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公开(公告)号：US09063156B2
公开(公告)日：2015-06-23
申请号：US12814075
申请日：2010-06-11
Applicant: Jonas Korlach , Stephen Turner , Benjamin Flusberg , Mark Chaisson , Eric Schadt , Jeffrey Wegener
Inventor： Jonas Korlach , Stephen Turner , Benjamin Flusberg , Mark Chaisson , Eric Schadt , Jeffrey Wegener
IPC: C12Q1/68 , G01N33/53 , G01N33/68 , G01N33/542 , G01N33/543
CPC classification number: G01N33/68 , C12Q1/6825 , C12Q1/6827 , C12Q1/6869 , G01N33/542 , G01N33/54306 , G01N33/54373 , G01N33/582 , G01N33/6875 , G01N2333/705 , G01N2458/10 , C12Q2563/107 , C12Q2522/101 , C12Q2561/113 , C12Q2537/164 , C12Q2523/125
Abstract: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions, and for determining various characteristics of the different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to stimulate, enhance, or inhibit such reactions.
Abstract translation: 本发明一般涉及用于进行各种不同生物反应的单分子实时分析以及用于确定不同生物反应的各种特征的组合物，方法和系统。 分析这些反应的能力提供研究这些反应的机会，并且潜在地鉴定影响这些反应的因素和/或方法，例如刺激，增强或抑制这些反应。
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2.发明授权Substrates and optical system having at least one optical waveguide, at least one nanometer-scale aperture and at least one lens array and methods of use thereof 有权具有至少一个光波导，至少一个纳米尺度孔径和至少一个透镜阵列的基板和光学系统及其使用方法公开(公告)号：US08274040B2
公开(公告)日：2012-09-25
申请号：US13274547
申请日：2011-10-17
Applicant: Cheng Frank Zhong , Paul Lundquist , Mathieu Foquet , Jonas Korlach , Hovig Bayandorian
Inventor： Cheng Frank Zhong , Paul Lundquist , Mathieu Foquet , Jonas Korlach , Hovig Bayandorian
IPC: H01J5/02
CPC classification number: C12Q1/6874 , C12Q1/68 , C12Q1/6825 , G01N21/6428 , G01N21/648 , G01N21/7703 , G01N33/54373 , G01N2021/6463 , G01N2201/06113 , G01N2201/0638 , G01N2201/08
Abstract: This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
Abstract translation: 本发明提供用于各种应用的底物，包括单分子分析反应。 提供了在基板内传播光能的方法。 提供了包括波导基板和电介质全向反射器的装置。 提供了在阵列的分析检测区域内具有改善的一个或多个波导上的光能强度均匀性和增强的波导照明效率的波导基板。
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公开(公告)号：US08252910B2
公开(公告)日：2012-08-28
申请号：US12621352
申请日：2009-11-18
Applicant: Jonas Korlach , Jeffrey Wegener
Inventor： Jonas Korlach , Jeffrey Wegener
CPC classification number: C12Q1/6869 , C07H19/10 , C12Q1/6818 , C12Q1/6874 , G01N33/5308
Abstract: Nucleic acid compositions, methods of making and using such compositions that comprise modular functional groups that can be configured to provide desired functionality to different nucleotide types through a swappable and preferably non-covalent linkage component. Such compositions are useful in a variety of applications including nucleic acid analyses.
Abstract translation: 核酸组合物，制备和使用这样的组合物的方法，所述组合物包含模块化官能团，其可被配置为通过可交换且优选非共价连接组分为不同核苷酸类型提供所需功能。 这样的组合物可用于各种应用，包括核酸分析。
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4.发明授权Uniform surfaces for hybrid material substrate and methods for making and using same 有权混合材料基材的均匀表面及其制造和使用方法公开(公告)号：US07935310B2
公开(公告)日：2011-05-03
申请号：US11604543
申请日：2006-11-27
Applicant: Jonas Korlach
Inventor： Jonas Korlach
IPC: G01N21/00
CPC classification number: G01N21/0303 , B01J2219/00317 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00635 , B01J2219/00637 , B01J2219/00722 , B01L3/5088 , G01N21/6452 , G01N21/648 , G01N21/7703 , Y10T428/24942 , Y10T428/24967 , Y10T428/31612
Abstract: Devices, systems and methods of using same where hybrid substrate materials are provided with a substantially uniform surface to provide uniformity of properties, including interaction with their environments. Uniform surfaces are applied as coatings over, e.g., hybrid metal/silica, metal/polymer, metal/metal surfaces to mask different chemical properties of differing regions of the surface and to afford a protective surface for the hybrid structure.
Abstract translation: 使用相同的装置，系统和方法，其中混合基板材料具有基本均匀的表面，以提供特性的均匀性，包括与其环境的相互作用。 均匀的表面作为涂层涂覆在例如混合金属/二氧化硅，金属/聚合物，金属/金属表面上以掩盖表面的不同区域的不同化学性质，并提供混合结构的保护表面。
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公开(公告)号：US20100323912A1
公开(公告)日：2010-12-23
申请号：US12814075
申请日：2010-06-11
Applicant: Jonas Korlach , Stephen Turner , Benjamin Flusberg , Mark Chaisson , Eric Schadt , Jeffrey Wegener
Inventor： Jonas Korlach , Stephen Turner , Benjamin Flusberg , Mark Chaisson , Eric Schadt , Jeffrey Wegener
IPC: C40B30/04 , C12Q1/68 , G01N33/566 , C40B50/14
CPC classification number: G01N33/68 , C12Q1/6825 , C12Q1/6827 , C12Q1/6869 , G01N33/542 , G01N33/54306 , G01N33/54373 , G01N33/582 , G01N33/6875 , G01N2333/705 , G01N2458/10 , C12Q2563/107 , C12Q2522/101 , C12Q2561/113 , C12Q2537/164 , C12Q2523/125
Abstract: The present invention is generally directed to compositions, methods, and systems for performing single-molecule, real-time analysis of a variety of different biological reactions, and for determining various characteristics of the different biological reactions. The ability to analyze such reactions provides an opportunity to study those reactions as well as to potentially identify factors and/or approaches for impacting such reactions, e.g., to stimulate, enhance, or inhibit such reactions.
Abstract translation: 本发明一般涉及用于进行各种不同生物反应的单分子实时分析以及用于确定不同生物反应的各种特征的组合物，方法和系统。 分析这些反应的能力提供研究这些反应的机会，并且潜在地鉴定影响这些反应的因素和/或方法，例如刺激，增强或抑制这些反应。
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Patent Agency Ranking
公开(公告)号：US20100065726A1
公开(公告)日：2010-03-18
申请号：US12560308
申请日：2009-09-15
Applicant: CHENG FRANK ZHONG , Paul Lundquist , Mathieu Foquet , Jonas Korlach , Hovig Bayandorian
Inventor： CHENG FRANK ZHONG , Paul Lundquist , Mathieu Foquet , Jonas Korlach , Hovig Bayandorian
CPC classification number: C12Q1/6874 , C12Q1/68 , C12Q1/6825 , G01N21/6428 , G01N21/648 , G01N21/7703 , G01N33/54373 , G01N2021/6463 , G01N2201/06113 , G01N2201/0638 , G01N2201/08
Abstract: This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
Abstract translation: 本发明提供用于各种应用的底物，包括单分子分析反应。 提供了在基板内传播光能的方法。 提供了包括波导基板和电介质全向反射器的装置。 提供了在阵列的分析检测区域内具有改善的一个或多个波导上的光能强度均匀性和增强的波导照明效率的波导基板。
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公开(公告)号：US20100009872A1
公开(公告)日：2010-01-14
申请号：US12384097
申请日：2009-03-30
Applicant: John Eid , Stephen Turner , Ravi Dalal , Benjamin Flusberg , Jonas Korlach , Steven Lin , Adrian Fehr , Fred Christians , Robin Emig
Inventor： John Eid , Stephen Turner , Ravi Dalal , Benjamin Flusberg , Jonas Korlach , Steven Lin , Adrian Fehr , Fred Christians , Robin Emig
CPC classification number: B01J19/0046 , B01J2219/00596 , C12N2310/50 , C12N2310/51 , C12Q1/6869 , C12Q2535/122 , C40B40/06 , G01N33/54313 , G01N33/54366
Abstract: Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided.
Abstract translation: 提供了将单一分析物分子非随机加载到阵列结构中的方法，组合物和阵列。
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8.发明授权Methods, systems and compositions for monitoring enzyme activity and applications thereof 有权用于监测酶活性的方法，系统和组合物及其应用公开(公告)号：US07563574B2
公开(公告)日：2009-07-21
申请号：US11394637
申请日：2006-03-31
Applicant: Jonas Korlach , Stephen Turner
Inventor： Jonas Korlach , Stephen Turner
CPC classification number: C12Q1/66 , C12Q1/42 , G01N33/573
Abstract: Methods of monitoring enzyme mediated reactions, and particularly nucleic acid synthesis reactions such as pyrosequencing methods that employ enzymatic reporter systems. The methods and systems provide elevated signal levels as compared to conventional pyrosequencing processes, and/or mediate de-phasing of sequencing analyses employing pyrosequencing or other “sequencing by synthesis” methods.
Abstract translation: 监测酶介导的反应的方法，特别是使用酶报告系统的核酸合成反应，如焦磷酸测序方法。 与常规焦磷酸测序方法相比，该方法和系统提供升高的信号水平，和/或介导使用焦磷酸测序或其他“合成测序”方法的测序分析的脱相。
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公开(公告)号：US20080176769A1
公开(公告)日：2008-07-24
申请号：US11978171
申请日：2007-10-26
Applicant: David R. Rank , Jeffery Wegener , Jonas Korlach , Daniel Roitman , Yue Xu , John Lyle , Stephen Turner , Paul Peluso , Geoff Otto
Inventor： David R. Rank , Jeffery Wegener , Jonas Korlach , Daniel Roitman , Yue Xu , John Lyle , Stephen Turner , Paul Peluso , Geoff Otto
IPC: C40B80/00
CPC classification number: C12Q1/6874 , B01J19/0046 , B01J2219/00427 , B01J2219/0045 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y20/00 , B82Y30/00 , C12Q1/6837 , Y10T29/49002 , C12Q2565/629 , C12Q2527/127
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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公开(公告)号：US20080145278A1
公开(公告)日：2008-06-19
申请号：US11981638
申请日：2007-10-31
Applicant: Jonas Korlach
Inventor： Jonas Korlach
CPC classification number: G01N21/0303 , B01J2219/00317 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00635 , B01J2219/00637 , B01J2219/00722 , B01L3/5088 , G01N21/6452 , G01N21/648 , G01N21/7703 , Y10T428/24942 , Y10T428/24967 , Y10T428/31612
Abstract: Devices, systems and methods of using same where hybrid substrate materials are provided with a substantially uniform surface to provide uniformity of properties, including interaction with their environments. Uniform surfaces are applied as coatings over, e.g., hybrid metal/silica, metal/polymer, metal/metal surfaces to mask different chemical properties of differing regions of the surface and to afford a protective surface for the hybrid structure.
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