govari ,  Shahram Moaddeb ,  Michael Olen Zirkle ,  Christopher Beeckler ,  Philippa Hill ,  Andres Claudio Altmann

IPC: A61B18/18

CPC classification number: A61B18/1492 ,  A61B5/06 ,  A61B2017/00867 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00375 ,  A61B2018/00577 ,  A61B2018/1407 ,  A61B2018/1467 ,  A61B2034/2051 ,  A61B2218/002 ,  A61N1/056 ,  C08L2201/12

Abstract: A medical device includes an insertion shaft, having a longitudinal axis and having a distal end adapted for insertion into a body of a patient. A resilient end section is fixed to the distal end of the insertion shaft and is formed so as to define, when unconstrained, an arc oriented obliquely relative to the axis and having a center of curvature on the axis. One or more electrodes are disposed at respective locations along the end section.

Abstract translation: 医疗装置包括插入轴，其具有纵向轴线并且具有适于插入患者体内的远端。 弹性端部固定到插入轴的远端，并且形成为当不受约束时限定相对于轴线倾斜定向并且在轴线上具有曲率中心的电弧。 一个或多个电极设置在沿着端部的相应位置处。

公开(公告)号：US20110237861A1

公开(公告)日：2011-09-29

申请号：US13158117

申请日：2011-06-10

Applicant: Scott Pool ,  Blair Walker ,  Jay R. McCoy ,  Peter P. Tran ,  Richard L. Quick ,  Shahram Moaddeb ,  Arvin Chang

Inventor： Scott Pool ,  Blair Walker ,  Jay R. McCoy ,  Peter P. Tran ,  Richard L. Quick ,  Shahram Moaddeb ,  Arvin Chang

IPC: A61N2/12 ,  A61F2/02

CPC classification number: A61F5/0053 ,  A61F5/003 ,  A61F5/0059 ,  A61F5/0066 ,  A61F2005/002

Abstract: A system includes an adjustable implant configured for implantation internally within a subject, the adjustable implant comprising a first permanent magnet configured for rotation about a first axis, the first permanent magnet operatively coupled to a drive transmission configured to alter a dimension of the adjustable implant. The system further includes an external adjustment device configured for placement on or adjacent to the skin of the subject, the external adjustment device comprising a second permanent magnet configured for rotation about a second axis and a third permanent magnet configured for rotation about a third axis different from the second axis; and wherein cooperative rotation of the second permanent magnet about the second axis and rotation of the third permanent magnet about the third axis result in rotation of the first permanent magnet about the first axis.

Abstract translation: 系统包括被配置用于在对象内部进行植入的可调节植入物，所述可调节植入物包括被配置为围绕第一轴线旋转的第一永久磁体，所述第一永久磁体可操作地耦合到构造成改变所述可调节植入物的尺寸的驱动变速器。 该系统还包括外部调节装置，其被配置用于放置在与受试者皮肤相邻或相邻的外部，所述外部调节装置包括构造成围绕第二轴线旋转的第二永磁体和被配置为围绕第三轴线旋转的第三永磁体 从第二轴; 并且其中所述第二永磁体围绕所述第二轴线的协同旋转和所述第三永磁体围绕所述第三轴线的旋转导致所述第一永磁体围绕所述第一轴线的旋转。

公开(公告)号：US07877142B2

公开(公告)日：2011-01-25

申请号：US11773311

申请日：2007-07-03

Applicant: Shahram Moaddeb ,  Samuel M. Shaolian ,  Emanuel Shaoulian

Inventor： Shahram Moaddeb ,  Samuel M. Shaolian ,  Emanuel Shaoulian

IPC: A61N1/362

CPC classification number: A61N1/3627

Abstract: Systems, methods and devices are provided for improving the hemodynamic efficiency of a patient's heart by implanting one or more reinforcement elements on or with the heart and providing electrical stimulation to the heart. The reinforcement elements may include magnetic and/or shape memory material and are configured to reshape the heart so as to boost the heart's mechanical energy during a response to the electrical stimulation. In some embodiments, at least one reinforcement element includes an electrode configured to sense electrocardiogram signals within the heart. An electrical stimulation device such as an implantable or external pacemaker/defibrillator may be configured to control delivery of electrical pulses to the heart based on the sensed electrocardiogram signals. In addition, or in other embodiments, at least one reinforcement element includes an electrode configured to deliver the electrical pulses to the heart.

Abstract translation: 提供了系统，方法和装置，用于通过在心脏上或与心脏一起植入一个或多个增强元件并向心脏提供电刺激来改善患者心脏的血液动力学效率。 加强元件可以包括磁性和/或形状的记忆材料，并且被配置成重塑心脏，以便在对电刺激的响应期间增强心脏的机械能。 在一些实施例中，至少一个加强元件包括被配置为感测心脏内的心电图信号的电极。 诸如植入式或外部起搏器/除颤器之类的电刺激装置可以被配置成基于感测到的心电图信号来控制向心脏的电脉冲的传递。 另外或在其它实施例中，至少一个加强元件包括被配置为将电脉冲传送到心脏的电极。

公开(公告)号：US07713298B2

公开(公告)日：2010-05-11

申请号：US11124364

申请日：2005-05-06

Applicant: Emanuel Shaoulian ,  Shahram Moaddeb ,  Sanuel M. Shaolian

Inventor： Emanuel Shaoulian ,  Shahram Moaddeb ,  Sanuel M. Shaolian

IPC: A61F2/24

CPC classification number: A61F2/2448 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a shape memory material that is responsive to changes in temperature and/or exposure to a magnetic field. A material having enhanced absorption characteristics with regard to a desired heating energy may be used in order to facilitate heating and adjustment of the support device.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，装置包括响应温度变化和/或暴露于磁场的形状记忆材料。 可以使用具有关于期望的加热能量的增强的吸收特性的材料，以便于支撑装置的加热和调节。

公开(公告)号：US20080293995A1

公开(公告)日：2008-11-27

申请号：US12177052

申请日：2008-07-21

Applicant: Shahram Moaddeb ,  Samuel M. Shaolian ,  Emanuel Shaoulian ,  Richard Rhee ,  Steven C. Anderson

Inventor： Shahram Moaddeb ,  Samuel M. Shaolian ,  Emanuel Shaoulian ,  Richard Rhee ,  Steven C. Anderson

IPC: A61N2/10

CPC classification number: A61F2/2481 ,  A61B17/3468 ,  A61B2017/00876 ,  A61F2/2478 ,  A61F2/2487 ,  A61F2002/249 ,  A61F2210/009 ,  A61N2/00

Abstract: Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse.

Abstract translation: 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用磁力重塑心脏解剖结构治疗的心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 使用一个或多个植入心脏组织内或附着在心脏外表面和/或内部的磁性元件施加磁力。 磁力的各种电荷相互作用，使相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位通过磁性元件的力量随着时间的推移而保持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

公开(公告)号：US20080200981A1

公开(公告)日：2008-08-21

申请号：US12049240

申请日：2008-03-14

Applicant: Emanuel Shaoulian ,  Samuel M. Shaolian ,  Shahram Moaddeb

Inventor： Emanuel Shaoulian ,  Samuel M. Shaolian ,  Shahram Moaddeb

IPC: A61F2/24

CPC classification number: A61F2/2448 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a tubular member configured to be attached to or near a cardiac valve annulus. The tubular member includes a receptacle end and an insert end configured to couple with the receptacle end of the tubular member such that the tubular member substantially forms a shape of a ring. The insert end is configured to move with respect to the receptacle end to change a circumference of the ring.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，这些装置包括构造成附接到心脏瓣膜环上或附近的管状构件。 管状构件包括容置端和插入端，所述插入端构造成与管状构件的容置端相连，使得管状构件基本上形成环的形状。 插入端构造成相对于插座端移动以改变环的圆周。

公开(公告)号：US07402134B2

公开(公告)日：2008-07-22

申请号：US11142127

申请日：2005-05-31

Applicant: Shahram Moaddeb ,  Samuel M. Shaolian ,  Emanuel Shaoulian ,  Richard Rhee ,  Steven C. Anderson

Inventor： Shahram Moaddeb ,  Samuel M. Shaolian ,  Emanuel Shaoulian ,  Richard Rhee ,  Steven C. Anderson

IPC: A61F2/00

CPC classification number: A61F2/2481 ,  A61B17/3468 ,  A61B2017/00876 ,  A61F2/2478 ,  A61F2/2487 ,  A61F2002/249 ,  A61F2210/009 ,  A61N2/00

Abstract: Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Heart dilation treated by reshaping the heart anatomy with the use of magnetic forces. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The magnetic forces are applied with the use of one or more magnetic elements which are implanted within the heart tissue or attached externally and/or internally to a surface of the heart. The various charges of the magnetic forces interact causing the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the force of the magnetic elements, allowing the damaging effects of heart dilation to slow in progression or reverse.

Abstract translation: 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用磁力重塑心脏解剖结构治疗的心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 使用一个或多个植入心脏组织内或附着在心脏外表面和/或内部的磁性元件施加磁力。 磁力的各种电荷相互作用，使相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位通过磁性元件的力量随着时间的推移而保持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

公开(公告)号：US20080172072A1

公开(公告)日：2008-07-17

申请号：US11888537

申请日：2007-07-31

Applicant: Scott Pool ,  Jay R. McCoy ,  Richard L. Quick ,  Blair Walker ,  Shahram Moaddeb ,  Arvin Chang

Inventor： Scott Pool ,  Jay R. McCoy ,  Richard L. Quick ,  Blair Walker ,  Shahram Moaddeb ,  Arvin Chang

IPC: A61B17/08

CPC classification number: A61B17/1355 ,  A61B5/0084 ,  A61B5/03 ,  A61B5/05 ,  A61B5/14539 ,  A61B5/411 ,  A61B2017/00057 ,  A61B2017/00084 ,  A61B2090/063 ,  A61B2562/0238 ,  A61F5/0003 ,  A61F5/0053

Abstract: Apparatus and methods of monitoring gastric restriction devices are described. Internally mounted sensors detect at least one of a quantity of a test substance, a flow through the stomal opening produced by a restriction device, slippage of the device, and erosion of the gastric wall. In some embodiments flow versus no flow can be determined, or a flow rate can be calculated. Monitoring of internally mounted sensors permits optimization of the performance of a gastric restriction device, using noninvasive techniques.

Abstract translation: 描述了监测胃限制装置的装置和方法。 内部安装的传感器检测一定量的测试物质，通过限制装置产生的造口开口的流动，装置的滑动和胃壁的侵蚀中的至少一种。 在一些实施例中，可以确定流量与无流量，或者可以计算流量。 监测内部安装的传感器允许使用无创技术优化胃限制装置的性能。

公开(公告)号：US07357815B2

公开(公告)日：2008-04-15

申请号：US11123874

申请日：2005-05-06

Applicant: Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel M. Shaolian

Inventor： Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel M. Shaolian

IPC: A61F2/06

CPC classification number: A61F2/2451 ,  A61F2250/0001 ,  A61F2250/0039

Abstract: Tissue shaping methods and devices are provided. The devices can be adjusted within the body of a patient in a less invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. In one example, the device is positioned within the coronary sinus of the patient so as to effect changes in at least one dimension of the mitral valve annulus. The device may also advantageously include a shape memory material that is responsive to changes in temperature and/or exposure to a magnetic field. In one example, the shape memory material is responsive to energy, such as electromagnetic or acoustic energy, applied from an energy source located outside the coronary sinus. A material having enhanced absorption characteristics with respect to the desired heating energy may also be used to facilitate heating and adjustment of the tissue shaping device.

Abstract translation: 提供组织成形方法和装置。 这些装置可以以较少侵入性或非侵入性方式在患者身体内进行调节，例如通过经皮或外部给患者身体施加能量。 在一个示例中，装置定位在患者的冠状窦内，以便实现二尖瓣环的至少一个维度的变化。 该装置还可以有利地包括响应温度变化和/或暴露于磁场的形状记忆材料。 在一个示例中，形状记忆材料响应于从位于冠状窦外侧的能量源施加的能量，例如电磁或声能。 相对于期望的加热能量具有增强的吸收特性的材料也可用于促进组织整形装置的加热和调节。