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公开(公告)号：US08257974B2
公开(公告)日：2012-09-04
申请号：US12803060
申请日：2010-06-18
CPC分类号： G01N35/1095 , B01L3/502723 , B01L3/502738 , B01L3/502784 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2400/0487 , B01L2400/0688 , G01N27/44756 , G01N2035/00158 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： In the case of passing a reagent in a reaction channel in a microchip, which carries a reactant capable of reacting with the reagent on the wall thereof, and bringing the reactant into contact with the reagent so as to carry out a reaction, the reagent is efficiently passed to the reactant to thereby promote the progress of the reaction. In carrying out the reaction as described above, the reagent (30a) is passed in such a manner that the periphery of the gas/liquid interface at the front end of the reagent moves forward and backward along the wall face of the reaction channel (10). After the completion of the reaction between the reagent (30a) and the reactant, another reagent (30b), which is to be reacted with the reactant capable of reacting with the reagent that is carried on the reaction channel, is passed into the reaction channel (10) while providing a gas in the front edge side thereof. In carrying out the reaction, the reagent (30b) is passed in such manner that the periphery of the gas/liquid interface at the front end of the reagent moves forward and backward along the wall face of the reaction channel (10).
摘要翻译： 在将反应物通过试剂的微芯片中，其携带能够与其壁上的试剂反应的反应物，并使反应物与试剂接触以进行反应，试剂为 有效地传递到反应物中，从而促进反应的进行。 在进行如上所述的反应时，试剂（30a）以这样的方式通过，即试剂前端的气/液界面的周边沿着反应通道（10）的壁面前后移动 ）。 反应物（30a）与反应物反应结束后，与反应物反应的反应物（反应物）与反应通道反应物反应的另一试剂（30b）进入反应通道 （10），同时在其前缘侧提供气体。 在进行反应时，试剂（30b）以这样的方式通过，使得试剂前端处的气/液界面的周边沿着反应通道（10）的壁面向前和向后移动。
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公开(公告)号：US07906318B2
公开(公告)日：2011-03-15
申请号：US11121096
申请日：2005-05-04
IPC分类号： C12M1/34
CPC分类号： B01L3/50273 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F15/0201 , B01F15/024 , B01L3/502723 , B01L3/502738 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0439 , B01L2400/0487 , B01L2400/0605 , B01L2400/0633 , B01L2400/0677
摘要： A micro-reactor for analyzing a sample, comprises (1) a plate-shaped chip; (2) a plurality of regent storage sections each having a chamber to store respective agents; (3) a regent mixing section to mix plural regents fed from the plurality of regent storage sections so as to produce a mixed reagent; (4) a sample receiving section having an injection port through which a sample is injected from outside; and (5) a reacting section to mix and react the mixed regent fed from the reagent mixing section and the sample fed from the sample receiving section. The plurality of regent storage sections, the regent mixing section, the sample receiving section and the reacting section are incorporated in the chip and are connected through flow paths, and the regent mixing section includes a feed-out preventing mechanism to prevent an initially-mixed regent from being fed out to the reacting section.
摘要翻译： 用于分析样品的微反应器包括（1）板状芯片; （2）多个存储部分，每个存储部分具有用于存储相应代理的室; （3）注射混合部，混合从多个摄取储存部供给的多个药剂，以制备混合试剂; （4）具有从外部注入样品的注入口的样本接收部分; 和（5）反应部分，用于混合并反应从试剂混合部分供给的混合注射器和从样品接收部分供给的样品。 多个摄取储存部分，摄取混合部分，样品接收部分和反应部分结合在芯片中并通过流动路径连接，并且摄像机混合部分包括防止初始混合的送出机构 摄政从被送到反应部分。
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公开(公告)号：US20090155927A1
公开(公告)日：2009-06-18
申请号：US12092116
申请日：2006-10-18
CPC分类号： B01L3/502738 , B01F5/0602 , B01F5/0647 , B01F13/0059 , B01J19/0093 , B01J2219/00891 , B01L3/502723 , B01L3/502746 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/1822 , B01L2400/0439 , B01L2400/0487 , B01L2400/0688 , B01L2400/084 , F16K99/0001 , F16K99/0017 , F16K99/0034 , F16K99/0057 , F16K2099/0084 , Y10T436/2575
摘要： A microreactor capable of reaction between a sample and a mixed reagent containing a mixture of multiple reagents, which microreactor avoids the interposition of air between driving solution and reagents and realizes high-precision controlling of the timing of mixing of reagents and other liquids, the mixing ratio of liquids, the pressure for liquid feeding, etc. Further, there is provided a method of liquid feeding making use of the same. Accordingly, a flow path branched at the position of an inlet from a flow path through which an opening communicating with an external pump communicates with the inlet is provided with an air evacuation flow path with its terminal open outward. Further, the flow path resistance of the air evacuation flow path for a liquid is made greater than the flow path resistance, for the liquid, of a flow channel from the reagent storage chamber to a reagent feed-out flow path.
摘要翻译： 能够在样品和含有多种试剂的混合物的混合试剂之间反应的微反应器，该微反应器避免在驱动溶液和试剂之间插入空气，并实现对试剂和其它液体的混合时间的高精度控制，混合 液体的比例，液体供给的压力等。此外，提供了一种使用该液体的方法。 因此，在与从外部泵连通的开口与流路连通的流路的入口位置分支的流路设置有使其端子向外侧开口的排气流路。 此外，使液体的排气流路的流路阻力大于液体对从试剂储存室到试剂送出流路的流路的流路阻力。
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公开(公告)号：US20060263914A1
公开(公告)日：2006-11-23
申请号：US11434253
申请日：2006-05-16
CPC分类号： B01L3/565 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2200/028 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0887 , B01L2400/0439 , G01N2035/00158 , Y10T137/87877
摘要： A testing chip includes (1) a first chip having a micro flow path that stores reagent; upstream-side opening provided on upstream-side of the micro flow path; downstream-side opening provided on downstream-side of the micro flow path; and one or more sealing members in a small thickness stuck to at least one surface of the first chip to seal the upstream-side opening and the downstream-side opening until the testing chip is used and (2) a second chip having a micro flow path for mixing and reaction between reagent and a specimen and detecting the reaction; and an opening provided on upstream-side of the micro flow path, wherein, when the testing chip is used, the first and second chips are superimposed on each other so that the downstream-side opening of the first chip and the opening of the second chip are positioned on each other.
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公开(公告)号：US20060213291A1
公开(公告)日：2006-09-28
申请号：US11378516
申请日：2006-03-17
IPC分类号： G01D21/00
CPC分类号： G01N35/00029 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/502715 , B01L2200/146 , B01L2200/147 , Y10T436/2575
摘要： An analyzer for analysis of a specimen in a testing chip that includes a micropump connecting section that is connected with a micropump to take in liquid from the micropump and includes a micro flow channel in which a reagent and the specimen are mixed so as to react with each other, the analyzer including: a mounting section for mounting the testing chip attachably and detachably thereto; a micropump unit that has a testing chip connecting section to be connected with the micropump connecting section of the testing chip which is mounted on the mounting section, and feeds liquid to the testing chip through the testing chip connecting section; and a pressing mechanism that presses the micropump connecting section and the testing chip connecting section against each other, the connecting sections being connected with each other.
摘要翻译： 一种用于分析测试芯片中的样本的分析器，其包括与微型泵连接以从微型泵吸取液体的微泵连接部分，并且包括微流道，其中将试剂和样品混合以便与 彼此分离器包括：安装部分，用于将测试芯片可安装和可拆卸地安装在其上; 微型泵单元，具有与安装在安装部上的测试用芯片的微型泵连接部连接的测试芯片连接部，并通过测试芯片连接部将液体供给到测试芯片; 以及将微型泵连接部和测试用芯片连接部彼此按压的按压机构，连接部彼此连接。
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6.发明申请Micro-reactor for biological substance inspection and biological substance inspection device 有权生物物质检验微生物检测装置及生物物质检测装置公开(公告)号：US20060088451A1
公开(公告)日：2006-04-27
申请号：US11254210
申请日：2005-10-19
IPC分类号： B01J19/00
CPC分类号： B01L3/50273 , B01L2200/04 , B01L2200/10 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2400/0439 , B01L2400/0655 , B01L2400/086 , Y10T436/25 , Y10T436/2575
摘要： The object of the present invention is to provide a micro-reactor, equipped with a high-precision liquid feed system of simple structure, capable of high-precision analysis of at least one item. The present invention provides a micro-reactor for biological substance inspection including a sample storage section, a reagent storage section, a sample pre-processing section, a micro-pump connecting section and a branched minute flow path. And a sample pre-processed by the sample pre-processing section is fed into the minute flow path branched off into at least two parts by a micro-pump and a liquid dividing section, and on the downstream side of each of the branched minute flow paths, the sample is fed to a flow path constituting a reaction site, and then to a flow path constituting the detection site, thereby providing simultaneous measurement of a plurality of items of a sample.
摘要翻译： 本发明的目的是提供一种微型反应器，其具有结构简单的高精度液体供给系统，能够对至少一个物品进行高精度分析。 本发明提供了一种用于生物物质检查的微反应器，包括样品存储部分，试剂储存部分，样品预处理部分，微泵连接部分和分支的微小流路。 并且由样品预处理部分预处理的样品通过微型泵和分液部分被分配到至少两部分的微小流路中，并且在每个分支微流量的下游侧 将样品送入构成反应部位的流路，然后送入构成检测部位的流路，从而同时测量多个样品。
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公开(公告)号：US20100261290A1
公开(公告)日：2010-10-14
申请号：US12803060
申请日：2010-06-18
IPC分类号： G01N1/00
CPC分类号： G01N35/1095 , B01L3/502723 , B01L3/502738 , B01L3/502784 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2400/0487 , B01L2400/0688 , G01N27/44756 , G01N2035/00158 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： In the case of passing a reagent in a reaction channel in a microchip, which carries a reactant capable of reacting with the reagent on the wall thereof, and bringing the reactant into contact with the reagent so as to carry out a reaction, the reagent is efficiently passed to the reactant to thereby promote the progress of the reaction. In carrying out the reaction as described above, the reagent (30a) is passed in such a manner that the periphery of the gas/liquid interface at the front end of the reagent moves forward and backward along the wall face of the reaction channel (10). After the completion of the reaction between the reagent (30a) and the reactant, another reagent (30b), which is to be reacted with the reactant capable of reacting with the reagent that is carried on the reaction channel, is passed into the reaction channel (10) while providing a gas in the front edge side thereof. In carrying out the reaction, the reagent (30b) is passed in such manner that the periphery of the gas/liquid interface at the front end of the reagent moves forward and backward along the wall face of the reaction channel (10).
摘要翻译： 在将反应物通过试剂的微芯片中，其携带能够与其壁上的试剂反应的反应物，并使反应物与试剂接触以进行反应，试剂为 有效地传递到反应物中，从而促进反应的进行。 在进行如上所述的反应时，试剂（30a）以这样的方式通过，即试剂前端的气/液界面的周边沿着反应通道（10）的壁面前后移动 ）。 反应物（30a）与反应物反应结束后，与反应物反应的反应物（反应物）与反应通道反应物反应的另一试剂（30b）进入反应通道 （10），同时在其前缘侧提供气体。 在进行反应时，试剂（30b）以这样的方式通过，使得试剂前端处的气/液界面的周边沿着反应通道（10）的壁面向前和向后移动。
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8.发明申请公开(公告)号：US20090233378A1
公开(公告)日：2009-09-17
申请号：US12225598
申请日：2007-02-21
CPC分类号： G01N35/1095 , B01L3/502723 , B01L3/502738 , B01L3/502784 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2400/0487 , B01L2400/0688 , G01N27/44756 , G01N2035/00158 , Y10T436/11 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： In case of performing a reaction between reacting material and reagent by bringing the reagent in contact with the reacting material through flowing the reagent into a reaction flow channel in which the reaction material which reacts with the reagent is carried on a wall surface of the reaction flow channel of a microchip, the reaction is expedited efficiently by passing the reagent to the reacting material. The reagent 30a is flowed such that a peripheral portion of a gas-liquid interface at a front end of the reagent moves back and forth on the wall surface of the reaction flow channel 10 when the reaction is performed.
摘要翻译： 通过使试剂与反应物质接触而使反应物质与试剂反应的反应流入反应流路，反应物质与反应物质反应的反应物质与试剂反应的反应物质在反应流的壁面上进行反应 微芯片的通道，通过使试剂通过反应材料而有效地加速反应。 试剂30a流动，使得当进行反应时，试剂前端的气 - 液界面的周边部分在反应流路10的壁表面上来回移动。
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9.发明申请Microchip Inspection System and Microchip Inspection System Program 审中-公开Microchip检测系统和Microchip检测系统程序公开(公告)号：US20080118369A1
公开(公告)日：2008-05-22
申请号：US11940598
申请日：2007-11-15
IPC分类号： F04B49/00
CPC分类号： F04B43/043 , B01L3/50273 , B01L7/00 , B01L2200/14 , B01L2200/143 , B01L2300/0627 , B01L2300/0645 , B01L2300/1822 , B01L2400/0487 , G01N2035/1034 , G01P13/0006 , G05D7/0694
摘要： An objective is to provide a microchip inspection system in which an amount of driving liquid filled in a flow path between a micropump and a microchip is kept constant. Also disclosed is a microchip inspection system possessing a micropump by which driving liquid is injected into a microchip from a flow path; a driving liquid sensing device by which a sensing signal is output by sensing presence or absence of the driving liquid at a predetermined position of the flow path; and a pump driving control section by which the driving liquid is moved to a position based on the predetermined position as a reference position by driving the micropump in response to the sensing signal obtained from the driving liquid sensing device.
摘要翻译： 目的是提供一种微芯片检查系统，其中填充在微型泵和微芯片之间的流动路径中的驱动液体的量保持恒定。 还公开了一种具有微型泵的微芯片检查系统，通过该微泵将驱动液体从流路注入微芯片; 驱动液体检测装置，通过在所述流路的预定位置处感测驱动液体的存在或不存在来输出感测信号; 以及泵驱动控制部，通过利用从驱动液体检测装置得到的感测信号，通过驱动微型泵将驱动液体移动到基于规定位置的位置作为基准位置。
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公开(公告)号：US20080101992A1
公开(公告)日：2008-05-01
申请号：US11923234
申请日：2007-10-24
IPC分类号： B01J19/00
CPC分类号： B01L3/502707 , B01L2200/16 , B01L2300/042 , B01L2300/049 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/1822 , B01L2400/0439 , B01L2400/0677
摘要： An objective is to provide a microchip exhibiting no scattering of stored reagent together with reduced size, which is capable of rapidly mixing the reagent when used. Also disclosed is a microchip possessing a reaction section in which reaction with a reagent or a specimen supplied from a flow path is conducted via heat, wherein the reaction section possesses a storage section to store the reagent in advance, and the reagent previously stored in the storage section is sealed with a material which generates phase transition from a solid phase to a liquid phase between a storage temperature and a reaction temperature.
摘要翻译： 目的是提供一种显示不存在的试剂的散射的微芯片以及减小的尺寸，其能够在使用时快速混合试剂。 还公开了具有反应部的微芯片，其中与从流路供给的试剂或试样的反应通过加热进行反应，其中反应部具有预先存储试剂的储存部，预先存储在试剂中的试剂 存储部分用在储存温度和反应温度之间产生从固相到液相的相变的材料密封。
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