公开(公告)号：US4327228A

公开(公告)日：1982-04-27

申请号：US156189

申请日：1980-06-03

申请人： Paul Smith

发明人： Paul Smith

IPC分类号： C07C215/28 ,  C07C67/00 ,  C07C201/00 ,  C07C205/16 ,  C07C205/26 ,  C07C213/00 ,  C07C4/00

CPC分类号： C07C205/26

摘要： A process for the preparation of 3-dimethylamino-1-phenyl-(m-chlorophenyl)propan-2-ol and its salts which comprises the Raney nickel catalysed reduction of 3-nitro-1-phenyl-(1-m-chlorophenyl)propan-2-ol with simultaneous or subsequent dimethylation and thereafter, if desired, salification.

摘要翻译： 一种制备3-二甲基氨基-1-苯基 - （间氯苯基）丙-2-醇及其盐的方法，其包括阮内镍催化还原3-硝基-1-苯基 - （1-间氯苯基） 丙-2-醇，同时或随后的二甲基化，然后如果需要，成盐。

公开(公告)号：US20210299487A1

公开(公告)日：2021-09-30

申请号：US17216336

申请日：2021-03-29

申请人： Mark English ,  Carlos R. Villamar ,  Paul Smith

发明人： Mark English ,  Carlos R. Villamar ,  Paul Smith

IPC分类号： A62B18/02 ,  A62B7/10

摘要： A system, method and computer program product for a do-it-yourself (DIY) system for assisted respirators, including a full-face snorkel mask with snorkel connection; a hose having a first end connected to the snorkel connection of the mask; a blower connected a second end of the hose; and a portable power supply powering the blower. The blower includes a HEPA level filter on an air input thereof, and the blower pumps HEPA filtered air through the hose into the mask.

公开(公告)号：US09759715B2

公开(公告)日：2017-09-12

申请号：US12749056

申请日：2010-03-29

申请人： Paul Smith ,  Laurence Patterson ,  Rachel Jane Errington

发明人： Paul Smith ,  Laurence Patterson ,  Rachel Jane Errington

IPC分类号： B01L3/00 ,  G01N33/50 ,  A61L31/14 ,  C11D3/37 ,  G01N21/27 ,  G01N21/64 ,  G01N33/545

CPC分类号： G01N33/5005 ,  A61L31/145 ,  C11D3/3707 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6458 ,  G01N33/545 ,  Y02A50/58

摘要： The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties, molecular sieving properties and biocompatibility. Further aspects of the invention provide (a) a support matrix composition comprising a block polymer, fluorescent beads and/or a dye for use in the manipulation, processing or analysis of particles, (b) a multichamber plate coated in a support matrix composition and (c) kits for producing the same.

公开(公告)号：US09629647B2

公开(公告)日：2017-04-25

申请号：US13727345

申请日：2012-12-26

申请人： Paul Smith ,  Samuel Raybin

发明人： Paul Smith ,  Samuel Raybin

IPC分类号： A61B1/00 ,  A61B17/32 ,  A61B17/00 ,  A61B17/30 ,  A61B90/00

CPC分类号： A61B17/00234 ,  A61B1/00087 ,  A61B1/00089 ,  A61B1/015 ,  A61B1/05 ,  A61B1/0676 ,  A61B17/30 ,  A61B17/320016 ,  A61B17/3205 ,  A61B90/39 ,  A61B2017/00269 ,  A61B2017/00336 ,  A61B2017/00818 ,  A61B2017/306 ,  A61B2090/033 ,  A61B2090/3966

摘要： A medical device and related method of use for resecting a tissue. The medical device may include an elongate member having a proximal end, a distal end, and a lumen extending therebetween. The elongate member may include a distal portion defining a cavity having an opening. In addition, a mechanism may be configured to adjust a volume of the cavity by altering a depth of the cavity.

公开(公告)号：US09463059B2

公开(公告)日：2016-10-11

申请号：US13763220

申请日：2013-02-08

申请人： Naroun Suon ,  Ra Nam ,  Samuel Raybin ,  Paul Smith ,  Jonathan Root

发明人： Naroun Suon ,  Ra Nam ,  Samuel Raybin ,  Paul Smith ,  Jonathan Root

IPC分类号： A61B17/26 ,  A61B18/14 ,  A61B18/04 ,  A61B17/32 ,  A61B18/00 ,  A61B17/00

CPC分类号： A61B18/04 ,  A61B17/32 ,  A61B18/1485 ,  A61B18/149 ,  A61B18/1492 ,  A61B2017/00269 ,  A61B2018/00184 ,  A61B2018/1407 ,  A61B2018/141 ,  A61B2018/144 ,  A61B2018/1475

摘要： A medical device and related method of use for cutting tissue is described. The device includes an elongate tubular member having a proximal end, a distal end, and first and second lumens extending between the proximal and distal ends. The device further includes a first elongate arm having a third lumen extending distally from the first lumen and a second elongate arm having a fourth lumen extending distally from the second lumen. A cutting element extends from the third lumen of the first arm to the fourth lumen of the second arm, such that the cutting element is slidably disposed in at least one of the third and fourth lumens.

摘要翻译： 描述了用于切割组织的医疗装置和相关的使用方法。 该装置包括具有近端，远端以及在近端和远端之间延伸的第一和第二腔的细长管状构件。 该装置还包括具有从第一内腔向远侧延伸的第三腔的第一细长臂和具有从第二腔向远侧延伸的第四腔的第二细长臂。 切割元件从第一臂的第三腔延伸到第二臂的第四腔，使得切割元件可滑动地设置在第三和第四腔中的至少一个腔中。

公开(公告)号：US09173671B2

公开(公告)日：2015-11-03

申请号：US13728078

申请日：2012-12-27

申请人： Paul Smith ,  Samuel Raybin ,  Naroun Suon ,  Gary Kappel

发明人： Paul Smith ,  Samuel Raybin ,  Naroun Suon ,  Gary Kappel

IPC分类号： A61B17/32 ,  A61B17/3205 ,  A61B17/00 ,  A61B18/00 ,  A61B17/30 ,  A61B18/14

CPC分类号： A61B17/320016 ,  A61B17/32 ,  A61B17/32056 ,  A61B18/00 ,  A61B18/1492 ,  A61B2017/00269 ,  A61B2017/003 ,  A61B2017/306 ,  A61B2018/141

摘要： A device configured to facilitate resection of tissue. The device may include a proximal end configured to be secured to a distal portion of an introduction sheath and a distal end defining an opening that may communicate with a channel extending between the proximal and distal ends. The opening may be defined by at least one straight edge.

摘要翻译： 被配置为便于切除组织的装置。 该装置可以包括被配置为固定到引入护套的远侧部分的近端和限定可在近端和远端之间延伸的通道连通的开口的远端。 开口可以由至少一个直边限定。

公开(公告)号：US09011434B2

公开(公告)日：2015-04-21

申请号：US13755579

申请日：2013-01-31

申请人： Gary Kappel ,  Sean Fleury ,  Paul Smith ,  Brandon Zalewski ,  Laurie Soderborn

发明人： Gary Kappel ,  Sean Fleury ,  Paul Smith ,  Brandon Zalewski ,  Laurie Soderborn

IPC分类号： A61B18/18 ,  A61B17/29 ,  A61B17/295 ,  A61B18/08 ,  A61B17/32 ,  A61B19/00 ,  A61B18/14

CPC分类号： A61B17/295 ,  A61B17/068 ,  A61B17/29 ,  A61B17/34 ,  A61B18/085 ,  A61B18/1445 ,  A61B2017/2901 ,  A61B2017/2926 ,  A61B2017/320044 ,  A61B2018/00595 ,  A61B2018/1455 ,  A61B2090/0817 ,  A61B2217/005 ,  A61B2217/007 ,  A61B2218/002 ,  A61B2218/007

摘要： A medical device including an elongate member having a proximal end, a distal end, and a lumen extending therebetween. The medical device may further include an end-effector disposed at the distal end of the elongate member. The end-effector may include a plurality of arms pivotally connected to one another, wherein each arm includes a tissue-contacting surface, a first portion of the tissue-contacting surface including a plurality of ridges configured to grasp tissue. Further, the tissue-contacting surface may include a channel oriented substantially parallel to a longitudinal axis of the medical device.

摘要翻译： 一种医疗装置，包括具有近端，远端和在其间延伸的内腔的细长构件。 医疗装置还可以包括设置在细长构件的远端处的末端执行器。 末端执行器可以包括彼此枢转地连接的多个臂，其中每个臂包括组织接触表面，组织接触表面的第一部分包括构造成抓住组织的多个脊。 此外，组织接触表面可以包括基本上平行于医疗装置的纵向轴线定向的通道。

公开(公告)号：US08979826B2

公开(公告)日：2015-03-17

申请号：US13326585

申请日：2011-12-15

申请人： Gary Kappel ,  Barry Weitzner ,  Paul Smith ,  Erin Daly

发明人： Gary Kappel ,  Barry Weitzner ,  Paul Smith ,  Erin Daly

IPC分类号： A61B17/00 ,  A61B19/00 ,  A61B1/00

CPC分类号： A61B19/201 ,  A61B1/0014 ,  A61B1/00149 ,  A61B17/00234 ,  A61B50/20 ,  A61B90/11 ,  A61B90/50

摘要： A support mechanism for a medical device may include an adjustable support that includes a plurality of elongate members movable relative to one another. The support mechanism may also include a bracket coupled to the adjustable support. The bracket may be adapted to be coupled to a first medical device that extends along a longitudinal axis. The support mechanism may also include an instrument holder that extends along a central axis. The instrument holder may be movably coupled to the bracket and adapted to be coupled to a second medical device. The bracket and the instrument holder may be oriented such that central axis of the instrument holder intersects the longitudinal axis at an angle.

摘要翻译： 用于医疗装置的支撑机构可以包括可调节的支撑件，其包括可相对于彼此移动的多个细长构件。 支撑机构还可以包括联接到可调节支撑件的支架。 支架可以适于联接到沿着纵向轴线延伸的第一医疗装置。 支撑机构还可以包括沿着中心轴延伸的器械保持器。 仪器保持器可以可移动地联接到支架并且适于联接到第二医疗装置。 支架和仪器支架可以被定向成使得仪器支架的中心轴线以纵向轴线成一角度相交。

公开(公告)号：US20150036125A1

公开(公告)日：2015-02-05

申请号：US13824413

申请日：2011-09-16

申请人： Aldo Bojarski ,  Klaus Erler ,  Katrin Kunzelmann ,  Andre Legner ,  Paul Smith ,  Tobby Strasseberger

发明人： Aldo Bojarski ,  Klaus Erler ,  Katrin Kunzelmann ,  Andre Legner ,  Paul Smith ,  Tobby Strasseberger

IPC分类号： G01N21/41

CPC分类号： G01N21/4133 ,  G01N21/41 ,  G01N2201/0221

摘要： The invention relates to sensors for monitoring a medium, comprising an electromagnetic radiation source and a detector of electromagnetic radiation, the medium being located in the ray path between the electromagnetic radiation source and the detector and the refraction varying when the medium varies. The sensors are characterized by their ease of production. To that end, the electromagnetic radiation source and detector are disposed in at least one housing. Furthermore, either at least one region or at least one component of the housing consists of material which is transparent to electromagnetic radiation, the medium being located in the region or at the component of the housing. At least one wall of the region is so disposed or designed that the radiation for refraction impinges on or emerges from the surface at an angle which is different from 90°. In addition, the detector is at least one photo diode, such that, when the medium varies, the radiation either does not impinge or impinges on the photo diode.

公开(公告)号：US08871131B2

公开(公告)日：2014-10-28

申请号：US12447866

申请日：2006-10-30

申请人： Hans Schmotzer ,  Yvo Dirix ,  Paul Smith ,  Theo Tervoort ,  Lorenz Brunner

发明人： Hans Schmotzer ,  Yvo Dirix ,  Paul Smith ,  Theo Tervoort ,  Lorenz Brunner

IPC分类号： C08J5/00 ,  C08J5/16 ,  C08J3/28 ,  C08J3/24 ,  A61F2/30 ,  A61F2/02 ,  A61L27/16 ,  A61L27/14 ,  B29C43/00 ,  B29L31/00 ,  B29K23/00

CPC分类号： B29C43/003 ,  B29C43/006 ,  B29K2023/0683 ,  B29L2031/7532

摘要： Provided are processes comprising crosslinking polyethylene or using crosslinked polyethylene. Furthermore, the processes may include compacting and/or sintering the polyethylene. The polyethylene can comprise virgin ultrahigh molecular weight polyethylene having a weight average molecular weight of at least 1,000,000 g/mol, to provide a compacted composition comprising virgin ultrahigh molecular weight polyethylene.

摘要翻译： 提供了包括交联聚乙烯或使用交联聚乙烯的方法。 此外，该方法可以包括压实和/或烧结聚乙烯。 聚乙烯可以包含重均分子量至少为1,000,000g / mol的原始超高分子量聚乙烯，以提供包含原始超高分子量聚乙烯的压实组合物。