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51.发明授权Uniform surfaces for hybrid material substrates and methods for making and using same 有权混合材料基材的均匀表面及其制造和使用方法公开(公告)号：US07931867B2
公开(公告)日：2011-04-26
申请号：US11981638
申请日：2007-10-31
Applicant: Jonas Korlach
Inventor： Jonas Korlach
IPC: G01N21/64
CPC classification number: G01N21/0303 , B01J2219/00317 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00635 , B01J2219/00637 , B01J2219/00722 , B01L3/5088 , G01N21/6452 , G01N21/648 , G01N21/7703 , Y10T428/24942 , Y10T428/24967 , Y10T428/31612
Abstract: Devices, systems and methods of using same where hybrid substrate materials are provided with a substantially uniform surface to provide uniformity of properties, including interaction with their environments. Uniform surfaces are applied as coatings over, e.g., hybrid metal/silica, metal/polymer, metal/metal surfaces to mask different chemical properties of differing regions of the surface and to afford a protective surface for the hybrid structure.
Abstract translation: 使用相同的装置，系统和方法，其中混合基板材料具有基本均匀的表面，以提供特性的均匀性，包括与其环境的相互作用。 均匀的表面作为涂层涂覆在例如混合金属/二氧化硅，金属/聚合物，金属/金属表面上以掩盖表面的不同区域的不同化学性质，并提供混合结构的保护表面。
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公开(公告)号：US07906284B2
公开(公告)日：2011-03-15
申请号：US11925607
申请日：2007-10-26
Applicant: Stephen Turner , Jonas Korlach
Inventor： Stephen Turner , Jonas Korlach
IPC: C12Q1/68
CPC classification number: G01N21/77 , C12Q1/6806 , C12Q1/6869 , G01N21/00 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N2021/6439 , G01N2021/6463 , G01N2021/7786 , G01N2201/06113
Abstract: The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.
Abstract translation: 本发明涉及光学限制，其制备方法和使用它们分析分子和/或监测化学反应的方法。 本发明中体现的装置和方法对于高通量和低成本的单分子分析特别有用。
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公开(公告)号：US20100221716A1
公开(公告)日：2010-09-02
申请号：US12635618
申请日：2009-12-10
Applicant: Benjamin Flusberg , Stephen Turner , Jessica Lee , Lei Jia , Jonas Korlach , Jon Sorenson , Dale Webster , John Lyle , Kevin Travers , Jeremiah Hanes
Inventor： Benjamin Flusberg , Stephen Turner , Jessica Lee , Lei Jia , Jonas Korlach , Jon Sorenson , Dale Webster , John Lyle , Kevin Travers , Jeremiah Hanes
IPC: C12Q1/68
CPC classification number: C12Q1/6869 , C12Q1/6837 , C12Q1/6858 , C12Q2561/113 , C12Q2537/164 , C12Q2527/113 , C12Q2521/101 , C12Q2525/307 , C12Q2525/117
Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
Abstract translation: 提供了方法，组合物和系统用于表征修饰的核酸。 在某些优选实施方案中，提供单分子测序方法用于鉴定核酸序列内的修饰的核苷酸。 通过本文提供的方法可检测的修饰物包括化学修饰的碱基，酶修饰的碱基，脱碱基位点，非天然碱基，二级结构和与模板核酸结合的试剂。
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公开(公告)号：US20080241866A1
公开(公告)日：2008-10-02
申请号：US12079944
申请日：2008-03-27
Applicant: Jonas Korlach , Kevan Samiee , Stephen W. Turner , Jake Freudenthal
Inventor： Jonas Korlach , Kevan Samiee , Stephen W. Turner , Jake Freudenthal
IPC: C12Q1/66 , C12Q1/00 , C12Q1/48 , C12Q1/37 , C07H21/00 , G01N21/64 , C12M1/00 , C12Q1/34 , C12Q1/42
CPC classification number: G01N21/6452 , G01N21/648
Abstract: Composition, systems, apparatus and methods of enhancing fluorescent signals in biochemical are described. Metal particle proximity to enzymes that produce fluorescent products provide enhanced fluorescence of the product and plasmon resonance of the metal particle. Multi-labeled nucleotides enhance signal production. Reflectance of illumination light and emitted fluorescence increase signal strength for a given illumination light.
Abstract translation: 描述了增强生物化学荧光信号的组成，系统，装置和方法。 与产生荧光产物的酶接近的金属颗粒提供产物的增强的荧光和金属颗粒的等离子体共振。 多标记核苷酸增强信号产生。 照明光的反射和发出的荧光增加给定照明光的信号强度。
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公开(公告)号：US20080161194A1
公开(公告)日：2008-07-03
申请号：US11925650
申请日：2007-10-26
Applicant: Stephen Turner , Jonas Korlach
Inventor： Stephen Turner , Jonas Korlach
CPC classification number: G01N21/77 , C12Q1/6806 , C12Q1/6869 , G01N21/00 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N2021/6439 , G01N2021/6463 , G01N2021/7786 , G01N2201/06113
Abstract: The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.
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Patent Agency Ranking
公开(公告)号：US07292742B2
公开(公告)日：2007-11-06
申请号：US11670906
申请日：2007-02-02
Applicant: Michael J. Levene , Jonas Korlach , Stephen W. Turner , Harold G. Craighead , Watt W. Webb
Inventor： Michael J. Levene , Jonas Korlach , Stephen W. Turner , Harold G. Craighead , Watt W. Webb
CPC classification number: C12Q1/25 , C12Q1/6825 , G01N21/47 , G01N21/6408 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/65 , G01N33/54373 , G01N2333/9015 , G01Q60/22 , G02B6/10 , G02B6/241
Abstract: The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode wave guide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.
Abstract translation: 本发明涉及用于分析分析物的方法和装置。 该方法包括提供零模式波导，该零模式波导包括围绕芯的包层，其中覆层被配置为阻止频率小于截止频率的电磁能量沿纵向穿过零模式波导的芯的传播。 分析物位于零模式波导的核心中，然后在零模式波导的核心中经受有效允许分析的条件下激活小于截止频率的频率的电磁辐射 分析物在有效观察体积中比如果在没有零模式波导的情况下进行分析时更紧凑。
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57.发明申请Methods, systems and compositions for monitoring enzyme activity and applications thereof 有权用于监测酶活性的方法，系统和组合物及其应用公开(公告)号：US20070231804A1
公开(公告)日：2007-10-04
申请号：US11394637
申请日：2006-03-31
Applicant: Jonas Korlach , Stephen Turner
Inventor： Jonas Korlach , Stephen Turner
CPC classification number: C12Q1/66 , C12Q1/42 , G01N33/573
Abstract: Methods of monitoring enzyme mediated reactions, and particularly nucleic acid synthesis reactions such as pyrosequencing methods that employ enzymatic reporter systems. The methods and systems provide elevated signal levels as compared to conventional pyrosequencing processes, and/or mediate de-phasing of sequencing analyses employing pyrosequencing or other “sequencing by synthesis” methods.
Abstract translation: 监测酶介导的反应的方法，特别是使用酶报告系统的核酸合成反应，如焦磷酸测序方法。 与常规焦磷酸测序方法相比，该方法和系统提供升高的信号水平，和/或介导使用焦磷酸测序或其他“合成测序”方法的测序分析的脱相。
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公开(公告)号：US20070206189A1
公开(公告)日：2007-09-06
申请号：US11626610
申请日：2007-01-24
Applicant: Stephen Turner , Jonas Korlach
Inventor： Stephen Turner , Jonas Korlach
CPC classification number: G01N21/77 , C12Q1/6806 , C12Q1/6869 , G01N21/00 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N2021/6439 , G01N2021/6463 , G01N2021/7786 , G01N2201/06113
Abstract: The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughout and low-cost single-molecular analysis.
Abstract translation: 本发明涉及光学限制，其制备方法和使用它们分析分子和/或监测化学反应的方法。 本发明中体现的装置和方法对于高整体和低成本的单分子分析特别有用。
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公开(公告)号：US20070141598A1
公开(公告)日：2007-06-21
申请号：US11556621
申请日：2006-11-03
Applicant: Stephen Turner , Jonas Korlach , Alex DeWinter
Inventor： Stephen Turner , Jonas Korlach , Alex DeWinter
CPC classification number: C12P19/34 , C12Q1/6806 , C12Q1/6813 , C12Q1/6869 , C12Q2521/319 , C12Q2533/101 , C12Q2521/101 , C12Q2527/127
Abstract: The present invention relates to preparation of nucleotide compositions and uses thereof for conducting nucleic acid analyses. The compositions and methods embodied in the present invention are particularly useful for nucleic acid analyses that require high-resolution detection of labeled nucleotides or labeled nucleic acid targets.
Abstract translation: 本发明涉及核苷酸组合物的制备及其用于进行核酸分析的用途。 本发明中体现的组合物和方法对于需要高分辨率检测标记的核苷酸或标记的核酸靶标的核酸分析特别有用。
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60.发明申请Zero-mode metal clad waveguides for performing spectroscopy with confined effective observation volumes 有权零模式金属包层波导用于执行限制有效观察体积的光谱公开(公告)号：US20070134716A1
公开(公告)日：2007-06-14
申请号：US11670906
申请日：2007-02-02
Applicant: Michael Levene , Jonas Korlach , Stephen Turner , Harold Craighead , Watt Webb
Inventor： Michael Levene , Jonas Korlach , Stephen Turner , Harold Craighead , Watt Webb
CPC classification number: C12Q1/25 , C12Q1/6825 , G01N21/47 , G01N21/6408 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/65 , G01N33/54373 , G01N2333/9015 , G01Q60/22 , G02B6/10 , G02B6/241
Abstract: The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode wave guide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.
Abstract translation: 本发明涉及用于分析分析物的方法和装置。 该方法包括提供零模式波导，该零模式波导包括围绕芯的包层，其中覆层被配置为阻止频率小于截止频率的电磁能量沿纵向穿过零模式波导的芯的传播。 分析物位于零模式波导的核心中，然后在零模式波导的核心中经受有效允许分析的条件下激活小于截止频率的频率的电磁辐射 分析物在有效观察体积中比如果在没有零模式波导的情况下进行分析时更紧凑。
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