公开(公告)号：US20140228443A1

公开(公告)日：2014-08-14

申请号：US14175959

申请日：2014-02-07

Applicant: Acucela Inc.

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Feng Hong ,  Ryo Kubota ,  Jennifer Gage

IPC: C07C211/49 ,  C07C233/25 ,  C07C225/06 ,  C07C233/62 ,  C07C215/08

CPC classification number: C07C233/25 ,  A61K31/167 ,  A61K31/18 ,  C07B59/001 ,  C07B2200/05 ,  C07C211/49 ,  C07C211/52 ,  C07C215/08 ,  C07C215/14 ,  C07C215/42 ,  C07C215/68 ,  C07C217/08 ,  C07C217/10 ,  C07C217/58 ,  C07C225/06 ,  C07C225/22 ,  C07C233/36 ,  C07C233/43 ,  C07C233/62 ,  C07C275/40 ,  C07C311/08 ,  C07C311/10 ,  C07C311/14 ,  C07C311/21 ,  C07C311/24 ,  C07C335/18 ,  C07C2601/08 ,  C07C2601/14 ,  C07D277/28

Abstract: Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

Abstract translation: 提供了化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和病症如老年性黄斑变性和Stargardt氏病的方法。

公开(公告)号：US20140039048A1

公开(公告)日：2014-02-06

申请号：US13887243

申请日：2013-05-03

Applicant: Acucela Inc.

Inventor： Claes Olof Bavik ,  Susan Hayes Henry ,  Ryo Kubota ,  Vladimir A. Kuksa

IPC: C07C215/08 ,  C07C323/32 ,  C07D309/06 ,  C07C211/27 ,  C07C217/20

CPC classification number: C07C215/08 ,  A61K31/137 ,  A61K31/138 ,  A61K31/35 ,  A61K31/765 ,  A61K45/06 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06

Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

Abstract translation: 本文提供了用于治疗患者眼科疾病或病症如眼科疾病或糖尿病相关病症的方法。 本文还提供了治疗患者的早产儿视网膜病变的方法。 此外，本文提供了治疗患者中湿性年龄相关性黄斑变性的方法。 所述方法包括将本文公开的化合物给予需要其的抑制或减缓这种病症的一种或多种体征或症状的患者。

公开(公告)号：US12226647B2

公开(公告)日：2025-02-18

申请号：US17052906

申请日：2019-05-03

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Amitava Gupta

IPC: A61N5/06 ,  A61N5/067 ,  G02C7/04

Abstract: A source of light energy such as a source of violet light energy is coupled to a structure configured to contact the eye. The light source and structure are arranged to provide therapeutic amounts of violet light energy to the eye in order to inhibit the progression of refractive error such as myopia. The light source can be configured in many ways and may comprise a radioisotope and a phosphorescent material. The structure configured to contact the eye may comprise a contact lens or an implant.

公开(公告)号：US12147092B2

公开(公告)日：2024-11-19

申请号：US18051804

申请日：2022-11-01

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Gordon Frederick Maccabee ,  Ferry Widjaja ,  Amitava Gupta

IPC: G02C11/00 ,  G02C7/04 ,  A61N5/06

Abstract: A contact lens may include a body of contact lens material extending between a first surface and a second surface. An electromechanical component may be supported in the contact lens material between the first surface and the second surface. A support comprising a plurality of pillars may be formed of the contact lens material and may extend from at least one of the first surface and the second surface to the electromechanical component.

公开(公告)号：US12105362B2

公开(公告)日：2024-10-01

申请号：US18330010

申请日：2023-06-06

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Amitava Gupta ,  Stefan Bauer ,  Benjamin Crook ,  Julien Sauvet

IPC: G02C7/08 ,  G02C7/02 ,  G02C7/06 ,  G02C7/10 ,  G02C7/14

CPC classification number: G02C7/08 ,  G02C7/022 ,  G02C7/06 ,  G02C7/10 ,  G02C7/14 ,  G02C2202/24

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

公开(公告)号：US11986669B2

公开(公告)日：2024-05-21

申请号：US18153000

申请日：2023-01-11

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Karim Haroud ,  Beat Wyss ,  Hans Bernhard ,  Jean-Noel Fehr ,  Patrizia Weber ,  Moritz Haeberli ,  Amitava Gupta

IPC: A61N5/06 ,  G02B27/01 ,  G02B27/30

CPC classification number: A61N5/0622 ,  G02B27/0172 ,  G02B27/30 ,  A61N2005/063 ,  A61N2005/0648 ,  A61N2005/0652 ,  A61N2005/0663 ,  G02B2027/0178

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US11911105B2

公开(公告)日：2024-02-27

申请号：US18005888

申请日：2021-09-30

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi

IPC: A61B3/103 ,  A61B3/00 ,  A61B3/10 ,  A61B3/135 ,  A61B3/14

CPC classification number: A61B3/103 ,  A61B3/0025 ,  A61B3/1015 ,  A61B3/135 ,  A61B3/14 ,  A61B3/102

Abstract: Embodiments of the present disclosure are directed to systems, apparatuses and methods for prediction, diagnosis, planning and monitoring for myopia and myopic progression. In some embodiments, one or more refractive properties of the eye is determined for each of a plurality of retinal locations of the eye. The plurality of locations may comprise a central region, such as a fovea of the eye, or non-foveal region such as a peripheral region or a region of the macula outside the fovea. Measuring the refractive properties of the eye for the plurality of locations may be helpful in diagnosing myopia and other ocular conditions by providing the refractive properties of the eye for locations away from the fovea, such as the peripheral retina.

公开(公告)号：US11795136B2

公开(公告)日：2023-10-24

申请号：US16934715

申请日：2020-07-21

Applicant: Acucela Inc.

Inventor： Claes Olof Bavik ,  Susan Hayes Henry ,  Ryo Kubota ,  Vladimir A. Kuksa

IPC: C07C215/08 ,  A61K31/138 ,  A61K45/06 ,  A61K31/137 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06 ,  A61K31/35 ,  A61K31/765

CPC classification number: C07C215/08 ,  A61K31/137 ,  A61K31/138 ,  A61K31/35 ,  A61K31/765 ,  A61K45/06 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06

Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

公开(公告)号：US11733545B2

公开(公告)日：2023-08-22

申请号：US17753773

申请日：2020-09-15

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Jean-Noël Fehr ,  Hans Bernhard ,  Patrizia Weber ,  Alain Saurer ,  Amitava Gupta

IPC: G02C7/04 ,  G02C11/00 ,  G02C11/04

CPC classification number: G02C7/047 ,  G02C11/04 ,  G02C11/10 ,  G02C2202/24

Abstract: An opto-electronic module is configured to fit between anterior and posterior surfaces of a contact lens. The opto-electronics module may comprise a plurality of light sources configured to direct a plurality of light beams to a region of the retina away from the fovea and in some embodiments away from the macula. Each of the plurality of light sources may comprises an LED and one or more projection optics. Each of the projection optics can be coupled to an LED with an adhesive prior to placing the opto-electronics module on a layer of contact lens material. The opto-electronics module may comprise a flex PCB with the plurality of light sources, an antenna, a battery, a capacitor and a processor supported on the flex PCB.

公开(公告)号：US11693259B2

公开(公告)日：2023-07-04

申请号：US17820738

申请日：2022-08-18

Applicant: ACUCELA INC.

Inventor： Philip M. Buscemi ,  Ryo Kubota

IPC: G02C7/04 ,  G02B27/01 ,  G02C7/14

CPC classification number: G02C7/04 ,  G02B27/017 ,  G02C7/14 ,  G02B2027/0178 ,  G02C2202/24

Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.