公开(公告)号：US08454812B2

公开(公告)日：2013-06-04

申请号：US11819191

申请日：2007-06-26

申请人： Miho Ozawa ,  Ryoji Inaba

发明人： Miho Ozawa ,  Ryoji Inaba

IPC分类号： G01N27/447

CPC分类号： G01N27/447 ,  G01N27/44743

摘要： A capillary electrophoresis apparatus capable of efficiently using a polymer in a polymer container is provided. The present invention relates to a mechanism for efficiently using the polymer in the polymer container in a capillary electrophoresis apparatus for the electrophoresis with a separation medium filled in a capillary. According to the present invention, since the polymer in the polymer container is not contacted with the air, deterioration of the polymer by oxidation can be prevented.

摘要翻译： 提供能够有效地使用聚合物容器中的聚合物的毛细管电泳装置。 本发明涉及一种用于在毛细管电泳装置中聚合物容器中有效地使用该聚合物的装置，该装置用于填充毛细管中的分离介质进行电泳。 根据本发明，由于聚合物容器中的聚合物不与空气接触，因此可以防止聚合物通过氧化而劣化。

公开(公告)号：USD681233S1

公开(公告)日：2013-04-30

申请号：US29390328

申请日：2011-04-22

申请人： Richard Thomas ,  Laurence Trigg ,  Mitsuru Oonuma ,  Jin Matsumura ,  Ryoji Inaba

设计人： Richard Thomas ,  Laurence Trigg ,  Mitsuru Oonuma ,  Jin Matsumura ,  Ryoji Inaba

公开(公告)号：US08349161B2

公开(公告)日：2013-01-08

申请号：US13263304

申请日：2010-04-06

申请人： Takashi Gomi ,  Ryoji Inaba ,  Taro Nakazawa ,  Takeshi Ohura ,  Mari Kotoura

发明人： Takashi Gomi ,  Ryoji Inaba ,  Taro Nakazawa ,  Takeshi Ohura ,  Mari Kotoura

IPC分类号： G01N27/453

CPC分类号： F04B19/006 ,  B01D57/02 ,  G01N27/44704

摘要： Bubbles can be removed regardless of an individual difference of a pump to fill an electrophoresis medium into a capillary. Of flow passages formed between an inner side surface of a container for accommodating the electrophoresis medium and a side surface of a plunger, one of the flow passages causing an electrophoresis medium to be easily stagnant is formed to have the cross-sectional area larger than the cross-sectional area of the other flow passage on the opposite side. In other words, the flow passage portion causing the electrophoresis medium to be easily stagnant is formed in such a manner as to increase a flow amount of the electrophoresis medium. This can eliminate a region having an extremely small amount of electrophoresis medium flow in the pump.

摘要翻译： 不管泵的个体差异，将电泳介质填充到毛细管中，都可以去除气泡。 在容纳电泳介质的容器的内侧面和柱塞的侧面之间形成的流路之间形成有使电泳介质容易停滞的流路之一，其横截面积大于 另一个流动通道的相对侧的横截面面积。 换句话说，导致电泳介质容易停滞的流通部分以增加电泳介质的流量的方式形成。 这可以消除在泵中具有极少量的电泳介质流动的区域。

公开(公告)号：US20120329143A1

公开(公告)日：2012-12-27

申请号：US13532308

申请日：2012-06-25

申请人： Motohiro Yamazaki ,  Ryoji Inaba ,  Shuhei Yamamoto ,  Takuya Matsui ,  Kohshi Maeda ,  Yuichiro Ota ,  Hiroyuki Higashino

发明人： Motohiro Yamazaki ,  Ryoji Inaba ,  Shuhei Yamamoto ,  Takuya Matsui ,  Kohshi Maeda ,  Yuichiro Ota ,  Hiroyuki Higashino

IPC分类号： C12M1/34 ,  G01N21/64 ,  B01L3/00

CPC分类号： B01L3/527 ,  B01L3/523 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/045 ,  B01L2300/1894

摘要： A chilled reagent container comprises a reagent vessel containing part for containing therein a plurality of reagent vessels, a container lid including a container lid hole through which the reagent vessels contained by the reagent vessel containing part are accessible, anda cooling block for cooling the reagent vessels contained by the reagent vessel containing part, wherein the container lid slides to be changeable between an opened situation wherein the reagent is accessible from an outside and a closed situation wherein the reagent is prevented from being accessed from the outside, wherein the chilled reagent container further comprises a reagent container packing including another hole through which the reagent vessels are accessible and arranged between the container lid and the reagent vessel containing part to be pressed against the container lid.

摘要翻译： 冷冻试剂容器包括含有多个试剂容器的试剂容器的容纳部，容器盖，其具有可容纳由试剂容器容纳部容纳的试剂容器的容器盖孔，以及用于冷却试剂的冷却块 所述试剂容器容纳部所容纳的容器，其中所述容器盖滑动，其中所述试剂可从外部进入的打开状态和所述试剂被阻止从外部进入的封闭状态之间变化，其中所述冷冻试剂容器 还包括试剂容器填料，其包括另一孔，试剂容器可通过所述孔容纳在容器盖和待压靠在容器盖上的试剂容器容纳部分之间。

公开(公告)号：US20120248334A1

公开(公告)日：2012-10-04

申请号：US13339169

申请日：2011-12-28

申请人： Richard T. Reel ,  Eric S. Nordman ,  Tomoyuki Sakai ,  Satoshi Takahashi ,  Ryoji Inaba

发明人： Richard T. Reel ,  Eric S. Nordman ,  Tomoyuki Sakai ,  Satoshi Takahashi ,  Ryoji Inaba

IPC分类号： G01N21/64 ,  F21V33/00 ,  F21V13/04

CPC分类号： G01N21/64 ,  F21V5/00 ,  G01N21/645 ,  G01N27/44721 ,  G01N2021/6463 ,  G01N2201/068 ,  Y10T436/143333

摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.

摘要翻译： 用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

公开(公告)号：US20080302665A1

公开(公告)日：2008-12-11

申请号：US12189629

申请日：2008-08-11

申请人： Syozo Kasai ,  Takayasu Furukawa ,  Ryoji Inaba ,  Daiki Numai ,  Tomoyuki Tobita

发明人： Syozo Kasai ,  Takayasu Furukawa ,  Ryoji Inaba ,  Daiki Numai ,  Tomoyuki Tobita

IPC分类号： G01N27/26 ,  B29C65/52

CPC分类号： B01L7/00 ,  B01L3/5025 ,  B01L2300/0838 ,  B01L2300/1805 ,  B01L2300/1894 ,  B01L2400/0421 ,  G01N27/44726

摘要： An electrophoresis analysis method and apparatus capable of maintaining high reliability upon a repeated use of the same gel. A heat transfer medium selected from the group consisting of solids, liquids and gels is filled in substantially all of the gaps between the electrode and each capillary. A hollow electrode into which a capillary is inserted has a plurality of retaining shapes such that the capillary can be fixed at the center of the electrode. The heat from the capillary can be efficiently dissipated via the electrode, and also the temperature increase in the capillary can be prevented. Further, temperature increases due to the heating of the capillaries during operation can be controlled and thereby thermal deterioration of the gel can be prevented.

摘要翻译： 一种能够在重复使用相同凝胶时保持高可靠性的电泳分析方法和装置。 选自固体，液体和凝胶的传热介质填充在电极和每个毛细管之间的基本上所有的间隙中。 插入有毛细管的中空电极具有多个保持形状，使得毛细管可以固定在电极的中心。 可以通过电极有效地消耗来自毛细管的热量，并且可以防止毛细管中的温度升高。 此外，可以控制由于操作期间毛细管的加热引起的温度升高，从而可以防止凝胶的热劣化。

公开(公告)号：US06808610B2

公开(公告)日：2004-10-26

申请号：US09815329

申请日：2001-03-23

申请人： Ryoji Inaba ,  Satoshi Takahashi ,  Miho Ozawa ,  Yoshitaka Kodama

发明人： Ryoji Inaba ,  Satoshi Takahashi ,  Miho Ozawa ,  Yoshitaka Kodama

IPC分类号： G01N27447

CPC分类号： G01N27/44721 ,  G01N27/44782

摘要： When irradiating laser beam from the side face of the capillary array, an optical axis of the laser beam is inclined in vertical direction with respect to a plane face formed by the capillary array, thus, reflection light by the capillary array and returning light is prevented from entering into a laser beam source, thereby, instability of laser oscillation is eliminated.

摘要翻译： 当从毛细管阵列的侧面照射激光束时，激光束的光轴相对于由毛细管阵列形成的平面在垂直方向上倾斜，因此防止了毛细管阵列的反射光和返回光 从而进入激光束源，消除了激光振荡的不稳定性。

公开(公告)号：US09523124B2

公开(公告)日：2016-12-20

申请号：US13996638

申请日：2011-12-13

申请人： Masatoshi Narahara ,  Taro Nakazawa ,  Ryoji Inaba

发明人： Masatoshi Narahara ,  Taro Nakazawa ,  Ryoji Inaba

IPC分类号： C12Q1/68 ,  B01L3/00

CPC分类号： C12Q1/6869 ,  B01J2219/00286 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01L3/5027 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0877 ,  B01L2300/0887

摘要： Sample nucleic acids are prevented from removing from a sample-immobilizing layer during a sequencing reaction. A reaction device for nucleic acid analysis is provided that enables high throughput analysis by increasing the number of nucleic acid samples that can be analyzed. The reaction device for nucleic acid analysis comprises a substrate, a sample-immobilizing layer on the substrate, nucleic acid samples or carriers having nucleic acid samples on their surfaces, which are immobilized on the sample-immobilizing layer, and a blocking layer that covers areas other than areas where the nucleic acid samples or the carriers are bound to the sample-immobilizing layer, wherein the immobilizing layer is formed of an inorganic oxide.

摘要翻译： 在测序反应期间，防止样品核酸从样品固定层中除去。 提供了用于核酸分析的反应装置，其通过增加可分析的核酸样品的数量来实现高通量分析。 用于核酸分析的反应装置包括底物，底物上的样品固定层，其表面上具有固定在样品固定层上的核酸样品的核酸样品或载体，以及覆盖区域的阻挡层 除了核酸样品或载体与样品固定层结合的区域以外，其中固定层由无机氧化物形成。

公开(公告)号：US20130316336A1

公开(公告)日：2013-11-28

申请号：US13983340

申请日：2012-01-13

申请人： Takuya Matsui ,  Ryoji Inaba ,  Kazumichi Imai ,  Ryusuke Kimura

发明人： Takuya Matsui ,  Ryoji Inaba ,  Kazumichi Imai ,  Ryusuke Kimura

IPC分类号： C12Q1/68

CPC分类号： B01L3/502 ,  B01L3/0224 ,  B01L2300/026 ,  B01L2400/0406 ,  C12Q1/6869 ,  G01N35/0098 ,  G01N35/1002 ,  G01N35/1004 ,  G01N35/1095 ,  G01N2035/1039

摘要： Provided is an analyzer capable of reducing the amount of wasted reagents and shortening time required for solution sending, thus increasing throughput for analysis. A microsyringe sucks a minimum required amount of reagent that is substantially the same amount of capacity of a flow cell to a sampling nozzle. Then, the sampling nozzle is inserted into an injection port of the flow cell, and the reagent is injected into the flow cell by driving the microsyringe. The inside of the sampling nozzle is cleaned by moving the sampling nozzle to the cleaning tank and ejecting cleaning water from the sampling nozzle, and the outside of the sampling nozzle is cleaned by spraying cleaning water from an inner wall of the cleaning tank.

摘要翻译： 提供了能够减少试剂浪费量和溶液发送所需时间缩短的分析装置，从而提高分析用量。 微量注射器将最小所需量的试剂吸收到与采样喷嘴相当的流动池的容量基本上相同的量。 然后，将取样喷嘴插入流通池的注入口，通过驱动微量注射器将试剂注入到流通池中。 通过将采样喷嘴移动到清洗槽并从采样喷嘴喷射清洗水来清洁采样喷嘴的内部，并且通过从清洗槽的内壁喷射清洁水来清洁采样喷嘴的外部。

公开(公告)号：US20130084629A1

公开(公告)日：2013-04-04

申请号：US13696962

申请日：2011-04-20

申请人： Taro Nakazawa ,  Masatoshi Narahara ,  Ryoji Inaba ,  Yoshihiro Nagaoka ,  Shigenori Togashi

发明人： Taro Nakazawa ,  Masatoshi Narahara ,  Ryoji Inaba ,  Yoshihiro Nagaoka ,  Shigenori Togashi

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6844 ,  B01L3/502746 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2400/086 ,  G01N27/447 ,  G01N35/1095

摘要： A nucleic acid analysis reaction cell and a nucleic acid analyzer are provided, in which a uniform flow rate is realised, so that a portion where a flow rate is low is removed and washing time for reagent removal is shortened.A flow path (103) is provided which includes a detection area (108) for detecting sequence information of a nucleic acid fragment and detection outer areas (107) disposed at both ends of the detection area (108). An inflow port (105) is provided in one of the detection outer areas (107) and a discharge port (106) is provided in the other of the detection outer areas (107). The detection outer areas (107) disposed at both the ends of the detection area (108) are areas whose widths become narrow toward ends, and guides (104) for branching a liquid are provided in at least the detection outer area (107) in which the inflow port (105) is provided.

摘要翻译： 提供了一种核酸分析反应池和核酸分析仪，其中实现了均匀的流速，从而消除了流速低的部分，缩短了除去试剂的洗涤时间。 提供了一种流路（103），其包括用于检测核酸片段的序列信息的检测区域（108）和设置在检测区域（108）两端的检测外部区域（107）。 在一个检测外部区域（107）中设置有流入口（105），并且在另一个检测外部区域（107）中设置有排出口（106）。 设置在检测区域（108）的两端的检测外部区域（107）是宽度朝向端部变窄的区域，并且至少在检测外部区域（107）中设置用于分支液体的引导件（104） 其中设置有流入口（105）。