摘要:
The invention is directed to novel CDRs and immunoglobulin products that bind to A33 antigens and methods for their use. The invention also involves a method for making humanized antibodies, using a rabbit as a host animal, and phage display library methodologies, and the antibodies themselves. The methodology is useful, for example, in generating humanized antibodies against molecules associated with cancer, such as A33, which is associated with colon cancer.
摘要:
This invention relates to methods of reducing the effects of colon cancer tumors. Various agents are conjugated to monoclonal antibodies which are specific for colon cancer cells. The conjugates are administered to patients having colon cancer such that the effects of the cancer are reduced.
摘要:
A filter material forming a filter layer consisting substantially exclusively of celluloses and cellulose derivatives. In addition to cellulose acetate fibers, the filter layer contains, in the form of additives, microcrystalline cellulose and microfine cellulose, or else microcrystalline cellulose only. The amount of microcrystalline cellulose can be as high as 70% of the weight of the filter layer and that of microfine cellulose up to 50% of the weight of the filter layer. Cellulose acetate fibers can be excluded if in their place, microcrystalline cellulose having particle sizes less than 10 .mu.m. are used. The manufacturing method provides for cellulose acetate fibers to be first mixed in a wet state with microfine cellulose and microcrystalline cellulose, after which differently prepared celluloses are admixed. The mash formed by mixing is formed into a fleece by means of a known felting method, and the fleece is subsequently dried. With layers of the filter material, filtration efficiencies up to and including a sterilizing range are achieved, which renders them comparable to known kieselguhr layers.
摘要:
A flexible fleece-like filter material is provided wherein in a matrix-like basic framework consisting of synthetic or natural fibres, ultra-finely fibrillated fibres and/or inert porous particles are incorporated as a filter medium, the filter medium forming, anchored in the matrix, chain structures provided with a cationic or anionic charge or possibly charged with other substances which influence the filtering properties or with immobilised cells and/or catalysts. A fleece is formed with a thickness of between 0.5 mm and 5 mm and preferably up to 2 mm, which is flexible and which can even be pleated. This filter material can be produced by a simple method without harming the environment.
摘要:
In a filter bed (11) for the solid/fluid separation of media which contain substances that attack or dissolve cellulose, for example cellulase-containing enzymes, a matrix comprising a fibrous material structure of polyolefin fibrid particles (12) which are matted and anchored in one another and which can additionally contain up to 20% by weight of narrower fibrid polyolefin fibres and/or polyolefin fibres that have a fibre length of up to 5 mm. and have just started to fibrillate, in order to strengthen the sheet formation of the matrix. The actual filter-active particles, in particular kieselguhr particles and/or perlite particles having grain sizes of 5 to 100 um., are embedded in the cellulose-free fiber matrix.
摘要:
A system and method for modeling properties of data and events of a business application is presented. The system include a user interface frontend system that displays a user interface, and a user interface backend system that hosts a business application that generates the user interface for display in the user interface frontend system. The system further includes an enterprise service framework comprising one or more data processors that define one or more properties of data and/or events related to the business application, and model each of the one or more properties as a data field of the business application. A dynamic properties calculator includes one or more data processors that access a set of transformation logic representing data transformation rules for each of the data fields of the business application, and apply the transformation rules to the data fields that represent the one or more properties.
摘要:
Methods and systems consistent with the present invention provide a data processing system having a business object model reflecting the data used during a business transaction. Consistent interfaces are generated from the business object model. These interfaces are suitable for use across industries, across businesses, and across different departments within a business during a business transaction.
摘要:
The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要:
There are disclosed compound of formula I, in which R1 represents a hydrophobic moiety adapted to occupy the C′ channel of human CDId, R2 represents a hydrophobic moiety adapted to occupy the A′ channel of human CDId, such that R1 fills at least at least 30% of the occupied volume of the C′ channel compared to the volume occupied by the terminal nC14H29 of the sphingosine chain of α-galactosylceramide when bound to human CDId and R2 fills at least 30% of the occupied volume of the A′ channel compared to the volume occupied by the terminal nC25H51 of the acyl chain of α-galactosylceramide when bound to human CDId R3 represents hydrogen or OH, Ra and Rb each represent hydrogen and in addition, when R3 represents hydrogen, Ra and Rb together may form a single bond, X represents or —CHA(CHOH)nY or —P(=0)(0−)0CH2(CH0H)mY, in which Y represents CHB1B2, n represents an integer from 1 to 4, m represents 0 or 1, A årepresents hydrogen, one of B1 and B2 represents H, OH or phenyl, and the other represents hydrogen or one of B1 and B2 represents hydroxyl and the other represents phenyl, in addition, when n represents 4, then A together with one of B1 and B2 together forms a single bond and the other of B1 and B2 represents H, OH or OSO3H and pharmaceutically acceptable salts thereof; the compounds of formula I are indicted for use in the treatment of a virus, microbial infection, parasite, an autoimmune disease, cancer, allergy or asthma.