摘要:
The present invention provides an electro-optic modulator and an optical communication system in which a wider signal electrode may be used without affecting the characteristic impedance of the device or the efficiency of the optical modulation. In embodiments of the invention, asymmetric coplanar electrodes are provided such that the gap between the signal electrode and one reference electrode may be optimized for the optical waveguide and the semiconductor section surrounding it, and the gap between the signal electrode and the other reference electrode may be optimized for a particular characteristic impedance.
摘要:
Compounds of Formula (I) wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要:
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要:
Provided is a method for separating two or more analytes in a fluid, which method comprises: (a) binding each different analyte to a different functional particle in one or more binding zones, to produce two or more bound analytes; (b) allowing the bound analytes to move through a separating conduit to two or more separate functional zones; wherein, each different functional particle has, or can be controlled to have, a different function in the fluid as compared with the other functional particles; and wherein the separating conduit separates into two or more functional conduits, such that the separating conduit serves to separate the bound analytes into the separate functional conduits by means of the different functions of the different functional particles. Also provided is an apparatus for separating two or more analytes in a fluid, which apparatus comprises: (a) a binding zone; (b) two or more functional conduits; (c) a separating conduit connecting the binding zone to the two or more functional conduits; (d) a transporter for transporting the analyte through the separating conduit from the binding zone to the two or more functional conduits; and (e) optionally one or more concentrating zones in connection with at least one of the functional conduits.
摘要:
Provided is a method for separating two or more analytes in a fluid, which method comprises: (a) binding each different analyte to a different particle in a binding zone, to produce two or more bound analytes; (b) allowing the bound analytes to move through a separating conduit to two or more separate functional conduits; wherein each different particle has, or can be controlled to have, a different buoyancy in the fluid as compared with the other particles; and wherein the separating conduit is in fluid communication with the two or more functional conduits, each functional conduit being situated at a different height from the other functional conduits; and each functional conduit containing a fluid having a different fluid density from the fluids in the other functional conduits such that each different particle when attached to an analyte has neutral buoyancy in at least one of the functional conduits, thereby allowing separation of the bound analytes by means of the neutral buoyancies of the different particles in the different functional conduits.
摘要:
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要:
Compounds of Formula (IA) and (IB) wherein R1, R2, R3, A, B, C, D, and E are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要:
A compound of Formula (IA) or Formula (IB) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要:
Compounds of Formula (IA) wherein R1, R2, R3, R4 and R5 are as defined herein for Formula (IA), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要:
A closure assembly for a mouth and neck portion of a container for liquid has a sleeve adapted to lie substantially concentrically with respect to the mouth and provided with a mechanism for fixing the sleeve on the container. A first outer sleeve is coaxially mounted over the sleeve and a second outer sleeve separate from the first outer sleeve and substantially tight fit with a container closure member. The first and second outer sleeves are axially aligned and have respective initially adjacent portions. A mechanism is provided for spacing apart the initially adjacent portions of the first and second outer sleeves upon reclosure of the assembly after an initial opening of the container.