公开(公告)号：US20240302290A1

公开(公告)日：2024-09-12

申请号：US18591212

申请日：2024-02-29

Applicant: Carl Zeiss SMT GmbH

Inventor： Lutz BREKERBOHM ,  Ulrich MATEJKA

IPC: G01N21/95

CPC classification number: G01N21/95 ,  G01N2201/023

Abstract: A sensor arrangement for arrangement on a measurement chamber, wherein the sensor arrangement comprises: a sensor; an intake opening; an outlet; and a fluid connection between the intake opening and the outlet.

公开(公告)号：US11958048B2

公开(公告)日：2024-04-16

申请号：US17681802

申请日：2022-02-27

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Ryan Denomme ,  Lidija Malic ,  Daniel Brassard ,  Keith Morton ,  Teodor Veres

IPC: B01L3/00 ,  G01N21/552 ,  G01N33/543

CPC classification number: B01L3/502715 ,  B01L3/502746 ,  B01L3/502784 ,  B01L3/502792 ,  G01N21/554 ,  G01N33/54386 ,  B01L2300/0645 ,  B01L2300/0663 ,  G01N2201/023 ,  G01N2201/061

Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.

公开(公告)号：US20180172584A1

公开(公告)日：2018-06-21

申请号：US15833075

申请日：2017-12-06

Applicant: Hitachi, Ltd.

Inventor： Takuya KANBAYASHI ,  Shinichi TANIGUCHI ,  Akihiro NOJIMA ,  Yusuke KAGA

IPC: G01N21/53 ,  G01N21/01

CPC classification number: G01N21/534 ,  G01N21/01 ,  G01N21/1717 ,  G01N2021/1729 ,  G01N2201/023

Abstract: The invention optically analyzes a component in a sample having a material suspended. An optical analysis system that irradiates a liquid sample with light and analyzes a component of the sample using transmitted light transmitted through the sample includes a container accommodating the sample and an ultrasonic irradiation unit irradiating an ultrasonic wave for exciting the sample. The container includes a pair of light transmission wall portions between which the sample is disposed and which has light transmissivity, and one of the light transmission wall portions and the other of the light transmission wall portions are disposed to be separated from each other at a distance shorter than a wavelength of the ultrasonic wave.

公开(公告)号：US09739708B2

公开(公告)日：2017-08-22

申请号：US15290684

申请日：2016-10-11

Applicant: MKS Instruments, Inc. ,  Pason Systems Corp.

Inventor： Vidi A. Saptari

IPC: G01N21/3518 ,  G01N33/22 ,  G01N21/3504 ,  G01N21/05 ,  G01N21/31 ,  G01N21/359 ,  G01N21/35

CPC classification number: G01N21/3518 ,  G01N21/05 ,  G01N21/31 ,  G01N21/3504 ,  G01N21/359 ,  G01N33/225 ,  G01N2021/3536 ,  G01N2021/3595 ,  G01N2201/023

Abstract: Described herein is a spectroscopic system and method for measuring and monitoring the chemical composition and/or impurity content of a sample or sample stream using absorption light spectroscopy. Specifically, in certain embodiments, this invention relates to the use of sample pressure variation to alter the magnitude of the absorption spectrum (e.g., wavelength-dependent signal) received for the sample, thereby obviating the need for a reference or ‘zero’ sample. Rather than use a reference or ‘zero’ sample, embodiments described herein obtain a spectrum/signal from a sample-containing cell at both a first pressure and a second (different) pressure.

公开(公告)号：US20170030829A1

公开(公告)日：2017-02-02

申请号：US15290684

申请日：2016-10-11

Applicant: MKS Instruments, Inc. ,  Pason Systems Corp.

Inventor： Vidi A. Saptari

IPC: G01N21/3518 ,  G01N33/22

CPC classification number: G01N21/3518 ,  G01N21/05 ,  G01N21/31 ,  G01N21/3504 ,  G01N21/359 ,  G01N33/225 ,  G01N2021/3536 ,  G01N2021/3595 ,  G01N2201/023

Abstract: Described herein is a spectroscopic system and method for measuring and monitoring the chemical composition and/or impurity content of a sample or sample stream using absorption light spectroscopy. Specifically, in certain embodiments, this invention relates to the use of sample pressure variation to alter the magnitude of the absorption spectrum (e.g., wavelength-dependent signal) received for the sample, thereby obviating the need for a reference or ‘zero’ sample. Rather than use a reference or ‘zero’ sample, embodiments described herein obtain a spectrum/signal from a sample-containing cell at both a first pressure and a second (different) pressure.

Abstract translation: 本文描述的是使用吸收光谱测量和监测样品或样品流的化学成分和/或杂质含量的光谱系统和方法。 具体来说，在某些实施方案中，本发明涉及使用样品压力变化来改变为样品接收的吸收光谱的幅度（例如，依赖于波长的信号），从而避免了对参考或“零”样品的需要。 不是使用参考或“零”样本，本文所述的实施例在第一压力和第二（不同）压力下都从含样品的电池获得光谱/信号。

公开(公告)号：US20150346474A1

公开(公告)日：2015-12-03

申请号：US14727337

申请日：2015-06-01

Applicant: OLYMPUS CORPORATION

Inventor： Yoshihito IGUCHI

IPC: G02B21/00

CPC classification number: G01N21/6458 ,  G01N2201/023 ,  G02B21/0032 ,  G02B21/0048 ,  G02B21/0076

Abstract: An illumination apparatus used for fluorescence observation of a sample containing a fluorescent material by a microscope apparatus, comprising an excitation light emission unit that emits excitation light for exciting the fluorescent material contained in the sample. The excitation light emission unit illuminates at least a bleaching reduction illumination region around an observed region in which the sample is present.

Abstract translation: 一种用于通过显微镜装置对包含荧光材料的样品进行荧光观察的照明装置，包括：激发光发射单元，其发射用于激发包含在样品中的荧光材料的激发光。 激发光发射单元至少照射存在样品的观察区域周围的漂白还原照射区域。

公开(公告)号：US20150276590A1

公开(公告)日：2015-10-01

申请号：US14734895

申请日：2015-06-09

Applicant: Serguei Koulikov ,  Alexander Kachanov

Inventor： Serguei Koulikov ,  Alexander Kachanov

IPC: G01N21/39 ,  G01N21/59

CPC classification number: G01N21/39 ,  G01J3/4338 ,  G01N21/1702 ,  G01N21/59 ,  G01N21/61 ,  G01N29/2425 ,  G01N2021/1704 ,  G01N2201/023 ,  G01N2201/06113 ,  G01N2291/021

Abstract: Systems and methods for measuring the isotope ratio of one or more trace gases and/or components of gas mixtures such as different gas species present in a gas mixture. The system includes a resonant optical cavity having two or more mirrors and containing a gas, the cavity having a free spectral range that equals the difference between frequencies of two measured absorption lines of different gas species in the gas, or of two different isotopes, divided onto an integer number. The system also includes a continuous-wave tunable laser optically coupled with the resonant optical cavity, and a detector system for measuring an absorption of laser light by the gas in the cavity. The detector system includes one of a photo-detector configured to measure an intensity of the intra-cavity light or both a photo-acoustic sensor configured to measure photo-acoustic waves generated in the cavity and a photo-detector configured to measure an intensity of the intra-cavity light.

Abstract translation: 用于测量气体混合物中存在的气体混合物（例如不同气体物质）的一种或多种痕量气体和/或组分的同位素比的系统和方法。 该系统包括具有两个或更多个反射镜并且包含气体的谐振光学腔，空腔具有等于气体中不同气体种类或两个不同同位素的两个测量的吸收线的频率之间的差的自由光谱范围 到一个整数。 该系统还包括与谐振光腔光学耦合的连续波可调谐激光器，以及用于测量腔内的气体对激光的吸收的检测器系统。 检测器系统包括被配置为测量腔内光强度或被配置为测量在空腔中产生的光声波的光声传感器的光检测器和被配置为测量腔内光的强度的光检测器 腔内光。

公开(公告)号：US20150131093A1

公开(公告)日：2015-05-14

申请号：US14511842

申请日：2014-10-10

Applicant: Precisive, LLC

Inventor： Vidi A. Saptari

IPC: G01N21/31 ,  G01N21/05

CPC classification number: G01N21/3518 ,  G01N21/05 ,  G01N21/31 ,  G01N21/3504 ,  G01N21/359 ,  G01N33/225 ,  G01N2021/3536 ,  G01N2021/3595 ,  G01N2201/023

Abstract: Described herein is a spectroscopic system and method for measuring and monitoring the chemical composition and/or impurity content of a sample or sample stream using absorption light spectroscopy. Specifically, in certain embodiments, this invention relates to the use of sample pressure variation to alter the magnitude of the absorption spectrum (e.g., wavelength-dependent signal) received for the sample, thereby obviating the need for a reference or ‘zero’ sample. Rather than use a reference or ‘zero’ sample, embodiments described herein obtain a spectrum/signal from a sample-containing cell at both a first pressure and a second (different) pressure.

Abstract translation: 本文描述的是使用吸收光谱测量和监测样品或样品流的化学成分和/或杂质含量的光谱系统和方法。 具体来说，在某些实施方案中，本发明涉及使用样品压力变化来改变为样品接收的吸收光谱的幅度（例如，依赖于波长的信号），从而避免了对参考或“零”样品的需要。 不是使用参考或“零”样本，本文所述的实施例在第一压力和第二（不同）压力下都从含样品的电池获得光谱/信号。

公开(公告)号：US08785857B2

公开(公告)日：2014-07-22

申请号：US13242677

申请日：2011-09-23

Applicant: Christopher D. Starta ,  Robert E. Uber ,  Thomas Trautzsch ,  Frederick J. Schuler

Inventor： Christopher D. Starta ,  Robert E. Uber ,  Thomas Trautzsch ,  Frederick J. Schuler

IPC: G01J5/02

CPC classification number: G01N21/59 ,  G01N21/3151 ,  G01N21/3504 ,  G01N2201/023 ,  G01N2201/0636 ,  G01N2201/0662

Abstract: A closed path infrared sensor includes an enclosure, a first energy source within the enclosure, at least a second energy source within the enclosure, at least one detector system within the enclosure and a mirror system external to the enclosure and spaced from the enclosure. The mirror system reflects energy from the first energy source to the at least one detector system via a first analytical path and reflects energy from the second energy source to the at least one detector system via a second analytical path. Each of the first analytical path and the second analytical path are less than two feet in length.

Abstract translation: 封闭路径红外传感器包括外壳，外壳内的第一能量源，外壳内的至少第二能量源，外壳内的至少一个检测器系统和外壳外部与外壳隔开的反射镜系统。 反射镜系统经由第一分析路径将来自第一能量源的能量反射到至少一个检测器系统，并且经由第二分析路径将来自第二能量源的能量反射到至少一个检测器系统。 第一分析路径和第二分析路径中的每一条长度小于两英尺。

公开(公告)号：US20140192347A1

公开(公告)日：2014-07-10

申请号：US14156842

申请日：2014-01-16

Applicant: Serguei Koulikov ,  Alexander Kachanov

Inventor： Serguei Koulikov ,  Alexander Kachanov

IPC: G01N21/61

CPC classification number: G01N21/39 ,  G01J3/4338 ,  G01N21/1702 ,  G01N21/59 ,  G01N21/61 ,  G01N29/2425 ,  G01N2021/1704 ,  G01N2201/023 ,  G01N2201/06113 ,  G01N2291/021

Abstract: Systems and methods for measuring the isotope ratio of one or more trace gases and/or components of gas mixtures such as different gas species present in a gas mixture. The system includes a resonant optical cavity having two or more mirrors and containing a gas, the cavity having a free spectral range that equals the difference between frequencies of two measured absorption lines of different gas species in the gas, or of two different isotopes, divided onto an integer number. The system also includes a continuous-wave tunable laser optically coupled with the resonant optical cavity, and a detector system for measuring an absorption of laser light by the gas in the cavity. The detector system includes one of a photo-detector configured to measure an intensity of the intra-cavity light or both a photo-acoustic sensor configured to measure photo-acoustic waves generated in the cavity and a photo-detector configured to measure an intensity of the intra-cavity light.

Abstract translation: 用于测量气体混合物中存在的气体混合物（例如不同气体物质）的一种或多种痕量气体和/或组分的同位素比的系统和方法。 该系统包括具有两个或更多个反射镜并且包含气体的谐振光学腔，空腔具有等于气体中不同气体种类或两个不同同位素的两个测量的吸收线的频率之间的差的自由光谱范围 到一个整数。 该系统还包括与谐振光腔光学耦合的连续波可调谐激光器，以及用于测量腔内的气体对激光的吸收的检测器系统。 检测器系统包括被配置为测量腔内光强度或被配置为测量在空腔中产生的光声波的光声传感器的光检测器和被配置为测量腔内光的强度的光检测器 腔内光。