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    Multiplexed digital assay with data exclusion for calculation of target levels
    3.
    发明授权
    Multiplexed digital assay with data exclusion for calculation of target levels 有权
    用于计算目标水平的数据排除的多重数字化验

    公开(公告)号：US09523116B2

    公开(公告)日：2016-12-20

    申请号：US14171754

    申请日：2014-02-03

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Svilen S. Tzonev ,  Claudia Litterst

    IPC: C12Q1/68

    CPC classification number: C12Q1/6851 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2545/107

    Abstract: Digital assay system, including methods and apparatus, for calculating a level of one or more targets. In an exemplary method, data for amplification of a plurality of targets including a first target may be collected from partitions. A level of the first target may be calculated from only a subset of the data that excludes partitions according to target content.

    Abstract translation: 数字测定系统，包括用于计算一个或多个目标的水平的方法和装置。 在示例性方法中，可以从分区收集用于放大包括第一目标的多个目标的数据。 可以仅从根据目标内容排除分区的数据的子集计算第一目标的级别。

    MULTIPLEXED DIGITAL ASSAY FOR VARIANT AND NORMAL FORMS OF A GENE OF INTEREST
    8.
    发明申请
    MULTIPLEXED DIGITAL ASSAY FOR VARIANT AND NORMAL FORMS OF A GENE OF INTEREST 有权
    用于变异基因的变体和正常形式的多重数字测定

    公开(公告)号：US20140274799A1

    公开(公告)日：2014-09-18

    申请号：US14215516

    申请日：2014-03-17

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Ryan T. Koehler ,  Svilen S. Tzonev

    IPC: C12Q1/68

    CPC classification number: C12Q1/6886 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2600/156 ,  C12Q2535/125 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2563/159 ,  C12Q2537/16 ,  C12Q2545/101

    Abstract: System, including methods, apparatus, and compositions, for performing a multiplexed digital assay of at least three targets. In an exemplary method, partitions may be formed each including a portion of a same sample. The sample may include a first target that is a reference sequence, a second target that is a variant sequence from a gene of interest, and a third target that is a normal sequence from the gene of interest. The target may be amplified in the partitions and amplification data may be collected. A level of the second target may be determined. A copy number of the third target may be determined from a level of the first target and a level of the third target.

    Abstract translation: 用于执行至少三个目标的多路复用数字测定的系统，包括方法，装置和组合物。 在示例性方法中，可以形成每个包括相同样品的一部分的分隔。 样品可以包括作为参考序列的第一靶，作为来自目标基因的变体序列的第二靶，以及来自目的基因的正常序列的第三靶。 可以在分区中放大目标，并且可以收集放大数据。 可以确定第二目标的水平。 可以从第一目标的级别和第三目标的级别确定第三目标的副本号码。

    Multiplexed digital assay for variant and normal forms of a gene of interest
    10.
    发明授权
    Multiplexed digital assay for variant and normal forms of a gene of interest 有权
    用于感兴趣的基因的变体和正常形式的多重数字测定

    公开(公告)号：US09458511B2

    公开(公告)日：2016-10-04

    申请号：US14215516

    申请日：2014-03-17

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Ryan T. Koehler ,  Svilen S. Tzonev

    IPC: C12Q1/68 ,  C12P19/34

    CPC classification number: C12Q1/6886 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2600/156 ,  C12Q2535/125 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2563/159 ,  C12Q2537/16 ,  C12Q2545/101

    Abstract: System, including methods, apparatus, and compositions, for performing a multiplexed digital assay of at least three targets. In an exemplary method, partitions may be formed each including a portion of a same sample. The sample may include a first target that is a reference sequence, a second target that is a variant sequence from a gene of interest, and a third target that is a normal sequence from the gene of interest. The target may be amplified in the partitions and amplification data may be collected. A level of the second target may be determined. A copy number of the third target may be determined from a level of the first target and a level of the third target.

    Abstract translation: 用于执行至少三个目标的多路复用数字测定的系统，包括方法，装置和组合物。 在示例性方法中，可以形成每个包括相同样品的一部分的分隔。 样品可以包括作为参考序列的第一靶，作为来自目标基因的变体序列的第二靶，以及来自目的基因的正常序列的第三靶。 可以在分区中放大目标，并且可以收集放大数据。 可以确定第二目标的水平。 可以从第一目标的级别和第三目标的级别确定第三目标的副本号码。

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