公开(公告)号：US20110147408A1

公开(公告)日：2011-06-23

申请号：US12991354

申请日：2009-05-01

Applicant: Akihisa Nakajima ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Youichi Aoki

Inventor： Akihisa Nakajima ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Youichi Aoki

IPC: B67D99/00

CPC classification number: B01L3/502715 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0487 ,  B01L2400/049 ,  B01L2400/086 ,  Y10T436/11

Abstract: Provided is a microchip which is capable of determining the quantity of the liquid in the chip and dividing the liquid, and has a relatively simple flow passage structure. In the microchip liquid supply system, a portion of the liquid in an upstream passage among the liquid injected into a first flow passage is supplied from a liquid discharge passage by operating a suction pump connected to a liquid supply passage in such a state that an air vent hole is closed. Thereafter, the suction pump is operated with the air vent hole closed, whereby a portion of the liquid in a quantity determination passage among the liquid injected into the first flow passage is supplied from a liquid supply passage.

Abstract translation: 提供一种微芯片，其能够确定芯片中的液体的量并分离液体，并且具有相对简单的流动通道结构。 在微芯片液体供给系统中，在喷射到第一流路内的液体中的上游流路中的液体的一部分通过在与液体供给通路连接的吸引泵的情况下从液体排出通路供给， 通风孔关闭。 此后，在排气孔关闭的状态下操作抽吸泵，从液体供给通道供给在第一流路中注入的液体中的一定量通道中的一部分液体。

公开(公告)号：US07909063B2

公开(公告)日：2011-03-22

申请号：US11938464

申请日：2007-11-12

Applicant: Yasuhiro Sando ,  Akihisa Nakajima ,  Kusunoki Higashino ,  Youichi Aoki

Inventor： Yasuhiro Sando ,  Akihisa Nakajima ,  Kusunoki Higashino ,  Youichi Aoki

IPC: F15C1/04

CPC classification number: G01N35/1016 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2400/0439 ,  B01L2400/0487 ,  B01L2400/082 ,  G01F1/7086 ,  G01N11/04 ,  G01N2011/0013 ,  G01N2035/1034 ,  Y10T137/2196 ,  Y10T137/6416

Abstract: There is described a microchip inspection system, which makes it possible not only to correct the influence of the viscosity change of the liquid, but also to accurately conduct the liquid conveyance controlling operation. The microchip inspection system includes: a micro pump to inject a driving liquid from a liquid flow path into a microchip; a liquid temperature adjusting section to adjust a liquid temperature of the driving liquid; a driving liquid detecting section to detect presence or absence of the driving liquid at two predetermined positions located in the liquid flow path, so as to output detection signals; a fluid velocity calculating section to calculate a fluid velocity based on the detection signals outputted by the driving liquid detecting section; and a liquid temperature controlling section to control the liquid temperature adjusting section, based on the fluid velocity calculated by the fluid velocity calculating section.

Abstract translation: 描述了一种微芯片检查系统，其不仅可以校正液体的粘度变化的影响，而且可以精确地进行液体输送控制操作。 微芯片检查系统包括：将来自液体流路的驱动液体注入微芯片的微型泵; 液体温度调节部分，用于调节驱动液体的液体温度; 驱动液体检测部分，用于检测位于所述液体流路中的两个预定位置处的驱动液体的存在或不存在，以便输出检测信号; 流体速度计算部，其基于由所述驱动液体检测部输出的检测信号来计算流体速度; 以及液体温度控制部，其基于由流体速度计算部计算出的流体速度来控制液体温度调节部。

公开(公告)号：US07820109B2

公开(公告)日：2010-10-26

申请号：US11404931

申请日：2006-04-14

Applicant: Akihisa Nakajima ,  Kusunoki Higashino ,  Yasuhiro Sando

Inventor： Akihisa Nakajima ,  Kusunoki Higashino ,  Yasuhiro Sando

IPC: B01L3/02

CPC classification number: B01L3/50273 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2400/0487 ,  B01L2400/0688

Abstract: A testing chip that analyzes a specimen includes: a reagent storage section; a mixing and reaction flow channel to perform a series of operations to mix a specimen and aqueous reagent, make the specimen and reagent react with each other, and detect the reaction; and a liquid feed control section provided between an outlet flow channel of the reagent storage section and the inlet of the mixing and reaction flow channel. Herein, aqueous reagent, lipophilic liquid, and aqueous liquid having greater surface tension than that of the aqueous reagent are disposed in the reagent storage section in this order toward the outlet flow channel, the aqueous liquid being stored in contact with the liquid feed control section; and aqueous liquid passes the micro flow path of the liquid feed control section by applying a liquid feed pressure higher than or equal to a predetermined pressure to the reagent storage section.

Abstract translation: 分析标本的测试芯片包括：试剂储存部分; 混合反应流道，进行一系列操作，将样品和含水试剂混合，使试样和试剂相互反应，检测反应; 以及设置在试剂储存部的出口流路和混合反应流路的入口之间的液体供给控制部。 这里，具有比水性试剂更大的表面张力的水性试剂，亲油性液体和水性液体以这种顺序设置在试剂储存部分中，使其与出液流路保持接触， ; 并且水性液体通过将高于或等于预定压力的液体进料压力施加到试剂储存部分而通过液体供给控制部分的微流动路径。

公开(公告)号：US20100101660A1

公开(公告)日：2010-04-29

申请号：US12528750

申请日：2008-02-21

Applicant: Ken Kitamura ,  Toshihito Kido ,  Shinji Harada ,  Kenichi Miyata ,  Yasuhiro Sando

Inventor： Ken Kitamura ,  Toshihito Kido ,  Shinji Harada ,  Kenichi Miyata ,  Yasuhiro Sando

IPC: G05D11/00 ,  F16K31/64 ,  G01N35/08

CPC classification number: F16K99/0001 ,  F16K99/0017 ,  F16K99/0023 ,  F16K99/0032 ,  F16K99/0036 ,  F16K99/0038 ,  F16K99/0061 ,  F16K2099/0086 ,  Y10T137/218 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/2559

Abstract: A channel switching system includes two microvalves i.e. a first valve (stopper valve) and a second valve (water retaining valve). The first valve is openable and closable, and the second valve is operable to block fluid flow by a surface tension force. Changing the first valve from an open state to a close state enables to switch the system from a condition that the fluid flows through the channel where the first valve is mounted by blocking the flow at the second valve by the surface tension force to a condition that the fluid flows through the channel where the second valve is mounted by releasing the system from the condition that the flow is blocked at the second valve by the surface tension force.

Abstract translation: 通道切换系统包括两个微型阀，即第一阀（止动阀）和第二阀（保水阀）。 第一阀是可开启和关闭的，并且第二阀可操作以通过表面张力阻止流体流动。 将第一阀从打开状态改变到关闭状态使得能够通过将表面张力阻挡第二阀处的流动而使系统从流体流过安装有第一阀的通道的状态切换到以下条件： 通过从第二阀的流动被表面张力阻止的状态释放系统，流体流过安装有第二阀的通道。

公开(公告)号：US07482585B2

公开(公告)日：2009-01-27

申请号：US11434253

申请日：2006-05-16

Applicant: Yasuhiro Sando ,  Akihisa Nakajima ,  Kusunoki Higashino

Inventor： Yasuhiro Sando ,  Akihisa Nakajima ,  Kusunoki Higashino

IPC: F15C1/06 ,  B01D27/26

CPC classification number: B01L3/565 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0439 ,  G01N2035/00158 ,  Y10T137/87877

Abstract: A testing chip includes (1) a first chip having a micro flow path that stores reagent; upstream-side opening provided on upstream-side of the micro flow path; downstream-side opening provided on downstream-side of the micro flow path; and one or more sealing members in a small thickness stuck to at least one surface of the first chip to seal the upstream-side opening and the downstream-side opening until the testing chip is used and (2) a second chip having a micro flow path for mixing and reaction between reagent and a specimen and detecting the reaction; and an opening provided on upstream-side of the micro flow path, wherein, when the testing chip is used, the first and second chips are superimposed on each other so that the downstream-side opening of the first chip and the opening of the second chip are positioned on each other.

Abstract translation: 测试芯片包括（1）具有存储试剂的微流路的第一芯片; 设置在微流路的上游侧的上游侧开口; 设置在微流路的下游侧的下游侧开口; 并且将一个或多个小密封件粘贴到第一芯片的至少一个表面上以密封上游侧开口和下游侧开口，直到使用测试芯片，以及（2）具有微流量的第二芯片 试剂和样品之间进行混合和反应的途径，检测反应; 以及设置在微流路的上游侧的开口，其中，当使用测试芯片时，第一和第二芯片彼此重叠，使得第一芯片的下游侧开口和第二芯片的打开 芯片彼此定位。

公开(公告)号：US20080112851A1

公开(公告)日：2008-05-15

申请号：US11936148

申请日：2007-11-07

Applicant: Kusunoki Higashino ,  Akihisa Nakajima ,  Yasuhiro Sando ,  Youichi Aoki

Inventor： Kusunoki Higashino ,  Akihisa Nakajima ,  Yasuhiro Sando ,  Youichi Aoki

IPC: B01J19/00

CPC classification number: F16K99/0017 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/146 ,  B01L2300/1822 ,  B01L2400/0439 ,  B01L2400/0487 ,  B01L2400/0688 ,  F16K99/0001 ,  F16K99/0057 ,  F16K2099/0074 ,  F16K2099/0084

Abstract: There is described a micro total analysis chip, which makes it possible not only to stabilize the liquid transportation amount and the liquid conveying velocity of the sample liquid, but also to improve the accuracy of analysis. The chip includes: a first connecting section to connect with a first liquid conveying device; a sample liquid injecting section coupled to a downstream side of the first connecting section; a first sample liquid conveying path coupled to a downstream side of the sample injecting section; a second connecting section to connect with a second liquid conveying device; a sample liquid reservoir coupled to the second connecting section and a downstream side of the first sample liquid conveying path, to accommodate the sample liquid; and a second sample liquid conveying path coupled to a downstream side of the sample liquid reservoir, so that the sample liquid is conveyed downstream.

Abstract translation: 描述了一种微型总分析芯片，其不仅可以稳定液体输送量和液体输送速度，而且可以提高分析的准确性。 该芯片包括：与第一液体输送装置连接的第一连接部分; 连接到所述第一连接部的下游侧的样品液体注入部; 第一样品液体输送路径，其耦合到所述样品注入部分的下游侧; 与第二液体输送装置连接的第二连接部分; 连接到第二连接部分和第一样品液体输送路径的下游侧的样品液体储存器，以容纳样品液体; 以及第二样品液体输送路径，其耦合到样品储液器的下游侧，使得样品液体向下游传送。

公开(公告)号：US20080112850A1

公开(公告)日：2008-05-15

申请号：US11936143

申请日：2007-11-07

Applicant: Kusunoki Higashino ,  Akihisa Nakajima ,  Yasuhiro Sando ,  Youichi Aoki

Inventor： Kusunoki Higashino ,  Akihisa Nakajima ,  Yasuhiro Sando ,  Youichi Aoki

IPC: B01J19/00

CPC classification number: B01L3/502746 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0439 ,  B01L2400/0487 ,  B01L2400/086 ,  B01L2400/088

Abstract: A micro total analysis chip including: a main flow path for feeding a liquid; and a divided flow path branched into a plurality of divided paths for dividing and feeding the liquid fed from the main flow path at a predetermined division ratio, wherein a ratio of flow path resistance between each of the divided paths is approximately equal to a reciprocal of the predetermined ratio with which the liquid is divided and fed to the each of the divided paths.

Abstract translation: 一种微型总分析芯片，包括：用于供给液体的主流路; 以及分支流路，其分支成多个分割路径，用于以预定的分配比对从主流路供给的液体进行分流和供给，其中每个分开路径之间的流路阻力的比率近似等于 将液体分配并供给到每个分割路径的预定比例。

公开(公告)号：US07361315B2

公开(公告)日：2008-04-22

申请号：US11254210

申请日：2005-10-19

Applicant: Akihisa Nakajima ,  Eiichi Ueda ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Nobuhisa Ishida

Inventor： Akihisa Nakajima ,  Eiichi Ueda ,  Kusunoki Higashino ,  Yasuhiro Sando ,  Nobuhisa Ishida

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0439 ,  B01L2400/0655 ,  B01L2400/086 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The object of the present invention is to provide a micro-reactor, equipped with a high-precision liquid feed system of simple structure, capable of high-precision analysis of at least one item. The present invention provides a micro-reactor for biological substance inspection including a sample storage section, a reagent storage section, a sample pre-processing section, a micro-pump connecting section and a branched minute flow path. And a sample pre-processed by the sample pre-processing section is fed into the minute flow path branched off into at least two parts by a micro-pump and a liquid dividing section, and on the downstream side of each of the branched minute flow paths, the sample is fed to a flow path constituting a reaction site, and then to a flow path constituting the detection site, thereby providing simultaneous measurement of a plurality of items of a sample.

Abstract translation: 本发明的目的是提供一种微型反应器，其具有结构简单的高精度液体供给系统，能够对至少一个物品进行高精度分析。 本发明提供了一种用于生物物质检查的微反应器，包括样品存储部分，试剂储存部分，样品预处理部分，微泵连接部分和分支的微小流路。 并且由样品预处理部分预处理的样品通过微型泵和分液部分被分配到至少两部分的微小流路中，并且在每个分支微流量的下游侧 将样品送入构成反应部位的流路，然后送入构成检测部位的流路，从而同时测量多个样品。

公开(公告)号：US20070048155A1

公开(公告)日：2007-03-01

申请号：US11511046

申请日：2006-08-28

Applicant: Kusunoki Higashino ,  Yasuhiro Sando

Inventor： Kusunoki Higashino ,  Yasuhiro Sando

IPC: F04B17/00

CPC classification number: F04B43/043 ,  F04B53/1077

Abstract: A fluid transportation system includes: a micropump provided with a chamber and a diaphragm driven by an actuator; fluid communication sections communicating with both ends of the chamber of the micropump; a pressure absorbing section that is provided at least one of the fluid communication sections so as to absorb or reduce a fluid vibration pressure; and a narrow section that is provided at a position further than the pressure absorbing section from the chamber so as to narrow a flow path cross-section, wherein, when R represents a flow path resistance value of the narrow section and C represents an acoustic capacitance value of the pressure absorbing section, a value obtained by multiplication between R and C is not smaller than a driving cycle period value of the micropump.

Abstract translation: 流体输送系统包括：具有腔室的微型泵和由致动器驱动的隔膜; 与微型泵的室的两端连通的流体连通部; 压力吸收部，其设置在所述流体连通部中的至少一个上，以吸收或降低流体振动压力; 以及狭窄部，其设置在比所述室的所述压力吸收部更远的位置，以使流路横截面变窄，其中，当R表示所述窄部的流路阻力值时，C表示声电容 压力吸收部的值，通过R和C之间的相乘获得的值不小于微型泵的驱动循环周期值。

公开(公告)号：US20060239862A1

公开(公告)日：2006-10-26

申请号：US11404931

申请日：2006-04-14

Applicant: Akihisa Nakajima ,  Kusunoki Higashino ,  Yasuhiro Sando

Inventor： Akihisa Nakajima ,  Kusunoki Higashino ,  Yasuhiro Sando

IPC: G01N33/00

CPC classification number: B01L3/50273 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2400/0487 ,  B01L2400/0688

Abstract: A testing chip that analyzes a specimen includes: a reagent storage section; a mixing and reaction flow channel to perform a series of operations to mix a specimen and aqueous reagent, make the specimen and reagent react with each other, and detect the reaction; and a liquid feed control section provided between an outlet flow channel of the reagent storage section and the inlet of the mixing and reaction flow channel. Herein, aqueous reagent, lipophilic liquid, and aqueous liquid having greater surface tension than that of the aqueous reagent are disposed in the reagent storage section in this order toward the outlet flow channel, the aqueous liquid being stored in contact with the liquid feed control section; and aqueous liquid passes the micro flow path of the liquid feed control section by applying a liquid feed pressure higher than or equal to a predetermined pressure to the reagent storage section.

Abstract translation: 分析标本的测试芯片包括：试剂储存部分; 混合反应流道，进行一系列操作，将样品和含水试剂混合，使试样和试剂相互反应，检测反应; 以及设置在试剂储存部的出口流路和混合反应流路的入口之间的液体供给控制部。 这里，具有比水性试剂更大的表面张力的水性试剂，亲油性液体和水性液体以这种顺序设置在试剂储存部分中，使其与出液流路保持接触， ; 并且水性液体通过将高于或等于预定压力的液体进料压力施加到试剂储存部分而通过液体供给控制部分的微流动路径。