公开(公告)号：US20200096448A1

公开(公告)日：2020-03-26

申请号：US16609146

申请日：2018-04-06

申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

发明人： Arnold GILLNER ,  Nadine NOTTRODT ,  Martin WEHNER ,  Dominik RIESTER ,  Anke BURGER-KENTISCHER ,  Monika BACH ,  Eva BRAUCHLE ,  Katja SCHENKE-LAYLAND ,  Benjamin GREINER ,  Andreas PIPPOW ,  Phuong-Ha NGUYEN ,  Katharina HOFER-SCHMITZ

IPC分类号： G01N21/65 ,  G01N33/68 ,  G16B40/30

摘要： The invention relates to a method for providing a cell line having a desired target protein expression and to a device for selecting cell lines having a desired target protein expression.

公开(公告)号：US20200013482A1

公开(公告)日：2020-01-09

申请号：US16338445

申请日：2017-09-29

申请人： GUARDANT HEALTH, INC.

发明人： Marcin SIKORA

IPC分类号： G16B30/00 ,  G16B40/30 ,  G16B5/00

摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.

公开(公告)号：US20190284270A1

公开(公告)日：2019-09-19

申请号：US16394046

申请日：2019-04-25

申请人： Scipher Medicine Corporation

发明人： Keith J. Johnson ,  Susan Dina Ghiassian

IPC分类号： C07K16/24 ,  G16H50/30 ,  A61P19/02 ,  C12Q1/6827 ,  C12Q1/6851 ,  G16B20/20 ,  G16B40/30 ,  G16B45/00

摘要： Methods and systems for administering anti-TNF therapy to subjects who have been determined to display a gene expression response signature established to distinguish between responsive and non-responsive prior subjects who have received the anti-TNF therapy.

公开(公告)号：US20240355472A1

公开(公告)日：2024-10-24

申请号：US18604287

申请日：2024-03-13

申请人： H42 Inc.

发明人： Wim VAN CRIEKINGE ,  An Nijs ,  Johan Vandersmissen

IPC分类号： G16H50/20 ,  C12Q1/6834 ,  C12Q1/686 ,  G01N21/64 ,  G16B40/30 ,  G16H50/30

CPC分类号： G16H50/20 ,  C12Q1/6834 ,  C12Q1/686 ,  G01N21/6486 ,  G16B40/30 ,  G16H50/30 ,  C12Q2600/154

摘要： A variational autoencoder, comprising an encoder neural network and a decoder neural network, is configured to process a plurality of non-sequence altering change marker inputs, and to encode them in a non-sequence altering change latent space, which comprises respective feature embeddings that compress respective non-sequence altering change marker inputs in the plurality of non-sequence altering change marker inputs into a jointly Gaussian distribution. A method for predictive diagnosis of rheumatoid arthritis (RA) in a patient is also disclosed. Selected marker genes associated with patients having rheumatoid arthritis are formed by methods including deep learning analysis (e.g., via the variational autoencoder). A patient's blood products are assayed to detect the marker genes associated with rheumatoid arthritis. Selected marker genes include RCNA3, HDAC4, and SIPA1. The method may be extended to detect diseases different than or in addition to rheumatoid arthritis.

公开(公告)号：US12100482B2

公开(公告)日：2024-09-24

申请号：US18503392

申请日：2023-11-07

申请人： GUARDANT HEALTH, INC.

发明人： Darya Chudova ,  Helmy Eltoukhy ,  Stefanie Ann Ward Mortimer ,  Diana Abdueva

IPC分类号： G16B30/00 ,  C12Q1/6806 ,  C12Q1/6827 ,  G16B5/00 ,  G16B25/10 ,  G16B40/30

CPC分类号： G16B30/00 ,  C12Q1/6806 ,  C12Q1/6827 ,  G16B5/00 ,  G16B25/10 ,  G16B40/30 ,  C12Q2535/122 ,  C12Q2537/159

摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.

公开(公告)号：US12094573B2

公开(公告)日：2024-09-17

申请号：US18506734

申请日：2023-11-10

申请人： GUARDANT HEALTH, INC.

发明人： Darya Chudova ,  Helmy Eltoukhy ,  Stefanie Ann Ward Mortimer ,  Diana Abdueva

IPC分类号： G16B30/00 ,  C12Q1/6806 ,  C12Q1/6827 ,  G16B5/00 ,  G16B25/10 ,  G16B40/30

CPC分类号： G16B30/00 ,  C12Q1/6806 ,  C12Q1/6827 ,  G16B5/00 ,  G16B25/10 ,  G16B40/30 ,  C12Q2535/122 ,  C12Q2537/159

摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.

公开(公告)号：US12094571B2

公开(公告)日：2024-09-17

申请号：US17174310

申请日：2021-02-11

申请人： DHRISTI INC.

发明人： Parag Jain ,  Rajat Roy ,  Bijay Shankar Jaiswal

IPC分类号： G06N5/04 ,  G06N20/00 ,  G06T7/00 ,  G06T7/11 ,  G16B20/10 ,  G16B20/20 ,  G16B40/30 ,  G16H10/40 ,  G16H30/40 ,  G16H50/20 ,  A61B10/00

CPC分类号： G16B20/20 ,  G06N5/04 ,  G06N20/00 ,  G06T7/0012 ,  G06T7/11 ,  G16B20/10 ,  G16B40/30 ,  G16H10/40 ,  G16H30/40 ,  G16H50/20 ,  A61B10/0041 ,  G06T2207/20081 ,  G06T2207/30024 ,  G06T2207/30096 ,  G06T2207/30204

摘要： Methods and systems for identifying and quantifying molecular biomarkers and for predicting patient response to cancer therapy are provided. The disclosed methods and systems make use of artificial intelligence to capture morphometric changes from histopathology tissue that correlate with molecular changes. The system may analyze molecular markers which are predictive of tumor response and have no defined correlation with morphological features. The system may use artificial intelligence to correlate morphometric changes with critical gene modifications and molecular changes.

公开(公告)号：US20240290433A1

公开(公告)日：2024-08-29

申请号：US18653527

申请日：2024-05-02

申请人： Ohio State Innovation Foundation

发明人： Metin Nafi Gurcan ,  Caglar Senaras ,  Gerard Lozanski

IPC分类号： G16B40/30 ,  G01N33/50 ,  G06N3/045 ,  G06N3/088 ,  G06N20/20

CPC分类号： G16B40/30 ,  G01N33/5005 ,  G06N3/045 ,  G06N3/088 ,  G06N20/20

摘要： Disclosed herein are systems, methods and computer-program products to create synthetic immunohistochemistry (IHC) stained digital slides generated using artificial neural networks (ANNs). In some implementations, the created digital slides can be used as a ground truth to evaluate a method of analyzing IHC stained tissues.

公开(公告)号：US12044681B2

公开(公告)日：2024-07-23

申请号：US17372575

申请日：2021-07-12

申请人： MeMed Diagnostics Ltd.

发明人： Eran Eden ,  Kfir Oved ,  Assaf Cohen-Dotan ,  Roy Navon ,  Olga Boico ,  Gali Kronenfeld ,  Meital Paz ,  Ellen Bamberger

IPC分类号： C07K16/18 ,  C07K14/525 ,  C07K14/54 ,  C07K14/555 ,  C07K14/575 ,  C07K16/12 ,  C07K16/24 ,  C07K16/26 ,  C07K16/28 ,  G01N33/50 ,  G01N33/52 ,  G01N33/53 ,  G01N33/535 ,  G01N33/543 ,  G01N33/547 ,  G01N33/569 ,  G01N33/577 ,  G01N33/58 ,  G01N33/60 ,  G01N33/68 ,  G16B40/20 ,  G16B40/30 ,  G16B20/00 ,  G16B40/00

CPC分类号： G01N33/56911 ,  C07K14/525 ,  C07K14/5412 ,  C07K14/555 ,  C07K14/57527 ,  C07K16/12 ,  C07K16/18 ,  C07K16/241 ,  C07K16/248 ,  C07K16/249 ,  C07K16/26 ,  C07K16/2818 ,  C07K16/2875 ,  G01N33/5091 ,  G01N33/52 ,  G01N33/53 ,  G01N33/535 ,  G01N33/54306 ,  G01N33/547 ,  G01N33/577 ,  G01N33/581 ,  G01N33/582 ,  G01N33/60 ,  G01N33/6863 ,  G01N33/6869 ,  G01N33/6893 ,  G16B40/20 ,  G16B40/30 ,  G01N2333/525 ,  G01N2333/5412 ,  G01N2333/555 ,  G01N2333/5753 ,  G01N2333/585 ,  G01N2333/70578 ,  G01N2333/70596 ,  G01N2333/7155 ,  G01N2333/902 ,  G01N2333/916 ,  G01N2469/00 ,  G01N2800/122 ,  G01N2800/26 ,  G16B20/00 ,  G16B40/00

摘要： Methods of diagnosing infections are disclosed. In one embodiment, the method comprises measuring the amount of each of the polypeptides TRAIL, CRP, IP10 and at least one additional polypeptide selected from the group consisting of IL-6 and PCT.

公开(公告)号：US20240203533A1

公开(公告)日：2024-06-20

申请号：US18542377

申请日：2023-12-15

申请人： Ancestry.com DNA, LLC

发明人： Shiya Song ,  Neal Craig Varner ,  Ross E. Curtis ,  Brian Jerel Kerr ,  Kelly McCloy Becker ,  Brett Frederick Jorgensen ,  Bryce Damon Ririe ,  Michael Joseph Mulligan ,  Justin Matthew Robert Van Dyke ,  Michaela Black Bonkemeyer

IPC分类号： G16B45/00 ,  G16B40/20 ,  G16B40/30

CPC分类号： G16B45/00 ,  G16B40/20 ,  G16B40/30

摘要： A user may select one or more potential common ancestors with a DNA match to view the target individual's relationship with them. The process may include identifying, from a first genealogical profile of the target individual. A first individual has a first linkage that connects the target individual towards the selected potential common ancestor. The process may also include identifying, from a second genealogical profile of the DNA match, a second individual who has a second linkage that connects the DNA match towards the selected potential common ancestor. The process may further include connecting the first linkage and the second linkage with the selected potential common ancestor by adding one or more individuals whose profiles are retrieved from other searchable genealogical profiles stored in the online system. With the nodes and connections available, the process may generate a map of visual connections between the target individual and the DNA match.