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    Treatment and warning of recurring therapy and other events using an implantable device
    52.
    发明申请
    Treatment and warning of recurring therapy and other events using an implantable device 有权
    使用植入式装置对复发性治疗和其他事件进行治疗和警告

    公开(公告)号：US20080021514A1

    公开(公告)日：2008-01-24

    申请号：US11490818

    申请日：2006-07-21

    申请人： Benjamin D. Pless

    发明人： Benjamin D. Pless

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36082 ,  A61B5/04001 ,  A61B5/04004 ,  A61B5/0476 ,  A61B5/4094 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0539

    摘要： An implantable neurostimulator system is capable of responsively treating epileptiform activity with electrical stimulation and other therapies and is further configured to detect periods of increased susceptibility to clinical seizures. The event densities of therapy applications (or detections or other events) in time are observed and calculated, and if high enough, measures are taken to warn the patient or provide additional therapy.

    摘要翻译： 可植入式神经刺激器系统能够通过电刺激和其它治疗来响应性地治疗癫痫样活性，并且还被配置为检测对临床发作敏感性增加的时期。 观察和计算治疗应用（或检测或其他事件）的事件密度，如果足够高，采取措施来警告患者或提供额外的治疗。

    Electrical stimulation strategies to reduce the incidence of seizures
    53.
    发明授权
    Electrical stimulation strategies to reduce the incidence of seizures 有权
    电刺激策略，以减少癫痫发作

    公开(公告)号：US07174213B2

    公开(公告)日：2007-02-06

    申请号：US09952871

    申请日：2001-09-11

    申请人： Benjamin D. Pless

    发明人： Benjamin D. Pless

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36064

    摘要： An implantable multimodal neurostimulator having improved efficacy in treating epilepsy and other neurological disorders and processes of using that neurostimulator are described herein. The neurostimulator itself generally has two modes of electrical stimulation. The first involves delivering a non-responsive electrical stimulation signal that is applied to the central nervous system to reduce the likelihood of a seizure or other undesirable neurological even from occurring. Various waveform morphologies are described for non-responsive stimulation signals. A second mode involves delivering a responsive electrical stimulation signal when epileptiform waveforms are impending or extant. The responsive electrical stimulation signal is intended to terminate epileptiform activity, e.g., to desynchronize abnormally synchronous brain electrical activity.

    摘要翻译： 本文描述了具有改善的治疗癫痫和其它神经障碍的功效的植入式多模式神经刺激器和使用该神经刺激器的过程。 神经刺激器本身通常具有两种电刺激模式。 第一个涉及提供应用于中枢神经系统的无反应性电刺激信号，以减少甚至发生癫痫发作或其他不希望的神经系统的可能性。 描述了用于无响应刺激信号的各种波形形态。 第二模式涉及当癫痫样波形即将到来或现存时递送响应电刺激信号。 响应性电刺激信号旨在终止癫痫样活动，例如使异常同步的脑电活动失步。

    Ferrule for cranial implant
    54.
    发明授权
    Ferrule for cranial implant 有权
    用于颅骨植入物的套圈

    公开(公告)号：US07158833B2

    公开(公告)日：2007-01-02

    申请号：US10639842

    申请日：2003-08-12

    申请人： Benjamin D. Pless ,  Dennis Potts

    发明人： Benjamin D. Pless ,  Dennis Potts

    IPC分类号： A61N1/36

    CPC分类号： A61N1/375 ,  A61B2090/103 ,  A61M39/0247 ,  A61N1/0539

    摘要： A ferrule for removably retaining a self-contained implantable device within a cranial opening of a patient is set forth. The ferrule includes a shelf portion, a wall portion, and at least one supporting tab connected to the wall portion. The shelf portion has an inner surface and an outer surface. The inner surface of the shelf portion substantially conforms to an implantable device. The wall portion has an inner surface and an outer surface and encompasses the shelf portion. The inner surface of the wall portion substantially conforms to the implantable device and the outer surface of the wall portion substantially conforms to the cranial opening.

    摘要翻译： 阐述了用于可拆卸地将自包含可植入装置保持在患者的颅内开口内的套圈。 套圈包括搁板部分，壁部分和连接到壁部分的至少一个支撑片。 搁板部分具有内表面和外表面。 搁板部分的内表面基本上符合可植入装置。 壁部具有内表面和外表面并且包围搁板部分。 壁部分的内表面基本上符合可植入装置，并且壁部分的外表面基本上符合头开口。

    Implantable defibrillation electrode system
    56.
    发明授权
    Implantable defibrillation electrode system 失效
    植入式除颤电极系统

    公开(公告)号：US5176135A

    公开(公告)日：1993-01-05

    申请号：US793325

    申请日：1991-11-15

    申请人： Eric S. Fain ,  Thomas J. Fogarty ,  Benjamin D. Pless

    发明人： Eric S. Fain ,  Thomas J. Fogarty ,  Benjamin D. Pless

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0587

    摘要： An electrode system is provided for an implantable cardiac defibrillator. The electrode system includes a first endocardial lead having at least one electrode and a second epicardial or extrapericardial lead with an electrode that has a flexible configuration such that it is able to be straightened or compressed into an introducer but will expand when released from the introducer to provide a substantially larger surface area simulating the surface area of a patch electrode.

    摘要翻译： 为可植入心脏除颤器提供电极系统。 电极系统包括具有至少一个电极的第一心内膜引线和具有电极的第二心外膜或心包外引线，该电极具有柔性构造，使得其能够被拉直或压缩成导引器，但是当从引导器释放到扩张器时会膨胀 提供模拟贴片电极的表面积的基本更大的表面积。

    Implantable cardiac defibrillator with current leakage detecting means
    57.
    发明授权
    Implantable cardiac defibrillator with current leakage detecting means 失效
    具有电流泄漏检测手段的可植入式心脏除颤器

    公开(公告)号：US5163428A

    公开(公告)日：1992-11-17

    申请号：US597204

    申请日：1990-10-11

    申请人： Benjamin D. Pless

    发明人： Benjamin D. Pless

    IPC分类号： A61N1/37 ,  A61N1/39

    CPC分类号： A61N1/3931 ,  A61N1/37 ,  A61N1/3937 ,  A61N1/3981 ,  Y10S128/908

    摘要： An implantable cardiac deibrillator is provided having a battery, capacitive means, means coupled to the battery for charging the capacitive means, and means for coupling the capacitive means to a patient's heart, for delivering a high voltage shock to the heart. Current leakage from the capacitive means is detected. If the current leakage exceeds a predetermined amount, charging of the capacitive means is terminated. In one embodiment, voltage at the patient is directly sensed. In another embodiment, the voltage across a resistance located in series with the patient is sensed. In another embodiment, a test charge is provided for a short interval. The capacitive means is sensed to determine excessive loss of energy after the test charge. If excessive loss of energy is determined, charging is terminated.

    Pacemaker lead with enhanced sensitivity
    58.
    发明授权
    Pacemaker lead with enhanced sensitivity 失效
    起搏器引导增强灵敏度

    公开(公告)号：US4662382A

    公开(公告)日：1987-05-05

    申请号：US692352

    申请日：1985-01-16

    申请人： James E. Sluetz ,  Benjamin D. Pless ,  Paul R. Spehr

    发明人： James E. Sluetz ,  Benjamin D. Pless ,  Paul R. Spehr

    IPC分类号： A61N1/372 ,  A61N1/05 ,  A61N1/04

    CPC分类号： A61N1/0565

    摘要： A cardiac pacemaker lead has a structure which provides an enhanced sensitivity to atrial P-waves. The distal end of the lead has two sensing electrodes disposed thereon to contact atrial cardiac tissue and to detect near field P-waves with greater sensitivity than far field R-waves.

    摘要翻译： 心脏起搏器引线具有提供对心房P波的增强灵敏度的结构。 引线的远端具有设置在其上的两个感测电极，以接触心房心脏组织并且检测比远场R波具有更大灵敏度的近场P波。