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公开(公告)号：US5225513A
公开(公告)日：1993-07-06
申请号：US742047
申请日：1991-08-08
IPC分类号： C07D295/15 , C08G18/10 , C08G18/18 , C08G18/20
CPC分类号： C07D295/15 , C08G18/10 , C08G18/1841 , C08G18/2081 , Y10T442/2738
摘要： Catalyzes methods and curable compositions involving amino-ester catalysts and isocyanate-functional materials. Also disclosed are casting articles and methods of orthopedic casting.
摘要翻译： 催化方法和涉及氨基酯催化剂和异氰酸酯官能材料的可固化组合物。 还公开了铸造制品和矫形方法。
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52.发明授权
公开(公告)号：US4713446A
公开(公告)日：1987-12-15
申请号：US890847
申请日：1986-08-06
CPC分类号： C07K14/78 , A61L27/24 , C08H1/06 , A61F2310/00365 , Y10S128/08 , Y10S514/801 , Y10S514/912
摘要： Chemically-modified collagen is prepared by reacting native collagen with a di or tri-carboxylic acid halide, di or tri-sulfonyl halide, di or tri-anhydride, or di or tri-reactive active ester coupling agent. The reaction is done in a controlled manner so that the degree of cross-linking is limited. Any remaining lysine epsilon amino groups present in the coupled collagen product may be converted to carboxyamido or sulfonamido groups by acid halide, anhydride, sulfonyl halide or active ester amine-modifying agents. The resultant product when dissolved in a physiological buffer provides a viscoelastic solution having therapeutic application in a variety of surgical procedures, particularly in ophthalmic surgery. This viscoelastic solution "melts," i.e., exhibits a dramatic loss of viscosity, when subjected to temperatures of between 32.degree. and 48.degree. C.
摘要翻译： 通过使天然胶原与二或三羧酸卤化物，二或三磺酰卤，二或三酐或二或三反应活性酯偶联剂反应来制备化学修饰的胶原蛋白。 反应以受控的方式进行，使得交联程度受到限制。 存在于偶联胶原产物中的任何残留的赖氨酸ε氨基可以通过酰卤，酸酐，磺酰卤或活性酯胺改性剂转化为羧酰胺基或亚磺酰氨基。 所得产物当溶解在生理缓冲液中时，提供了一种在各种外科手术中具有治疗应用的粘弹性溶液，特别是在眼科手术中。 这种粘弹性溶液在经受32至48℃的温度时“熔化”，即表现出显着的粘度损失。
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公开(公告)号：US09480760B2
公开(公告)日：2016-11-01
申请号：US13379573
申请日：2010-06-23
申请人： Maria A. Appeaning , Audrey A. Sherman , Michael A. Meis , Marie A. Boulos , Kevin D. Landgrebe , Kevin R. Schaffer , Matthew T. Scholz , Thu-Van T. Tran , Narina Y. Stepanova , Caroline M. Ylitalo
发明人： Maria A. Appeaning , Audrey A. Sherman , Michael A. Meis , Marie A. Boulos , Kevin D. Landgrebe , Kevin R. Schaffer , Matthew T. Scholz , Thu-Van T. Tran , Narina Y. Stepanova , Caroline M. Ylitalo
CPC分类号： A61L2/088
摘要： Light-activated antimicrobial devices and articles are disclosed. The devices include a light source and a light-activated antimicrobial article comprising a photosensitizer and a viscoelastic material such as a pressure sensitive adhesive adapted to receive light from the light source. The viscoelastic material may be adapted to transport light by total internal reflection. The photosensitizer may comprise a dye, a metal oxide or a composition that comprises anions that oxidize or react to form a gas. Upon activation of the light source, the photosensitizer absorbs light from the light source such that antimicrobial activity is exhibited. The photosensitizer may be included in the light-activated antimicrobial article or it may be provided as a topical composition that is separate from the article. The light-activated antimicrobial articles and devices may have constructions similar to those of wound dressings.
摘要翻译： 公开了光活化的抗微生物装置和制品。 所述装置包括光源和光活化的抗微生物制品，其包含光敏剂和粘弹性材料，例如适于接收来自光源的光的压敏粘合剂。 粘弹性材料可以适于通过全内反射传输光。 光敏剂可以包含染料，金属氧化物或包含氧化或反应形成气体的阴离子的组合物。 在光源激活时，光敏剂吸收光源的光，从而显示出抗微生物活性。 光敏剂可以包括在光激活的抗微生物制品中，或者它可以作为与制品分离的局部组合物提供。 光活化的抗菌制品和装置可以具有与伤口敷料相似的结构。
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公开(公告)号：US08991239B2
公开(公告)日：2015-03-31
申请号：US13571748
申请日：2012-08-10
CPC分类号： G01N1/38 , A61B10/0038 , A61B10/0096 , B01F11/0005 , B01F15/00837 , B01L3/502 , B01L2300/046 , B01L2300/0681 , G01N1/18 , G01N33/02 , G01N33/487 , G01N2001/4088 , Y10T436/25375 , Y10T436/25625
摘要： A system and method for preparing samples for analyte testing. The sample preparation system can include a freestanding receptacle. The method can include providing a liquid composition comprising a source and a diluent, and positioning the liquid composition in a reservoir defined by the freestanding receptacle. The method can further include filtering the liquid composition to form a filtrate comprising an analyte of interest, removing at least a portion of the filtrate from the sample preparation system to form a sample, and analyzing the sample for the analyte of interest.
摘要翻译： 用于制备分析物测试样品的系统和方法。 样品制备系统可以包括独立的容器。 该方法可以包括提供包含源和稀释剂的液体组合物，并将液体组合物定位在由独立容器限定的储存器中。 该方法还可以包括过滤液体组合物以形成包含感兴趣的分析物的滤液，从样品制备系统中除去至少一部分滤液以形成样品，并分析样品中感兴趣的分析物。
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公开(公告)号：US20150024019A1
公开(公告)日：2015-01-22
申请号：US13699345
申请日：2011-05-25
申请人： Mahfuza B. Ali , Naiyong Jing , Valeri Lirine , Pradnya V. Nagarkar , Caroline M. Ylitalo , Nancy S. Lennhoff , Matthew T. Scholz , Ranjani V. Parthasarathy
发明人： Mahfuza B. Ali , Naiyong Jing , Valeri Lirine , Pradnya V. Nagarkar , Caroline M. Ylitalo , Nancy S. Lennhoff , Matthew T. Scholz , Ranjani V. Parthasarathy
CPC分类号： C09D5/1637 , A61L29/085 , A61L29/16 , A61L2300/216 , A61L2300/404 , A61L2420/02 , B05D3/02 , B05D3/06 , C03C17/30 , C03C17/42 , C08F220/06 , C08F220/18 , C08F220/34 , C08F230/08 , C08G77/26 , C09D5/1675 , C09D5/1693 , C09D183/10 , G06F3/041 , G06F3/047 , Y10T428/31663
摘要： The disclosure provides polymers having antimicrobial activity and articles with the polymers coated thereon. The polymers include a first pendant group comprising a first cationic component, a second pendant group comprising a nonpolar component, and a third pendant group comprising an organosilane component. The disclosure also includes methods of coating medical device articles and body fluid-receiving substrates with the antimicrobial polymers. The methods further include the use of adhesion-promoting components.
摘要翻译： 本公开提供具有抗微生物活性的聚合物和其上涂覆有聚合物的制品。 聚合物包括包含第一阳离子组分的第一侧基，包含非极性组分的第二侧基和包含有机硅烷组分的第三侧基。 本公开还包括用抗微生物聚合物涂覆医疗器械制品和体液接收基底的方法。 所述方法还包括使用粘附促进组分。
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56.发明授权公开(公告)号：US08636993B2
公开(公告)日：2014-01-28
申请号：US11242314
申请日：2005-10-03
申请人： Matthew T. Scholz , Gilbert L. Eian , Ling Lu
发明人： Matthew T. Scholz , Gilbert L. Eian , Ling Lu
CPC分类号： A61K9/0014 , A01N59/12 , A61K8/06 , A61K8/064 , A61K8/8152 , A61K8/8158 , A61K8/8182 , A61K33/18 , A61K47/32 , A61K47/58 , A61Q19/00 , C08L33/06 , C08L33/066 , C08L33/14 , Y10S514/844 , Y10S514/845 , Y10S514/846 , Y10S514/847 , Y10S514/848 , Y10S514/938 , A01N25/10 , A01N25/04 , A01N2300/00
摘要： Water-in-oil emulsions, compositions, and methods that include a vinyl polymer having a pKa of less than 4 that includes anionic group-containing side chains and alkyl-Y-containing side chains, wherein Y is O or NR, wherein R is hydrogen or methyl, and wherein the alkyl group of the alkyl-Y-containing side chain has at least 4 carbon atoms on average in a cyclic, branched-, or straight-chain configuration and optionally including one or more heteroatoms.
摘要翻译： 包含pKa小于4的乙烯基聚合物的油包水乳液，组合物和方法，包括含阴离子基团侧链和含烷基Y的侧链，其中Y是O或NR，其中R是 氢或甲基，并且其中所述含烷基Y的侧链的烷基在环状，支化或直链构型中平均具有至少4个碳原子，并任选地包括一个或多个杂原子。
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公开(公告)号：US08617199B2
公开(公告)日：2013-12-31
申请号：US13119267
申请日：2009-09-30
IPC分类号： A61M29/00
CPC分类号： A61F5/08
摘要： The present invention discloses a nasal dilator comprising at least one breathable layer of adhesive-coated high MVTR layer, such as a polyurethane film, one or more adhesive-coated high modulus “spring” elements for dilating the nasal passages by applying a tension force to the skin, and a carrier delivery system. The carrier delivery system comprises a separation line or split through the carrier to allow for easy delivery of the nasal dilator. The carrier aids in the handling and delivery of the thin adhesive-coated high MVTR layer.
摘要翻译： 本发明公开了一种鼻扩张器，其包括粘合剂涂覆的高MVTR层的至少一个透气层，例如聚氨酯膜，一个或多个粘合剂涂覆的高模量“弹簧”元件，用于通过施加张力来扩张鼻通道 皮肤和载体输送系统。 载体递送系统包括分离线或通过载体分离以允许容易地递送鼻扩张器。 载体有助于处理和输送薄的涂有粘合剂的高MVTR层。
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公开(公告)号：US08476319B2
公开(公告)日：2013-07-02
申请号：US11908185
申请日：2006-03-10
IPC分类号： A61K31/23 , C07C69/533 , C07C69/58 , C07C69/28 , C07C69/30 , A61K31/225
CPC分类号： A61K31/20 , A61K31/045 , A61K31/075 , A61K31/19 , A61K31/215 , A61K31/23 , A61K31/231 , A61K2300/00
摘要： Methods of treating and/or preventing otitis media in a subject are provided. Methods of treating and/or preventing otitis externa are also provided.
摘要翻译： 提供了治疗和/或预防受试者中耳炎的方法。 还提供治疗和/或预防外耳炎的方法。
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公开(公告)号：US20120100039A1
公开(公告)日：2012-04-26
申请号：US13379573
申请日：2010-06-23
申请人： Maria A. Appeaning , Audrey A. Sherman , Michael A. Meis , Marie A. Boulos , Kevin D. Landgrebe , Kevin R. Schaffer , Matthew T. Scholz , Thu-Van T. Tran , Narina Y. Stepanova , Caroline M. Ylitalo
发明人： Maria A. Appeaning , Audrey A. Sherman , Michael A. Meis , Marie A. Boulos , Kevin D. Landgrebe , Kevin R. Schaffer , Matthew T. Scholz , Thu-Van T. Tran , Narina Y. Stepanova , Caroline M. Ylitalo
CPC分类号： A61L2/088
摘要： Light-activated antimicrobial devices and articles are disclosed. The devices include a light source and a light-activated antimicrobial article comprising a photosensitizer and a viscoelastic material such as a pressure sensitive adhesive adapted to receive light from the light source. The viscoelastic material may be adapted to transport light by total internal reflection. The photosensitizer may comprise a dye, a metal oxide or a composition that comprises anions that oxidize or react to form a gas. Upon activation of the light source, the photosensitizer absorbs light from the light source such that antimicrobial activity is exhibited. The photosensitizer may be included in the light-activated antimicrobial article or it may be provided as a topical composition that is separate from the article. The light-activated antimicrobial articles and devices may have constructions similar to those of wound dressings.
摘要翻译： 公开了光活化的抗微生物装置和制品。 所述装置包括光源和光活化的抗微生物制品，其包含光敏剂和粘弹性材料，例如适于接收来自光源的光的压敏粘合剂。 粘弹性材料可以适于通过全内反射传输光。 光敏剂可以包含染料，金属氧化物或包含氧化或反应形成气体的阴离子的组合物。 在光源激活时，光敏剂吸收光源的光，从而显示出抗微生物活性。 光敏剂可以包括在光激活的抗微生物制品中，或者它可以作为与制品分离的局部组合物提供。 光活化的抗菌制品和装置可以具有与伤口敷料相似的结构。
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公开(公告)号：US20120077886A1
公开(公告)日：2012-03-29
申请号：US13260589
申请日：2010-03-25
摘要： Melt additive ionic and non-ionic surfactants to impart stable durable hydrophilicity to thermoplastic polymers or blends thereof.
摘要翻译： 熔融添加剂离子和非离子表面活性剂，以赋予热塑性聚合物或其共混物稳定的持久亲水性。
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