公开(公告)号：US11167005B2

公开(公告)日：2021-11-09

申请号：US16474831

申请日：2018-01-04

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Edna Mozes

IPC: A61K38/04 ,  A61K38/10 ,  A61P11/00 ,  A61P15/00 ,  A61P17/00 ,  A61P17/16 ,  A61P19/02 ,  A61P1/02 ,  A61P27/02 ,  A61P37/02 ,  A61P43/00 ,  C07K7/08

Abstract: Compositions and methods for the treatment of Sjogren's syndrome (SS) and SS-related symptoms in human subjects are described. The compositions comprise synthetic peptides based on the sequence of CDR1 of an anti-DNA monoclonal antibody.

公开(公告)号：US20210332024A1

公开(公告)日：2021-10-28

申请号：US17370216

申请日：2021-07-08

Applicant: Yeda Research and Development Co. Ltd. ,  Dana-Farber Cancer Institute, Inc. ,  Beth Israel Deaconess Medical Center, Inc.

Inventor： Nir LONDON ,  Daniel ZAIDMAN ,  Christian DUBIELLA ,  Nathanael S. GRAY ,  Benika Joan PINCH ,  Kun Ping LU ,  Alfred Thomas LOOK ,  Shuning HE ,  Xiao Zhen ZHOU ,  Xiaolan LIAN

IPC: C07D333/16

Abstract: Disclosed herein are compounds comprising an electrophilic moiety and rigid moiety for use in modulating an activity of Pin1. The rigid moiety comprises at least one functional group that is capable of forming hydrogen bonds with hydrogen atoms, wherein the electrophilic moiety and the rigid moiety are arranged such that the electrophilic moiety is capable of covalently binding to the Cys113 residue of Pin1, and the rigid moiety is capable of forming hydrogen bonds with the Gln131 and His 157 residues of Pin1. Further disclosed are novel compounds having Formula Id: wherein the dashed line, W, X, Y, Z, Ra-Rc, R1, R2, L1, L2 and n are as defined herein, and libraries comprising such compounds. Further disclosed are methods of identifying a compound capable of modulating an activity of Pin1, by screening a library of compounds.

公开(公告)号：US20210292437A1

公开(公告)日：2021-09-23

申请号：US17267049

申请日：2019-08-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah FASS ,  Sarel FLEISHMAN ,  Shira WARSZAWSKI ,  Iris GROSSMAN ,  Lev KHMELNITSKY

IPC: C07K16/40

Abstract: Antibodies for binding QSOX1 are provided. Also provided are use of these antibodies.

公开(公告)号：US20210292338A1

公开(公告)日：2021-09-23

申请号：US17337570

申请日：2021-06-03

Applicant: Yeda Research and Development Co. Ltd. ,  Universitat de Barcelona ,  Institució Catalana de Recerca I Estudis Avançats

Inventor： Rony SEGER ,  Karen FLORES ,  Xavier BARRIL ALONSO ,  Carlos GALDEANO CANTADOR

IPC: C07D498/04 ,  A61K45/06 ,  A61P35/00

Abstract: Described herein are compounds having Formula I or Formula II: wherein each dashed line independently represents a saturated or unsaturated bond; R1 and R′1 are aryl or heteroaryl as defined herein; and R2 and R′2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula I or Formula II. The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.

公开(公告)号：US11111481B2

公开(公告)日：2021-09-07

申请号：US15764691

申请日：2016-09-29

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  SYNVACCINE LTD.

Inventor： Tamir Tuller ,  Eli Goz ,  Shimshi Atar ,  Hadas Zur

IPC: C12N7/00 ,  C12N7/04 ,  A61K35/76 ,  A61K35/12 ,  G16B99/00 ,  A61K39/12 ,  A61K39/00

Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.

公开(公告)号：US11053434B2

公开(公告)日：2021-07-06

申请号：US15758344

申请日：2016-09-08

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Milko E. Van Der Boom ,  Michal Lahav ,  Neta Elool Dov

IPC: G02F1/1516 ,  B05D5/06 ,  B05D1/00 ,  B05D7/00 ,  C09K9/02 ,  C07D213/22 ,  C07F15/02 ,  C09D5/29

Abstract: The invention is directed to methods for making an EC material comprising providing a substrate, applying at least one metal linker to the substrate, applying at least one metal-coordinated organic complex to form a layer, washing the layer, drying the layer, and repeating the applying steps to obtain a multiple layer EC material. The invention is further directed to EC materials made by the methods of this invention.

公开(公告)号：US20210186876A1

公开(公告)日：2021-06-24

申请号：US17190537

申请日：2021-03-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob KLEIN ,  Ronit GOLDBERG ,  Jasmine SEROR ,  Weifeng LIN ,  Reut MASHIACH

IPC: A61K9/127 ,  A61K9/00 ,  A61K47/32 ,  A61K47/10 ,  A61K47/36 ,  A61K9/08 ,  A61K31/728 ,  A61K31/77 ,  A61K31/79 ,  B65D35/00 ,  B65D75/36

Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.

公开(公告)号：US20210172077A1

公开(公告)日：2021-06-10

申请号：US16771243

申请日：2018-12-10

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ronny NEUMANN ,  Alexander KHENKiN ,  Miriam SOMEKH

IPC: C25B3/23 ,  B01J23/78 ,  C25B3/07 ,  C25B1/02

Abstract: The invention relates to electrocatalytic processes for the formation of formate esters using at least one catalyst or pre-catalyst; wherein the formate ester can be further hydrolyzed.

公开(公告)号：US20210154261A1

公开(公告)日：2021-05-27

申请号：US16633175

申请日：2018-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena SAMUELS ,  Rand ARAFEH ,  Karen FLORES ,  Rony SEGER ,  Ehud WAINSTEIN

IPC: A61K38/10 ,  A61K31/519 ,  A61K31/4184 ,  A61P35/00

Abstract: An article of manufacture is disclosed which comprises: (i) a peptide agent which is capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus; and (ii) a MEK inhibitor. Uses thereof are also disclosed.

公开(公告)号：US20210142905A1

公开(公告)日：2021-05-13

申请号：US17151232

申请日：2021-01-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Eran ELINAV

IPC: G16H50/20 ,  G06N20/00 ,  G16H10/60 ,  G16H50/70 ,  G16H20/60

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.