公开(公告)号：US11752236B2

公开(公告)日：2023-09-12

申请号：US17759760

申请日：2021-01-04

Applicant: University of Florida Research Foundation, Inc.

Inventor： Josephine F. Esquivel-Upshaw ,  Arthur E. Clark ,  Fan Ren ,  Samira Afonso Camargo

IPC: A61L27/30 ,  A61L27/04 ,  A61L27/10 ,  A61L27/54 ,  A61L31/08

CPC classification number: A61L27/306 ,  A61L27/04 ,  A61L27/10 ,  A61L27/54 ,  A61L31/08 ,  A61L2300/404 ,  A61L2430/12 ,  A61L2430/24

Abstract: In one aspect, the disclosure relates to protective, anti-bacterial coatings for medical implants and methods of making the same. Also disclosed herein are methods for improving the anti-bacterial properties of a medical device coated with silicon carbide (SiC) or titanium nitride (TiN). Further disclosed herein are medical devices including an anti-microbial layer prepared by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11742570B2

公开(公告)日：2023-08-29

申请号：US17315964

申请日：2021-05-10

Applicant: University of Florida Research Foundation, Inc.

Inventor： Yong-Kyu Yoon ,  Seahee Hwangbo

IPC: H01Q1/52 ,  H01Q21/06 ,  H01Q9/04 ,  H01Q3/00

CPC classification number: H01Q1/523 ,  H01Q1/52 ,  H01Q3/00 ,  H01Q9/04 ,  H01Q9/0407 ,  H01Q21/06 ,  H01Q21/065

Abstract: Various examples are provided for meander line (ML) slots, which can be used for mutual coupling reduction. In one example, an antenna array includes first and second patch antenna elements disposed on a first side of a substrate, the first and second patch antenna elements separated by a gap. The antenna array can include a meander line (ML) slot formed in a ground plane disposed on a second side of the substrate. A plurality of ML slots can be aligned with the gap between the first and second patch antenna elements. In another example, a method includes forming first and second antenna elements on a first side of a substrate and forming a ML slot in a ground plane disposed on a second side of the substrate aligned with a gap between the first and second antenna elements.

公开(公告)号：US11731197B2

公开(公告)日：2023-08-22

申请号：US17694162

申请日：2022-03-14

Applicant: University of Florida Research Foundation, Inc.

Inventor： Wei David Wei ,  Yueming Zhai

IPC: B22F9/24 ,  B82Y5/00 ,  C22B11/00 ,  C30B7/14 ,  C30B29/66 ,  B22F1/054 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: B22F9/24 ,  B22F1/054 ,  B22F1/056 ,  B22F1/0553 ,  B82Y5/00 ,  C22B11/04 ,  C30B7/14 ,  C30B29/66 ,  B82Y30/00 ,  B82Y40/00

Abstract: In one aspect, the present disclosure pertains to methods of making various noble metal nanoprisms, e.g., gold nanoprisms. In various aspects, the methods can comprise incubating, under dark conditions, a growth solution comprising: (a) a plurality of gold seed structures; (b) a gold precursor, and (c) a photocatalytic intermediary, such that during the incubating step multiply-twinned gold seed structures in the growth solution are preferentially enlarged. The disclosed methods can comprise separating the multiply-twinned gold seed structures from the growth solution based upon the size of the gold seed structures to produce an enriched growth solution. In some aspects, the methods comprise irradiating the enriched growth solution to produce the gold nanoprisms. In some aspects, the disclosed nanoprisms comprise silver.

公开(公告)号：US11725068B2

公开(公告)日：2023-08-15

申请号：US17484693

申请日：2021-09-24

Applicant: University of Florida Research Foundation, Inc.

Inventor： Adam S. Veige

IPC: C08F8/04 ,  C08F38/00 ,  C08F2/06 ,  C08F4/22 ,  C08F138/00

CPC classification number: C08F38/00 ,  C08F2/06 ,  C08F4/22 ,  C08F8/04 ,  C08F138/00 ,  C08F2800/10 ,  C08F8/04 ,  C08F138/00 ,  C08F238/00 ,  C08F238/02 ,  C08F238/02 ,  C08F238/00 ,  C08F8/04 ,  C08F238/00 ,  C08F8/04 ,  C08F238/02

Abstract: Disclosed are saturated cyclic monopolymers derived from hexyne, octyne, nonyne, pentadecyne and saturated cyclic copolymers derived from acetylene and a second alkyne monomer that is hexyne, octyne, nonyne, or pentadecyne.

公开(公告)号：US11705527B2

公开(公告)日：2023-07-18

申请号：US16956029

申请日：2018-12-18

Applicant: University of Florida Research Foundation, Inc.

Inventor： Peng Jiang ,  Zhuxiao Gu ,  Ruwen Tan

IPC: H01L31/18 ,  G02B1/118 ,  H01L31/0216

CPC classification number: H01L31/02168 ,  G02B1/118 ,  H01L31/186

Abstract: Embodiments of the present disclosure provide for methods of making substrates having an (AR) antireflective layer, substrates having an antireflective layer, devices including a substrate having an antireflective layer, and the like. The AR layer can have a total specular reflection of less than 10% at a wavelength of about 400-800 nm, and a height of about 500-1000 nm.

公开(公告)号：US11689089B2

公开(公告)日：2023-06-27

申请号：US17719472

申请日：2022-04-13

Applicant: University of Florida Research Foundation, Inc.

Inventor： David Patrick Arnold ,  Shuo Cheng ,  Vinod Reddy Challa

IPC: H02K35/02 ,  H02J50/10 ,  H02J50/50 ,  H02K99/00 ,  H02N1/08 ,  H02J50/00 ,  H02J50/70 ,  H02J50/90 ,  H02J50/12

CPC classification number: H02K35/02 ,  H02J50/00 ,  H02J50/001 ,  H02J50/10 ,  H02J50/12 ,  H02J50/50 ,  H02J50/70 ,  H02J50/90 ,  H02K99/10 ,  H02N1/08

Abstract: Wireless power transmission (WPT) systems are provided. For example, the WPT system can use one or more power transmitting coils and a receiver for electromagnetically coupled wireless power transfer. The electrodynamic receiver can be in the form of an electrodynamic transducer where a magnet is allowed to oscillate near a receiving coil to induce a voltage in the receiving coil, a piezoelectric transducer where the magnet causes a vibrating structure with a piezoelectric layer to move, an electrostatic transducer where movement of the magnet causes a capacitor plate to move, or a combination thereof. An alternating magnetic field from the transmitting coil(s) excites the magnet in the receiver into mechanical resonance. The vibrating magnet then functions similar to an energy harvester to induce voltage/current on an internal coil, piezoelectric material, or variable capacitor. Embodiments utilize magnetic coupling and electromechanical resonance for safe, spatially distributed, low-frequency power delivery to portable devices.

公开(公告)号：US20230182202A1

公开(公告)日：2023-06-15

申请号：US17926510

申请日：2021-05-14

Applicant: University of Florida Research Foundation, Inc.

Inventor： Wei David WEI ,  Wenxiao GUO

IPC: B22F1/054 ,  B22F9/24 ,  B01J23/52 ,  B01J23/72 ,  B01J37/34 ,  B01J35/02

CPC classification number: B22F1/0553 ,  B01J23/52 ,  B01J23/72 ,  B01J35/026 ,  B01J37/344 ,  B22F9/24 ,  B22F2202/11 ,  B22F2301/10 ,  B22F2301/255 ,  B22F2304/054

Abstract: The present disclosure provides for metal nanoparticles, such as gold nanoparticles that have six pointed areas so that the metal nanoparticle resembles a six-pointed star. The distance from opposing points of the six-pointed star is about 400 to 480 nanometers. The present disclosure also provides for a method of making the nanoparticle, where in an aspect, the method is a light-driven synthesis.

公开(公告)号：US11666578B2

公开(公告)日：2023-06-06

申请号：US17053652

申请日：2019-05-07

Applicant: The Scripps Research Institute

Inventor： William R. Roush ,  Derek R. Duckett ,  Andrii Monastyrskyi

IPC: A61K31/5377

CPC classification number: A61K31/5377

Abstract: The invention provides compounds and methods of inhibiting a cyclin-dependent kinase, comprising contacting the cyclin-dependent kinase and an effective amount or concentration of a compound of formula (I) wherein variables are as defined herein. Compounds of formula (I) can be highly selective inhibitors of cyclin-dependent kinases such as CDK12/13, relative to other kinases such as casein kinases, such as CK1δ/ε. Compounds can be used in treatment of cancers, such as breast cancer, brain cancer and ovarian cancer.

公开(公告)号：US11654159B2

公开(公告)日：2023-05-23

申请号：US16092119

申请日：2017-04-06

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Maria A. Grant ,  Tatiana E. Salazar ,  Huisheng Xie

IPC: A61K35/28 ,  A61H39/00 ,  A61N1/20 ,  A61N1/36 ,  A61H39/08 ,  A61N1/05 ,  A61N1/18 ,  A61P29/00 ,  A61K9/00 ,  A61K38/19 ,  A61K38/20 ,  C12N5/0775

CPC classification number: A61K35/28 ,  A61H39/002 ,  A61H39/086 ,  A61K9/0019 ,  A61K38/193 ,  A61K38/20 ,  A61N1/0502 ,  A61N1/18 ,  A61N1/20 ,  A61N1/3616 ,  A61N1/36017 ,  A61P29/00 ,  C12N5/0665 ,  A61H2203/03 ,  C12N2529/00

Abstract: Stimulation using EA of LI-4, LI-11, GV-14 and GV-20 in humans, horses, and rodents results in mobilization of MSCs into systemic circulation. Methods are provided for increasing mesenchymal stem cells in the circulating blood of a mammal by contacting acupuncture points LI-4, LI-11, GV-14, and GV-20 of the mammal with a therapeutically effective amount of EA stimulation to mobilize MSCs into the circulating blood of the mammal. Methods for treating damaged tissue, specifically damaged tendons are also provided. Isolated mesenchymal stem cells made according to these methods, methods of isolated them, and stem cell banks that store them are also provided.

公开(公告)号：US11649234B2

公开(公告)日：2023-05-16

申请号：US17250203

申请日：2019-06-13

Applicant: The Scripps Research Institute

Inventor： Courtney Miller ,  Patrick R. Griffin ,  Theodore Mark Kamenecka ,  Gavin Rumbaugh ,  Matthew Surman ,  Steve Young ,  Steven Duddy ,  Laszlo Radnai

IPC: C07D471/04 ,  C07D471/14 ,  C07D495/14 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D471/14 ,  C07D495/14 ,  C07D519/00

Abstract: The invention can provide compounds, analogs of blebbistatin, effective and selective inhibitors of nonmuscle myosin II relative to cardiac myosin II. Compounds can be used in the method of treating a disease, disorder, or medical condition in a patient, comprising modulating myosin II ATPase, such as treatment of substance abuse relapse disorder, or of renal disease, cancer and metastasis, benign prostate hyperplasia, hemostasis or thrombosis, nerve injury including retinal damage, lung fibrosis, liver fibrosis, arthrofibrosis, wound healing, spinal cord injury, periodontitis, glaucoma and immune-related diseases including multiple sclerosis; or wherein the disease, disorder, or medical condition comprises addiction including abuse of or addiction to anything classified as a Substance-Related or Addictive Disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM), such as, but not limited to, cocaine, opioids, amphetamines, ethanol, cannabis/marijuana, nicotine, and activities including gambling Compounds are of general formula (I) with substituents as defined herein.