公开(公告)号：US08905236B2

公开(公告)日：2014-12-09

申请号：US13016621

申请日：2011-01-28

申请人： Frank W. Denome ,  Steven G. Friedrich ,  Regine Labeque ,  David M. Lee ,  Roxane Rosmaninho ,  Jichun Shi ,  Andrew P. Verrall

发明人： Frank W. Denome ,  Steven G. Friedrich ,  Regine Labeque ,  David M. Lee ,  Roxane Rosmaninho ,  Jichun Shi ,  Andrew P. Verrall

IPC分类号： B65D85/84 ,  C08J5/18 ,  C11D17/04 ,  C08L29/04 ,  B65D65/46

CPC分类号： C08L29/04 ,  B65D65/46 ,  C08J5/18 ,  C08J2329/04 ,  C08L2203/16 ,  C08L2205/025 ,  C11D17/042 ,  C11D17/045 ,  Y10T428/1334 ,  Y10T428/1341 ,  Y10T428/1345

摘要： Disclosed is a pouch having at least one sealed compartment containing a first composition. At least one wall of the at least one sealed compartment is made from a water-soluble film having any suitable thickness. The water-soluble film comprises PVOH polymer such that when the film has a thickness of about 76 microns the film is characterized by a Dissolution Index of about 620 to about 920, or of about 665 to about 920, or about 710 to about 920; and a Stress Index of about 145 to about 626, or about 155 to about 480, or about 165 to about 325.

摘要翻译： 公开了一种具有至少一个包含第一组合物的密封隔室的袋。 至少一个密封隔室的至少一个壁由具有任何合适厚度的水溶性薄膜制成。 该水溶性膜包含PVOH聚合物，使得当该膜的厚度为约76微米时，该膜的特征在于溶解指数为约620至约920，或约665至约920，或约710至约920; 和约145至约626，或约155至约480，或约165至约325的应力指数。

公开(公告)号：US20140129747A1

公开(公告)日：2014-05-08

申请号：US14145376

申请日：2013-12-31

申请人： Jasmin Ajanovic ,  David Harriman ,  Blaise Fanning ,  David M. Lee

发明人： Jasmin Ajanovic ,  David Harriman ,  Blaise Fanning ,  David M. Lee

IPC分类号： G06F13/42

CPC分类号： H04L47/10 ,  G06F5/06 ,  G06F13/124 ,  G06F13/385 ,  G06F13/4059 ,  G06F13/42 ,  G06F13/4221 ,  G06F13/4252 ,  G06F13/4265 ,  G06F13/4269 ,  G06F13/4282 ,  H04L47/30

摘要： A storage device is provided to maintain a count of flow control credits to be granted to a device in association with transactions over a channel to be implemented on a data link and control logic is provided to communicate, to the device, an indication of an amount of flow control credits for the device in association with a reset of the data link.

摘要翻译： 提供一种存储装置，用于维持要通过要在数据链路上实现的信道上的事务相关联地授予设备的流量控制信用的计数，并且提供控制逻辑以向该设备传送数量的指示 与数据链路的重置相关联的设备的流量控制信用。

公开(公告)号：US08566473B2

公开(公告)日：2013-10-22

申请号：US12395497

申请日：2009-02-27

申请人： Jasmin Ajanovic ,  David Harriman ,  Blaise Fanning ,  David M. Lee

发明人： Jasmin Ajanovic ,  David Harriman ,  Blaise Fanning ,  David M. Lee

IPC分类号： G06F15/16

CPC分类号： H04L47/10 ,  G06F5/06 ,  G06F13/124 ,  G06F13/385 ,  G06F13/4059 ,  G06F13/42 ,  G06F13/4221 ,  G06F13/4252 ,  G06F13/4265 ,  G06F13/4269 ,  G06F13/4282 ,  H04L47/30

摘要： An enhanced general input/output communication architecture, protocol and related methods are presented. In one embodiment, a method for an enhanced general input/output communication architecture includes initializing a flow control mechanism within an general input/output (GIO) interface associated with a virtual channel upon initialization of the virtual channel, and tracking receive buffer availability in a remote GIO interface coupled with the GIO interface by the virtual channel by monitoring an indication associated with an amount of content transmitted from the GIO interface to the remote GIO interface.

摘要翻译： 提出了一种增强的通用输入/输出通信架构，协议和相关方法。 在一个实施例中，用于增强的一般输入/输出通信架构的方法包括：初始化虚拟通道初始化时初始化与虚拟通道相关联的通用输入/输出（GIO）接口内的流控制机制，以及在虚拟通道初始化时跟踪接收缓冲区可用性 通过监视与从GIO接口发送到远程GIO接口的内容量相关联的指示，通过虚拟通道与远程GIO接口耦合到GIO接口。

公开(公告)号：US08224579B2

公开(公告)日：2012-07-17

申请号：US11638254

申请日：2006-12-13

申请人： Reuben Gobezie ,  David M. Lee

发明人： Reuben Gobezie ,  David M. Lee

IPC分类号： G01N33/48 ,  C12Q1/68 ,  G06F7/60 ,  G06G7/58

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/105

摘要： The present invention relates to the identification and use of protein expression profiles with clinical relevance to osteoarthritis (OA). In particular, the invention provides the identity of marker proteins whose expressions are correlated with OA, OA subtype, and/or OA progression. Methods and kits are described for using these protein expression profiles in the study and/or diagnosis of OA, in the determination of the degree of advancement of OA, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that modulate expression of these proteins or nucleic acid molecules encoding these proteins, in particular for the development of disease-modifying OA agents.

摘要翻译： 本发明涉及与骨关节炎（OA）临床相关的蛋白质表达谱的鉴定和应用。 特别地，本发明提供其表达与OA，OA亚型和/或OA进展相关的标记蛋白的身份。 描述了在研究和/或诊断OA中使用这些蛋白质表达谱的方法和试剂盒，以确定OA的进展程度，以及在治疗方案的选择和/或监测中。 本发明还涉及调节这些蛋白质或编码这些蛋白质的核酸分子的表达的药物的筛选，特别是用于发展改变疾病的OA剂。

公开(公告)号：US08073530B2

公开(公告)日：2011-12-06

申请号：US12749312

申请日：2010-03-29

申请人： Matthew S. Solar ,  Thomas L. Bridges ,  David M. Lee ,  Mark S. Freas

发明人： Matthew S. Solar ,  Thomas L. Bridges ,  David M. Lee ,  Mark S. Freas

IPC分类号： A61B5/05

CPC分类号： A61B34/20 ,  A61B34/10 ,  A61B90/39 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/207 ,  A61B2034/2072 ,  A61B2090/0801 ,  A61B2090/363 ,  A61B2090/3916 ,  A61B2090/3937 ,  A61B2090/3954 ,  A61B2090/397 ,  A61B2090/3983 ,  A61B2090/3987 ,  A61B2090/3995

摘要： This document discusses, among other things, fiducial marker devices, tools, and methods. One example illustrates a combined imagable fiducial locator and divot for receiving a positioning wand of an image-guided surgical (IGS) workstation. A further example is reflective such that it is locatable by a remote detector of an optical positioning system. A generally cylindrical (e.g., faceted cylindrical) columnar locator permits easy application of reflective tape. Other examples discusses a unitary fiducial marker with multiple divots and a swiveling and/or tilted fiducial marker divot, each of which allows manipulation of a positioning wand into a remote camera's field of view. Another example includes at least one reflector that can be aimed. A further example discusses an imagable fiducial marker carrier that is attachable to a single location on a patient's skull to reduce trauma. A keying arrangement fixedly defines the orientation of the carrier, allowing detachment and reattachment in the same orientation.

摘要翻译： 本文件除其他外，讨论了基准标记设备，工具和方法。 一个示例示出了用于接收图像引导手术（IGS）工作站的定位棒的组合的可成像的基准定位器和纹章。 另一示例是反射性的，使得其可由光学定位系统的远程检测器定位。 通常为圆柱形（例如，小圆柱形）柱状定位器允许容易地使用反射带。 其他例子讨论了具有多个纹理的单一基准标记和一个旋转和/或倾斜的基准标记物，每个都可以将定位棒操纵到远程摄像机的视场。 另一示例包括可以瞄准的至少一个反射器。 另一个例子讨论了一个可以成像的基准标记载体，其可以附着到患者​​头骨上的单个位置以减少创伤。 键合装置固定地限定载体的取向，允许在相同取向上的分离和再附着。

公开(公告)号：US20110188784A1

公开(公告)日：2011-08-04

申请号：US13017437

申请日：2011-01-31

申请人： Frank William DENOME ,  Steven G. Friedrich ,  Regine Labeque ,  David M. Lee ,  Jichun Shi ,  Andrew P. Verrall ,  Roxane Rosmaninho

发明人： Frank William DENOME ,  Steven G. Friedrich ,  Regine Labeque ,  David M. Lee ,  Jichun Shi ,  Andrew P. Verrall ,  Roxane Rosmaninho

IPC分类号： B65D30/02 ,  B65D30/22

CPC分类号： C08L29/04 ,  B65D65/46 ,  C08J5/18 ,  C08J2329/04 ,  C08L2203/16 ,  C08L2205/025 ,  C11D17/042 ,  C11D17/045 ,  Y10T428/1334 ,  Y10T428/1341 ,  Y10T428/1345

摘要： Disclosed are plasticized, water-soluble films having favorable cold-water solubility, wet handling, and thermoforming characteristics, and which can include a PVOH resin made up of blend of two or more PVOH polymers each having a monomodal molecular weight distribution, and the PVOH resin characterized by a viscosity in a range of about 13.5 cP to about 20 cP (or a corresponding weight average molecular weight), a degree of hydrolysis of about 84% to about 92%, a polydispersity index value in a range of about 1 to about 5, a residual water content of about 4 wt. % to about 10 wt. %, and a Resin Selection Index value in a range of 0.255 to 0.315; methods of making the films; compositions including PVOH resins for making the films; and pouch and packet articles made from the films.

公开(公告)号：US20110186467A1

公开(公告)日：2011-08-04

申请号：US13016621

申请日：2011-01-28

申请人： Frank W. Denome ,  Steven G. Friedrich ,  Regine Labeque ,  David M. Lee ,  Roxane Rosmaninho ,  Jichun Shi ,  Andrew P. Verrall

发明人： Frank W. Denome ,  Steven G. Friedrich ,  Regine Labeque ,  David M. Lee ,  Roxane Rosmaninho ,  Jichun Shi ,  Andrew P. Verrall

IPC分类号： B65D85/00 ,  C08L29/04 ,  C08K5/053

CPC分类号： C08L29/04 ,  B65D65/46 ,  C08J5/18 ,  C08J2329/04 ,  C08L2203/16 ,  C08L2205/025 ,  C11D17/042 ,  C11D17/045 ,  Y10T428/1334 ,  Y10T428/1341 ,  Y10T428/1345

摘要： Disclosed is a pouch having at least one sealed compartment containing a first composition. At least one wall of the at least one sealed compartment is made from a water-soluble film having any suitable thickness. The water-soluble film comprises PVOH polymer such that when the film has a thickness of about 76 microns the film is characterized by a Dissolution Index of about 620 to about 920, or of about 665 to about 920, or about 710 to about 920; and a Stress Index of about 145 to about 626, or about 155 to about 480, or about 165 to about 325.

摘要翻译： 公开了一种具有至少一个包含第一组合物的密封隔室的袋。 至少一个密封隔室的至少一个壁由具有任何合适厚度的水溶性薄膜制成。 该水溶性膜包含PVOH聚合物，使得当该膜的厚度为约76微米时，该膜的特征在于溶解指数为约620至约920，或约665至约920，或约710至约920; 和约145至约626，或约155至约480，或约165至约325的应力指数。

公开(公告)号：US20090162516A1

公开(公告)日：2009-06-25

申请号：US12332561

申请日：2008-12-11

申请人： Solomon E. Brown ,  David M. Lee

发明人： Solomon E. Brown ,  David M. Lee

IPC分类号： A23G3/50 ,  A23L1/05

CPC分类号： C08L1/286 ,  C08L5/00 ,  C08L2666/26

摘要： An improvement in water-soluble polysaccharide films, such as pullulan films, by inclusion of carboxymethylcellulose (CMC) in the film is disclosed herein. The films exhibit surprisingly improved physical properties such as tear strength, and retain good water-solubility. The films optionally include other additives such as gelatin, plasticizers, and surfactants. Methods of making the films include first dissolving the polysaccharide polymer, such as pullulan, in water, heating the solution, next admixing gelatin, then CMC, and then optional ingredients including plasticizers and more water if desired.

摘要翻译： 本文公开了通过将羧甲基纤维素（CMC）包含在膜中的水溶性多糖膜，例如支链淀粉膜的改进。 这些膜表现出惊人的物理性能如撕裂强度，并保持良好的水溶性。 膜任选地包括其它添加剂，例如明胶，增塑剂和表面活性剂。 制备膜的方法包括首先将多糖聚合物如支链淀粉溶解在水中，加热溶液，然后混合明胶，然后将CMC，然后任选的成分，包括增塑剂和更多的水，如果需要的话。

公开(公告)号：US07536473B2

公开(公告)日：2009-05-19

申请号：US10227601

申请日：2002-08-23

申请人： Jasmin Ajanovic ,  David Harriman ,  Blaise Fanning ,  David M. Lee

发明人： Jasmin Ajanovic ,  David Harriman ,  Blaise Fanning ,  David M. Lee

IPC分类号： G06F15/16

CPC分类号： H04L47/10 ,  G06F5/06 ,  G06F13/124 ,  G06F13/385 ,  G06F13/4059 ,  G06F13/42 ,  G06F13/4221 ,  G06F13/4252 ,  G06F13/4265 ,  G06F13/4269 ,  G06F13/4282 ,  H04L47/30

摘要： An enhanced general input/output communication architecture, protocol and related methods are presented.

摘要翻译： 提出了一种增强的通用输入/输出通信架构，协议和相关方法。

公开(公告)号：US06977381B2

公开(公告)日：2005-12-20

申请号：US10451860

申请日：2003-01-29

申请人： Harry K. Charles, Jr. ,  Arthur S. Francomacaro ,  Allen C. Keeney ,  David M. Lee ,  Timothy J. Cornish

发明人： Harry K. Charles, Jr. ,  Arthur S. Francomacaro ,  Allen C. Keeney ,  David M. Lee ,  Timothy J. Cornish

IPC分类号： H01F7/06 ,  H01J1/46 ,  H01J9/12 ,  H01J37/147 ,  H01J49/06 ,  H01J49/40 ,  H04R17/00 ,  H05K3/06

CPC分类号： H01J49/061 ,  H01J37/147 ,  H01J49/06 ,  H01J49/40 ,  H01J2237/151 ,  H04R17/00 ,  Y10T29/4902 ,  Y10T29/49117 ,  Y10T29/49155

摘要： A gating grid for deflecting ions includes an insulating substrate (16), a conducting layer (28) adhered to the insulating substrate (16), and interdigitated electrodes (14) patterned in the conducting layer by a photolithographic process. A hole (18) in the insulating substrate beneath the interdigitated electrodes allows ions to pass through the hole in the substrate. A process for making a gating grid for deflecting ions includes adhering a conducting layer (28) to an insulating substrate (16), forming interdigitated electrodes (14) on the conducting layer (28), and then forming a hole (18) in the insulating substrate beneath the interdigitated electrodes.

摘要翻译： 用于偏转离子的选通栅格包括绝缘衬底（16），粘附到绝缘衬底（16）的导电层（28）和通过光刻工艺在导电层中图案化的交错电极（14）。 在交叉电极下方的绝缘基板中的孔（18）允许离子穿过衬底中的孔。 制造用于偏转离子的选通栅格的方法包括将导电层（28）粘附到绝缘基板（16）上，在导电层（28）上形成交错电极（14），然后在导电层（28）中形成孔 绝缘衬底在交叉电极下面。