公开(公告)号：US09968550B2

公开(公告)日：2018-05-15

申请号：US15262344

申请日：2016-09-12

Applicant: Wake Forest University Health Sciences

Inventor： Benjamin S. Harrison ,  Steve J. Hodges

IPC: A61K9/00 ,  A61K31/17 ,  A61K9/14 ,  A61K47/02 ,  A61K47/12 ,  A61K47/44 ,  A61K9/06 ,  A61K47/14 ,  A61K47/10 ,  A61K45/06 ,  A61K31/327 ,  A61M5/178 ,  A61J1/05

CPC classification number: A61K9/0014 ,  A61J1/05 ,  A61K9/06 ,  A61K9/14 ,  A61K31/17 ,  A61K31/327 ,  A61K45/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/44 ,  A61M5/178 ,  A61K2300/00

Abstract: A topical wound treatment composition comprises a hydrogen peroxide generator; alkaline powder; not more than 5 percent by weight of water; additional topical active agent if desired, and emollient (preferably hygroscopic emollient) to balance. When topically applied to a wound and water from the surrounding environment diffuses into the composition, the hydrogen peroxide generator and/or the alkaline compound diffuse into one another, causing a chemical reaction that generates treatment-effective amounts of oxygen to occur. The oxygen can then diffuse out of the composition and aid in wound treatment or healing.

公开(公告)号：US09962160B2

公开(公告)日：2018-05-08

申请号：US15162986

申请日：2016-05-24

Applicant: Wake Forest University Health Sciences

Inventor： John K. Petty ,  Lucas P. Neff

IPC: A61B17/072 ,  A61B17/068 ,  A61B17/00 ,  A61F5/00 ,  A61B17/32 ,  A61B90/00

CPC classification number: A61B17/072 ,  A61B17/00234 ,  A61B17/068 ,  A61B17/07207 ,  A61B2017/00818 ,  A61B2017/00827 ,  A61B2017/07214 ,  A61B2017/07228 ,  A61B2017/07271 ,  A61B2017/07285 ,  A61B2017/320052 ,  A61B2090/061 ,  A61F5/0086

Abstract: Surgical staplers include: (a) a stapler head having opposed first and second elongate jaws with opposing proximal and distal end portions; (b) a staple cartridge held in at least one of the first and second jaws, the stapler cartridge configured to concurrently deliver a plurality of parallel rows of staples; and (c) a tissue protection segment held in a proximal portion of at least one of the first and second jaws. The jaws are configured to close against target tissue and, at stapler firing, staples are delivered to a subset of tissue held inside the jaws so that tissue held by the tissue protection segment adjacent the proximal end portion of the stapler is not stapled.

公开(公告)号：US20180105880A1

公开(公告)日：2018-04-19

申请号：US15822994

申请日：2017-11-27

Applicant: Beth Israel Deaconess Medical Center, Inc. ,  Wake Forest University Health Sciences

Inventor： Giulio Genovese ,  David J. Friedman ,  Martin R. Pollak ,  Barry I. Freedman

IPC: C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

Abstract: Methods are disclosed herein for detecting a genetic predisposition to focal segmental glomerulosclerosis (FSGS) or hypertensive end-stage kidney disease (ESKD) or both in a human subject. The methods include detecting the presence of at least one single nucleotide polymorphism (SNP) in an APOL1 gene, such as the C-terminal exon of an APOL1 gene. In a further embodiment, methods are disclosed for detecting resistance of a subject to a disease associated with Trypanosoma infection. The methods include detecting the presence of at least one single nucleotide polymorphism (SNP) in an APOL1 gene, such as the C-terminal exon of an APOL1 gene. Also disclosed are methods for treating a subject infected with T. brucei (such as T. brucei brucei, T. b. rhodesiense, or T. b. gambiense). The methods include administering a therapeutically effective amount of an APOL1 protein including a S342G substitution, an I384M substitution, and/or a deletion of N388 and Y389 to the subject.

公开(公告)号：US09895426B2

公开(公告)日：2018-02-20

申请号：US15384976

申请日：2016-12-20

Applicant: Wake Forest University Health Sciences ,  Genethon ,  Children's Medical Center Corporation

Inventor： Martin K. Childers ,  Alan H. Beggs ,  Ana Maria Buj Bello

IPC: A61K48/00 ,  A61K38/46 ,  C12N7/00 ,  C07H21/00 ,  C07H21/04 ,  C12N15/00 ,  C12N15/85 ,  C12P21/06

CPC classification number: A61K38/465 ,  A61K48/005 ,  A61K48/0058 ,  C12N7/00 ,  C12N9/16 ,  C12N2750/14143 ,  C12Y301/03 ,  C12Y301/03064

Abstract: The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces the increased expression of myotubularin in the muscle of a subject. The invention provides sustained regional and global increases in muscle function.

公开(公告)号：US09879278B2

公开(公告)日：2018-01-30

申请号：US14382816

申请日：2013-02-27

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Baisong Lu ,  Qingguo Zhao ,  James Yoo ,  Anthony Atala

IPC: C12N15/85

CPC classification number: C12N15/85 ,  C12N2800/40 ,  C12N2840/007

Abstract: The invention includes compositions and methods for the selective expression of a target gene in a subset of cells. In certain embodiments, the present invention includes a construct comprising a first nucleic acid sequence comprising an episomal maintenance element and a second nucleic acid sequence comprising a target gene wherein the expression of the episomal maintenance element is regulated by a constitutive promoter and the expression of the target gene is regulated by a non-constitutive promoter. The construct is able to maintain episomal state, no matter whether the target gene is expressed in the cell.

公开(公告)号：US09868788B2

公开(公告)日：2018-01-16

申请号：US14776356

申请日：2014-03-14

Applicant: Wake Forest University Health Sciences

Inventor： Waldemar Debinski ,  Denise Mazess Herpai

IPC: C07K16/28 ,  A61K47/48 ,  A61K49/00 ,  C12N9/00 ,  A61K39/395

CPC classification number: C07K16/2866 ,  A61K39/3955 ,  A61K47/6813 ,  A61K47/6829 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6911 ,  A61K49/0004 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C12N9/93 ,  C12Y603/01004

Abstract: Provided herein is an antibody (e.g., an isolated antibody) that specifically binds an epitope (e.g., linear epitope) within amino acids spanning the extracellular portion of human IL-13RA2. In some embodiments, the amino acids spanning the extracellular portion of human IL-13RA2 have at least 90% identity with the corresponding canine sequence of IL-13RA2. In some embodiments, the antibody specifically binds both human and canine IL-13RA2. In some embodiments, the antibody is a monoclonal antibody. In some embodiments, the antibody is a recombinant antibody. In some embodiments, the antibody is humanized. In some embodiments, the antibody is the monoclonal antibody produced by hybridoma 1E10B9 or a recombinant form thereof.

公开(公告)号：US20180002275A1

公开(公告)日：2018-01-04

申请号：US15545818

申请日：2016-01-25

Applicant: Wake Forest University Health Sciences ,  UAB Research Foundation

Inventor： W. Todd Lowther ,  Ross P. Holmes ,  Daniel Yohannes

IPC: C07C229/48 ,  C07D307/68 ,  C07D307/24 ,  C07C62/24 ,  C07C62/02 ,  C07C59/11 ,  C07D333/38 ,  C07D233/90 ,  C07C2601/08

CPC classification number: C07C229/48 ,  C07C59/11 ,  C07C62/02 ,  C07C62/24 ,  C07C2601/08 ,  C07D233/90 ,  C07D307/24 ,  C07D307/68 ,  C07D333/38

Abstract: Provided herein are compounds of Formula (I), Formula (II), and Formula (III), and compositions comprising the same, as well as methods of use thereof for controlling or inhibiting the formation of calcium oxalate kidney stones, inhibiting the production of glyoxylate and/or oxalate, and/or inhibiting hydroxyproline dehydrogenase (HYPDH).

公开(公告)号：US20170368242A1

公开(公告)日：2017-12-28

申请号：US15700667

申请日：2017-09-11

Applicant: Wake Forest University Health Sciences

Inventor： Louis C. Argenta ,  David L. Carroll ,  Nicole H. Levi ,  Jie Liu ,  Michael J. Morykwas ,  Stephen Tatter ,  William D. Wagner

IPC: A61M1/00 ,  A61F13/00

CPC classification number: A61M1/0088 ,  A61F13/00021 ,  A61M1/0023 ,  A61M2210/1003

Abstract: The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.

公开(公告)号：US09801723B2

公开(公告)日：2017-10-31

申请号：US15164192

申请日：2016-05-25

Applicant: Wake Forest University Health Sciences

Inventor： Ryan P. Terlecki

IPC: A61F2/26 ,  B29C45/00 ,  B29K83/00 ,  B29L31/00

CPC classification number: A61F2/26 ,  A61F2230/0065 ,  A61F2240/001 ,  A61F2240/004 ,  B29C45/00 ,  B29C2045/0093 ,  B29K2083/00 ,  B29L2031/7532 ,  Y10T29/49826

Abstract: Rear tip extenders having a tether attached to a collar for penile implants that can be mounted onto a respective cylinder forward of a fluid line (that communicates with a scrotal pump) to prevent full separation or detachment from the cylinder during a revision procedure can be fabricated by molding. The fabrication methods include: providing a mold with a mold cavity configured to define three attached members of defined shapes, including a rear tip extender, a collar and a tether attaching the rear tip extender and collar; and flowably introducing moldable material into the mold cavity to form the collar, rear tip extender and attached tether as a molded assembly.

公开(公告)号：US09737455B2

公开(公告)日：2017-08-22

申请号：US14082951

申请日：2013-11-18

Applicant: Wake Forest University Health Sciences

Inventor： Louis C Argenta ,  Michael J Morykwas ,  Lawrence X Webb

IPC: A61M35/00 ,  A61M1/00 ,  A61H7/00 ,  A61F13/00 ,  A61F13/02 ,  A61B5/00 ,  A61L15/16 ,  A61K9/70

CPC classification number: A61H7/001 ,  A61M1/0037 ,  A61M1/0088

Abstract: A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.