利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

105 条记录 (耗时 0.038 秒)

    Methods and apparatus for in situ formation of hydrogels
    51.
    发明授权
    Methods and apparatus for in situ formation of hydrogels 有权
    水凝胶原位形成方法和装置

    公开(公告)号：US06179862B2

    公开(公告)日：2001-01-30

    申请号：US09134198

    申请日：1998-08-14

    申请人： Amarpreet S. Sawhney

    发明人： Amarpreet S. Sawhney

    IPC分类号： A61B1704

    CPC分类号： A61M35/00 ,  A61B17/00491 ,  A61B2017/00495 ,  A61M25/0071

    摘要： Methods and apparatus of forming in situ tissue adherent barriers are provided using a sprayer capable of applying two or more viscous crosslinkable components to tissue. The sprayer comprises separate spray nozzles for each of two or more crosslinkable solutions, with each nozzle surrounded by an annular gas flow outlet. Crosslinkable solutions are stored in separate compartments and communicated under pressure to the spray nozzles. In the presence of gas flow through the annular gas flow outlets, the crosslinkable solutions are atomized and mixed in the gas flow to form a spray. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.

    摘要翻译： 使用能够向组织施加两种或更多种粘性可交联组分的喷雾器来提供形成原位组织粘附屏障的方法和装置。 喷雾器包括用于两个或更多个可交联溶液中的每一个的单独的喷嘴，每个喷嘴由环形气流出口包围。 可交联溶液储存在独立的隔间中，并在压力下与喷嘴相通。 在存在通过环形气流出口的气流的情况下，将可交联溶液雾化并在气流中混合形成喷雾。 还描述了适用于本发明方法和装置的多组分水凝胶体系。

    Drug delivery through hydrogel plugs
    57.
    发明授权
    Drug delivery through hydrogel plugs 有权
    通过水凝胶塞送药

    公开(公告)号：US08409606B2

    公开(公告)日：2013-04-02

    申请号：US12704692

    申请日：2010-02-12

    申请人： Amarpreet S. Sawhney ,  Peter Jarrett ,  Michael Bassett ,  Charles Blizzard

    发明人： Amarpreet S. Sawhney ,  Peter Jarrett ,  Michael Bassett ,  Charles Blizzard

    IPC分类号： A61F2/00 ,  B29B9/06 ,  A01N43/42 ,  A01N37/08 ,  A61K31/44 ,  A61K31/215

    CPC分类号： A61K9/0051 ,  A61B17/12099 ,  A61B17/12159 ,  A61B17/1219 ,  A61F9/00772 ,  A61F2250/0067 ,  A61K31/135 ,  A61K31/437

    摘要： An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.

    摘要翻译： 一个实施方案是用于阻断或减少穿过人眼的泪点或泪管的泪液的药物假体，并将药物递送到眼睛，该药物包括脱水的共价交联的合成亲水性聚合物水凝胶，其尺寸通过泪点，脱水 水凝胶吸收生理水以横截面宽度膨胀至至少1mm，并且顺应地配合小孔，其中水凝胶包含分散在水凝胶中的治疗剂以释放至眼睛，水凝胶的水含量至少约为 当在生理盐水中体外充分水合时，其重量为50％或体积。

    Radioopaque covalently crosslinked hydrogel particle implants
    58.
    发明授权
    Radioopaque covalently crosslinked hydrogel particle implants 有权
    不透射线共价交联水凝胶颗粒植入物

    公开(公告)号：US08383161B2

    公开(公告)日：2013-02-26

    申请号：US12968527

    申请日：2010-12-15

    申请人： Patrick Campbell ,  Amarpreet S. Sawhney

    发明人： Patrick Campbell ,  Amarpreet S. Sawhney

    IPC分类号： A61K9/50

    CPC分类号： A61K49/0442 ,  A61K49/0419 ,  A61K51/1244 ,  A61K2123/00 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  A61L31/145 ,  A61L31/148 ,  A61L31/18

    摘要： A pharmaceutically acceptable implant system comprising a collection of pharmaceutically acceptable, covalently-crosslinked hydrogel particles having a radioopaque agent covalently attached to a plurality of the particles in the collection, with the radioopaque agent being present in the collection at a concentration of at least about 0.1% w/w. The implantable materials may be used, for instance, in an iatrogenic site and for fiducial marking.

    摘要翻译： 药学上可接受的植入物系统，其包含药学上可接受的，共价交联的水凝胶颗粒的集合，所述水凝胶颗粒具有共价附着到所述收集物中的多个颗粒的放射性不透性试剂，所述放射性斑块剂以至少约0.1的浓度存在于所述收集物中 ％w / w。 可植入材料可用于例如医源性部位和基准标记。

    Biocompatible hydrogels made with small molecule precursors
    59.
    发明授权
    Biocompatible hydrogels made with small molecule precursors 有权
    用小分子前体制备的生物相容性水凝胶

    公开(公告)号：US08003705B2

    公开(公告)日：2011-08-23

    申请号：US12156085

    申请日：2008-05-29

    申请人： Amarpreet S. Sawhney ,  Steven Bennett ,  Peter G. Edelman

    发明人： Amarpreet S. Sawhney ,  Steven Bennett ,  Peter G. Edelman

    IPC分类号： A61K47/30 ,  A61K47/32 ,  A61K47/34

    CPC分类号： A61K47/42 ,  A61K9/0014 ,  A61K9/0019 ,  A61L27/52 ,  A61L27/58 ,  A61L31/145 ,  A61L31/148 ,  C07K14/75 ,  C08L89/00 ,  C08L2666/02

    摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable, or not, are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers. Embodiments that include hydrogels having isolated hydrolytically degradable esters are set forth. Embodiments including the use of low molecular weight amines to make degradable hydrogels are also set forth.

    摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子和亲核官能团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解的方法也可以提供，以及用于控制降解速率的方法。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。 可交联剂可以与交联聚合物一起包含。 阐述包括具有分离的水解可降解酯的水凝胶的实施方案。 还阐述了包括使用低分子量胺来制备可降解水凝胶的实施方案。