公开(公告)号：US20160329113A1

公开(公告)日：2016-11-10

申请号：US15102169

申请日：2014-12-05

Applicant: STC.UNM

Inventor： Mohamed S. El-Genk

IPC: G21C15/12 ,  G21C3/06 ,  G21D3/04 ,  G21C1/32 ,  G21C3/32

CPC classification number: G21C15/12 ,  G21C1/322 ,  G21C3/06 ,  G21C3/32 ,  G21C5/20 ,  G21C11/00 ,  G21C13/02 ,  G21D3/04 ,  Y02E30/35

Abstract: The present invention provides a modular nuclear reactor system comprising a reactor pressure vessel having a lower section having a first wall and a second wall and an upper section having a first wall and a second wall. The reactor includes a chimney with an attached heat exchanger. First and second passageways create a circulation loop wherein heated heat transfer fluid circulates up from the reactor core, through the chimney, through an upper plenum and downwardly past the heat exchanger, into a lower plenum and back into the core.

Abstract translation: 本发明提供了一种模块式核反应堆系统，其包括反应堆压力容器，其具有具有第一壁和第二壁的下部，以及具有第一壁和第二壁的上部。 反应器包括具有附接的热交换器的烟囱。 第一和第二通道产生循环回路，其中加热的传热流体从反应堆堆芯向上循环通过烟囱，通过上部通风室，并向下通过热交换器，进入下部增压室并返回到芯中。

公开(公告)号：US09463255B1

公开(公告)日：2016-10-11

申请号：US13617042

申请日：2012-09-14

Applicant: Yubin Miao

Inventor： Yubin Miao

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/08

CPC classification number: A61K51/086 ,  A61K38/00 ,  A61K38/17 ,  A61K51/082 ,  C07K7/56

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue, suggesting favorable selective activity of compounds according to the present invention, which can be used as effective therapeutic agents against melanoma, including metastatic melanoma. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are useful to initiate therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic and therapeutic tools for a number of conditions and diseases states, especially melanoma.

Abstract translation: 本发明涉及用于成像癌症的新型非侵入性诊断工具/化合物，特别是黑素瘤，包括体内转移性黑素瘤。 本发明化合物在癌细胞和组织中表现出增强的摄取，表明根据本发明的化合物的有利选择性活性，其可以用作抗黑素瘤（包括转移性黑素瘤）的有效治疗剂。 根据本发明的化合物代表使用非侵入性分子成像技术在黑色素瘤的诊断和治疗中的进展，包括转移性黑素瘤。 本发明的新型探针可用于开始黑色素瘤的治疗以及监测患者对化疗治疗的反应以及用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。 根据本发明的化合物可用作许多病症和疾病状态的诊断和治疗工具，特别是黑素瘤。

公开(公告)号：US09352059B2

公开(公告)日：2016-05-31

申请号：US14093260

申请日：2013-11-29

Applicant: STC.UNM

Inventor： Jeffrey P. Norenberg

IPC: A61K51/00 ,  A61M36/14 ,  A61K31/4178 ,  G01N33/569 ,  A61K51/04

CPC classification number: A61K51/0453 ,  A61K31/4178 ,  A61K51/00 ,  A61K51/044 ,  A61K51/0497 ,  G01N33/569 ,  G01N2333/70525 ,  G01N2333/70553 ,  Y02A50/47 ,  Y02A50/481

Abstract: The present invention is directed to novel non-invasive diagnostic tools to diagnose numerous infectious disease states or conditions. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. This represents a quantum step forward in the diagnosis and staging of NHL using non-invasively molecular imaging techniques. This novel probe will also be useful to monitor patients response to therapeutic treatments and other interventions or therapies used in the treatment of these disease states or conditions. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states. Pharmaceutical compositions are also described.

Abstract translation: 本发明涉及用于诊断许多传染病状态或病症的新型非侵入性诊断工具。 本发明代表了本领域的显着进步，其目前依赖于组织活检以诊断这些疾病状态。 该新型成像探针能够检测感染的细胞以及组织。 这代表了使用非侵入性分子成像技术在NHL的诊断和分期中向前推进的量子进程。 这种新型探针也可用于监测患者治疗治疗和治疗这些疾病状态或病症的其他干预措施或疗法的反应。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。 还描述了药物组合物。

公开(公告)号：US09350977B1

公开(公告)日：2016-05-24

申请号：US14202915

申请日：2014-03-10

Applicant: Sudhakar Prasad

Inventor： Sudhakar Prasad

IPC: H04N13/02

CPC classification number: H04N13/204 ,  G02B21/36 ,  G02B27/0075

Abstract: An optical imaging system having an aperture comprised of a plurality of concentric annuli. The outer radius of each annulus is proportional to the square root of the number of annuli. Each annulus also having an azimuthally linearly increasing phase profile comprising for a given light wavelength.

Abstract translation: 一种光学成像系统，具有由多个同心圆环组成的孔。 每个环的外半径与环数的平方根成比例。 每个环也具有包括给定光波长的方位线性增加的相位分布。

公开(公告)号：US09275857B1

公开(公告)日：2016-03-01

申请号：US14090150

申请日：2013-11-26

Applicant: Stephen D. Hersee

Inventor： Stephen D. Hersee

IPC: H01L29/15 ,  H01L21/02 ,  H01L29/20

CPC classification number: H01L21/0254 ,  B82Y10/00 ,  H01L21/02439 ,  H01L21/02488 ,  H01L21/02516 ,  H01L21/02603 ,  H01L21/02609 ,  H01L21/02639 ,  H01L29/0676 ,  H01L29/2003 ,  H01L29/66439 ,  H01L29/66469 ,  H01L29/7787

Abstract: Various embodiments provide non-planar nanowires, nanowire arrays, and nanowire networks as well as methods of their formation and applications. The non-planar nanowires and their arrays can be formed in a controlled manner on surfaces having a non-planar orientation. In embodiments, two or more adjacent nanowires from different surfaces can grow to merge together forming one or more nanowire branches and thus forming a nanowire network. In embodiments, the non-planar nanowires and nanowire networks can be used for cantilever oscillation, switching and transistor actions.

Abstract translation: 各种实施例提供非平面纳米线，纳米线阵列和纳米线网络以及它们的形成和应用的方法。 非平面纳米线及其阵列可以以受控的方式形成在具有非平面取向的表面上。 在实施例中，来自不同表面的两个或更多个相邻的纳米线可以生长以合并在一起形成一个或多个纳米线分支，从而形成纳米线网络。 在实施例中，非平面纳米线和纳米线网络可用于悬臂振荡，开关和晶体管动作。

公开(公告)号：US09273305B1

公开(公告)日：2016-03-01

申请号：US13869799

申请日：2013-04-24

Applicant: Sandia Corporation ,  STC.UNM

Inventor： Bryan J. Kaehr ,  C. Jeffrey Brinker ,  Jason L. Townson

IPC: C12N11/14

CPC classification number: G01N1/2806 ,  C08K3/36 ,  C12N11/14 ,  G01N1/2853

Abstract: The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.

Abstract translation: 本发明涉及使用硅酸将生物材料（包括细胞结构）转化为无机材料以提供具有稳定结构和功能的生物复合材料（纳米材料）。 在本发明中，已经发现了稳定生物材料的结构和功能的手段，包括细胞，生物分子，肽，蛋白质（特别是酶），脂质，脂质囊泡，多糖，细胞骨架细丝，组织和器官与硅 酸，使得这些材料可以用作生物复合材料。 在许多情况下，这些材料保留其原始生物活性，并且可以在恶劣条件下使用，否则会破坏生物材料的完整性。 在某些情况下，这些生物材料可能长时间保持稳定，并在储存后重构，以将生物材料返回其原始形式。 此外，通过暴露整个细胞以形成CSCs，CSC可以起到提供独特的系统来研究否则不可用的酶或级联的酶。

公开(公告)号：US09267889B1

公开(公告)日：2016-02-23

申请号：US13651166

申请日：2012-10-12

Applicant: STC.UNM

Inventor： Mike Klopfer ,  Ravinder Jain

IPC: H01J61/00 ,  G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/648 ,  G01N21/6489 ,  G01N2021/6439

Abstract: Apparatus, systems, and methods using multi-shelled nanostructures can be used in a variety of applications. In various embodiments, a multi-shelled nanostructure can include one or more light-absorbing and light-emitting cores enclosed by a number of nanoshells. For a multi-shelled nanostructure having multiple conductive nanoshells, the nanoshells are separated from each other by a dielectric. Additional apparatus, systems, and methods are disclosed.

Abstract translation: 使用多层纳米结构的装置，系统和方法可用于各种应用中。 在各种实施方案中，多壳纳米结构可以包括由许多纳米壳包围的一个或多个光吸收和发光的核。 对于具有多个导电纳米壳的多壳纳米结构，纳米壳通过电介质彼此分离。 公开了附加装置，系统和方法。

公开(公告)号：US09242210B1

公开(公告)日：2016-01-26

申请号：US14215964

申请日：2014-03-17

Applicant: Ying-Bing Jiang ,  Joseph L. Cecchi ,  Susan Rempe ,  Yaqin Fu ,  C. Jeffrey Brinker

Inventor： Ying-Bing Jiang ,  Joseph L. Cecchi ,  Susan Rempe ,  Yaqin Fu ,  C. Jeffrey Brinker

IPC: C12N11/02 ,  C12N11/04 ,  B01D53/62

CPC classification number: B01D53/62 ,  B01D53/228 ,  B01D53/229 ,  B01D53/84 ,  B01D2255/804 ,  B01D2257/504 ,  Y02A50/2358 ,  Y02C10/02 ,  Y02C10/10

Abstract: An ultra-thin, catalyzed liquid transport medium-based membrane structure fabricated with a porous supporting substrate may be used for separating an object species such as a carbon dioxide object species. Carbon dioxide flux through this membrane structures may be several orders of magnitude higher than traditional polymer membranes with a high selectivity to carbon dioxide. Other gases such as molecular oxygen, molecular hydrogen, and other species including non-gaseous species, for example ionic materials, may be separated using variations to the membrane discussed.

Abstract translation: 用多孔支撑基底制造的超薄催化液体输送介质膜结构可用于分离物体物质如二氧化碳物体物质。 通过该膜结构的二氧化碳通量可以比具有高二氧化碳选择性的传统聚合物膜高几个数量级。 可以使用对所讨论的膜的变化来分离其它气体，例如分子氧，分子氢和包括非气态物质的其它物质，例如离子物质。

公开(公告)号：US20160000489A1

公开(公告)日：2016-01-07

申请号：US14854387

申请日：2015-09-15

Applicant: STC.UNM

Inventor： Paul E. Kaloostian

IPC: A61B17/86 ,  A61B17/70

CPC classification number: A61B17/864 ,  A61B17/68 ,  A61B17/7002 ,  A61B17/702 ,  A61B17/7035 ,  A61B17/7037 ,  A61B17/7098 ,  A61B17/80 ,  A61B17/8605 ,  A61B17/8615 ,  A61B17/8625 ,  A61B17/866 ,  A61B17/8685 ,  A61B17/8841 ,  A61B2017/00933 ,  A61B2017/00964 ,  A61F2/44 ,  A61F2002/2835 ,  A61F2002/30405 ,  A61F2002/3055 ,  A61F2002/30601 ,  A61F2002/30784 ,  A61F2002/30787 ,  A61F2310/00023 ,  A61F2310/00359 ,  A61F2310/00958 ,  A61F2310/0097

Abstract: Composite orthopedic devices that facilitate spine stabilization, such as: bone screws, rods, plates, interbodies, and corpectomy cages are disclosed. They are designed to provide both strength and load carrying capabilities, while increasing bio-integration of the devices with the surrounding bone tissue. They are constructed of composite layers of allograft and/or autograft bone and a structural material, such as titanium alloy or carbon/graphite fiber composite. Cannulations within the device are loaded with a mixture of stem cells, particles of allograft and/or autograft bone, and bone growth factors, such as BMP-2. The cannulations are connected to the surface of the device via multiple fenestrations that provide pathways to supply the bone/stem cell mixture to the surface, allowing living bone tissue to grow and insure bio-integration. The devices can also have radiofrequency (RF) stimulation implantation within the structure of the implanted device, capable of responding to external RF stimulation of enhanced bone growth.

Abstract translation: 公开了促进脊柱稳定的复合矫形装置，例如：骨螺钉，杆，板，中间体和椎骨切除术笼。 它们旨在提供强度和负载能力，同时增加设备与周围骨组织的生物整合。 它们由同种异体移植和/或自体骨的复合层和诸如钛合金或碳/石墨纤维复合材料的结构材料构成。 装置内的装置装载有干细胞，同种异体移植物和/或自体骨的颗粒和骨生长因子如BMP-2的混合物。 插管通过多个窗口连接到装置的表面，这些开窗提供将骨/干细胞混合物提供给表面的途径，允许活骨组织生长并确保生物整合。 该装置还可以在植入装置的结构内具有射频（RF）刺激植入，能够响应增强的骨生长的外部RF刺激。

公开(公告)号：US09156004B2

公开(公告)日：2015-10-13

申请号：US13831537

申请日：2013-03-14

Applicant: Steven R. J. Brueck ,  Deying Xia ,  Yuliya Kuznetsova ,  Alexander Neumann

Inventor： Steven R. J. Brueck ,  Deying Xia ,  Yuliya Kuznetsova ,  Alexander Neumann

IPC: B01D69/04 ,  G03F7/20 ,  B81C1/00 ,  B82Y30/00

CPC classification number: B01D69/04 ,  B81C1/00071 ,  B82Y30/00 ,  G03F7/2051 ,  Y10S977/78 ,  Y10S977/84 ,  Y10T137/0324 ,  Y10T137/3006

Abstract: In accordance with the invention, there is a method of forming a nanochannel including depositing a photosensitive film stack over a substrate and forming a pattern on the film stack using interferometric lithography. The method can further include depositing a plurality of silica nanoparticles to form a structure over the pattern and removing the pattern while retaining the structure formed by the plurality of silica nanoparticles, wherein the structure comprises an enclosed nanochannel.

Abstract translation: 根据本发明，存在一种形成纳米通道的方法，其包括在衬底上沉积感光膜堆叠并且使用干涉光刻在膜堆上形成图案。 该方法可以进一步包括沉积多个二氧化硅纳米颗粒以在图案上形成结构并除去图案，同时保留由多个二氧化硅纳米颗粒形成的结构，其中该结构包括封闭的纳米通道。