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    SYSTEM, METHOD, AND DEVICE FOR FORMING AN ARRAY OF EMULSIONS
    61.
    发明申请
    SYSTEM, METHOD, AND DEVICE FOR FORMING AN ARRAY OF EMULSIONS 有权

    公开(公告)号：US20220097068A1

    公开(公告)日：2022-03-31

    申请号：US17549163

    申请日：2021-12-13

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Thomas Henry CAULEY, III ,  John DZENITIS ,  Steve HOBBS ,  Stefano SCHIAFFINO

    IPC: B01L3/00 ,  G01N1/38 ,  B01F3/08 ,  B01F13/10

    Abstract: Systems, methods, and devices for forming an array of emulsions. An exemplary device comprises a frame and at least one or a plurality of separate microfluidic modules mounted to the frame and each configured to form an array of emulsions. In some embodiments, each module may be mounted by snap-fit attachment. The device also may include the same sealing member bonded to a top side of each module and hermetically sealing each of the modules. Another exemplary microfluidic device for forming an array of emulsions comprises a stack of layers bonded together. The stack may comprise a port layer forming a plurality of ports. Each port may have a top rim formed by a protrusion that encircles the central axis of the port. The rims may be coplanar with one another to facilitate bonding of a sealing member to each rim.

    Saturation avoidance in digital imaging
    64.
    发明授权
    Saturation avoidance in digital imaging 有权

    公开(公告)号：US11212454B2

    公开(公告)日：2021-12-28

    申请号：US16597665

    申请日：2019-10-09

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Michael Griffin ,  Stephen Swihart

    IPC: H04N5/235

    Abstract: A method of image capture helps avoid saturation in digital imaging. In one implementation, the method includes capturing a first digital image of a target using an electronic array light sensor, and identifying one or more saturated pixels in the first digital image. The method further includes identifying a region of interest in the first digital image, the region of interest encompassing the one or more identified saturated pixels. The method also includes capturing a second digital image of the target using the electronic array light sensor. The second digital image encompasses only the region of interest, and the second digital image is captured with a shorter exposure time than the first digital image. The first and second digital images may be combined into a high dynamic range image. Systems for digital imaging may be based on complementary metal oxide semiconductor (CMOS) or charge coupled device (CCD) sensors.

    SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS
    68.
    发明申请
    SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS 有权

    公开(公告)号：US20210283608A1

    公开(公告)日：2021-09-16

    申请号：US17333142

    申请日：2021-05-28

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Kalyan Handique ,  Vishal Sharma ,  Priyadarshini Gogoi ,  William Chow ,  Austin Payne ,  Kyle Gleason ,  Brian Boniface ,  John Connolly ,  Sam Tuck

    IPC: B01L3/00 ,  C12M1/00 ,  G01N33/574 ,  C12Q1/6816 ,  G01N33/543 ,  G01N33/569 ,  G01N15/14

    Abstract: A system and method for isolating and analyzing single cells, wherein the system includes: an array of wells defined at a substrate, each well including an open surface and a well cavity configured to capture cells in one of a single-cell format and single-cluster format, and a fluid delivery module including a fluid reservoir superior to the array of wells through which fluid flow is controlled along a fluid path in a direction parallel to the broad face of the substrate; and wherein the method includes: capturing a population of non-cell particles into the array of wells in single-particle format; releasing, from the non-cell particles, a set of probes into the array of wells; capturing a population of cells into the array of wells in single-cell format; releasing biomolecules from each captured cell into the array of wells; and generating a set of genetic complexes comprising the biomolecules associated with a single captured cell and a subset of probes within individual wells of the array of wells.

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